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1. 发明授权

US4372484A Device for the separation of a liquid, especially whole blood 失效
标题翻译：用于分离液体，特别是全血的装置
公开(公告)号：US4372484A
公开(公告)日：1983-02-08
申请号：US232024
申请日：1981-02-04
申请人： Lars-Ake L. Larsson , Claes-Ake Gullberg , Kaj Stenberg , Nils G. E. Boberg
发明人： Lars-Ake L. Larsson , Claes-Ake Gullberg , Kaj Stenberg , Nils G. E. Boberg
IPC分类号： B04B5/04 , B04B11/00
CPC分类号： B04B5/0442 , B04B2005/0492
摘要： Apparatus for separating a liquid, such as whole blood, into fractions having different densities includes a separation chamber and a transfer device, such as a continuous piece of flexible tubing, for supplying the liquid to the separation chamber and discharging the liquid fractions therefrom. The separation chamber and the transfer device are conjointly rotated about a first axis which passes through a stationary end of the transfer device, while being simultaneously and conjointly rotated about a second axis which is coincident with a medial longitudinal axis of the rotating end of the transfer device so as to prevent the transfer device from twisting as a result of its rotation about the first axis.
摘要翻译： PCT No.PCT / SE79 / 00128 Sec。 371日期：1981年2月4日 102（e）1981年2月4日PCT PCT。公开号WO80 / 02653 日本1990年12月11日。用于将诸如全血的液体分离成具有不同密度的级分的装置包括分离室和诸如连续的柔性管的传送装置，用于将液体供应到分离室，排出液体部分。分离室和传送装置围绕第一轴线共同旋转，该第一轴线穿过传送装置的固定端，同时并且围绕与转印件的旋转端的中间纵向轴线重合的第二轴线共同旋转装置，以便防止转印装置由于围绕第一轴线的转动而扭转。

2. 发明授权

US4293409A Artificial kidney dialysate preparation system 失效
标题翻译：人造肾透析液制剂系统
公开(公告)号：US4293409A
公开(公告)日：1981-10-06
申请号：US964275
申请日：1978-11-28
申请人： Gerhard Riede , Lars-Ake L. Larsson , Roland J. E. Andersson , Sven A. Josson , Lars J. C. Traven
发明人： Gerhard Riede , Lars-Ake L. Larsson , Roland J. E. Andersson , Sven A. Josson , Lars J. C. Traven
IPC分类号： A61M1/14 , A61M1/16 , B01D61/24 , B01D61/28 , B01D61/32 , B01D61/54 , B01D65/02 , G05D27/00 , B01D31/00
CPC分类号： A61M1/16 , A61M1/1664
摘要： A dialysis system is disclosed for treatment of a first fluid with dialysis fluid, the dialysis fluid being a mixture of water and dialysis concentrate. The system comprises a dialyzer, a source of water, a source of dialysis concentrate, first and second fluid conducting means communicating with the sources of water and dialysis concentrate, pump means associated with the first and second fluid conducting means, and third fluid conducting means for conducting fluid from the pump means to the dialyzer. The pump means serves to draw water and dialysis concentrate through the first and second fluid conducting means respectively, and to mix the water and dialysis concentrate so that a mixture of water and dialysis concentrate is conducted through the third fluid conducting means.
摘要翻译：公开了一种用于用透析流体处理第一流体的透析系统，所述透析流体是水和透析浓缩物的混合物。该系统包括透析器，水源，透析浓缩物源，与水源和透析浓缩物连通的第一和第二流体传导装置，与第一和第二流体传导装置相关联的泵装置，以及第三流体传导装置用于将流体从泵装置传导到透析器。泵装置用于分别通过第一和第二流体导入装置抽取水和透析浓缩物，并将水和透析浓缩物混合，使得水和透析浓缩物的混合物通过第三流体传导装置进行。

