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1. 发明授权

US08041240B2 Closed loop charge control to minimize low frequency charge non-uniformity 有权
标题翻译：闭环充电控制以最小化低频电荷的不均匀性
公开(公告)号：US08041240B2
公开(公告)日：2011-10-18
申请号：US12190335
申请日：2008-08-12
申请人： Moritz Patrick Wagner
发明人： Moritz Patrick Wagner
IPC分类号： G03G15/00
CPC分类号： G03G15/5037 , G03G15/0266
摘要： This is a system to improve final xerographic image by providing uniformity in both pre-imaged and imaged photoconductive drums or belts. An ESV is placed after the exposure imaging station so that it can measure the voltage on the photoreceptor (PR) belt or drum obtaining a periodic photoreceptor signature. This signature is communicated to a controller and stored therein. After both pre-imaged and imaged signatures are obtained, the controller compensates for these signatures to all imaging runs thereafter to ensure uniform voltage and thereby uniform final images.
摘要翻译：这是通过在预成像和成像的感光鼓或皮带中提供均匀性来改进最终静电复印图像的系统。将ESV放置在曝光成像站之后，使得其可以测量感光体（PR）带或滚筒上的电压，从而获得周期性感光体特征。该签名被传送到控制器并存储在其中。在获得预成像和成像签名之后，控制器补偿这些签名到其后的所有成像运行，以确保均匀的电压，从而使均匀的最终图像。

2. 发明授权

US09228970B2 Heat-transfer resistance based analysis bioparticles 有权
标题翻译：基于传热电阻的分析生物颗粒
公开(公告)号：US09228970B2
公开(公告)日：2016-01-05
申请号：US13991227
申请日：2011-11-25
申请人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner , Luc Michiels
发明人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner , Luc Michiels
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C12Q1/68 , C07H21/02 , C07H21/04 , G01N15/06 , G01N27/00 , G01N25/00 , G01N31/22 , G01N27/327 , G01N27/02 , B01L3/00 , G05B15/02
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for characterizing DNA and/or RNA duplexes. The biosensing device comprises a heating element using a power and being suitable for providing thermal denaturation of target DNA and/or RNA bioparticles, a sample holder adapted for receiving a biocompatible substrate having a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes can be attached, the sample holder further being adapted for exposing the biocompatible substrate at one side to the heating element, a first temperature sensing element for sensing a temperature at the side where the biocompatible substrate can be exposed to the heating element and a second temperature sensing element for sensing a temperature at the side opposite thereto with respect to the biocompatible substrate. The device also comprises a processing means programmed for calculating at least one heat transfer resistivity value based on temperature values obtained with the first temperature sensing element and the second temperature sensing element and the power for the heating element, for deriving a characteristic of the target DNA and/or RNA bioparticles from said heat transfer resistivity value.
摘要翻译：公开了用于表征DNA和/或RNA双链体的方法。生物传感装置包括使用功率并适合于提供靶DNA和/或RNA生物颗粒的热变性的加热元件，适于接收生物相容性底物的样品保持器，其具有涂覆有探针DNA和/或RNA的官能化表面，可以连接靶DNA和/或RNA双链体，样品保持器还适于将一侧的生物相容性基底暴露于加热元件，第一温度感测元件，用于感测生物相容性基底可以暴露于的一侧的温度加热元件和第二温度感测元件，用于感测与生物相容性基底相对的一侧的温度。该装置还包括一个处理装置，其被编程用于基于用第一温度感测元件和第二温度感测元件获得的温度值和加热元件的功率来计算至少一个传热电阻率值，用于导出靶DNA的特征和/或RNA生物颗粒从所述传热电阻率值。

3. 发明申请

US20130327656A1 Biosensor Using Impedimetric Real-Time Monitoring 有权
公开(公告)号：US20130327656A1
公开(公告)日：2013-12-12
申请号：US13991223
申请日：2011-11-25
申请人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner
发明人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner
IPC分类号： G01N27/02 , G01N27/327
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.

