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1. 发明申请

US20120209051A1 METHOD AND APPARATUS FOR THE DELIVERY OF PHOTOCHEMICAL (CROSS-LINKING) TREATMENT TO SCLERAL TISSUE 有权
标题翻译：用于将化学（交联）处理给药物组织的方法和装置
公开(公告)号：US20120209051A1
公开(公告)日：2012-08-16
申请号：US13396454
申请日：2012-02-14
申请人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
发明人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
IPC分类号： A61M37/00 , A61F9/00
CPC分类号： A61F9/0017 , A61F9/0079 , A61K9/0051 , A61K31/525 , A61K41/0038 , A61K41/0057 , A61N5/062
摘要： Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
摘要翻译：公开了将核黄素（R / F）和UVA照射用于巩膜的递送系统和方法。传送R / F，然后通过使用LED或光纤进行UVA照射激活，从而引起胶原组织的交联。输送系统包括提供符合巩膜的表面的可植入结构。递送系统包括用于将R / F递送到巩膜表面上的各种类型的结构。另外，递送系统包括在巩膜胶原组织中提供R / F照射的UVA源。

2. 发明授权

US09005099B2 Method and apparatus for the delivery of photochemical (cross-linking) treatment to scleral tissue 有权
标题翻译：用于向巩膜组织递送光化学（交联）治疗的方法和装置
公开(公告)号：US09005099B2
公开(公告)日：2015-04-14
申请号：US13396454
申请日：2012-02-14
申请人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
发明人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
IPC分类号： A61M37/00 , A61F9/00 , A61F9/007 , A61K31/525 , A61K41/00 , A61N5/06
CPC分类号： A61F9/0017 , A61F9/0079 , A61K9/0051 , A61K31/525 , A61K41/0038 , A61K41/0057 , A61N5/062
摘要： Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
摘要翻译：公开了将核黄素（R / F）和UVA照射用于巩膜的递送系统和方法。传送R / F，然后通过使用LED或光纤进行UVA照射激活，从而引起胶原组织的交联。输送系统包括提供符合巩膜的表面的可植入结构。递送系统包括用于将R / F递送到巩膜表面上的各种类型的结构。另外，递送系统包括在巩膜胶原组织中提供R / F照射的UVA源。

3. 发明申请

US20110282333A1 Method and apparatus for treatment of ocular tissue using combined modalities 有权
标题翻译：使用组合方式治疗眼组织的方法和装置
公开(公告)号：US20110282333A1
公开(公告)日：2011-11-17
申请号：US13068126
申请日：2011-05-02
申请人： Satish V. Herekar , Edward E. Manche , Donald J. Eaton
发明人： Satish V. Herekar , Edward E. Manche , Donald J. Eaton
IPC分类号： A61F9/011 , A61B18/22 , A61F9/01 , A61B18/20
CPC分类号： A61F9/00821 , A61F9/0079 , A61F2009/00851 , A61F2009/00853 , A61F2009/00872 , A61N5/062 , A61N2005/0659
摘要： An apparatus and a method are provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that further enables cross-linking (CXL) therapy to be combined with thermal therapy.
摘要翻译：提供了一种设备和方法，用于以组织维持方式治疗眼组织的目标区域，包括使用两种或多种治疗方式，包括热辐射源（例如CW红外光纤激光器），其操作在波长范围在水中具有高吸收性和光化学胶原蛋白交联（CXL），以及一种或多种特定的系统改进，例如用于定制治疗方式的围手术期反馈测量，眼组织表面热控制/冷却机制和在紫外线辐射存在下靶向眼组织的输送系统中氘代水/核黄素溶液的来源。提供了快速交联（RXL）的其他方法，其进一步使交联（CXL）治疗与热疗相结合。

4. 发明授权

US08945101B2 Method and apparatus for treatment of ocular tissue using combine modalities 有权
标题翻译：使用组合方式治疗眼组织的方法和装置
公开(公告)号：US08945101B2
公开(公告)日：2015-02-03
申请号：US13068126
申请日：2011-05-02
申请人： Satish V. Herekar , Edward E. Manche , Donald J. Eaton
发明人： Satish V. Herekar , Edward E. Manche , Donald J. Eaton
IPC分类号： A61B18/20 , A61N5/067 , A61F7/00 , A61N5/06 , A61F9/008 , A61F9/007
CPC分类号： A61F9/00821 , A61F9/0079 , A61F2009/00851 , A61F2009/00853 , A61F2009/00872 , A61N5/062 , A61N2005/0659
摘要： An apparatus and a method are provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that further enables cross-linking (CXL) therapy to be combined with thermal therapy.
摘要翻译：提供了一种设备和方法，用于以组织维持方式治疗眼组织的目标区域，包括使用两种或多种治疗方式，包括热辐射源（例如CW红外光纤激光器），其操作在波长范围在水中具有高吸收性和光化学胶原蛋白交联（CXL），以及一种或多种特定的系统改进，例如用于定制治疗方式的围手术期反馈测量，眼组织表面热控制/冷却机制和在紫外线辐射存在下靶向眼组织的输送系统中氘代水/核黄素溶液的来源。提供了快速交联（RXL）的其他方法，其进一步使交联（CXL）治疗与热疗相结合。

