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    • 5. 发明授权
    • Novel substituted polyamides and process for producing them
    • 新型取代聚酰胺及其制备方法
    • US3970597A
    • 1976-07-20
    • US476320
    • 1974-06-04
    • Mordechai SokolovskyAmihay FreemanLeon Goldstein
    • Mordechai SokolovskyAmihay FreemanLeon Goldstein
    • C08G69/48C08G69/50C08G18/00
    • C08G69/48
    • Novel substituted polyamides of the general formula ##EQU1## wherein A and B, which may be identical or different, are the hydrocarbon backbone groups of the formula --(CH.sub.2).sub.n --, where n is an integer, R.sub.2 and R.sub.3 are the residues of an aldehyde R.sub.2 --CHO or of an isocyanide R.sub.3 --N.tbd.C, where R.sub.2 and R.sub.3 are aliphatic, aromatic or heterocyclic residues of the respective aldehyde or isocyanide, or where R.sub.3 is a chromophoric moiety. R.sub.2 and R.sub.3 can be substituted, and amongst the possible substituents there may be R.sub.3 designating --(CH.sub.2).sub.n --NHCO--CHR.sub.2 --N(CO)(R.sub.4)--X, where R.sub.4 is the residue of a monocarboxylic or dicarboxylic acid and X is the lysyl residue of a protein, which may be biologically active, or the residue of a low-molecular weight compound containing a primary amine moiety. Preferred polyamides are various types of nylons. Amongst proteins chemically bound to the polyamide there may be mentioned enzymes, antibodies and peptide hormones. When R.sub.3 is a chromophoric moiety, the product is a chemically dyed polyamide. The invention relates also to a process for the production of such novel substituted polyamides.
    • 通式-CONH-A-CONH-B-CO-NA-CONH-B-CONH-A- | CH-R2 | CO-NH-R3的新型取代聚酰胺其中A和B可以相同或不同, 是式 - (CH 2)n - 的烃主链基团,其中n是整数,R 2和R 3是醛R 2 -CHO或异氰酸酯R 3 -N N BOND C的残基,其中R 2和R 3是脂族基, 相应醛或异氰化物的芳族或杂环残基,或其中R3是发色部分。 R2和R3可以被取代,并且在可能的取代基中可以有R3表示 - (CH 2)n -NHCO-CHR 2 -N(CO)(R 4)-X,其中R 4是一元羧酸或二羧酸的残基,X 是可能是生物活性的蛋白质的赖氨酰残基,或含有伯胺部分的低分子量化合物的残基。 优选的聚酰胺是各种类型的尼龙。 与聚酰胺化学结合的蛋白质中,可以提及酶,抗体和肽激素。 当R3是发色部分时,产物是化学染色的聚酰胺。 本发明还涉及生产这种新型取代的聚酰胺的方法。