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1. 发明授权

US07842242B2 Optical coupling device and method 失效
标题翻译：光耦合装置及方法
公开(公告)号：US07842242B2
公开(公告)日：2010-11-30
申请号：US10555818
申请日：2004-04-01
申请人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
发明人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
IPC分类号： G01N21/00 , G02B6/26 , G01N21/55
CPC分类号： G01N21/05 , G01N21/0303 , G01N21/553 , G01N2021/0346 , G01N2021/0389 , G01N2021/0396 , G01N2021/058 , G02B5/00
摘要： A device for optically coupling a first optical element to a second optical element comprises a first optical element with a first radiation penetration surface; a second optical element with a second radiation penetration surface located across from the first radiation penetration surface; and a chamber delimited by the first and second radiation penetration surfaces and a circumferentially closed side wall which connects the first and second radiation penetration surfaces. The circumferentially closed side wall defines a first sector in the first radiation penetration surface and a second sector in the second radiation penetration surface, the area of the first sector being smaller than the area of the first radiation penetration surface, and the area of the second sector being smaller than the area of the second radiation penetration surface. The device further comprises a feeding conduit to the chamber for delivering index-adjusting liquid; and a discharge conduit from the chamber for evacuating index-adjusting liquid or gas from the chamber.
摘要翻译：用于将第一光学元件光学耦合到第二光学元件的装置包括具有第一辐射穿透表面的第一光学元件; 第二光学元件，具有位于第一辐射穿透表面的第二辐射穿透表面; 以及由第一和第二辐射穿透表面限定的室和连接第一和第二辐射穿透表面的周向封闭的侧壁。周向封闭的侧壁限定了第一辐射穿透表面中的第一扇区和第二辐射穿透表面中的第二扇区，第一扇区的面积小于第一辐射穿透表面的面积，第二扇区的面积扇区小于第二辐射穿透表面的面积。该装置还包括一个用于输送折射率调节液体的输送管道，以及来自所述室的排出管道，用于从所述室排出折射率调节液体或气体。

2. 发明授权

US06795192B2 SPR sensor and SPR sensor array 失效
标题翻译： SPR传感器和SPR传感器阵列
公开(公告)号：US06795192B2
公开(公告)日：2004-09-21
申请号：US10223010
申请日：2002-08-19
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).
摘要翻译：本发明涉及一种用于多个样本的并行测量的SPR表面等离子体共振光谱传感器，包括具有多个SPR传感器区域（2）的主体（1a），用于引导辐射以进行SPR测量并且涂覆有适合于SPR的材料，使得每个SPR传感器区域（2）可以与单个样品完全相关联。辐射导电体（1a）与SPR传感器区域（2）形成一个单元，由此由SPR传感器区域（2）引导的射线的路径也可以延伸穿过辐射导电体（1a）。

3. 发明授权

US06441906B2 Set-up of measuring instruments for the parallel readout of SPR sensors 失效
公开(公告)号：US06441906B2
公开(公告)日：2002-08-27
申请号：US09859677
申请日：2001-05-18
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to a set-up of measuring instruments for the parallel readout of SPR sensors. The aim of the invention is to provide a measuring arrangement for the parallel readout of a plurality of SPR sensors, wherein the readout process should be terminated within an integration period of less than 30 minutes. To this end, a wavelength-selective component (5) and an optical imaging system (L2, L3) are arranged downstream of a light source (3). Said optical imaging system (L2, L3) is in such a manner that at a first wavelength it guarantees a parallel illumination of the light entrance sides of the waveguides (13) which are provided with SPR-compatible sensor zones, and that the light emerging from the individual light waveguides (13) may simultaneously be imaged onto a CCD chip (20) via an optical system (L4) in such a way that the light emerging from each individual light waveguide (13) is respectively detectable by several adjacent CCD pixels of the CCD chip (20), and from these pixel areas a respective light intensity value is calculable by means of image processing software, and, after data storage of an intensity value, a set wave length and coordinate in the waveguide array (10), an adjustment of the wavelength-selective assembly (5) to a second, arbitrarily providable, further light wavelength is performable by means of a computer (30) via a control line (31).

