专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06469023B1 Heterocyclic spiro-derivative 失效
标题翻译：杂环螺衍生物
公开(公告)号：US06469023B1
公开(公告)日：2002-10-22
申请号：US08875863
申请日：1997-08-07
申请人： Makoto Takemura , Youichi Kimura , Hitoshi Ohki
发明人： Makoto Takemura , Youichi Kimura , Hitoshi Ohki
IPC分类号： A61K3144
CPC分类号： C07D401/04
摘要： The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which contains the same, more particularly a compound which possesses high safety and excellent activity against a broad range of bacterial species including quinolone-resistant strains. A quinolone derivative of the following formula (I) which has a group derived from the heterocyclic spiro-compound at the 7-positioned R2 and the halogenocyclopropyl group at the N1-position, prefereably a compound of pure isomer, and an antibacterial agent containing the derivative compound.
摘要翻译：本发明提供了可用作药物，动物药物，渔业药物或抗菌防腐剂的抗菌化合物，以及含有该抗菌剂或抗菌剂的抗菌剂或制剂，更具体地，涉及对广泛的细菌种类具有高安全性和优异活性的化合物，包括喹诺酮耐药株。下述式（I）的喹啉酮衍生物，其具有衍生自7-位R2上的杂环螺环化合物和N1位上的卤代环丙基的基团，优选纯异构体的化合物和含有衍生化合物。

2. 发明授权

US06194434B1 Cycloalkylaminomethylpyrrolidine derivatives 失效
标题翻译：环烷基氨基甲基吡咯烷衍生物
公开(公告)号：US06194434B1
公开(公告)日：2001-02-27
申请号：US09171637
申请日：1998-10-22
申请人： Makoto Takemura , Youichi Kimura , Katsuhiro Kawakami , Hitoshi Ohki
发明人： Makoto Takemura , Youichi Kimura , Katsuhiro Kawakami , Hitoshi Ohki
IPC分类号： A61K3147
CPC分类号： C07D401/04
摘要： A quinolone derivative represented by formula (I): wherein R1 represents a cycloalkyl group; R2 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R3 represents an amino group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R5 represents a cycloalkyl group having 3 to 6 carbon atoms; the above R1 to R5 may be substituted; X represents a halogen atom or a hydrogen atom; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, or a phenylalkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof, or a salt thereof. The compound exhibits high and broad antimicrobial activity against various bacteria including bacteria resistant to drugs and high safety.
摘要翻译：由式（I）表示的喹诺酮衍生物：其中R1表示环烷基; R2表示氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基或烷氧基; R3表示氨基，卤代甲基，卤代甲氧基，烷基，烯基，炔基或烷氧基; R4表示氢原子或碳原子数1〜6的烷基。 R5表示碳原子数3〜6的环烷基; 上述R 1〜R 5可以被取代; X表示卤素原子或氢原子; Y表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基，苯酞基，5-烷基-2-氧代 - 1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，碳原子数1〜6的烷基，碳原子数2〜7的烷氧基甲基或碳原子数1〜6的苯基烷基其烷基部分的原子，或其盐。该化合物对各种细菌（包括对药物有抗性的细菌和高安全性）具有高而广的抗菌活性。

3. 发明授权

US08445504B2 Tricyclic pyrazolopyrimidine derivatives 有权
标题翻译：三环吡唑并嘧啶衍生物
公开(公告)号：US08445504B2
公开(公告)日：2013-05-21
申请号：US13452665
申请日：2012-04-20
申请人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
发明人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , C07D495/16
摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).
摘要翻译：由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物，和使用式（1）表示的化合物治疗癌症的方法。

