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1. 发明申请

US20120202833A1 TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES 有权
标题翻译：三聚吡咯并吡啶衍生物
公开(公告)号：US20120202833A1
公开(公告)日：2012-08-09
申请号：US13452665
申请日：2012-04-20
申请人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
发明人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , C07D495/16
摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).
摘要翻译：由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物，和使用式（1）表示的化合物治疗癌症的方法。

2. 发明申请

US20070272005A1 Probe position control system and method 有权
标题翻译：探头位置控制系统及方法
公开(公告)号：US20070272005A1
公开(公告)日：2007-11-29
申请号：US11802624
申请日：2007-05-24
申请人： Masayuki Abe , Masahiro Ota , Yoshiaki Sugimoto , Kenichi Morita , Noriaki Oyabu , Seizo Morita , Oscar Custance
发明人： Masayuki Abe , Masahiro Ota , Yoshiaki Sugimoto , Kenichi Morita , Noriaki Oyabu , Seizo Morita , Oscar Custance
IPC分类号： G12B21/20 , G01N13/10
CPC分类号： G01Q30/06 , G01Q70/04
摘要： The present invention provides a technique for eliminating the effect of the thermal drift and other variances and to improve the observing or manipulating accuracy of a scanning probe microscope or atom manipulator by using the technique to correct the aforementioned change in the relative position of the probe and the sample due to heat or other factors during the observation or manipulation. To obtain an image of the sample surface at the atomic level or perform a certain manipulation on an atom on the sample surface, the present invention can be applied to a probe position control method for controlling the relative position of the probe and the sample while measuring an interaction between the objective atom on the sample surface and the tip of the probe. In the present method, the relative position of the probe and the sample are changed while the probe is oscillated relative to the sample in two directions parallel to the sample surface at frequencies of f1 and f2 (S1a). Meanwhile, a point (or characteristic point) where the frequencies f1 and f2 disappear from the measured value of the interaction working in the direction perpendicular to the sample surface is detected (S1b). Then, the relative movement of the probe and the sample is controlled so that the measurement value thereby detected is maintained (i.e. the characteristic point is tracked; S1c), and the speed of the aforementioned relative movement is determined (S1d). Subsequently, the relative position control is corrected using the detected speed (S2).
摘要翻译：本发明提供了一种用于消除热漂移和其它方差的影响的技术，并且通过使用该技术来校正探针的相对位置的上述变化来提高扫描探针显微镜或原子操纵器的观察或操纵精度，以及在观察或操纵期间由于热或其他因素导致的样品。为了获得原子级别的样品表面的图像或对样品表面上的原子进行一定的操作，本发明可以应用于用于在测量时控制探针和样品的相对位置的探针位置控制方法样品表面上的目标原子与探针尖端之间的相互作用。在本方法中，探针和样品的相对位置在f 1和f 2的频率下相对于样品在平行于样品表面的两个方向上振荡的同时发生变化， 2（S 1a）。同时，检测频率f 1和f 2 2的点（或特征点）从垂直于样品表面的方向上工作的相互作用的测量值消失（S 1b）。然后，控制探头和样品的相对移动，使得由此检测到的测量值被维持（即跟踪特征点; S1c），并且确定上述相对移动的速度（S1d）。随后，使用检测速度来校正相对位置控制（S 2）。

3. 发明申请

US20110071170A1 TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES 有权
标题翻译：三聚吡咯并吡啶衍生物
公开(公告)号：US20110071170A1
公开(公告)日：2011-03-24
申请号：US12915982
申请日：2010-10-29
申请人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
发明人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
IPC分类号： A61K31/519 , C07D495/16 , A61P35/00
CPC分类号： A61K31/519 , C07D495/16
摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).
摘要翻译：由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物，和使用式（1）表示的化合物治疗癌症的方法。

4. 发明授权

US4865915A Resin coated permanent magnet 失效
标题翻译：树脂涂层永久磁铁
公开(公告)号：US4865915A
公开(公告)日：1989-09-12
申请号：US169530
申请日：1988-03-17
申请人： Itaru Okonogi , Yukihiko Shiohara , Mitsuru Sakurai , Masahiro Ota
发明人： Itaru Okonogi , Yukihiko Shiohara , Mitsuru Sakurai , Masahiro Ota
IPC分类号： H01F1/055 , H01F41/02
CPC分类号： H01F1/0558 , H01F41/026 , Y10S428/90 , Y10T428/265 , Y10T428/3154 , Y10T428/31544
摘要： A waterproof resin coated permanent magnet is provided. The resin coating is either a waterproof fluoroplastic resin material or a mixture of fluoroplastic resin material and at least one organic resin such as epoxy resin, polyester resin, acrylic resin, phenol resin and mixtures thereof. The magnet has superior corrosion and weathering resistance.