5. 发明申请

US20090149923A1 METHOD FOR EQUI-DOSED TIME FRACTIONATED PULSED UVA IRRADIATION OF COLLAGEN/RIBOFLAVIN MIXTURES FOR OCULAR STRUCTURAL AUGMENTATION 审中-公开
标题翻译：方法用于组织时间分解的脉冲UVA照射胶原蛋白/ RIBOFLAVIN混合物用于结构性结构
公开(公告)号：US20090149923A1
公开(公告)日：2009-06-11
申请号：US12273444
申请日：2008-11-18
申请人： Satish V. Herekar
发明人： Satish V. Herekar
IPC分类号： A61N5/06
CPC分类号： A61F9/008 , A61F9/0079 , A61F2009/00872 , A61N5/062 , A61N2005/0661
摘要： Equi-dosed time-fractionated pulsed UVA is employed to irradiate a class of riboflavin/collagen mixture in the presence of copious oxygen to cause rapid crosslinking causing gelation of the riboflavin/collagen mixture in situ and to effect adhesion to underlying structure specifically ocular tissue such as scleral and corneal tissue. Irradiation according to an embodiment of the invention results in depletion of dissolved oxygen at a rate inversely related to irradiance and more particularly depletion of dissolved oxygen occurs rapidly during the process of generation/cross-linking of reactive oxygen species (ROS), specifically singlet oxygen, such that the pulsed fractionation of UVA radiation exposure increases cross-linking efficiency by allowing the re-diffusion of oxygen during pauses in exposure.
摘要翻译：在大量氧气存在的情况下，使用等分时间脉冲UVA照射一类核黄素/胶原混合物，引起快速交联，导致核黄素/胶原混合物原位凝胶化，并实现对下列结构的粘附，特别是眼组织如巩膜和角膜组织。根据本发明的实施方案的照射导致溶解氧的消耗以与辐照度成反比的速率，更特别地，溶解氧的消耗在活性氧（ROS）的产生/交联过程中发生，特别是单线态氧，使得UVA辐射暴露的脉冲分级通过在暴露期间暂停期间允许氧的再扩散来提高交联效率。

6. 发明申请

US20120203161A1 DEUTERATED WATER AND RIBOFLAVIN SOLUTION FOR EXTENDING SINGLET OXYGEN LIFETIMES IN TREATMENT OF OCULAR TISSUE AND METHOD OF USE 审中-公开
标题翻译：用于延长治疗眼组织中单一氧化物质的消除水和RIBOFLAVIN解决方案及其使用方法
公开(公告)号：US20120203161A1
公开(公告)日：2012-08-09
申请号：US13390061
申请日：2010-08-12
申请人： Satish V. Herekar
发明人： Satish V. Herekar
IPC分类号： A61F9/00 , A61P27/02 , A61K31/525
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/205 , A61K33/00 , A61K2300/00
摘要： A solution of deuterated water containing a riboflavin-based photosensitizer is provided in order to extend life-times of UVA/Rf photo-generated intra-stromal singlet oxygen, in combination with UVA delivery profiles of pulsing, fractionation, and optionally auxiliary stromal/Rf hyper-oxygenation in order to accelerate protein cross-linking density rates in ocular tissue. A 100% deuterated water solution with 0.1% riboflavin in solution increases singlet oxygen lifetimes by at least an order of magnitude without inducing endothelial cell apoptosis, thereby also permitting use of some combination of lower percentages of deuterated water, lower concentrations of riboflavin or lower dosages of UVA on intact (un-debrided) epithelium for equivalent cross-link densities compared to current acceptable corneal cross-linking procedures. Lower concentrations of deuterated water with regular water, for example, yields shorter singlet oxygen lifetimes in approximately linear proportion to concentration, which are considered acceptable in therapies known or being developed in the art of corneal cross-linking.
摘要翻译：提供含有基于核黄素的光敏剂的氘代水溶液，以延长UVA / Rf光生产的基质内单线态氧的寿命，结合脉冲，分馏和任选的辅助基质/ Rf的UVA递送分布高氧合作用以加速眼组织中的蛋白质交联密度。具有0.1％核黄素的100％氘代水溶液将单线态氧寿命提高至少一个数量级，而不会引起内皮细胞凋亡，从而也允许使用较低百分比的氘代水，较低浓度的核黄素或较低剂量的一些组合的UVA在完整（未清除的）上皮上与当前可接受的角膜交联程序相比具有等同的交联密度。例如，具有常规水的较低浓度的氘代水产生与浓度大致线性比例的较短的单线态氧寿命，其在角膜交联领域中已知或正在开发的治疗中被认为是可接受的。

