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1. 发明申请

US20170216262A1 AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES 审中-公开
公开(公告)号：US20170216262A1
公开(公告)日：2017-08-03
申请号：US15473110
申请日：2017-03-29
申请人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Xiongcai LIU , Snahel PATEL , Po-Wai YUEN , Mark ZAK , Guiling ZHAO , Yamin ZHANG , Xiaozhang ZHENG
发明人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Xiongcai LIU , Snahel PATEL , Po-Wai YUEN , Mark ZAK , Guiling ZHAO , Yamin ZHANG , Xiaozhang ZHENG
IPC分类号： A61K31/438 , C07D471/04 , C07D495/04 , C07D487/04 , A61K31/519 , C07D491/048 , A61K31/496 , A61K31/4545 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/513 , A61K31/541 , A61K31/506 , A61K31/501 , C07D519/00 , A61K45/06
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

2. 发明申请

US20150104384A1 AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES 审中-公开
标题翻译： AMIDO-苄基硫醚和硫代衍生物
公开(公告)号：US20150104384A1
公开(公告)日：2015-04-16
申请号：US14382141
申请日：2013-03-01
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D519/00 , A61K31/454 , A61K31/5386 , C07D491/048 , A61K31/4545 , A61K45/06 , C07D471/04 , C07D495/04 , A61K31/496 , A61K31/5025 , A61K31/46 , A61K31/551 , C07D487/04 , A61K31/5377
摘要： The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
摘要翻译：本发明涉及某些酰氨基 - 苄基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。

3. 发明申请

US20160355514A1 PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES 审中-公开
公开(公告)号：US20160355514A1
公开(公告)日：2016-12-08
申请号：US15243289
申请日：2016-08-22
申请人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
发明人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
IPC分类号： C07D471/04 , C07D491/048 , C07D495/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

4. 发明申请

US20050092130A1 Process and apparatus for the direct reduction of iron oxides in an electrothermal fluidized bed and resultant product 审中-公开
标题翻译：用于在电热流化床和所得产物中直接还原氧化铁的方法和装置
公开(公告)号：US20050092130A1
公开(公告)日：2005-05-05
申请号：US10506764
申请日：2003-03-19
申请人： William Golberger , Mark Zak
发明人： William Golberger , Mark Zak
IPC分类号： B01J8/00 , B01J8/18 , B01J8/42 , C21B13/00 , C21B13/12 , C22B1/245 , C22B4/08 , C22B5/10 , C22B5/14 , F27B15/00 , F27B15/04 , F27B15/08 , F27B15/09 , F27B15/10 , F27B15/14 , F27D3/00 , F27D3/16 , F27D7/06 , F27D13/00 , F27D15/02 , F27D17/00 , F27D99/00 , H05B3/00 , H05B3/60 , C21C5/52
CPC分类号： F27D99/0006 , B01J8/0075 , B01J8/1818 , B01J8/42 , B01J2208/00398 , B01J2208/00557 , B01J2219/00006 , B01J2219/0809 , B01J2219/0828 , B01J2219/083 , B01J2219/0879 , B01J2219/1946 , C21B13/0033 , C21B13/0046 , C21B13/12 , C22B1/245 , C22B4/08 , C22B5/10 , C22B5/14 , F27B15/006 , F27B15/04 , F27B15/08 , F27B15/09 , F27B15/10 , F27B15/14 , F27D3/0033 , F27D7/06 , F27D13/00 , F27D15/02 , F27D17/004 , F27D2003/166 , F27D2099/0025 , H05B3/0004 , H05B3/60 , Y02P10/136 , Y02P10/212
摘要： A method and an apparatus (50) for producing direct reduced iron (37) from dry pellets (25) composed of iron oxide and carbonaceous material. A mixture of pellets (25) and free coke particles (38) with weight relation from 3:1 to 5:1 is fed into the top of an electrothermal fluidized bed (32) that is fluidized by nitrogen. By exposing pellets (25) in the electrothermal fluidized bed (32) to temperatures of between approximately 850-1,100° C. for an average period of between approximately 15-60 minutes, the volatiles are removed and the pellets (25) metallized. Reduced pellets (37) mixed with free coke (38) are discharged from the bottom of fluidized bed (32) and cooled. The reduced iron pellets (37) are physically separated from any free coke (38) and the free coke (38) is recycled back into the fluidized bed (32).
摘要翻译：一种用于由由氧化铁和碳质材料构成的干燥颗粒（25）制备直接还原铁（37）的方法和装置（50）。将颗粒（25）和游离焦炭颗粒（38）的混合物加入到由氮气流化的电热流化床（32）的顶部，重量关系为3:1至5:1。通过将电热流化床（32）中的颗粒（25）暴露于约850-1100℃之间的温度平均约15-60分钟之间，除去挥发物并将颗粒（25）金属化。与游离焦炭（38）混合的还原颗粒（37）从流化床（32）的底部排出并冷却。还原铁丸（37）与任何游离焦炭（38）物理分离，游离焦炭（38）再循环回流化床（32）。

