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1. 发明授权

US08673942B2 Fused ring compounds and use thereof 失效
标题翻译：稠环化合物及其用途
公开(公告)号：US08673942B2
公开(公告)日：2014-03-18
申请号：US12936785
申请日：2009-04-09
申请人： Tsuneo Yasuma , Nobuyuki Takakura
发明人： Tsuneo Yasuma , Nobuyuki Takakura
IPC分类号： A61K31/4436 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.
摘要翻译：本发明的目的在于提供一种用作预防或治疗糖尿病，肥胖症等药物的药剂的葡糖激酶活化剂。本发明提供含有式（I）表示的化合物的葡糖激酶活化剂：其中每个符号在说明书中定义，或其盐或其前药。

2. 发明授权

US08557805B2 Fused ring compound and use thereof 失效
标题翻译：熔融环化合物及其用途
公开(公告)号：US08557805B2
公开(公告)日：2013-10-15
申请号：US13142507
申请日：2009-12-28
申请人： Tsuneo Yasuma , Nobuyuki Takakura , Yasufumi Miyamoto
发明人： Tsuneo Yasuma , Nobuyuki Takakura , Yasufumi Miyamoto
IPC分类号： A61K31/535 , C07D277/04
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/541
摘要： The present invention provides an agent for the prophylaxis or treatment of diabetes, obesity and the like, a glucokinase activator, containing a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供了用于预防或治疗糖尿病，肥胖症等的药剂，含有式（I）表示的化合物的葡糖激酶活化剂：其中每个符号如说明书中所定义，或其盐或前药。

3. 发明申请

US20120270922A1 Antiangiogenic Agent and Method for Inhibition of Angiogenesis 审中-公开
标题翻译：抗血管生成剂和抑制血管发生的方法
公开(公告)号：US20120270922A1
公开(公告)日：2012-10-25
申请号：US13392196
申请日：2010-08-26
申请人： Nobuyuki Takakura , Hiroyasu Kidoya , Fumitaka Muramatsu
发明人： Nobuyuki Takakura , Hiroyasu Kidoya , Fumitaka Muramatsu
IPC分类号： A61K31/7052 , A61P27/02 , A61P29/00 , A61P35/00 , A61P9/00
CPC分类号： A61K31/7105 , A61K38/177 , C12N15/1138 , C12N2310/141 , C12N2330/10 , C12N2330/51
摘要： This invention provides an antiangiogenic agent having a higher treatment effect than those of conventional antiangiogenic agents, and a method for inhibiting angiogenesis using the same. An antiangiogenic agent comprising at least one miRNA type selected from the group consisting of miRNAs, pre-miRNAs, and pri-miRNAs, each having a miRNA activity on VE-cadherin.
摘要翻译：本发明提供了具有比常规抗血管生成剂更高治疗效果的抗血管生成剂，以及使用其的抑制血管发生的方法。一种抗血管生成剂，其包含选自miRNA，前miRNA和pri-miRNA中的至少一种miRNA型，其各自在VE-钙粘蛋白上具有miRNA活性。

4. 发明申请

US20060135578A1 Five-membered heterocyclic compounds 失效
标题翻译：五元杂环化合物
公开(公告)号：US20060135578A1
公开(公告)日：2006-06-22
申请号：US10527426
申请日：2003-09-09
申请人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
发明人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号： A61K31/422 , C07D413/14
CPC分类号： C07D263/32 , C07F9/6558 , C07F9/65583
摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.
摘要翻译：本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2）（n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

5. 发明申请

US20130296276A2 HETEROCYCLIC RING COMPOUND 有权
标题翻译：杂环化合物
公开(公告)号：US20130296276A2
公开(公告)日：2013-11-07
申请号：US13810021
申请日：2011-07-14
申请人： Osamu UJIKAWA , Kazuaki TAKAMI , Nobuyuki TAKAKURA , Nozomu SAKAI
发明人： Osamu UJIKAWA , Kazuaki TAKAMI , Nobuyuki TAKAKURA , Nozomu SAKAI
IPC分类号： C07F9/58 , C07D213/56 , C07D401/12 , C07D413/12
CPC分类号： C07F9/58 , A61K31/4418 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D213/56 , C07D401/12 , C07D413/12
摘要： The present invention provides a compound having a muscle cell or adipocyte differentiation regulating action, useful for the prophylaxis or treatment of diseases such as diabetes, obesity, dyslipidemia and the like, and the like, and having superior efficacy.The present invention provides a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof.
摘要翻译：本发明提供具有肌肉细胞或脂肪细胞分化调节作用的化合物，其用于预防或治疗诸如糖尿病，肥胖症，血脂异常等疾病等，并具有优异的疗效。本发明提供由下式表示的化合物：其中每个符号如说明书中所定义，或其盐。

6. 发明申请

US20130116214A1 HETEROCYCLIC RING COMPOUND 有权
公开(公告)号：US20130116214A1
公开(公告)日：2013-05-09
申请号：US13810021
申请日：2011-07-14
申请人： Osamu Ujikawa , Kazuaki Takami , Nobuyuki Takakura , Nozomu Sakai
发明人： Osamu Ujikawa , Kazuaki Takami , Nobuyuki Takakura , Nozomu Sakai
IPC分类号： C07F9/58 , C07D213/56 , C07D401/12 , C07D413/12
CPC分类号： C07F9/58 , A61K31/4418 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D213/56 , C07D401/12 , C07D413/12
摘要： The present invention provides a compound having a muscle cell or adipocyte differentiation regulating action, useful for the prophylaxis or treatment of diseases such as diabetes, obesity, dyslipidemia and the like, and the like, and having superior efficacy.The present invention provides a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof.

