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1. 发明授权

US3970597A Novel substituted polyamides and process for producing them 失效
标题翻译：新型取代聚酰胺及其制备方法
公开(公告)号：US3970597A
公开(公告)日：1976-07-20
申请号：US476320
申请日：1974-06-04
申请人： Mordechai Sokolovsky , Amihay Freeman , Leon Goldstein
发明人： Mordechai Sokolovsky , Amihay Freeman , Leon Goldstein
IPC分类号： C08G69/48 , C08G69/50 , C08G18/00
CPC分类号： C08G69/48
摘要： Novel substituted polyamides of the general formula ##EQU1## wherein A and B, which may be identical or different, are the hydrocarbon backbone groups of the formula --(CH.sub.2).sub.n --, where n is an integer, R.sub.2 and R.sub.3 are the residues of an aldehyde R.sub.2 --CHO or of an isocyanide R.sub.3 --N.tbd.C, where R.sub.2 and R.sub.3 are aliphatic, aromatic or heterocyclic residues of the respective aldehyde or isocyanide, or where R.sub.3 is a chromophoric moiety. R.sub.2 and R.sub.3 can be substituted, and amongst the possible substituents there may be R.sub.3 designating --(CH.sub.2).sub.n --NHCO--CHR.sub.2 --N(CO)(R.sub.4)--X, where R.sub.4 is the residue of a monocarboxylic or dicarboxylic acid and X is the lysyl residue of a protein, which may be biologically active, or the residue of a low-molecular weight compound containing a primary amine moiety. Preferred polyamides are various types of nylons. Amongst proteins chemically bound to the polyamide there may be mentioned enzymes, antibodies and peptide hormones. When R.sub.3 is a chromophoric moiety, the product is a chemically dyed polyamide. The invention relates also to a process for the production of such novel substituted polyamides.
摘要翻译：通式-CONH-A-CONH-B-CO-NA-CONH-B-CONH-A- | CH-R2 | CO-NH-R3的新型取代聚酰胺其中A和B可以相同或不同，是式 - （CH 2）n - 的烃主链基团，其中n是整数，R 2和R 3是醛R 2 -CHO或异氰酸酯R 3 -N N BOND C的残基，其中R 2和R 3是脂族基，相应醛或异氰化物的芳族或杂环残基，或其中R3是发色部分。 R2和R3可以被取代，并且在可能的取代基中可以有R3表示 - （CH 2）n -NHCO-CHR 2 -N（CO）（R 4）-X，其中R 4是一元羧酸或二羧酸的残基，X 是可能是生物活性的蛋白质的赖氨酰残基，或含有伯胺部分的低分子量化合物的残基。优选的聚酰胺是各种类型的尼龙。与聚酰胺化学结合的蛋白质中，可以提及酶，抗体和肽激素。当R3是发色部分时，产物是化学染色的聚酰胺。本发明还涉及生产这种新型取代的聚酰胺的方法。

2. 发明授权

US4303786A Isonitrile derivatives of macromolecules containing hydroxyl groups 失效
标题翻译：含有羟基的大分子的异腈衍生物
公开(公告)号：US4303786A
公开(公告)日：1981-12-01
申请号：US929229
申请日：1978-07-31
申请人： Leon Goldstein , Amihay Freeman , Mordechai Sokolovsky
发明人： Leon Goldstein , Amihay Freeman , Mordechai Sokolovsky
IPC分类号： C08B15/06 , C08B37/00 , C12N11/08 , C12N11/10 , C08B37/02 , C08B11/155 , C08B31/08
CPC分类号： C08B37/00 , C08B15/06 , C12N11/08 , C12N11/10
摘要： The present invention relates to novel isocyano derivatives of linear or cross-linked, natural or synthetic macromolecules, the derivatives being of the general formula P--O--Q--NC, wherein P is the macromolecular backbone, the oxygen atom is part of the hydroxy group, Q is a group --(CH.sub.2).sub.n --wherein n is an integer of at least 3 carbon atoms, and up to about 20 carbon atoms, or Q is an aralkyl group, to a process for preparing such derivatives and to a process of linking to same biologically active proteins and to the products thus obtained.
摘要翻译：本发明涉及线型或交联天然或合成大分子的新型异氰酸衍生物，其衍生物为通式POQ-NC，其中P为高分子主链，氧原子为羟基的一部分，Q为一个 - （CH 2）n - ，其中n是至少3个碳原子的整数，以及至多约20个碳原子，或Q是一个芳烷基，用于制备这种衍生物的方法和连接到其上的方法生物活性蛋白质和由此获得的产物。

