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1. 发明授权

US08986626B2 Probe arrangement for exchanging in a controllable way liquids with micro-sized samples of material like biological cells 有权
标题翻译：以可控方式交换液体与微尺寸样品的物质如生物细胞的探针安排
公开(公告)号：US08986626B2
公开(公告)日：2015-03-24
申请号：US12737557
申请日：2009-07-24
申请人： Michael Gabi , Janos Vörös , Tomaso Zambelli , Pascal Behr
发明人： Michael Gabi , Janos Vörös , Tomaso Zambelli , Pascal Behr
IPC分类号： B01L3/00 , B01L3/02 , B82Y35/00 , G01Q30/14 , G01Q70/02
CPC分类号： B01L3/0244 , B01L3/0293 , B01L2400/0484 , B82Y35/00 , G01Q30/14 , G01Q70/02 , Y10S977/864
摘要： The invention relates to a probe arrangement (10g) for exchanging in a controllable way liquids with micro-sized samples of material like biological cells, especially in connection with an scanning probe microscope, said probe arrangement (10g) comprising a probe holder (11) with at least one embedded first channel (18) and a cantilever (12) with at least one embedded second channel (15) and being provided to be attached to said probe holder (11) in a way that at least one aperture (19) of the first channel (18) is connected to at least one aperture (17) of the second channel (15) in a way that permits the liquid-tight transfer of a liquid between said first and second channels (15, 18). A safe and easy use of the probe arrangement is achieved by having the cantilever (12) permanently attached to said probe holder (11) to form a prefabricated probe unit (10g).
摘要翻译：本发明涉及一种探针装置（10g），用于以可控的方式将液体与诸如生物细胞的材料的微尺寸样品进行交换，特别是与扫描探针显微镜结合，所述探针装置（10g）包括探针保持器（11）具有至少一个嵌入式第一通道（18）和具有至少一个嵌入式第二通道（15）的悬臂（12），并且设置成以至少一个孔（19）连接到所述探针保持器（11）第一通道（18）的第一通道（18）的第一通道（15,18）的第二通道（15）的至少一个孔（17）以允许液体在所述第一和第二通道（15,18）之间的液密传递的方式连接。通过使悬臂（12）永久地附接到所述探针支架（11）以形成预制的探针单元（10g）来实现探针装置的安全和容易的使用。

2. 发明授权

US09162778B2 Method for spatially manipulating a microscopic object and device for conducting said method 有权
标题翻译：用于空间操纵微观物体的方法和用于进行所述方法的装置
公开(公告)号：US09162778B2
公开(公告)日：2015-10-20
申请号：US13580936
申请日：2011-02-07
申请人： Michael Gabi , Janos Voeroes , Stefan Pablo Doerig , Pascal Behr , Philipp Stiefel , Thomaso Zambelli , Julia Vorholt-Zambelli
发明人： Michael Gabi , Janos Voeroes , Stefan Pablo Doerig , Pascal Behr , Philipp Stiefel , Thomaso Zambelli , Julia Vorholt-Zambelli
IPC分类号： B01L9/00 , G01N35/00 , B65B1/04 , B82Y35/00 , C12M1/26 , G01Q60/38 , B82Y5/00 , B82Y30/00 , G01Q80/00
CPC分类号： B65B1/04 , B82Y5/00 , B82Y30/00 , B82Y35/00 , C12M33/04 , G01Q60/38 , G01Q80/00
摘要： The invention relates to a method for spatially manipulating a microscopic object including providing a cantilever (12) having a tip with an opening (19) and a microchannel (15) extending through the cantilever (12) in its longitudinal direction. A suspension means is provided for holding the cantilever (12) and spatially moving the cantilever along a predetermined spatial path. A pressurizing means is provided for applying a predetermined pressure to the microchannel (15) and the cantilever (12) is moved with its tip to the microscopic object to be spatially manipulated. At least a part of the microscopic object is picked up with said cantilever (12) by reducing the pressure within the microchannel (15) relative to the pressure outside the tip of the cantilever (12). The microscopic object is then moved along a predetermined spatial path by means of the cantilever (12).
摘要翻译：本发明涉及一种用于空间操纵微观物体的方法，包括提供具有尖端的悬臂（12），所述悬臂具有开口（19）和在其纵向方向延伸穿过悬臂（12）的微通道（15）。提供悬挂装置用于保持悬臂（12）并且沿着预定的空间路径空间地移动悬臂。提供加压装置用于向微通道（15）施加预定的压力，并且使悬臂（12）的尖端移动到微观物体以进行空间操作。通过相对于悬臂（12）的尖端外部的压力减小微通道（15）内的压力，用所述悬臂（12）拾取至少一部分微观物体。然后通过悬臂（12）沿着预定的空间路径移动微观物体。