3. 发明授权

US4158034A Sterilization method and apparatus for dialysis system 失效
标题翻译：透析系统的灭菌方法和装置
公开(公告)号：US4158034A
公开(公告)日：1979-06-12
申请号：US841898
申请日：1977-10-13
申请人： Gerhard Riede , Lars-Ake L. Larsson , Roland J. E. Andersson , Sven A. Jonsson
发明人： Gerhard Riede , Lars-Ake L. Larsson , Roland J. E. Andersson , Sven A. Jonsson
IPC分类号： A61M1/14 , A61M1/16 , B01D61/24 , B01D61/28 , B01D61/30 , B01D61/32 , B01D61/54 , B01D65/02 , B01D65/10 , A61L1/00 , A61L3/00 , B01D13/00
CPC分类号： A61M1/169 , A61M1/1607 , A61M1/1688 , A61M1/1686
摘要： A method and apparatus for sterilization of a dialysis system. The dialysis system comprises a dialyzer, a receptacle for water and a receptacle for dialysis concentrate, and fluid conducting means for conducting fluids from the receptacles for water and dialysis concentrate to and through the dialyzer. The method includes the steps of terminating the conducting of dialysis concentrate through the fluid conducting means, introducing sterilizing agent into the fluid conducting means at a first point in the fluid conducting means, conducting the sterilizing agent through the fluid conducting means downstream of the first point, and directing a portion of the sterilizing agent from a second point in the fluid conducting means to a third point in the fluid conducting means, the second point being downstream of the first point and the third point being upstream of the first point. The apparatus includes a source of sterilizing agent, means for introducing sterilizing agent into the fluid conducting means at a first point in the fluid conducting means, and fluid return means for conducting a portion of the sterilizing agent from a second point in the fluid conducting means to a third point in the fluid conducting means, the second point being downstream of the first point and the third point being upstream of the first point. With such a method and apparatus, sterilizing agent is conducted substantially throughout the fluid conducting means of the dialysis system.
摘要翻译：一种用于透析系统灭菌的方法和装置。透析系统包括透析器，用于水的容器和用于透析浓缩物的容器，以及流体传导装置，用于将流体从用于水和透析浓缩物的容器导入并通过透析器。该方法包括以下步骤：终止通过流体传导装置进行透析浓缩物的导入，在流体传导装置的第一点处将灭菌剂引入流体传导装置，将灭菌剂通过第一点下游的流体传导装置并且将所述灭菌剂的一部分从所述流体传导装置中的第二点引导到所述流体传导装置中的第三点，所述第二点在所述第一点的下游，所述第三点在所述第一点的上游。所述装置包括灭菌剂源，在所述流体传导装置的第一点处将灭菌剂引入所述流体传导装置的装置，以及用于从所述流体传导装置中的第二点导入所述灭菌剂的一部分的流体返回装置到所述流体传导装置中的第三点，所述第二点在所述第一点的下游，所述第三点在所述第一点的上游。使用这种方法和装置，基本上贯穿透析系统的流体传导装置进行灭菌剂。

4. 发明授权

US4708714A Apparatus for the separation of fractions from body fluids 失效
$Apparatus for the separation of fractions from body fluids$
标题翻译：用于从体液分离级分的装置
公开(公告)号：US4708714A
公开(公告)日：1987-11-24
申请号：US787009
申请日：1985-10-11
申请人： Lars-Ake L. Larsson , Ake W. Nilsson , Bo Ingemar W. Johannson , Lars Olof V. Naucler
发明人： Lars-Ake L. Larsson , Ake W. Nilsson , Bo Ingemar W. Johannson , Lars Olof V. Naucler
IPC分类号： G01N33/48 , A61M1/34 , A61M1/36 , G01N33/538 , G01N33/543 , A61M1/03
CPC分类号： A61M1/3679 , A61M1/3472 , A61M1/3486 , A61M2205/707 , A61M2205/7554 , A61M2205/7581
摘要： An apparatus is disclosed for the separation of one or more fractions out of whole blood, plasma, or other similar body fluids utilizing an adsorption column comprising means for feeding the fluid to the column and means for the removal of same. The apparatus includes an analyzing device for the coarse analysis of the fluid and a valve device which is adapted to conduct the fluid flow from the column as a function of the analysis carried out to one of two analyzing devices for the fine analysis of the fluid to determine if the fluid is to be conveyed to a collection container, conveyed back to the source or conveyed to a drain.
摘要翻译：公开了一种用于使用吸附塔从全血，血浆或其它类似体液中分离出一种或多种级分的装置，所述吸附柱包括用于将流体供给到柱中的装置和用于除去其的装置。该装置包括用于粗略分析流体的分析装置和阀装置，其适于根据进行的分析将来自塔的流体流作为两个分析装置中的一个进行分析，以便精细地分析流体至确定流体是否被输送到收集容器，被输送回到源或输送到排水管。