5. 发明申请

US20050063892A1 Thermally modified carbon blacks for various type applications and a process for producing same 审中-公开
标题翻译：用于各种类型应用的热改性炭黑及其制备方法
公开(公告)号：US20050063892A1
公开(公告)日：2005-03-24
申请号：US10666048
申请日：2003-09-18
申请人： Deepak Tandon , Jore Ayala , Rodney Taylor , Mark Zak , Igor Barsukov , Joseph Doninger , Peter Booth
发明人： Deepak Tandon , Jore Ayala , Rodney Taylor , Mark Zak , Igor Barsukov , Joseph Doninger , Peter Booth
IPC分类号： C09C1/50 , C09C1/56 , H01M4/62 , H01M4/90 , H01M8/02 , H01M12/08 , C09C1/48
CPC分类号： H01M4/625 , B82Y30/00 , C01P2004/62 , C01P2004/64 , C01P2006/19 , C01P2006/40 , C09C1/50 , C09C1/56 , H01M4/9083 , H01M8/0234 , H01M12/08 , Y02E60/128
摘要： An electro thermal fluidized bed furnace is adapted to be used in a process for continuously heat treating of fine particulate matter, such as carbon black material, by continuously introducing a non-reactive fluidizing gas through the nozzles of the furnace at a pre-determined rate, continuously introducing untreated carbon black material through the feed pipe of the furnace at a predetermined rate so that it forms a fluidized bed, energizing the electrode so as to heat the fluidized bed, and continuously collecting the treated carbon black from the discharge pipe. The carbon black collected from the discharge pipe exhibits properties of having the PAHs and sulfur removed, the carbon black has been graphitized, the moisture pick-up by the carbon black has been eliminated and the carbon black is more oxidation resistant, Furthermore, the resultant furnace carbon backs have a particle size of 7-100 nm and an oil absorption number of 50-300 ml/100 g., while the thermal blacks have a particle size of 200-500 nm and an oil absorption number of less than 50 ml/100 g. All of these properties result in thermally modified carbon blacks having such properties and of such purity so as to provide improved performance properties in food contact type applications, moisture cured polymer systems, zinc-carbon dry cell battery applications, and semi-conductive wire and cable applications.
摘要翻译：电热流化床炉适用于通过以预定的速率连续引入非反应性流化气体通过炉的喷嘴而连续热处理细颗粒物质如炭黑材料的方法以预定的速率连续地引入未处理的炭黑材料通过炉的进料管，从而形成流化床，给电极通电以加热流化床，并从排出管中连续收集经处理的炭黑。从排出管收集的炭黑具有除去多环芳烃和硫的性质，炭黑已被石墨化，炭黑的吸湿性已经消除，炭黑更耐氧化。此外，所得物炉碳背部具有7-100nm的粒度和50-300ml / 100g的吸油量，而热黑色的粒度为200-500nm，吸油量小于50ml /100克。所有这些性质都导致具有这种性质和纯度的热改性炭黑，以便在食品接触型应用中提供改进的性能特性，湿固化聚合物体系，锌 - 碳干电池电池应用和半导体电线电缆应用程序。