3. 发明授权

US4440903A Dihaloisocyanide derivatives of polymers for coupling nucleophiles 失效
标题翻译：用于偶联亲核体的聚合物的二卤代吖啶衍生物
公开(公告)号：US4440903A
公开(公告)日：1984-04-03
申请号：US921055
申请日：1978-06-30
申请人： Leon Golstein , Mordechai Sokolovsky , Amihay Freeman
发明人： Leon Golstein , Mordechai Sokolovsky , Amihay Freeman
IPC分类号： C08G12/40 , C08G63/685 , C08G63/91 , C08G85/00 , C12N11/08 , C07C143/00 , C07G7/00 , C12N11/06
CPC分类号： C08G63/91 , C08G12/40 , C08G63/685 , C08G85/004 , C12N11/08 , Y10S525/921
摘要： The present invention relates to novel key intermediates for the production of biologically active compounds coupled to polymers, of the general formula P--NCX.sub.2, wherein X designates a halogen atom selected from chlorine and bromine, and wherein P designates the polymer backbone of a polymer of the polyamide, polyester and ureaformaldehyde type. The invention further relates to compounds obtained by the reaction of the above compound P--NCX.sub.2 with a bifunctional or polyfunctional nucleophile. Suitable nucleophiles are hydrazides of dicarboxylic acids and amongst these there may be mentioned polyacrylamides partially substituted with acylhydrazide groups; polyfunctional amines selected from alkylamines, aralkylamines, arylamines and macromolecular compounds containing amino groups. The key intermediate PNCX.sub.2 may be coupled directly to biologically active macromolecules and amongst the preferred compounds of this type there are the various biologically active proteins and enzymes. The coupling of the biologically active macromolecules may also be effected via hydrophilic polymer moieties first grafted onto the polymer P via said dihaloisocyanide groups.
摘要翻译：本发明涉及用于生产与通式为P-NCX2的聚合物偶联的生物活性化合物的新型关键中间体，其中X表示选自氯和溴的卤素原子，其中P表示聚合物的聚合物主链聚酰胺，聚酯和脲甲醛型。本发明还涉及通过上述化合物P-NCX2与双官能或多官能亲核试剂的反应获得的化合物。合适的亲核试剂是二羧酸的酰肼，其中可以提及部分被酰基酰肼基团取代的聚丙烯酰胺; 选自烷基胺，芳烷基胺，芳基胺和含有氨基的高分子化合物的多官能胺。关键的中间体PNCX2可以直接与生物活性大分子偶联，并且在这种类型的优选化合物中存在各种生物活性蛋白质和酶。生物活性大分子的偶联也可以通过首先通过所述二卤代吖啶基接枝到聚合物P上的亲水性聚合物部分来实现。