4. 发明申请

US20070191356A1 Pyridobenzoxazine derivative 审中-公开
标题翻译：吡啶并苯并恶嗪衍生物
公开(公告)号：US20070191356A1
公开(公告)日：2007-08-16
申请号：US10587946
申请日：2005-02-01
申请人： Makoto Takemura , Hitoshi Ohki
发明人： Makoto Takemura , Hitoshi Ohki
IPC分类号： A61K31/535 , C07D265/38
CPC分类号： C07D498/06 , A23K20/111 , A23K20/195 , A23K50/80 , A23L3/3544 , A61K31/5383
摘要： A quinolone antimicrobial agent having potent antimicrobial activity against gram positive and gram negative bacteria and having high safety is provided. A compound represented by the following formula (1): [Chemical formula 1] [wherein, R1: hydrogen, alkyl, cycloalkyl, or substituted carbonyl derived from amino acid, peptide or tripeptide; R2: hydrogen, alkyl, or cycloalkyl; R3: hydrogen, amino, halogen, or alkyl; R4: hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl; X, X1, X2: hydrogen or halogen] or salt thereof, or a hydrate thereof; and antimicrobial agent and therapeutic agent for infections, each containing the compound, salt thereof or a hydrate thereof.
摘要翻译：提供了对革兰氏阳性和革兰氏阴性细菌具有强抗微生物活性并具有高安全性的喹诺酮类抗微生物剂。由下式（1）表示的化合物：[化学式1] [其中，R 1，H 2，氢，烷基，环烷基或衍生自氨基酸，肽或三肽的取代的羰基; R 2：氢，烷基或环烷基; 氢，氨基，卤素或烷基; 吡啶，二甲基氨基乙基，5-茚满基，邻苯二甲酰基，5-烷基-2-氧代-1,3-二氧杂环戊烯-4-基甲基，3-甲氧基羰基，乙酰氧基-2-氧代丁基，烷基，烷氧基甲基或苯基烷基; X，X 1，X 2：氢或卤素]或其盐或其水合物; 和抗微生物剂和感染治疗剂，各自含有化合物，其盐或其水合物。

5. 发明授权

US08556332B2 Vehicle door 有权
标题翻译：车门
公开(公告)号：US08556332B2
公开(公告)日：2013-10-15
申请号：US13606532
申请日：2012-09-07
申请人： Atsushi Nakashima , Hitoshi Ohki
发明人： Atsushi Nakashima , Hitoshi Ohki
IPC分类号： B60R5/04
CPC分类号： B60J5/0416 , B60R13/0243 , B60R21/04 , B60R21/0428
摘要： A vehicle door includes a door main body having a hollow portion, a work hole, a door hole seal that covers the work hole, a door trim, a protruding member provided so as to protrude from the door trim toward the vehicle interior side surface, and a harness routed through the door hole seal to the door trim side. The door hole seal is provided with a general surface, a bulging portion facing the protruding member and bulging from the general surface toward the inside of the hollow portion, and a harness pull-out hole through which the harness is passed. The bulging portion has an inclined surface.
摘要翻译：车门包括具有中空部分的门主体，工作孔，覆盖工作孔的门孔密封件，门装饰件，设置成从门饰件朝向车辆内侧表面突出的突出构件，以及通过门孔密封件通向门饰边的线束。门孔密封件设置有一般表面，与突出构件相对的凸出部分，并且从一般表面朝向中空部分的内侧突出，以及线束拉出孔，线束穿过该孔。凸出部分具有倾斜表面。

6. 发明申请

US20130076060A1 VEHICLE DOOR 有权
标题翻译：车门
公开(公告)号：US20130076060A1
公开(公告)日：2013-03-28
申请号：US13606532
申请日：2012-09-07
申请人： Atsushi Nakashima , Hitoshi Ohki
发明人： Atsushi Nakashima , Hitoshi Ohki
IPC分类号： B60R11/02
CPC分类号： B60J5/0416 , B60R13/0243 , B60R21/04 , B60R21/0428
摘要： A vehicle door includes a door main body having a hollow portion, a work hole, a door hole seal that covers the work hole, a door trim, a protruding member provided so as to protrude from the door trim toward the vehicle interior side surface, and a harness routed through the door hole seal to the door trim side. The door hole seal is provided with a general surface, a bulging portion facing the protruding member and bulging from the general surface toward the inside of the hollow portion, and a harness pull-out hole through which the harness is passed. The bulging portion has an inclined surface.
摘要翻译：车门包括具有中空部分的门主体，工作孔，覆盖工作孔的门孔密封件，门装饰件，设置成从门饰件朝向车辆内侧表面突出的突出构件，以及通过门孔密封件通向门饰边的线束。门孔密封件设置有一般表面，与突出构件相对的凸出部分，并且从一般表面朝向中空部分的内侧突出，以及线束拉出孔，线束穿过该孔。凸出部分具有倾斜表面。

7. 发明申请

US20120202833A1 TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES 有权
标题翻译：三聚吡咯并吡啶衍生物
公开(公告)号：US20120202833A1
公开(公告)日：2012-08-09
申请号：US13452665
申请日：2012-04-20
申请人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
发明人： Hitoshi Ohki , Tooru Okayama , Masahiro Ikeda , Masahiro Ota , Yoshihiro Shibata , Toshiyuki Nakanishi , Yasusi Ueda , Nobuyuki Suzuki , Shinji Matuura
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , C07D495/16
摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).
摘要翻译：由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物，和使用式（1）表示的化合物治疗癌症的方法。