7. 发明授权

US08093047B2 Induction of myocardial cell from mammalian bone marrow cell or cord blood-derived cell and fat tissue 失效
标题翻译：从哺乳动物骨髓细胞或脐带血来源的细胞和脂肪组织诱导心肌细胞
公开(公告)号：US08093047B2
公开(公告)日：2012-01-10
申请号：US10584028
申请日：2004-12-21
申请人： Nobuyuki Takakura , Yoshihiro Yamada
发明人： Nobuyuki Takakura , Yoshihiro Yamada
IPC分类号： C12N5/07 , C12N5/0775
CPC分类号： A61L27/383 , A61L27/3826 , A61L27/3839 , A61L27/3895 , C12N5/0657 , C12N2502/1305 , C12Q1/02
摘要： This invention provides a method for differentiating mammalian bone marrow cells or cord blood-derived cells into myocardial precursor cells and/or myocardial cells by culturing said bone marrow cells or cord blood-derived cells with cells isolated from mammalian fat tissues or a culture supernatant thereof.
摘要翻译：本发明提供了通过用哺乳动物脂肪组织分离的细胞培养所述骨髓细胞或脐带血来源的细胞或其培养上清液来将哺乳动物骨髓细胞或脐带血衍生细胞分化为心肌前体细胞和/或心肌细胞的方法。

8. 发明申请

US20110070297A1 GLUCOKINASE ACTIVATORS 审中-公开
公开(公告)号：US20110070297A1
公开(公告)日：2011-03-24
申请号：US12958265
申请日：2010-12-01
申请人： Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang
发明人： Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang
IPC分类号： A61K31/5377 , C07D249/12 , A61K31/4196 , A61K9/127 , C07D401/12 , A61K31/4439 , C07D413/12 , C07D231/20 , A61K31/415 , C07D403/10 , C07D403/12 , A61K31/496 , A61K31/4178 , A61K31/506 , A61K31/427 , A61K31/4184 , C07D413/04 , A61K31/423 , C07D471/04 , A61K31/4353 , A61K31/517 , A61P3/10
CPC分类号： C07D249/12 , C07D231/12 , C07D231/20 , C07D249/08 , C07D249/14 , C07D401/04 , C07D401/12 , C07D407/04 , C07D409/12 , C07D417/12
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的葡糖激酶：其中变量如本文所定义。

9. 发明授权

US07238716B2 Alkanoic acid derivatives process for their production and use thereof 失效
标题翻译：用于其生产和使用的烷酸衍生物方法
公开(公告)号：US07238716B2
公开(公告)日：2007-07-03
申请号：US10465938
申请日：2001-12-28
申请人： Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
发明人： Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
IPC分类号： A61K31/4439 , C07D413/12
CPC分类号： C07D403/04 , C07D263/32 , C07D277/24 , C07D277/42 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula wherein R1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1-(n is an integer of 1 to 8 and Z1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.
摘要翻译：可用作糖尿病，高脂血症，葡萄糖耐量异常等的预防或治疗剂的链烷酸衍生物可由下式表示的化合物提供：其中R 1为任选取代的5元芳香族杂环基; X是一个键等; Q为碳原子数为1〜20的二价烃基; Y是一个债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - n 1 - （n是1至8的整数，Z <1） SUP>是氧原子等）等; 环B是任选还含有1至3个取代基的吡啶环等; U是一个债券等; W是碳原子数为1〜20的二价烃基; 且R 3为-OH等，条件是当环B为任选还含有1至3个取代基的苯环时，U应为键或其盐。

10. 发明授权

US09320770B2 Blood vessel maturation, normalization or stabilization agent and wrinkle preventer/improver 有权
标题翻译：血管成熟，正常化或稳定剂和防皱剂/改良剂
公开(公告)号：US09320770B2
公开(公告)日：2016-04-26
申请号：US12736316
申请日：2009-03-31
申请人： Masahiro Ota , Koji Kobayashi , Ken Kusakari , Makoto Tsunenaga , Nobuyuki Takakura
发明人： Masahiro Ota , Koji Kobayashi , Ken Kusakari , Makoto Tsunenaga , Nobuyuki Takakura
IPC分类号： A61K36/54 , A61K8/97 , A61Q19/08
CPC分类号： A61K36/54 , A61K8/97 , A61Q19/08
摘要： A vascular maturation, normalization or stabilization agent, or a Tie-2 activation agent, is provided comprising an extract derived from a plant belonging to the genus Cinnamomum.
摘要翻译：提供血管成熟，归一化或稳定剂或Tie-2活化剂，其包含衍生自属于樟脑属植物的植物的提取物。

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