3. 发明申请

US20130105034A1 METHOD FOR SPATIALLY MANIPULATING A MICROSCOPIC OBJECT AND DEVICE FOR CONDUCTING SAID METHOD 有权
标题翻译：用于空间控制微观物体的方法和用于引导方法的装置
公开(公告)号：US20130105034A1
公开(公告)日：2013-05-02
申请号：US13580936
申请日：2011-02-07
申请人： Michael Gabi , Janos Voeroes , Stefan Pablo Doerig , Pascal Behr , Phillipp Stiefel , Thomaso Zambelli , Julia Vorholt-Zambelli
发明人： Michael Gabi , Janos Voeroes , Stefan Pablo Doerig , Pascal Behr , Phillipp Stiefel , Thomaso Zambelli , Julia Vorholt-Zambelli
IPC分类号： B65B1/04
CPC分类号： B65B1/04 , B82Y5/00 , B82Y30/00 , B82Y35/00 , C12M33/04 , G01Q60/38 , G01Q80/00
摘要： The invention relates to a method for spatially manipulating a microscopic object (20,23,33), said method comprising the steps of providing a cantilever (12) having a tip with an opening (19) and a microchannel (15) extending through the cantilever (12) in its longitudinal direction, said microchannel (15) being fluidly connected to the opening (19) at the tip of the cantilever; providing suspension means for holding the cantilever (12) and spatially moving the cantilever along a predetermined spatial path; providing pressurizing means for applying a predetermined pressure to the microchannel (15) within the cantilever; moving the cantilever (12) with its tip to the microscopic object (20,23,33) to be spatially manipulated, such that the opening (19) of the tip is adjacent to the microscopic object (20,23,33); picking up, with said cantilever (12), a part of the microscopic object (20,23,33) or the microscopic object (20,23,33) as a whole by reducing the pressure within the microchannel (15) relative to the pressure outside the tip of the cantilever (12); and moving said part of the microscopic object (20,23,33) or said microscopic object (20,23,33) as a whole along a predetermined spatial path by means of the cantilever (12).
摘要翻译：本发明涉及一种用于空间操纵微观物体（20,23,33）的方法，所述方法包括以下步骤：提供具有尖端的悬臂（12），所述悬臂具有开口（19）和延伸穿过所述孔的微通道（15）悬臂（12）在其纵向方向上，所述微通道（15）在悬臂的尖端处流体地连接到开口（19）; 提供用于保持悬臂（12）并沿预定空间路径空间移动悬臂的悬挂装置; 提供用于向悬臂内的微通道（15）施加预定压力的加压装置; 将悬臂（12）的尖端移动到微观物体（20,23,33）以进行空间操作，使得尖端的开口（19）与微观物体（20,23,33）相邻; 通过减小微通道（15）内的压力相对于所述微通道（15）中的压力，与所述悬臂（12）一起拾取所述微观物体（20,23,33）或所述微观物体（20,23,33）的整体的一部分悬臂（12）尖端外的压力; 并且通过所述悬臂（12）沿预定的空间路径整体移动所述微观物体（20,23,33）或所述微观物体（20,23,33）的所述部分。

