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1. 发明授权

US5709874A Device for local drug delivery and methods for using the same 失效
公开(公告)号：US5709874A
公开(公告)日：1998-01-20
申请号：US660203
申请日：1996-06-03
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/088 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

2. 发明授权

US5523092A Device for local drug delivery and methods for using the same 失效
标题翻译：用于局部药物输送的装置及其使用方法
公开(公告)号：US5523092A
公开(公告)日：1996-06-04
申请号：US188248
申请日：1994-01-28
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/088 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译：用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。该装置具有物质输送段，其提供用于将物质局部输送到流过导管的流体的边界层中的手段，而不会中断通过其的流体流动。例如，提供留置导管用于将物质局部血管内输送到目标治疗区域。还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

3. 发明授权

US5383928A Stent sheath for local drug delivery 失效
标题翻译：支架用于局部药物输送
公开(公告)号：US5383928A
公开(公告)日：1995-01-24
申请号：US109149
申请日：1993-08-19
申请人： Neal A. Scott , Stephen R. Hanson , Spencer B. King, III , Laurence A. Harker
发明人： Neal A. Scott , Stephen R. Hanson , Spencer B. King, III , Laurence A. Harker
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/16 , A61F2/04
CPC分类号： A61F2/88 , A61F2/07 , A61L31/04 , A61L31/16 , A61F2002/075 , A61F2250/0067 , A61L2300/25 , A61L2300/42
摘要： This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.
摘要翻译：本发明提供了一种护套，用于包围至少一部分支架以将药物局部输送到已经插入支架的动脉壁或内腔，其包括聚合物和掺入聚合物内的药物，所述聚合物护套至少包括支架的一部分和允许药物受控释放的厚度。还提供了一种预防血栓形成并促进和抑制受试者血管生长的方法，包括将本发明的护套包围的支架插入受试者的血管。

4. 发明授权

US5985307A Device and method for non-occlusive localized drug delivery 失效
标题翻译：用于非闭塞性局部药物递送的装置和方法
公开(公告)号：US5985307A
公开(公告)日：1999-11-16
申请号：US982537
申请日：1997-12-02
申请人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Christos Markou
发明人： Stephen R. Hanson , Neal A. Scott , Spencer B. King, III , Christos Markou
IPC分类号： A61F2/00 , A61F2/06 , A61M25/00 , A61M25/088 , A61M31/00 , A61M37/00
CPC分类号： A61F2/06 , A61F2/064 , A61M25/00 , A61M25/0021 , A61M25/1002 , A61M31/00 , A61M37/00 , A61F2250/0003 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/105 , A61M2025/1072 , A61M2025/1081 , A61M25/0041 , A61M25/0068 , A61M25/0074 , A61M25/0082
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without substantially disrupting the fluid flow therethrough. For example, an indwelling endovascular support device is provided for delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译：用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。该装置提供了将物质局部输送到流过导管的流体的边界层中的装置，而不会基本上破坏流过其中的流体流。例如，提供留置的血管内支持装置用于将物质局部递送至目标治疗区域。还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

5. 发明授权

US06355055B1 Endovascular support device and method of use 失效
标题翻译：血管内支持装置及使用方法
公开(公告)号：US06355055B1
公开(公告)日：2002-03-12
申请号：US08967331
申请日：1997-10-21
申请人： Ron Waksman , Spencer B. King, III , Neal A. Scott
发明人： Ron Waksman , Spencer B. King, III , Neal A. Scott
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/90 , A61F2/95 , A61F2002/072 , A61F2002/075 , A61F2250/0067 , A61L27/54 , A61L2300/412 , A61L2300/416 , A61L2300/42 , A61L2300/432 , A61L2300/602
摘要： An endovascular support device adapted for local delivery of a therapeutic agent and for minimizing the rate of restinosis having a cylindrical support body with an inside surface and an opposite outside surface, and at least one layer of pericardial tissue covering at least a portion of at least a selected one of the inside surface or the outside surface of the cylindrical support body. At least one therapeutic agent is disposed on a portion of the support device.
摘要翻译：一种适于局部递送治疗剂并用于使具有内表面和相对外表面的圆柱形支撑体的再狭窄率最小化的血管内支持装置，以及至少覆盖至少一部分至少一层心包组织圆柱形支撑体的内表面或外表面中的一个选定的一个。至少一种治疗剂设置在支撑装置的一部分上。