6. 发明申请

US20110201593A1 TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 失效
标题翻译：三元杂环化合物，组合物及其使用方法
公开(公告)号：US20110201593A1
公开(公告)日：2011-08-18
申请号：US13004808
申请日：2011-01-11
申请人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
发明人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
IPC分类号： A61K31/397 , C07D471/14 , A61K31/437 , C07D413/14 , A61K31/5377 , A61K31/496 , A61K31/55 , A61K31/506 , A61P19/02 , A61P17/06 , A61P37/06 , A61P11/06
CPC分类号： C07D471/14 , C07D487/10
摘要： The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
摘要翻译：本发明提供具有以下通式的新颖的式I化合物：其中R1，R2，R3，X和Y如本文所述。因此，化合物可以以药学上可接受的组合物提供，并用于治疗免疫学或过度增殖性疾病。

7. 发明申请

US20150175621A1 PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES 有权
标题翻译：吡啶并吡啶衍生物和硫代衍生物
公开(公告)号：US20150175621A1
公开(公告)日：2015-06-25
申请号：US14382123
申请日：2013-03-01
申请人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
发明人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC分类号： C07D495/04 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D491/048
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
摘要翻译：公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。

8. 发明授权

US08461328B2 Tricyclic heterocyclic compounds, compositions and methods of use thereof 失效
标题翻译：三环杂环化合物，其组合物及其使用方法
公开(公告)号：US08461328B2
公开(公告)日：2013-06-11
申请号：US13004808
申请日：2011-01-11
申请人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
发明人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
IPC分类号： A61P11/06 , A61P17/06 , A61P19/02 , A61P37/06 , C07D413/14 , C07D471/14
CPC分类号： C07D471/14 , C07D487/10
摘要： The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
摘要翻译：本发明提供具有以下通式的新颖的式I化合物：其中R1，R2，R3，X和Y如本文所述。因此，化合物可以以药学上可接受的组合物提供，并用于治疗免疫学或过度增殖性疾病。

9. 发明申请

US20120190665A1 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS 有权
标题翻译：吡唑并嘧啶酮抑制剂化合物和方法
公开(公告)号：US20120190665A1
公开(公告)日：2012-07-26
申请号：US13382145
申请日：2010-07-02
申请人： Paul Gibbons , Emily Hanan , Wendy Liu , Joseph P. Lyssikatos , Steven R. Magnuson , Rohan Mendonca , Richard Pastor , Thomas E. Rawson , Michael Siu , Mark Zak , Aihe Zhou , Bing-Yan Zhu
发明人： Paul Gibbons , Emily Hanan , Wendy Liu , Joseph P. Lyssikatos , Steven R. Magnuson , Rohan Mendonca , Richard Pastor , Thomas E. Rawson , Michael Siu , Mark Zak , Aihe Zhou , Bing-Yan Zhu
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P7/00 , A61P1/00 , A61P17/06 , A61P17/00 , A61P19/02 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.
摘要翻译：其中R 1，R 2和R 3在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作一种或多种Janus激酶的抑制剂。公开了包含式I化合物和药学上可接受的载体，佐剂或媒介物的药物组合物，以及对患者中Janus激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

10. 发明授权

US08169214B2 Angular position sensor 有权
标题翻译：角位置传感器
公开(公告)号：US08169214B2
公开(公告)日：2012-05-01
申请号：US12134524
申请日：2008-06-06
申请人： Mark Zak
发明人： Mark Zak
IPC分类号： G01B7/30
CPC分类号： G01P3/487 , B60T8/171 , B60T8/329 , G01D5/145 , G01R33/0094
摘要： An angular position sensor and method that relies on a stationary circular array of Hall sensors and a rotatable circular array of magnets arranged about a common axis. A periodic and simultaneous reading of all of the Hall sensor outputs is used to determine angular velocity.
摘要翻译：一种角位置传感器和方法，其依赖于霍尔传感器的固定圆形阵列和围绕共同轴线布置的可旋转的圆形磁体阵列。使用所有霍尔传感器输出的周期性和同步读数来确定角速度。

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