4. 发明申请

US20080167196A1 Surface for the immobilization of ligands 失效
标题翻译：用于固定配体的表面
公开(公告)号：US20080167196A1
公开(公告)日：2008-07-10
申请号：US11980015
申请日：2007-10-30
申请人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
IPC分类号： C40B20/02 , C40B50/18 , C40B30/10
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/54353 , G01N33/553
摘要： The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
摘要翻译：本发明涉及用于固定配体，配体表面和存在多个相同或不同配体的结构化表面阵列的结合表面。本发明还涉及一种用于制备和使用这些表面的方法以及可用于其制备的特定粘合剂分子。

5. 发明申请

US20070273883A1 Sensor Arrangement 审中-公开
标题翻译：传感器布置
公开(公告)号：US20070273883A1
公开(公告)日：2007-11-29
申请号：US10564146
申请日：2004-06-21
申请人： Stefan Dickopf , Klaus Burkert , Alexander Maier , Kristina Schmidt
发明人： Stefan Dickopf , Klaus Burkert , Alexander Maier , Kristina Schmidt
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/253 , G01N2035/00158 , G01N2035/1037 , Y10T428/12549
摘要： The invention relates to a sensor arrangement comprising a radiation-conducting substrate, said arrangement having a plurality of sensor fields and separating regions for separating the individual sensor fields from the respectively adjacent sensor fields. Said separating regions are formed by a separating agent layer that causes a reflectivity lower than 0.5 for radiation from the substrate on the interface between the separating agent layer and the substrate, at least in a first region adjacent to the interface between the separating agent layer and the substrate, and an extinction higher than 0.95 at least in a second region located above the first region, on the side opposing the substrate.
摘要翻译：本发明涉及一种包括辐射传导基片的传感器装置，所述装置具有多个传感器场和分离区域，用于将各个传感器场与相邻的传感器场分开。所述分离区域由分离剂层形成，所述分离剂层至少在与分离剂层和基底之间的界面相邻的第一区域中引起反射率低于0.5，用于来自分离剂层和基底之间的界面上的基底的辐射衬底，并且至少在位于第一区域上方的第二区域中，在与衬底相对的一侧上高于0.95的消光。

6. 发明申请

US20070248300A1 Optical Coupling Device and Method 失效
标题翻译：光耦合装置及方法
公开(公告)号：US20070248300A1
公开(公告)日：2007-10-25
申请号：US10555818
申请日：2004-04-01
申请人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
发明人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , G01N21/0303 , G01N21/553 , G01N2021/0346 , G01N2021/0389 , G01N2021/0396 , G01N2021/058 , G02B5/00
摘要： A device for optically coupling a first optical element to a second optical element comprises a first optical element with a first radiation penetration surface; a second optical element with a second radiation penetration surface located across from the first radiation penetration surface; and a chamber delimited by the first and second radiation penetration surfaces and a circumferentially closed side wall which connects the first and second radiation penetration surfaces. The circumferentially closed side wall defines a first sector in the first radiation penetration surface and a second sector in the second radiation penetration surface, the area of the first sector being smaller than the area of the first radiation penetration surface, and the area of the second sector being smaller than the area of the second radiation penetration surface. The device further comprises a feeding conduit to the chamber for delivering index-adjusting liquid; and a discharge conduit from the chamber for evacuating index-adjusting liquid or gas from the chamber.
摘要翻译：用于将第一光学元件光学耦合到第二光学元件的装置包括具有第一辐射穿透表面的第一光学元件; 第二光学元件，具有位于第一辐射穿透表面的第二辐射穿透表面; 以及由第一和第二辐射穿透表面限定的室和连接第一和第二辐射穿透表面的周向封闭的侧壁。周向封闭的侧壁限定了第一辐射穿透表面中的第一扇区和第二辐射穿透表面中的第二扇区，第一扇区的面积小于第一辐射穿透表面的面积，第二扇区的面积扇区小于第二辐射穿透表面的面积。该装置还包括一个用于输送折射率调节液体的输送管道，以及来自所述室的排出管道，用于从所述室排出折射率调节液体或气体。

7. 发明授权

US07955638B2 Surface for the immobilization of ligands 失效
标题翻译：用于固定配体的表面
公开(公告)号：US07955638B2
公开(公告)日：2011-06-07
申请号：US11980015
申请日：2007-10-30
申请人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N1/31
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/54353 , G01N33/553
摘要： The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
摘要翻译：本发明涉及用于固定配体，配体表面和呈现多个相同或不同配体的结构化表面阵列的结合表面。本发明还涉及一种用于制备和使用这些表面的方法以及可用于其制备的特定粘合剂分子。