5. 发明授权

US4361484A Process for treating and/or removal of substances from liquid, especially whole blood 失效
标题翻译：用于处理和/或从液体，特别是全血中去除物质的方法
公开(公告)号：US4361484A
公开(公告)日：1982-11-30
申请号：US232037
申请日：1981-02-11
申请人： Lars-Ake L. Larsson , Lars O. V. Naucler , Ulf T. G. Nylen
发明人： Lars-Ake L. Larsson , Lars O. V. Naucler , Ulf T. G. Nylen
IPC分类号： A61M1/00 , A61K35/14 , A61M1/16 , A61M1/22 , A61M1/36 , B01D61/00 , B01D61/14 , B01D63/00 , B01D63/02 , B01D67/00 , B01D69/02 , B01D71/76 , B01J20/32 , B01D13/00 , B01D31/00
CPC分类号： B01D61/142 , A61K35/14 , A61M1/3679 , B01D61/18 , B01D69/02 , B01J20/28014 , B01J20/3242
摘要： A process for the treating of and/or removal of substances from a liquid, especially whole blood, via a semipermeable microporous membrane (13, 14, 15) through adsorption and/or biological reaction by means of a biologically active material. Said whole blood is exposed to pressure variations at the membrane surface in a way such that a penetrating fraction of said whole blood is flowing in an alternating flow path through the membrane walls for contacting said biologically active material.Said biologically active material is asymmetrically immobilized in and on the surface of the side of said membrane that faces away from said whole blood. Alternatively, said biologically active material may be bound to an unsoluble matrix behind said membrane.Said membrane is for example provided within a casing (7, 8, 9) comprising inlet (10) and outlet (11) for said whole blood. The space between said casing and said membrane is via a connecting nipple (12) in communication with for example an expansion chamber for the provision of pressure variations.By means of the device (3) it is possible to perform said process in one and the same step and by means of one and the same pumping system.
摘要翻译： PCT No.PCT / SE79 / 00132 Sec。 371日期1981年2月11日 102（e）日期1981年1月9日PCT提交1979年6月11日PCT公布。出版物WO80 / 02805 日期为1980年12月24日。一种通过吸附和/或生物反应通过半透膜微孔膜（13,14,15）从液体，特别是全血中处理和/或去除物质的方法，生物活性物质。所述全血暴露于膜表面的压力变化，使得所述全血的穿透部分在交替流动路径中流过膜壁以接触所述生物活性物质。所述生物活性材料不对称地固定在所述膜的面向远离所述全血的一侧的表面上。或者，所述生物活性材料可以结合到所述膜后面的不溶性基质。所述膜例如设置在包括用于所述全血的入口（10）和出口（11））的壳体（7,8,9）内。所述壳体和所述膜之间的空间经由与例如用于提供压力变化的膨胀室连通的连接接头（12）。借助于装置（3），可以在同一个步骤中并且通过同一个泵送系统来执行所述处理。