6. 发明授权

US08377084B1 Method of using a catheter for traversing total occlusions 有权
标题翻译：使用导管穿过全部闭塞的方法
公开(公告)号：US08377084B1
公开(公告)日：2013-02-19
申请号：US13249952
申请日：2011-09-30
申请人： Spencer B. King, III , Matt D. Pursley
发明人： Spencer B. King, III , Matt D. Pursley
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/22 , A61B2017/22044 , A61B2017/22049 , A61B2017/22069 , A61B2017/22094 , A61B2090/034 , A61M25/0097 , A61M25/0152 , A61M2025/0681 , A61M2025/09125
摘要： A medical device and method for traversing an occlusion in a vessel includes a straightening sleeve positioned at a distal aspect of a catheter, a steering sleeve having an arcuate distal end, and a guidewire disposed through the steering sleeve. The steering sleeve has a first position in which the arcuate distal end is straightened within the straightening sleeve, and a second position in which the steering sleeve extends distally past the straightening sleeve to expose the arcuate distal end. The tip of the arcuate distal end of the steering sleeve or the guidewire can be used to pierce the occlusion. An arrangement of hub assemblies with locking mechanisms and motion limiting structures facilitates adjusting and locking the relative positions of the straightening sleeve, the steering sleeve, and the guidewire. Detent mechanisms are associated with the motion limiting structures for providing controlled incremental movement of the sleeves and the guidewire.
摘要翻译：用于横穿容器中的闭塞的医疗装置和方法包括定位在导管的远侧方面的矫直套筒，具有弓形远端的转向套管和穿过转向套筒的导丝。转向套筒具有第一位置，其中弓形远端在矫直套筒内矫直，以及第二位置，转向套筒向远侧延伸穿过矫直套筒以暴露弓形远端。转向套筒或导丝的弓形远端的尖端可用于刺穿闭塞。具有锁定机构和运动限制结构的轮毂组件的布置有助于调节和锁定矫直套筒，转向套筒和导丝的相对位置。止动机构与运动限制结构相关联，用于提供套筒和导丝的受控的增量运动。

7. 发明授权

US08109953B1 Catheter device, hub assembly and method for traversing total occlusions 有权
标题翻译：导管装置，轮毂组件和穿过全部闭塞的方法
公开(公告)号：US08109953B1
公开(公告)日：2012-02-07
申请号：US11838313
申请日：2007-08-14
申请人： Spencer B. King, III , Matt D. Pursley
发明人： Spencer B. King, III , Matt D. Pursley
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/22 , A61B2017/22044 , A61B2017/22049 , A61B2017/22069 , A61B2017/22094 , A61B2090/034 , A61M25/0097 , A61M25/0152 , A61M2025/0681 , A61M2025/09125
摘要： A medical device for traversing an occlusion in a vessel includes a straightening sleeve positioned at a distal aspect of a catheter, a steering sleeve having an arcuate distal end, and a guidewire disposed through the steering sleeve. The steering sleeve has a first position in which the arcuate distal end is straightened within the straightening sleeve, and a second position in which the steering sleeve extends distally past the straightening sleeve to expose the arcuate distal end. The tip of the arcuate distal end of the steering sleeve or the guidewire can be used to pierce the occlusion. An arrangement of hub assemblies with locking mechanisms and motion limiting structures facilitates adjusting and locking the relative positions of the straightening sleeve, the steering sleeve, and the guidewire. Detent mechanisms are associated with the motion limiting structures for providing controlled incremental movement of the sleeves and the guidewire.
摘要翻译：用于穿过容器中的闭塞的医疗装置包括定位在导管的远侧方面的矫直套筒，具有弓形远端的转向套管和穿过转向套筒的导丝。转向套筒具有第一位置，其中弓形远端在矫直套筒内矫直，以及第二位置，转向套筒向远侧延伸穿过矫直套筒以暴露弓形远端。转向套筒或导丝的弓形远端的尖端可用于刺穿闭塞。具有锁定机构和运动限制结构的轮毂组件的布置有助于调节和锁定矫直套筒，转向套筒和导丝的相对位置。止动机构与运动限制结构相关联，用于提供套筒和导丝的受控的增量运动。

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