4. 发明授权

US08284455B2 Visual uniformity adjustment procedure using areas of different screen geometries and frequencies 有权
标题翻译：视觉均匀度调整程序使用不同屏幕几何和频率的区域
公开(公告)号：US08284455B2
公开(公告)日：2012-10-09
申请号：US12546077
申请日：2009-08-24
申请人： Moritz Patrick Wagner
发明人： Moritz Patrick Wagner
IPC分类号： G06T5/00 , H04N1/405 , G06K15/00
CPC分类号： H04N1/4078 , H04N1/00002 , H04N1/00015 , H04N1/00023 , H04N1/00031 , H04N1/00045 , H04N1/00053 , H04N1/00063 , H04N1/00076 , H04N1/00087 , H04N1/00413 , H04N2201/0006
摘要： A method for correcting at least one uniformity error selected from the group consisting of a process direction uniformity error and a cross-process direction uniformity error in an image printing system that prints on an image bearing surface movable in a process direction. The method includes printing on a media a test pattern that includes a plurality of segmented regions extending in the direction of the at least one uniformity error being corrected, receiving a correction data from the user, and adjusting a profile of the image printing system to correct for the at least one uniformity error based on the received correction data Each segmented region comprising a coarse halftone area and a fine halftone area adjacent one another. The resolution of the fine halftone area is at least about 1.5 times the resolution of the coarse halftone area.
摘要翻译：一种用于校正由图像打印系统中的过程方向均匀性误差和过程方向均匀性误差组成的组中选择的至少一个均匀性误差的方法，所述图像打印系统在可沿着处理方向移动的图像承载面上进行打印。该方法包括在介质上印刷测试图案，该测试图案包括在正被校正的至少一个均匀性误差的方向上延伸的多个分段区域，从用户接收校正数据，以及调整图像打印系统的轮廓以校正基于接收到的校正数据的至少一个均匀性误差。每个分段区域包括粗糙半色调区域和相邻的精细半色调区域。精细半色调区域的分辨率至少是粗糙半色调区域分辨率的约1.5倍。

5. 发明申请

US20110043865A1 VISUAL UNIFORMITY ADJUSTMENT PROCEDURE USING AREAS OF DIFFERENT SCREEN GEOMETRIES AND FREQUENCIES 有权
标题翻译：使用不同屏幕几何和频率的视觉均匀调整程序
公开(公告)号：US20110043865A1
公开(公告)日：2011-02-24
申请号：US12546077
申请日：2009-08-24
申请人： Moritz Patrick Wagner
发明人： Moritz Patrick Wagner
IPC分类号： G06T5/00
CPC分类号： H04N1/4078 , H04N1/00002 , H04N1/00015 , H04N1/00023 , H04N1/00031 , H04N1/00045 , H04N1/00053 , H04N1/00063 , H04N1/00076 , H04N1/00087 , H04N1/00413 , H04N2201/0006
摘要： A method for correcting at least one uniformity error selected from the group consisting of a process direction uniformity error and a cross-process direction uniformity error in an image printing system that prints on an image bearing surface movable in a process direction. The method includes printing on a media a test pattern that includes a plurality of segmented regions extending in the direction of the at least one uniformity error being corrected, receiving a correction data from the user, and adjusting a profile of the image printing system to correct for the at least one uniformity error based on the received correction data Each segmented region comprising a coarse halftone area and a fine halftone area adjacent one another. The resolution of the fine halftone area is at least about 1.5 times the resolution of the coarse halftone area.
摘要翻译：一种用于校正由图像打印系统中的过程方向均匀性误差和过程方向均匀性误差组成的组中选择的至少一个均匀性误差的方法，所述图像打印系统在可沿着处理方向移动的图像承载面上进行打印。该方法包括在介质上印刷测试图案，该测试图案包括在正被校正的至少一个均匀性误差的方向上延伸的多个分段区域，从用户接收校正数据，以及调整图像打印系统的轮廓以校正基于接收到的校正数据的至少一个均匀性误差。每个分段区域包括粗糙半色调区域和相邻的精细半色调区域。精细半色调区域的分辨率至少是粗糙半色调区域分辨率的约1.5倍。

6. 发明授权

US07410963B2 Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof 失效
标题翻译：苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶PDE2抑制剂，其制备和治疗用途
公开(公告)号：US07410963B2
公开(公告)日：2008-08-12
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： C07D243/24 , C07D413/04 , A61K31/5513
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译：本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。

