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1. 发明授权

US08618293B2 Redox mediators 失效
标题翻译：氧化还原介体
公开(公告)号：US08618293B2
公开(公告)日：2013-12-31
申请号：US12663821
申请日：2008-06-17
申请人： Christopher Paul Newman , Luet Lok Wong , Hugh Allen Oliver Hill , Tai-Chu Lau
发明人： Christopher Paul Newman , Luet Lok Wong , Hugh Allen Oliver Hill , Tai-Chu Lau
IPC分类号： C07F15/00 , C12Q1/32
CPC分类号： C12Q1/004 , C07F15/0026 , C07F15/0053
摘要： The present invention relates to ruthenium and osmium complexes of Formula [M(A)w(B)x(C)y]m(Xz)n, per se and the use of ruthenium and osmium complexes of Formula I as redox mediators in electrochemical biosensors.
摘要翻译：本发明涉及式[M（A）w（B）x（C）y] m（Xz）n本身的钌和锇络合物以及式I的钌和锇络合物作为氧化还原介体在电化学生物传感器

2. 发明申请

US20110262950A1 REDOX MEDIATORS 失效
标题翻译： REDOX介质
公开(公告)号：US20110262950A1
公开(公告)日：2011-10-27
申请号：US12663821
申请日：2008-06-17
申请人： Christopher Paul Newman , Luet Lox Wong , Tai-Chu Lau , Hugh Allen Oliver Hill
发明人： Christopher Paul Newman , Luet Lox Wong , Tai-Chu Lau , Hugh Allen Oliver Hill
IPC分类号： C12Q1/32 , C07F9/00
CPC分类号： C12Q1/004 , C07F15/0026 , C07F15/0053
摘要： The present invention relates to ruthenium and osmium complexes of Formula [M(A)w(B)xCy]m(Xz)n, per se and the use of ruthenium and osmium complexes of Formula I as redox mediators in electrochemical biosensors.
摘要翻译：本发明涉及式[M（A）w（B）xCy] m（Xz）n本身的钌和锇络合物以及在电化学生物传感器中使用式I的钌和锇络合物作为氧化还原介体。

3. 发明申请

US20110162095A1 TNFSF Single Chain Molecules 有权
标题翻译： TNFSF单链分子
公开(公告)号：US20110162095A1
公开(公告)日：2011-06-30
申请号：US13055109
申请日：2009-07-18
申请人： Oliver Hill , Christian Gieffers , Meinolf Thiemann
发明人： Oliver Hill , Christian Gieffers , Meinolf Thiemann
IPC分类号： C07K19/00 , C07H21/00 , C12N5/10 , C12N1/00 , A01K67/00 , A61K38/19 , A61P29/00 , A61P35/00 , A61P31/00 , A61P37/06 , A61P3/00 , A61P19/02 , A61P25/28
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
摘要翻译：本发明涉及包含三种可溶性TNF超家族（TNFSF）细胞因子结构域和编码这些融合蛋白的核酸分子的单链融合蛋白。融合蛋白基本上非聚集并且适用于治疗，诊断和/或研究应用。

4. 发明申请

US20110031988A1 REDUCING SIGNAL DISTORTIONS 审中-公开
标题翻译：减少信号失常
公开(公告)号：US20110031988A1
公开(公告)日：2011-02-10
申请号：US12697712
申请日：2010-02-01
申请人： Lindy Jane Murphy , Hugh Allen Oliver Hill
发明人： Lindy Jane Murphy , Hugh Allen Oliver Hill
IPC分类号： G01R27/08
CPC分类号： C12Q1/001
摘要： The invention relates to reducing signal distortions occurring when a potential is applied to an electrochemical cell. Electrochemical measurements are obtained in the presence of a specific chemical entity which is an aminoglycoside, an organic polyamine and/or a substance capable of raising the ionic strength of the sample.
摘要翻译：本发明涉及减少当将电位施加到电化学电池时发生的信号失真。在特定化学实体存在下获得电化学测量，所述特定化学实体是氨基糖苷，有机多胺和/或能够提高样品的离子强度的物质。