4. 发明授权

US08128589B2 Apparatus and methods for enzymatic debridement of skin lesions 有权
标题翻译：用于酶清除皮肤损伤的装置和方法
公开(公告)号：US08128589B2
公开(公告)日：2012-03-06
申请号：US11493381
申请日：2006-07-25
申请人： Amihay Freeman , Eran Hirszowicz , Michal Be'eri-Lipperman
发明人： Amihay Freeman , Eran Hirszowicz , Michal Be'eri-Lipperman
IPC分类号： A61N1/30
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
摘要翻译：一种用于清除皮肤病变中的失活组织的装置，其包括多个高度和角度可调的入口管以及至少一个出口管和在皮肤损伤周围形成封闭密封的部件。所述多个入口管适于将连续的酶溶液流引导到所述表面并进入所述病变的所述伤口床的整个体积，并且所述至少一个出口适于去除所述酶溶液，从所述病变排出的流体和来自闭塞的皮肤损伤的组织碎片。

5. 发明授权

US07825104B2 Methods and compositions for treating fungal infections 失效
标题翻译：用于治疗真菌感染的方法和组合物
公开(公告)号：US07825104B2
公开(公告)日：2010-11-02
申请号：US10484623
申请日：2002-07-23
申请人： Amihay Freeman , Rina Segal , Yael Dror
发明人： Amihay Freeman , Rina Segal , Yael Dror
IPC分类号： A01N55/08 , A01N33/02 , A01N35/00 , A61K31/69 , A61K31/135 , A61K31/12 , A61K31/11
CPC分类号： A61K31/69 , A01N55/00 , A01N55/08
摘要： Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.
摘要翻译：苯硼酸及其水溶性衍生物和相关硼酸化合物用于治疗真菌和细菌感染。

6. 发明申请

US20090127112A1 Biologically active metal-coated proteins 审中-公开
标题翻译：生物活性金属包被的蛋白质
公开(公告)号：US20090127112A1
公开(公告)日：2009-05-21
申请号：US11920689
申请日：2006-05-18
申请人： Amihay Freeman , Yosi Shacham-Diamand , Sefi Vernick , Hila Moscovich-Dagan
发明人： Amihay Freeman , Yosi Shacham-Diamand , Sefi Vernick , Hila Moscovich-Dagan
IPC分类号： G01N33/487 , C12N9/04 , A61K9/00 , A61K38/44
CPC分类号： G01N33/54373 , A61B5/1486 , G01N33/532 , G01N33/68 , G01N33/84 , Y10T428/12493
摘要： Metal-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein, a process and intermediates for preparing same are disclosed. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active metal-coated proteins. Conductive elements, electronic circuits containing same, electrodes and biosensor systems utilizing same, and imaging probes, all containing the metal-coated proteins, are also disclosed.
摘要翻译：公开了金属包覆的蛋白质，其可溶于或悬浮于水性介质中和/或保留蛋白质的生物活性，制备方法和中间体。还公开了一种药物组合物，其含有利用生物活性金属包被的蛋白质治疗细菌和真菌感染的方法。还公开了导电元件，含有它们的电子电路，使用它们的电极和生物传感器系统，以及全部含有金属包被的蛋白质的成像探针。

7. 发明授权

US5578073A Thromboresistant surface treatment for biomaterials 失效
标题翻译：生物材料的抗血栓表面处理
公开(公告)号：US5578073A
公开(公告)日：1996-11-26
申请号：US37335
申请日：1994-09-16
申请人： Beatrice Haimovich , Amihay Freeman , Ralph Greco
发明人： Beatrice Haimovich , Amihay Freeman , Ralph Greco
IPC分类号： A61F2/06 , A61L33/06 , C09D105/08 , A61F2/16 , C08L5/08
CPC分类号： C09D105/08 , A61F2/06 , A61L33/062
摘要： A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.
摘要翻译：提供具有抗血栓表面的生物材料及其形成方法。抗血栓表面由基于壳聚糖的膜和生物活性物质的不同的涂层组成。生物活性物质能够将壳聚糖膜涂层从高度血栓形成转变为基本上非致血性的。生物活性材料可以是聚合物质，例如聚乙烯醇，与壳聚糖形成聚合物共混物，或者可以是嵌入或连接到壳聚糖膜上的生物物质，例如血清白蛋白，其已经用治疗戊二醛。抗血栓生物材料适用于内径小于6毫米的血管移植物。