8. 发明授权

US06656952B2 Cis-substituted fluoromethylpyrrolidine derivative 失效
标题翻译：顺式取代的氟甲基吡咯烷衍生物
公开(公告)号：US06656952B2
公开(公告)日：2003-12-02
申请号：US09446696
申请日：1999-12-23
申请人： Makoto Takemura , Hisashi Takahashi , Hitoshi Ohki , Kenichi Kimura , Rie Miyauchi , Toshiyuki Takeda
发明人： Makoto Takemura , Hisashi Takahashi , Hitoshi Ohki , Kenichi Kimura , Rie Miyauchi , Toshiyuki Takeda
IPC分类号： A61K3147
CPC分类号： C07D401/04
摘要： An antibacterial drug having potent antibacterial activities upon various bacteria including resistant strains and high safety is disclosed, which comprises as an active ingredient, quinolone derivatives represented by the following formula (I), its salts or hydrates thereof: wherein R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 represents a halogenomethoxyl group or an alkoxyl group, R3 represents an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, a heteroaryl group, an alkoxyl group or an alkylamino group, and R4 represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, 3-acetoxy-2-oxobutyl group, an alkyl group, an alkoxylmethyl group or a phenylalkyl group. These substituents may further have additional substituents.
摘要翻译：本发明公开了一种对各种细菌（包括耐药菌株）和高度安全性具有有效抗菌活性的抗菌药物，其包含作为活性成分的由下式（I）表示的喹诺酮衍生物，其盐或水合物：其中R 1表示氢原子或碳原子数1〜6的烷基，R 2表示卤代甲氧基或烷氧基，R 3表示烷基，链烯基，卤代烷基，环状烷基，杂芳基基团，烷氧基或烷基氨基，R 4表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基， 5-烷基-2-氧代-1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，烷基，烷氧基甲基或苯基烷基。这些取代基还可以具有另外的取代基。

9. 发明授权

US06573377B1 Pyrazole derivatives and salts thereof 失效
标题翻译：吡唑衍生物及其盐
公开(公告)号：US06573377B1
公开(公告)日：2003-06-03
申请号：US09744428
申请日：2001-01-24
申请人： Akio Ejima , Satoru Ohsuki , Hitoshi Ohki , Hiroyuki Naito , Chie Makino
发明人： Akio Ejima , Satoru Ohsuki , Hitoshi Ohki , Hiroyuki Naito , Chie Makino
IPC分类号： C07D40314
CPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
摘要： This invention provides compounds having antitumor effect, namely a compound represented by the following formula (I) or (Ia) having various substituents in which G and G1 are condensed tricyclic heterocyclic rings or salts thereof, and a compound represented by the following formula (Ib) having various substituents or salts thereof.
摘要翻译：本发明提供具有抗肿瘤效果的化合物，即具有G和G1为稠合三环杂环的各种取代基的下式（I）或（Ia）表示的化合物或其盐，以及下式（Ib ）具有各种取代基或其盐。

10. 发明授权

US06384050B1 Tricyclic amine derivatives 失效
标题翻译：三环胺衍生物
公开(公告)号：US06384050B1
公开(公告)日：2002-05-07
申请号：US09284871
申请日：1999-04-22
申请人： Makoto Takemura , Hisashi Takahashi , Kenichi Kimura , Rie Miyauchi , Hitoshi Ohki , Katsuhiro Kawakami
发明人： Makoto Takemura , Hisashi Takahashi , Kenichi Kimura , Rie Miyauchi , Hitoshi Ohki , Katsuhiro Kawakami
IPC分类号： C07D40104
CPC分类号： C07D401/04 , C07D455/02 , C07D471/04 , C07D513/04
摘要： The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. wherein Q preferably represents the following partial structure which may have various substituents:
摘要翻译：本发明涉及可具有各种取代基的三环胺取代基的化合物，该化合物由式（I）表示，其盐或水合物，以及该盐的水合物和含有它们作为有效成分的药物。它们对革兰氏阴性细菌和革兰氏阳性菌表现出优异的抗微生物活性，具有令人满意的命运和安全性，可用于治疗感染性疾病。其中Q优选表示以下可能具有各种取代基的部分结构：

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式