7. 发明授权

US08932868B2 Biosensor using impedimetric real-time monitoring 有权
标题翻译：生物传感器采用阻抗实时监测
公开(公告)号：US08932868B2
公开(公告)日：2015-01-13
申请号：US13991223
申请日：2011-11-25
申请人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner
发明人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/68 , G01N27/02 , G01N27/327
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.
摘要翻译：公开了用于检测和/或分配靶DNA和/或RNA双链体中的至少一个点突变的方法。所述方法包括获得涂覆有靶DNA和/或RNA双链体的探针DNA和/或RNA的功能化表面，使所述功能化表面与流动池中具有中性pH的电解溶液接触并测量第一阻抗值在所述电解液中，然后向能够实现靶DNA和/或RNA变性的电解液中加入化学物质。该方法还包括在完成DNA和/或RNA靶变性后测量流动池内的第二阻抗值，然后获得代表该化学物质对电解溶液阻抗的影响的值。然后通过基于第一和第二阻抗值之间的差异计算变性 - 时间常数并考虑到化学品的影响来确定靶DNA和/或RNA内的点突变的量和/或分配通过第三阻抗值。

8. 发明申请

US20140011198A1 Heat-Transfer Resistance Based Analysis Bioparticles 有权
标题翻译：基于传热电阻的分析生物颗粒
公开(公告)号：US20140011198A1
公开(公告)日：2014-01-09
申请号：US13991227
申请日：2011-11-25
申请人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner , Luc Michiels
发明人： Bart Van Grinsven , Ward De Ceuninck , Patrick Wagner , Luc Michiels
IPC分类号： C12Q1/68
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for characterising DNA and/or RNA duplexes. The biosensing device comprises a heating element using a power and being suitable for providing thermal denaturation of target DNA and/or RNA bioparticles, a sample holder adapted for receiving a biocompatible substrate having a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes can be attached, the sample holder further being adapted for exposing the biocompatible substrate at one side to the heating element, a first temperature sensing element for sensing a temperature at the side where the biocompatible substrate can be exposed to the heating element and a second temperature sensing element for sensing a temperature at the side opposite thereto with respect to the biocompatible substrate. The device also comprises a processing means programmed for calculating at least one heat transfer resistivity value based on temperature values obtained with the first temperature sensing element and the second temperature sensing element and the power for the heating element, for deriving a characteristic of the target DNA and/or RNA bioparticles from said heat transfer resistivity value.
摘要翻译：公开了用于表征DNA和/或RNA双链体的方法。生物传感装置包括使用功率并适合于提供靶DNA和/或RNA生物颗粒的热变性的加热元件，适于接收生物相容性底物的样品保持器，其具有涂覆有探针DNA和/或RNA的官能化表面，可以连接靶DNA和/或RNA双链体，样品保持器还适于将一侧的生物相容性基底暴露于加热元件，第一温度感测元件，用于感测生物相容性基底可以暴露于的一侧的温度加热元件和第二温度感测元件，用于感测与生物相容性基底相对的一侧的温度。该装置还包括一个处理装置，其被编程用于基于用第一温度感测元件和第二温度感测元件获得的温度值和加热元件的功率来计算至少一个传热电阻率值，用于导出靶DNA的特征和/或RNA生物颗粒从所述传热电阻率值。

9. 发明申请

US20100040388A1 Closed Loop Charge Control to Minimize Low Frequency Charge Non-Uniformity 有权
标题翻译：闭环充电控制，以最大限度地降低低频充电不均匀性
公开(公告)号：US20100040388A1
公开(公告)日：2010-02-18
申请号：US12190335
申请日：2008-08-12
申请人： MORITZ PATRICK WAGNER
发明人： MORITZ PATRICK WAGNER
IPC分类号： G03G15/00
CPC分类号： G03G15/5037 , G03G15/0266
摘要： This is a system to improve final xerographic image by providing uniformity in both pre-imaged and imaged photoconductive drums or belts. An ESV is placed after the exposure imaging station so that it can measure the voltage on the photoreceptor (PR) belt or drum obtaining a periodic photoreceptor signature. This signature is communicated to a controller and stored therein. After both pre-imaged and imaged signatures are obtained, the controller compensates for these signatures to all imaging runs thereafter to ensure uniform voltage and thereby uniform final images.
摘要翻译：这是通过在预成像和成像的感光鼓或皮带中提供均匀性来改进最终静电复印图像的系统。将ESV放置在曝光成像站之后，使得其可以测量感光体（PR）带或滚筒上的电压，从而获得周期性感光体特征。该签名被传送到控制器并存储在其中。在获得预成像和成像签名之后，控制器补偿这些签名到其后的所有成像运行，以确保均匀的电压，从而使均匀的最终图像。

10. 发明申请

US20070123519A1 Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase pde2 inhibitors, preparation and therapeutic use thereof 失效
标题翻译：苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶pde2抑制剂，其制备和治疗用途
公开(公告)号：US20070123519A1
公开(公告)日：2007-05-31
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： A61K31/5513 , C07D243/14
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译：本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。

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