5. 发明授权

US09320770B2 Blood vessel maturation, normalization or stabilization agent and wrinkle preventer/improver 有权
标题翻译：血管成熟，正常化或稳定剂和防皱剂/改良剂
公开(公告)号：US09320770B2
公开(公告)日：2016-04-26
申请号：US12736316
申请日：2009-03-31
申请人： Masahiro Ota , Koji Kobayashi , Ken Kusakari , Makoto Tsunenaga , Nobuyuki Takakura
发明人： Masahiro Ota , Koji Kobayashi , Ken Kusakari , Makoto Tsunenaga , Nobuyuki Takakura
IPC分类号： A61K36/54 , A61K8/97 , A61Q19/08
CPC分类号： A61K36/54 , A61K8/97 , A61Q19/08
摘要： A vascular maturation, normalization or stabilization agent, or a Tie-2 activation agent, is provided comprising an extract derived from a plant belonging to the genus Cinnamomum.
摘要翻译：提供血管成熟，归一化或稳定剂或Tie-2活化剂，其包含衍生自属于樟脑属植物的植物的提取物。

6. 发明授权

US08367124B2 Lymphatic vessel stabilizer 有权
标题翻译：淋巴管稳定剂
公开(公告)号：US08367124B2
公开(公告)日：2013-02-05
申请号：US12737203
申请日：2009-06-17
申请人： Kentaro Kajiya , Masahiro Ota
发明人： Kentaro Kajiya , Masahiro Ota
IPC分类号： A01N65/00
CPC分类号： A61K38/1891 , A61K31/343 , A61K36/254 , A61K36/54 , A61K38/45 , A61K38/00
摘要： Provided is a lymphatic vessel stabilizer composed of Tie2 activator. The Tie2 activator is preferably at least one type selected from the group consisting of angiopoietin 1 (Ang-1), extract of Cinnamomum species plants, extract of Siberian Ginseng and syringaresinol.
摘要翻译：提供由Tie2激活剂组成的淋巴管稳定剂。 Tie2活化剂优选为选自血管生成素1（Ang-1），樟属植物提取物，西伯利亚人参提取物和铃兰素的至少一种。

7. 发明申请

US20120230908A1 SUBSTRATE FOR GROWING CARBON NANOTUBES, MANUFACTURING METHOD THEREOF, AND MANUFACTURING METHOD OF ORIENTED CARBON NANOTUBES 有权
标题翻译：用于生长碳纳米管的基板，其制造方法和面向碳纳米管的制造方法
公开(公告)号：US20120230908A1
公开(公告)日：2012-09-13
申请号：US13413776
申请日：2012-03-07
申请人： Toshiyuki OHASHI , Toshio TOKUNE , Masahiro OTA , Hidefumi NIKAWA , Hiroshi KAWARADA , Takumi OCHIAI
发明人： Toshiyuki OHASHI , Toshio TOKUNE , Masahiro OTA , Hidefumi NIKAWA , Hiroshi KAWARADA , Takumi OCHIAI
IPC分类号： D01F9/12 , H05H1/02 , B82Y40/00 , B82Y30/00
CPC分类号： B82Y30/00 , B82Y40/00 , C01B31/0233 , C01B32/162 , C01B2202/08 , C01P2002/82 , D01F9/127 , D01F9/133 , Y10S977/742 , Y10S977/843
摘要： A substrate for growing carbon nanotubes capable of elongating single-walled carbon nanotubes of an average diameter of less than 2 nm is provided. The substrate for growing carbon nanotubes 1 is equipped with a reaction prevention layer 3 formed on a base material 2, a catalyst material layer 4 formed on the reaction prevention layer 3, a dispersion layer 5 formed on the catalyst material layer 4, and a dispersion promotion layer 6 formed on the dispersion layer 5.
摘要翻译：提供了用于生长能够延长平均直径小于2nm的单壁碳纳米管的碳纳米管的基板。用于生长碳纳米管1的基板配备有形成在基材2上的反应防止层3，形成在反应防止层3上的催化剂材料层4，形成在催化剂材料层4上的分散层5和分散体促进层6形成在分散层5上。

8. 发明授权

US08236813B2 Tricyclic pyrazolopyrimidine derivatives 有权
标题翻译：三环吡唑并嘧啶衍生物
公开(公告)号：US08236813B2
公开(公告)日：2012-08-07
申请号：US12915982
申请日：2010-10-29
申请人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
发明人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
IPC分类号： C07D491/00 , C07D239/00 , C07D471/00 , C07D487/00 , A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , C07D495/16
摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).
摘要翻译：由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物，和使用式（1）表示的化合物治疗癌症的方法。