7. 发明申请

US20100057060A1 In Situ UV/Riboflavin Ocular Treatment System 审中-公开
标题翻译：原位UV /核黄素眼部治疗系统
公开(公告)号：US20100057060A1
公开(公告)日：2010-03-04
申请号：US12617069
申请日：2009-11-12
申请人： Satish V. Herekar
发明人： Satish V. Herekar
IPC分类号： A61F9/00
CPC分类号： A61F9/008 , A61F9/0079 , A61F2009/00853 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61N5/062 , A61N2005/0661
摘要： A system for accurately delivering bilateral simultaneous equi-dosed time-fractionated pulsed UVA to irradiate a class of riboflavin/collagen mixture in the presence of oxygen for treatment of ocular tissue such as scleral and corneal tissue. The system employs ocular trial frames for mounting on the face that are fitted with 1) a nozzle for introducing Riboflavin in solution to collagen on the surface of the ocular tissue, 2) a port for introducing oxygen-rich gas to the ocular tissue, and 3) a pair of optical collimator inserts mounted in the lens holders, wherein the collimator inserts have a mask in the optical path at an aperture on focal point to control the pattern of UVA radiation at the ocular target, the collimator inserts further having optical input ports coupled to a controlled source of UVA radiation that is operative in accordance with the related inventive method.
摘要翻译：一种用于准确输送双侧同步等时的分时脉冲UVA以在氧存在下照射一类核黄素/胶原混合物以用于治疗眼组织如巩膜和角膜组织的系统。该系统采用安装在面上的眼部试验框架，该装置配有1）用于将溶液中的核黄素引入眼组织表面的胶原的喷嘴，2）用于将富氧气体引入眼组织的口，以及 3）安装在透镜保持器中的一对光学准直器插入物，其中准直器插入件在光路上的焦点上的孔处具有掩模以控制目标物体上的UVA辐射的图案，准直器插入件还具有光学输入端口，其耦合到根据相关发明方法操作的受控UVA辐射源。

8. 发明申请

US20080015660A1 Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty 审中-公开
标题翻译：光化学眼部成形术/角膜移植术的方法和装置
公开(公告)号：US20080015660A1
公开(公告)日：2008-01-17
申请号：US11776470
申请日：2007-07-11
申请人： Satish V. Herekar
发明人： Satish V. Herekar
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61F9/0079 , A61F2009/00872 , A61N5/1017 , A61N2005/0654 , A61N2005/0661
摘要： Method and apparatus for performing oculoplasty including applying a photosensitizer solution to a human eye surface includes defining a treatment region within the human eye surface. The treatment region is associated with a predetermined spatial pattern. The method further includes irradiating the treatment region with controlled photoactivating radiation. In relation to presbyopia treatments, shrinkage of the paralimbal scleral region near the scleral spur results in improved near focus with no loss in far acuities.
摘要翻译：用于进行眼部成形术的方法和装置包括将光敏剂溶液施用于人眼表面包括限定人眼表面内的治疗区域。治疗区域与预定的空间模式相关联。该方法还包括用受控的光活化辐射照射治疗区域。关于老花眼治疗，巩膜刺激附近的平滑肌巩膜区域的收缩导致近焦点改善，远远达不到损失。

9. 外观设计

USD441080S1 Apparatus for generation and delivery of radiation 失效
标题翻译：用于产生和传播辐射的装置
公开(公告)号：USD441080S1
公开(公告)日：2001-04-24
申请号：US29093169
申请日：1998-09-04
申请人： Satish V. Herekar , Gary C. Ricco , David W. Laituri , Nicolas A. Denhez
设计人： Satish V. Herekar , Gary C. Ricco , David W. Laituri , Nicolas A. Denhez

10. 发明授权

US6159205A Radiation treatment method for treating eyes to correct vision 失效
标题翻译：用于治疗眼睛矫正视力的放射治疗方法
公开(公告)号：US6159205A
公开(公告)日：2000-12-12
申请号：US388635
申请日：1999-09-01
申请人： Satish V. Herekar , Benjamin W. Woodward
发明人： Satish V. Herekar , Benjamin W. Woodward
IPC分类号： A61F9/01 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00821 , A61F2009/00846 , A61F2009/00853 , A61F2009/00859 , A61F2009/00872
摘要： An automated method is described for advantageously preparing and treating an eye of the patient. The method further provides a vision-corrective procedure, such as photothermal keratoplasty. The automated method is useful to dry the cornea to reduce or eliminate a tear film on the corneal surface that might otherwise interfere with or reduce the efficacy of a vision-corrective procedure and thereafter to treat the cornea according to a vision-corrective procedure. The automated method is user-friendly, allowing the treatment provider to develop or to select an appropriate pre-treatment and treatment plan and to activate sane using a familiar "Windows" environment. The method has particular application in the area of automated corneal preparation and treatment, it may be used in the automated preparation and treatment of other tissues or substrates.
摘要翻译：描述了一种自动化方法，用于有利地准备和治疗患者的眼睛。该方法还提供了视觉矫正程序，例如光热角膜移植术。自动化方法可用于干燥角膜以减少或消除角膜表面上的泪膜，否则可能干扰或降低视力矫正程序的功效，然后根据视力矫正程序治疗角膜。自动化方法是用户友好的，允许治疗提供者开发或选择适当的预处理和治疗计划，并使用熟悉的“Windows”环境激活正常。该方法在自动化角膜制备和治疗领域具有特殊应用，可用于自动化制备和治疗其他组织或底物。

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