5. 发明申请

US20090324616A1 DIFFERENTIAL CYTOKINE EXPRESSION IN HUMAN CANCER 审中-公开
标题翻译：人类癌症中的差异细胞因子表达
公开(公告)号：US20090324616A1
公开(公告)日：2009-12-31
申请号：US12306070
申请日：2007-06-21
申请人： Giorgio Stassi , Christian Gieffers , Oliver Hill , Meinolf Thiemann , Matilde Todaro
发明人： Giorgio Stassi , Christian Gieffers , Oliver Hill , Meinolf Thiemann , Matilde Todaro
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/68 , C07K2/00 , C07H21/04 , A61P35/00
CPC分类号： G01N33/57484 , G01N33/6863
摘要： The invention concerns a method for diagnosing a cancer type, whereby the expression of anti-apoptotic cytokines is determined in the tumour cells. The differential diagnosis of the present invention is used to classify tumour disorders and to recommend the required treatment and to monitor the progress and response to the treatment.
摘要翻译：本发明涉及一种用于诊断癌症类型的方法，由此在肿瘤细胞中测定抗凋亡细胞因子的表达。本发明的鉴别诊断用于分类肿瘤病症并推荐所需治疗并监测治疗的进展和反应。

6. 发明申请

US20080044882A1 Oxidation by Hydrogen Peroxide 审中-公开
标题翻译：过氧化氢氧化
公开(公告)号：US20080044882A1
公开(公告)日：2008-02-21
申请号：US10590426
申请日：2005-02-23
申请人： Hugh Allen Oliver Hill , Luet Lok Wong , Barry Dean Fleming
发明人： Hugh Allen Oliver Hill , Luet Lok Wong , Barry Dean Fleming
IPC分类号： C12N9/08 , C12N9/04
CPC分类号： C12P7/00
摘要： The present invention provides a method of carrying out an oxidation reaction catalysed by a monooxygenase enzyme and using hydrogen peroxide as an oxidant, in which reaction a low level of oxidation damage of the monooxygenase occurs, said method comprising producing the hydrogen peroxide simultaneously with the oxidation reaction, wherein the hydrogen peroxide is produced at a rate less than or equal to the rate at which it is used in the reaction or said method comprising carrying out the reaction in the presence of an H2O2 or hydroxyl radical sequestering agent that controls the H2O2 or hydroxyl radical concentration.
摘要翻译：本发明提供一种进行由单加氧酶催化的氧化反应并使用过氧化氢作为氧化剂的方法，其中发生单加氧酶的低水平的氧化损伤，所述方法包括与氧化物同时生产过氧化氢反应，其中所述过氧化氢的产生速率小于或等于其在反应中使用的速率或所述方法，包括在H 2 O 2存在下进行反应，或者羟基自由基螯合剂，其控制H 2 O 2 O 2或羟基自由基浓度。

7. 发明申请

US20070265261A1 Dpp-IV Inhibitors 审中-公开
标题翻译： Dpp-IV抑制剂
公开(公告)号：US20070265261A1
公开(公告)日：2007-11-15
申请号：US11569552
申请日：2005-06-08
申请人： Paul Edwards , Claudia Rosenbaum , Christian Rummey , Silvia Cerezo-Galvez , Achim Feurer , Oliver Hill , Meinolf Thiemann , Victor Matassa , Sonja Nordhoff , Barbara Hoffmann
发明人： Paul Edwards , Claudia Rosenbaum , Christian Rummey , Silvia Cerezo-Galvez , Achim Feurer , Oliver Hill , Meinolf Thiemann , Victor Matassa , Sonja Nordhoff , Barbara Hoffmann
IPC分类号： A61K31/4545 , A61K31/4525 , A61K31/5377 , A61P3/04 , C07D211/06 , C07D211/96 , C07D401/06 , C07D405/06 , C07D413/06
CPC分类号： C07D211/26
摘要： The invention relates to compounds of formula (1) wherein Z, R1-3 and A have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.
摘要翻译：本发明涉及式（1）的化合物，其中Z，R 1-3和A具有在说明书和权利要求书中引用的含义。所述化合物可用作DPP-IV抑制剂。本发明还涉及这种化合物的制备以及其作为药物的生产和使用。

