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1. 发明授权

US06475644B1 Radioactive coating solutions methods, and substrates 失效
标题翻译：放射性涂层溶液方法和底物
公开(公告)号：US06475644B1
公开(公告)日：2002-11-05
申请号：US09386779
申请日：1999-08-31
申请人： Janet M. Hampikian , Neal A. Scott
发明人： Janet M. Hampikian , Neal A. Scott
IPC分类号： B23B1500
CPC分类号： A61N5/1015 , A61F2210/0095 , A61M25/0045 , A61M25/09 , A61M2025/0056 , A61N5/1007 , A61N5/1014 , A61N2005/1005 , A61N2005/1012 , A61N2005/1019 , C09D5/00 , C09D5/44 , C23C18/1651 , C23C18/1653 , C23C18/1662 , C23C18/31 , C25D3/02 , C25D15/02 , Y10S428/926 , Y10S428/935 , Y10S428/936 , Y10T428/12771 , Y10T428/12944 , Y10T428/12986 , Y10T428/31678
摘要： Radioactive coating solutions and sol-gels, and corresponding methods for making a substrate radioactive by the application of the radioactive coating solutions and sol-gels thereto. The radioactive coating solution comprises at least one carrier metal and a radioisotope, which may be soluble or insoluble, and may further comprise a reducing agent. The radioactive sol-gel comprises at least one metal alkoxide and a radioisotope, which may be soluble or insoluble. Methods of making a substrate radioactive by coating with radioactive coating solutions or sol-gels are also disclosed, including electrodeposition, electroless deposition, spin coating and dip coating. In a particular embodiment, the radioactive coating formed by the method is a composite coating. Radioactive substrates are also disclosed, comprising a substrate and one or more radioactive coatings, which coatings may be the same or different. Suitable substrates include medical devices, such as catheters, stents, brachytherapy devices and guidewires, or components thereof Medical devices capable of generating asymmetric, or targeted, radiation fields are also disclosed.
摘要翻译：放射性涂层溶液和溶胶凝胶，以及通过将放射性涂层溶液和溶胶凝胶施用于基质放射性的相应方法。放射性涂层溶液包含至少一种可溶于或不溶的载体金属和放射性同位素，并且还可以包含还原剂。放射性溶胶 - 凝胶包含至少一种可溶于或不溶的金属醇盐和放射性同位素。还公开了通过用放射性涂层溶液或溶胶 - 凝胶涂覆制造放射性底物的方法，包括电沉积，无电沉积，旋涂和浸涂。在一个具体实施方案中，通过该方法形成的放射性涂层是复合涂层。还公开了放射性基质，其包含基质和一种或多种放射性涂层，该涂层可以相同或不同。合适的基底包括医疗装置，例如导管，支架，近距离放射治疗装置和导线，或其组件。还公开了能够产生不对称或靶向辐射场的医疗装置。

2. 发明授权

US5709874A Device for local drug delivery and methods for using the same 失效
公开(公告)号：US5709874A
公开(公告)日：1998-01-20
申请号：US660203
申请日：1996-06-03
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/088 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

3. 发明授权

US5026685A NPY peptide analogs 失效
标题翻译： NPY肽类似物
公开(公告)号：US5026685A
公开(公告)日：1991-06-25
申请号：US219596
申请日：1988-07-15
申请人： Jaroslav H. Boublik , Jean E. F. Rivier , Marvin R. Brown , Neal A. Scott
发明人： Jaroslav H. Boublik , Jean E. F. Rivier , Marvin R. Brown , Neal A. Scott
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/57545 , A61K38/00
摘要： Human Neuropeptide Y(NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala- Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr- Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH.sub.2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs wherein the N-terminus is shortened and which may contain one or more specific subsitutions for the naturally occurring residues, or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
摘要翻译：人神经肽Y（NPY）具有下式：H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala- Pro-Ala-Glu-Asp-Met-Ala-Arg- Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2。猪和大鼠NPY具有相同的序列，除了Leu而不是17位的Met。猪PYY具有11个不同残基的同源物。 NPY类似物，其中N末端被缩短并且可以含有分散在药学上可接受的液体或固体载体中的天然存在的残基或其药学上可接受的盐的一个或多个特异性亚基，可以包括人哺乳动物在较长时间内显着降低血压或抵抗高血压。