9. 发明授权

US08037739B2 Method for analyzing sample in liquid 有权
标题翻译：分析液体样品的方法
公开(公告)号：US08037739B2
公开(公告)日：2011-10-18
申请号：US12197108
申请日：2008-08-22
申请人： Masahiro Ota , Noriaki Oyabu , Hiroaki Adachi , Masayuki Abe , Seizo Morita , Yusuke Mori , Takatomo Sasaki
发明人： Masahiro Ota , Noriaki Oyabu , Hiroaki Adachi , Masayuki Abe , Seizo Morita , Yusuke Mori , Takatomo Sasaki
IPC分类号： G01N11/00
CPC分类号： G01Q30/14 , G01N1/36 , G02B21/33 , G02B21/34
摘要： A method for analyzing a sample in a liquid is provided, which is suitable for easily and reliably preventing a liquid for analysis from being evaporated. When the sample in the liquid is observed by using a scanning probe microscope (SPM), a sealing liquid (17) immiscible with a liquid for analysis (16) is filled around the liquid for analysis (16), in which a sample (13) and a probe (15) are immersed, so as to form a sealing state, in which the liquid for analysis (16) is isolated from an external gas. The SPM enables the probe (15) disposed on a front end of a cantilever (14) to approach a surface of the sample (13) immersed in the liquid, scans the surface of the sample, and detects an interaction between the sample (13) and the probe (15), thereby generating an image.
摘要翻译：提供一种用于分析液体中的样品的方法，其适于容易且可靠地防止用于分析的液体蒸发。当使用扫描探针显微镜（SPM）观察液体中的样品时，将用于分析的液体（16）不混溶的密封液体（17）填充在用于分析的液体（16）周围，其中样品（13 ）和探针（15），以便形成用于分析用液体（16）与外部气体隔离的密封状态。 SPM使得布置在悬臂（14）的前端上的探针（15）接近浸入液体中的样品（13）的表面，扫描样品的表面，并检测样品（13）之间的相互作用）和探头（15），从而产生图像。

10. 发明授权

US07975316B2 Atomic force microscope and interaction force measurement method using atomic force microscope 有权
标题翻译：原子力显微镜和相互作用力测量方法使用原子力显微镜
公开(公告)号：US07975316B2
公开(公告)日：2011-07-05
申请号：US12523661
申请日：2008-01-07
申请人： Masahiro Ota , Noriaki Oyabu , Masayuki Abe , Oscar Custance , Yoshiaki Sugimoto , Seizo Morita
发明人： Masahiro Ota , Noriaki Oyabu , Masayuki Abe , Oscar Custance , Yoshiaki Sugimoto , Seizo Morita
IPC分类号： G01B5/28
CPC分类号： G01Q60/32 , G01Q30/04 , Y10S977/863
摘要： A frequency shift Δf obtained by an FM-AFM can be expressed by a simple linear coupling of a ΔfLR derived from a long-range interaction force and a ΔfSR derived from a short-range interaction force. Given this factor, a Δf curve on an atomic defect and a Δf curve on a target atom on the sample surface are each measured for only a relatively short range scale (S1 and S2), and a difference Δf curve of those two curves is obtained (S3). Since the difference Δf curve is derived only from a short-range interaction force, a known conversion operation is applied to this curve obtain an F curve which illustrates the relationship between the force and the distance Z, and then the short-range interaction force on the target atom is obtained from the F curve (S4). Since the range scale in measuring the Δf curve can be narrowed, the measurement time can be shortened, and since the conversion from the Δf curve into F curve is required only once, the computational time can also be shortened. Consequently, in obtaining the short-range interaction force which acts between the atom on the sample surface and the probe, the time required for the Δf curve's measurement and the computational time are shortened, which leads to accuracy improvement and throughput enhancement.
摘要翻译：通过FM-AFM获得的频移和Dgr f可以通过从远程相互作用力得到的＆Dgr; fLR和从短程相互作用力得到的＆Dgr; fSR的简单线性耦合来表示。考虑到这个因素，样品表面上的原子缺陷和目标原子上的＆Dgr; f曲线每个都只测量相对较短的范围尺度（S1和S2），并且差分Dgr f曲线得到这两条曲线（S3）。由于差值Dgr f曲线仅来自短距离相互作用力，因此将已知的转换操作应用于该曲线，获得F曲线，该F曲线说明了力与距离Z之间的关系，然后是短距离相互作用从F曲线获得目标原子上的力（S4）。由于可以缩小＆Dgr。f曲线的测量范围，所以可以缩短测量时间，由于从＆Dgr。f曲线到F曲线的转换只需要一次，所以计算时间也可以缩短。因此，在获得样品表面上的原子和探针之间作用的短程相互作用力时，缩短了＆Dgr。f曲线测量所需的时间和计算时间，从而提高了精度和提高了生产率。

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