4. 发明申请

US20110124027A1 PROBE ARRANGEMENT FOR EXCHANGING IN A CONTROLLABLE WAY LIQUIDS WITH MICRO-SIZED SAMPLES OF MATERIAL LIKE BIOLOGICAL CELLS 有权
标题翻译：用可变形方式流动的探针装置与材料样品生物细胞的微尺寸样品
公开(公告)号：US20110124027A1
公开(公告)日：2011-05-26
申请号：US12737557
申请日：2009-07-24
申请人： Michael Gabi , Janos Vörös , Tomaso Zambelli , Pascal Behr
发明人： Michael Gabi , Janos Vörös , Tomaso Zambelli , Pascal Behr
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： B01L3/0244 , B01L3/0293 , B01L2400/0484 , B82Y35/00 , G01Q30/14 , G01Q70/02 , Y10S977/864
摘要： The invention relates to a probe arrangement (10g) for exchanging in a controllable way liquids with micro-sized samples of material like biological cells, especially in connection with an scanning probe microscope, said probe arrangement (10g) comprising a probe holder (11) with at least one embedded first channel (18) and a cantilever (12) with at least one embedded second channel (15) and being provided to be attached to said probe holder (11) in a way that at least one aperture (19) of the first channel (18) is connected to at least one aperture (17) of the second channel (15) in a way that permits the liquid-tight transfer of a liquid between said first and second channels (15, 18). A safe and easy use of the probe arrangement is achieved by having the cantilever (12) permanently attached to said probe holder (11) to form a prefabricated probe unit (10g).
摘要翻译：本发明涉及一种探针装置（10g），用于以可控的方式将液体与诸如生物细胞的材料的微尺寸样品进行交换，特别是与扫描探针显微镜结合，所述探针装置（10g）包括探针保持器（11）具有至少一个嵌入式第一通道（18）和具有至少一个嵌入式第二通道（15）的悬臂（12），并且设置成以至少一个孔（19）连接到所述探针保持器（11）第一通道（18）的第一通道（18）的第一通道（15,18）的第二通道（15）的至少一个孔（17）以允许液体在所述第一和第二通道（15,18）之间的液密传递的方式连接。通过使悬臂（12）永久地附接到所述探针支架（11）以形成预制的探针单元（10g）来实现探针装置的安全和容易的使用。

5. 发明申请

US20150160260A1 TOUCH-SCREEN BASED SCANNING PROBE MICROSCOPY (SPM) 审中-公开
标题翻译：基于触摸屏的扫描探针显微镜（SPM）
公开(公告)号：US20150160260A1
公开(公告)日：2015-06-11
申请号：US14390343
申请日：2013-03-12
申请人： Michael Gabi , Pascal Behr , Stephan Jud , Johann Wolf , Christian Weber
发明人： Michael Gabi , Pascal Behr , Stephan Jud , Johann Wolf , Christian Weber
IPC分类号： G01Q30/04 , G06F3/0484 , G06F3/0488
CPC分类号： G01Q30/04
摘要： A scanning probe microscopy (SPM) system includes a sample stage and one or more sample motion stages for actuating the sample stage, a SPM probe and one or more probe motion stages for actuating the SPM probe and for performing an SPM scan of a sample on the sample stage, and a system controller. The system controller includes an image acquisition module to collect from an image acquisition device one or more images of the sample carried by the sample stage, a touch-screen control module to display the one or more images of the sample together with one or more tools on a touch-screen and to generate one or more control actions depending on the detection of a gesture of a user touching the touchscreen, and a control module to receive one or more control actions generated by the touch-screen control module and to control the SPM system according to the received control actions.
摘要翻译：扫描探针显微镜（SPM）系统包括样品台和用于致动样品台的一个或多个样品运动级，SPM探针和用于致动SPM探针的一个或多个探针运动级，并用于对样品执行SPM扫描样品台和系统控制器。所述系统控制器包括：图像获取模块，用于从图像采集装置收集由样本台携带的样本的一个或多个图像;触摸屏控制模块，用于将一个或多个图像与一个或多个工具一起显示并且根据触摸触摸屏的用户的手势的检测来产生一个或多个控制动作;以及控制模块，用于接收由触摸屏控制模块生成的一个或多个控制动作，并且控制 SPM系统根据收到的控制动作。

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