4. 发明授权

US06355055B1 Endovascular support device and method of use 失效
标题翻译：血管内支持装置及使用方法
公开(公告)号：US06355055B1
公开(公告)日：2002-03-12
申请号：US08967331
申请日：1997-10-21
申请人： Ron Waksman , Spencer B. King, III , Neal A. Scott
发明人： Ron Waksman , Spencer B. King, III , Neal A. Scott
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/90 , A61F2/95 , A61F2002/072 , A61F2002/075 , A61F2250/0067 , A61L27/54 , A61L2300/412 , A61L2300/416 , A61L2300/42 , A61L2300/432 , A61L2300/602
摘要： An endovascular support device adapted for local delivery of a therapeutic agent and for minimizing the rate of restinosis having a cylindrical support body with an inside surface and an opposite outside surface, and at least one layer of pericardial tissue covering at least a portion of at least a selected one of the inside surface or the outside surface of the cylindrical support body. At least one therapeutic agent is disposed on a portion of the support device.
摘要翻译：一种适于局部递送治疗剂并用于使具有内表面和相对外表面的圆柱形支撑体的再狭窄率最小化的血管内支持装置，以及至少覆盖至少一部分至少一层心包组织圆柱形支撑体的内表面或外表面中的一个选定的一个。至少一种治疗剂设置在支撑装置的一部分上。

5. 发明授权

US5985307A Device and method for non-occlusive localized drug delivery 失效
标题翻译：用于非闭塞性局部药物递送的装置和方法
公开(公告)号：US5985307A
公开(公告)日：1999-11-16
申请号：US982537
申请日：1997-12-02
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Christos Markou
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Christos Markou
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/088 , A61M31/00 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/00 , A61M25/0021 , A61M25/1002 , A61M31/00 , A61M37/00 , A61F2250/0003 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/105 , A61M2025/1072 , A61M2025/1081 , A61M25/0041 , A61M25/0068 , A61M25/0074 , A61M25/0082
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without substantially disrupting the fluid flow therethrough. For example, an indwelling endovascular support device is provided for delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译：用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。该装置提供了将物质局部输送到流过导管的流体的边界层中的装置，而不会基本上破坏流过其中的流体流。例如，提供留置的血管内支持装置用于将物质局部递送至目标治疗区域。还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

6. 发明授权

US5523092A Device for local drug delivery and methods for using the same 失效
标题翻译：用于局部药物输送的装置及其使用方法
公开(公告)号：US5523092A
公开(公告)日：1996-06-04
申请号：US188248
申请日：1994-01-28
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/088 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译：用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。该装置具有物质输送段，其提供用于将物质局部输送到流过导管的流体的边界层中的手段，而不会中断通过其的流体流动。例如，提供留置导管用于将物质局部血管内输送到目标治疗区域。还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

7. 发明授权

US5383928A Stent sheath for local drug delivery 失效
标题翻译：支架用于局部药物输送
公开(公告)号：US5383928A
公开(公告)日：1995-01-24
申请号：US109149
申请日：1993-08-19
申请人： Neal A. Scott , Stephen R. Hanson , Spencer B. King, III , Laurence A. Harker
发明人： Neal A. Scott , Stephen R. Hanson , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/16 , A61F2/04
CPC分类号： A61F2/88 , A61F2/07 , A61L31/04 , A61L31/16 , A61F2002/075 , A61F2250/0067 , A61L2300/25 , A61L2300/42
摘要： This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.
摘要翻译：本发明提供了一种护套，用于包围至少一部分支架以将药物局部输送到已经插入支架的动脉壁或内腔，其包括聚合物和掺入聚合物内的药物，所述聚合物护套至少包括支架的一部分和允许药物受控释放的厚度。还提供了一种预防血栓形成并促进和抑制受试者血管生长的方法，包括将本发明的护套包围的支架插入受试者的血管。

8. 发明授权

US5328899A NPY peptide analogs 失效
标题翻译： NPY肽类似物
公开(公告)号：US5328899A
公开(公告)日：1994-07-12
申请号：US882923
申请日：1992-05-12
申请人： Jaroslav H. Boublik , Jean E. F. Rivier , Marvin R. Brown , Neal A. Scott
发明人： Jaroslav H. Boublik , Jean E. F. Rivier , Marvin R. Brown , Neal A. Scott
IPC分类号： A61K38/00 , C07K14/575 , A61K37/02 , C07K7/08 , C07K7/10
CPC分类号： C07K14/57545 , A61K38/00
摘要： Human Neuropeptide Y (NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro- Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile- Thr-Arg-Gln-Arg -Tyr-NH.sub.2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs and N-terminally-shortened fragments, e.g. NPY(18-36), which contain one or more specific D-isomer substitutions for the naturally occurring residues (as well as pharmaceutically acceptable salts thereof), dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
摘要翻译：人神经肽Y（NPY）具有下式：H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg- Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2。猪和大鼠NPY具有相同的序列，除了Leu而不是17位的Met。猪PYY具有11个不同残基的同源物。 NPY类似物和N-末端缩短的片段，例如对于分散在药学上可接受的液体或固体载体中的天然存在的残基（以及其药学上可接受的盐）含有一个或多个特异性D-异构体取代的NPY（18-36）可以施用于包括人在内的哺乳动物，以在更长的时间内大幅降低血压或抵抗高血压。

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