8. 发明授权

US4904592A Stabilized enzymes 失效
标题翻译：稳定酶
公开(公告)号：US4904592A
公开(公告)日：1990-02-27
申请号：US219927
申请日：1988-07-15
申请人： Amihay Freeman , Ruth Tor
发明人： Amihay Freeman , Ruth Tor
IPC分类号： C12N9/96 , C12N11/08
CPC分类号： C12N9/96 , C12N11/08
摘要： Enzymes are stabilized by encagement in a double layer having a polyaldeh base coat linked to the amino groups of the enzyme, and an outer polymer coat crosslinked therewith. The outer coat is made of a polymer which in the unlinked state has free amino and/or acyl hydrazide groups.Optionally the stabilized enzyme is immobilized within a matrix.Processes for the preparation of the encaged and optionally immobilized enzymes are described.

9. 发明申请

US20100203158A1 ANTISEPTIC COMPOSITIONS AND USES THEREOF 有权
标题翻译：抗菌组合物及其用途
公开(公告)号：US20100203158A1
公开(公告)日：2010-08-12
申请号：US12703853
申请日：2010-02-11
申请人： Noa HADAR , Amihay Freeman
发明人： Noa HADAR , Amihay Freeman
IPC分类号： A61K33/38 , A61P31/00 , A61P17/02 , A61P31/04 , A61P31/10
CPC分类号： A61K31/045 , A61K9/0014 , A61K33/38 , A61K45/06 , A61K2300/00
摘要： Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
摘要翻译：公开了含有银离子和薄荷醇源的防腐组合物和试剂盒，其协同作用使得组合物中银离子的浓度显着降低。进一步公开了防腐组合物作为消毒剂和伤口治疗的用途。

10. 发明授权

US07364565B2 Controlled enzymatic removal and retrieval of cells 有权
标题翻译：控制细胞的酶促去除和回收
公开(公告)号：US07364565B2
公开(公告)日：2008-04-29
申请号：US10768749
申请日：2004-01-27
申请人： Amihay Freeman
发明人： Amihay Freeman
IPC分类号： A61N1/30
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： Method and device, including a uniquely operative applicator, and pharmaceutical compositions, for the controlled, non-surgical removal and retrieval of cells from a variety of skin lesions and tissue surfaces are disclosed. A synergistic effect of proteolytic digestion of the intracellular matrix and “stripping” flow is achieved by treating a defined area with a controlled, continuous stream of proteolytic enzyme solution, causing gentle but effective tissue erosion. Isolated cells from the skin lesion and/or tissue surface may be collected from the protease solution stream for histological analysis and/or cell culture, affording a method of “enzymatic biopsy”. The protease solution may be supplemented with anesthetics, coagulants, anticoagulants and antibiotics to decrease the discomfort, erythema, bleeding, risk of infection and scarring traditionally associated with surgical treatment of skin lesions. Delivery of precise levels of catalytic activity is ensured by controlled activation of stable, inactivated enzyme stock solutions and powders shortly prior to application.
摘要翻译：公开了包括独特操作的施用器和药物组合物的方法和装置，用于从各种皮肤损伤和组织表面控制，非手术移除和取回细胞。通过用受控的连续的蛋白水解酶溶液处理限定区域来实现细胞内基质的蛋白水解消化和“剥离”流的协同效应，引起温和但有效的组织侵蚀。可以从蛋白酶溶液流中收集来自皮肤病变和/或组织表面的分离的细胞用于组织学分析和/或细胞培养，提供“酶活检”的方法。蛋白酶溶液可以用麻醉剂，凝结剂，抗凝剂和抗生素补充，以减少传统上与皮肤损伤手术治疗相关的不适，红斑，出血，感染风险和瘢痕。通过在施用前不久稳定的灭活酶储备溶液和粉末的控制活化来确保提供精确水平的催化活性。

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