8. 发明申请

US20050014135A1 Method for the selection and identification of peptide or protein molecules by means of phage display 审中-公开
标题翻译：通过噬菌体展示法选择和鉴定肽或蛋白质分子的方法
公开(公告)号：US20050014135A1
公开(公告)日：2005-01-20
申请号：US10855668
申请日：2004-05-27
申请人： Oliver Hill , Holger Ottleben , Stefan Dickopf , Klaus Burkert
发明人： Oliver Hill , Holger Ottleben , Stefan Dickopf , Klaus Burkert
IPC分类号： B01L3/00 , G01N21/55 , C12Q1/70
CPC分类号： G01N21/553 , B01L3/5085 , B82Y30/00
摘要： The invention relates to a method for the selection and identification of at least on representative (interaction partner) from a plurality of peptide or protein molecules, which can specifically interact with at least one representative from a plurality of target molecules, forming a bond. The inventive method comprises the following steps: (a) a virus system consisting of a plurality of viruses, wherein each virus respectively presents at least on representative from the plurality of peptide or protein molecules on the surface thereof, is brought into contact with the plurality of target molecules (ligands) which are immobilized on the surface of a solid phase carrier such that they are position addressable in a two-dimensional grade; (b) unbound viruses removed from the surface thereof; and (c) the interaction partner is identified by detection and determination of the position of the bond between the immobilized ligand and the interaction partner presented by the virus with the aid of a marker-free detection method. The described method makes it possible to concentrate viruses presenting interaction partners by means of an optionally cyclic repetition of selection. Optionally, selected interaction partners are recombinantly expressed after identification of the coding nucleotide sequence.
摘要翻译：本发明涉及一种用于从多个肽或蛋白质分子中选择和鉴定至少一个代表性（相互作用配偶体）的方法，其可与多个靶分子的至少一个代表特异性相互作用，形成键。本发明的方法包括以下步骤：（a）由多种病毒组成的病毒系统，其中每个病毒分别至少表现出其表面上的多个肽或蛋白质分子的代表，与多个病毒接触的固定在固相载体的表面上的靶分子（配体），使得它们位于二维等级的位置; （b）从其表面去除未结合的病毒; 和（c）通过利用无标记检测方法的检测和确定固定的配体与病毒所呈现的相互作用配偶之间的键的位置来鉴定相互作用配偶体。所描述的方法使得可以通过可选地循环重复的选择来浓缩呈现相互作用伴侣的病毒。任选地，在识别编码核苷酸序列后重组表达所选择的相互作用伴侣。

9. 发明授权

US06752963B2 SPR sensor system 失效
标题翻译： SPR传感器系统
公开(公告)号：US06752963B2
公开(公告)日：2004-06-22
申请号：US09789015
申请日：2001-02-21
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter , Klaus Burkert
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter , Klaus Burkert
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to an SPR sensor array comprising a plurality of SPR sensor surface areas (120) arranged on a substrate (10, 20) in a two-dimensional matrix located in a plane to which the SPR sensor surface areas (120) are parallel and whereby radiation capable of exciting surface plasmons in the SPR sensor surface areas (120) under specific physical conditions can be guided through the substrate (10, 20) to be reflected from the SPR sensor surface areas, as well as separating means (110) for separating each SPR sensor surface area (120) from its neighboring SPR sensor surface area (120), wherein the separating means (110) and SPR sensor surface areas (120) are provided such that at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) the radiation (40) guided through the substrate (10, 20) is reflected in the region of the separating means to a different degree than in the region of the SPR sensor surface areas (120) to create a contrast between the separating means (110) and the SPR sensor surface areas (120) at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) in the radiation reflected by the SPR sensor surface areas (120) and the separating means (110).
摘要翻译：本发明涉及一种SPR传感器阵列，其包括布置在位于SPR传感器表面区域（120）平行的平面中的二维矩阵中的衬底（10,20）上的多个SPR传感器表面区域（120）并且由此能够在特定物理条件下激发SPR传感器表面区域（120）中的表面等离子体激元的辐射能够被引导穿过衬底（10,20）以从SPR传感器表面区域反射，以及分离装置（110）用于将每个SPR传感器表面区域（120）与其相邻的SPR传感器表面区域（120）分离，其中分离装置（110）和SPR传感器表面区域（120）被设置成使得至少在表面等离子体共振引导穿过衬底（10,20）的辐射（40）的SPR传感器表面区域（120）在分离装置的区域中被反射到与SPR传感器表面区域（120）的区域不同的程度，以产生对比是在由SPR传感器表面区域（120）和分离装置（120）反射的辐射中至少在出现在SPR传感器表面区域（120）中的表面等离子体共振之外的分离装置（110）和SPR传感器表面区域（120）（110）。

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