6. 发明授权

US4191646A Apparatus for conducting fluids in a dialysis system 失效
标题翻译：用于在透析系统中传导流体的装置
公开(公告)号：US4191646A
公开(公告)日：1980-03-04
申请号：US841896
申请日：1977-10-13
申请人： Lars-Ake L. Larsson , Lars J. C. Traven
发明人： Lars-Ake L. Larsson , Lars J. C. Traven
IPC分类号： A61M1/14 , A61M1/16 , B01D61/14 , B01D61/20 , B01D61/22 , B01D61/26 , B01D61/28 , B01D61/30 , B01D61/32 , B01D61/34 , F16K7/02 , B01D31/00
CPC分类号： F16K7/02 , A61M1/1696 , Y10S210/929
摘要： Fluid conducting apparatus is disclosed for a dialysis system having a dialyzer, a source of dialysis fluid for the dialyzer, a heating chamber for heating dialysis fluid before introduction into the dialyzer, and pump means for pumping heated dialysis fluid from the heating chamber to and through the dialyzer. The fluid conducting apparatus includes first and second fluid conducting means. The first fluid conducting means is adapted to be connected to the source of dialysis fluid and to the heating chamber for introducing dialysis fluid into the heating chamber, and the second fluid conducting means is adapted to be connected to the heating chamber, the dialyzer and the pump means for conducting the fluid from the heating chamber to and through the dialyzer. The apparatus also includes shut-off means adapted to terminate the flow of heated dialysis fluid from the heating chamber to the dialyzer when the rate of flow of fluid out of the chamber exceeds the rate of flow of fluid into the chamber. In this way, the heating chamber will not be emptied of dialysis fluid.
摘要翻译：公开了一种用于透析系统的流体传导装置，该透析系统具有透析器，用于透析器的透析液源，用于在引入透析器之前加热透析液的加热室，以及用于将加热的透析流体从加热室泵送并通过透析器。流体传导装置包括第一和第二流体传导装置。第一流体传导装置适于连接到透析流体源和加热室，用于将透析流体引入加热室，第二流体传导装置适于连接到加热室，透析器和用于将流体从加热室导入并通过透析器的泵装置。该装置还包括切断装置，当流体离开腔室的流速超过流入腔室的流体流速时，该切断装置适于将加热的透析流体从加热室流出至透析器。这样，加热室不会排空透析液。

7. 发明授权

US4191359A Control apparatus for controlling positioning of a control member 失效
标题翻译：控制装置，用于控制控制构件的定位
公开(公告)号：US4191359A
公开(公告)日：1980-03-04
申请号：US857285
申请日：1977-12-05
申请人： Roland J. E. Andersson , Lars-Ake L. Larsson , Lars J. C. Traven
发明人： Roland J. E. Andersson , Lars-Ake L. Larsson , Lars J. C. Traven
IPC分类号： F16H25/20 , A61M5/175 , A61M39/28 , F16K7/04 , F16K7/06
CPC分类号： A61M39/284 , F16K7/045
摘要： Control apparatus for controlling or adjusting the position of a control member is disclosed. The control apparatus includes first and second members, pivotally connected together to pivot about a point. A control member is mounted on the first member and is disposed at a first distance from the pivot point. Coarse control means operatively associated with the control member are provided for coarsely adjusting the position of the control member relative to the second member. Further, fine control means are provided for finely adjusting the position of the control member relative to the second member. The fine control means acts at an action point on one of the first and second members to pivot the first and second members relative to each other about the pivot point. The action point at which the fine control means acts is a second distance from the pivot point which is greater than the first distance such that a selected amount of movement of the action point results in a change in position of the control member relative to the second member, the amount of change in position being less than the selected amount of movement.
摘要翻译：公开了一种用于控制或调整控制部件的位置的控制装置。控制装置包括第一和第二构件，枢转地连接在一起以围绕点枢转。控制构件安装在第一构件上并且设置在离枢转点第一距离处。提供与控制构件可操作地相关联的粗调控制装置用于粗调地调节控制构件相对于第二构件的位置。此外，精细控制装置用于精细地调节控制构件相对于第二构件的位置。精细控制装置作用于第一和第二构件中的一个上的作用点，以使第一和第二构件相对于彼此围绕枢转点枢转。精细控制装置起作用的作用点距枢转点大于第一距离的第二距离，使得动作点的选定量的运动导致控制构件相对于第二距离的位置改变成员，位置的变化量小于所选择的移动量。

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