8. 发明申请

US20050014135A1 Method for the selection and identification of peptide or protein molecules by means of phage display 审中-公开
标题翻译：通过噬菌体展示法选择和鉴定肽或蛋白质分子的方法
公开(公告)号：US20050014135A1
公开(公告)日：2005-01-20
申请号：US10855668
申请日：2004-05-27
申请人： Oliver Hill , Holger Ottleben , Stefan Dickopf , Klaus Burkert
发明人： Oliver Hill , Holger Ottleben , Stefan Dickopf , Klaus Burkert
IPC分类号： B01L3/00 , G01N21/55 , C12Q1/70
CPC分类号： G01N21/553 , B01L3/5085 , B82Y30/00
摘要： The invention relates to a method for the selection and identification of at least on representative (interaction partner) from a plurality of peptide or protein molecules, which can specifically interact with at least one representative from a plurality of target molecules, forming a bond. The inventive method comprises the following steps: (a) a virus system consisting of a plurality of viruses, wherein each virus respectively presents at least on representative from the plurality of peptide or protein molecules on the surface thereof, is brought into contact with the plurality of target molecules (ligands) which are immobilized on the surface of a solid phase carrier such that they are position addressable in a two-dimensional grade; (b) unbound viruses removed from the surface thereof; and (c) the interaction partner is identified by detection and determination of the position of the bond between the immobilized ligand and the interaction partner presented by the virus with the aid of a marker-free detection method. The described method makes it possible to concentrate viruses presenting interaction partners by means of an optionally cyclic repetition of selection. Optionally, selected interaction partners are recombinantly expressed after identification of the coding nucleotide sequence.
摘要翻译：本发明涉及一种用于从多个肽或蛋白质分子中选择和鉴定至少一个代表性（相互作用配偶体）的方法，其可与多个靶分子的至少一个代表特异性相互作用，形成键。本发明的方法包括以下步骤：（a）由多种病毒组成的病毒系统，其中每个病毒分别至少表现出其表面上的多个肽或蛋白质分子的代表，与多个病毒接触的固定在固相载体的表面上的靶分子（配体），使得它们位于二维等级的位置; （b）从其表面去除未结合的病毒; 和（c）通过利用无标记检测方法的检测和确定固定的配体与病毒所呈现的相互作用配偶之间的键的位置来鉴定相互作用配偶体。所描述的方法使得可以通过可选地循环重复的选择来浓缩呈现相互作用伴侣的病毒。任选地，在识别编码核苷酸序列后重组表达所选择的相互作用伴侣。

9. 发明授权

US4039624A Method of producing phosphoric acid from high iron and aluminum content phosphate rocks using nitric acid 失效
标题翻译：使用硝酸从高铁和铝含量磷酸盐岩生产磷酸的方法
公开(公告)号：US4039624A
公开(公告)日：1977-08-02
申请号：US596777
申请日：1975-07-17
申请人： Robert Oliver Hill
发明人： Robert Oliver Hill
IPC分类号： C01B25/22 , C01B25/234 , C05B11/06 , C01B25/16
CPC分类号： C05B11/06 , C01B25/22 , C01B25/234
摘要： This invention concerns the solubilization of phosphate values in phosphate bearing rock which contains high contents of aluminium and/or iron by attacking the phosphate rock with a nitric acid leach solution for a time suitable to produce a phosphate rich leach solution containing no more than 10 parts Fe and Al in solution calculated as R.sub.2 O.sub.3 per 100 parts of P.sub.2 O.sub.5 in solution.
摘要翻译：本发明涉及通过用硝酸浸出溶液攻击磷酸盐岩，适当地生产含有不超过10份的富含磷酸盐的浸出溶液的时间，使磷酸盐值溶解在含磷酸盐岩的含磷岩石中 Fe和Al在溶液中按每100份P 2 O 5计算为R2O3。

10. 发明授权

US08450460B2 Single-chain TNFSF fusion polypeptides 有权
标题翻译：单链TNFSF融合多肽
公开(公告)号：US08450460B2
公开(公告)日：2013-05-28
申请号：US13055109
申请日：2009-07-18
申请人： Oliver Hill , Christian Gieffers , Meinolf Thiemann
发明人： Oliver Hill , Christian Gieffers , Meinolf Thiemann
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , C07H21/04
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
摘要翻译：本发明涉及包含三种可溶性TNF超家族（TNFSF）细胞因子结构域和编码这些融合蛋白的核酸分子的单链融合蛋白。融合蛋白基本上非聚集并且适用于治疗，诊断和/或研究应用。

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