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1. 发明申请

US20130202577A1 DIAGNOSTIC AND PROGNOSTIC ASSAY FOR BREAST CANCER 审中-公开
标题翻译：乳腺癌的诊断和预后测定
公开(公告)号：US20130202577A1
公开(公告)日：2013-08-08
申请号：US13576541
申请日：2011-02-03
申请人： Tony Tiganis , Benjamin James Shields , Catriona Ann McLean , Robert Sutherland
发明人： Tony Tiganis , Benjamin James Shields , Catriona Ann McLean , Robert Sutherland
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K38/465 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Y301/03048 , G01N33/57415 , G01N2800/52
摘要： The invention relates to the finding that T cell protein tyrosine phosphatase (TCPTP) has a tumour suppressor function. In one particular application, the invention provides a method of diagnosis and/or prognosis of cancer in a subject involving the assessment, in a suitable body sample, of any lack or reduction of TCPTP protein and/or Ptpn2 gene expression. The invention also provides a method of treating or preventing cancer in a subject involving administering to a subject an agent for modulating the activity of TCPTP.
摘要翻译：本发明涉及T细胞蛋白酪氨酸磷酸酶（TCPTP）具有肿瘤抑制功能的发现。在一个特定应用中，本发明提供了一种在受试者中诊断和/或预测癌症的方法，所述方法涉及在合适的身体样品中评估TCPTP蛋白和/或Ptpn2基因表达的任何缺乏或减少。本发明还提供了治疗或预防患者癌症的方法，包括向受试者施用调节TCPTP活性的药剂。

2. 发明申请

US20070099197A1 Methods of prognosis of prostate cancer 审中-公开
标题翻译：前列腺癌预后的方法
公开(公告)号：US20070099197A1
公开(公告)日：2007-05-03
申请号：US11365745
申请日：2006-02-28
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译：本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。

3. 发明申请

US20060147922A1 Novel diagnostic and therapeutic methods and reagents therefor 审中-公开
标题翻译：新型诊断和治疗方法及其试剂
公开(公告)号：US20060147922A1
公开(公告)日：2006-07-06
申请号：US10526905
申请日：2003-09-05
申请人： Colin Watts , Darren Saunders , Michelle Henderson , Jennifer Clancy , Susan Henshall , Robert Sutherland , Philippa O'Brien
发明人： Colin Watts , Darren Saunders , Michelle Henderson , Jennifer Clancy , Susan Henshall , Robert Sutherland , Philippa O'Brien
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , Y02A90/26
摘要： This invention provides novel methods of detecting or treating aberrant cell cycle regulation associated with expression of a nuclear protein encoded by a gene that is linked to map position 8q22.3 of the human genome, and to novel reagents that are useful therefor. More particularly, the invention provides novel nucleic acid and proteinaceous probes, for detecting a gene that is linked to map position 8q22.3 of the human genome or the expression products thereof, wherein expression or elevated expression of said gene is associated with the appearance or occurrence of tumors associated with cancer, DNA damage and progesterone-receptor-mediated effects on cells. The invention also provides reagents and methods for detecting or modulating the expression products of the gene, such as, for example, in the diagnosis or treatment of cancer, cellular proliferation, DNA damage or progesterone receptor-mediated effects on cells.
摘要翻译：本发明提供了检测或治疗与由人基因组的图谱位置8q22.3连接的基因编码的核蛋白的表达相关的异常细胞周期调节的新方法，以及对其有用的新型试剂。更具体地，本发明提供新的核酸和蛋白质探针，用于检测与人基因组的图8q22.3的表达或其表达产物连接的基因，其中所述基因的表达或升高的表达与外观或与癌症相关的肿瘤的发生，DNA损伤和孕激素受体介导的对细胞的作用。本发明还提供用于检测或调节基因的表达产物的试剂和方法，例如在癌症的诊断或治疗中，细胞增殖，DNA损伤或孕酮受体介导的对细胞的作用。

4. 发明申请

US20050145685A1 Carton with top dispensing feature 有权
标题翻译：纸箱具有顶部分配功能
公开(公告)号：US20050145685A1
公开(公告)日：2005-07-07
申请号：US11069238
申请日：2005-03-01
申请人： Robert Sutherland , Raymond Spivey , Glen Harrelson
发明人： Robert Sutherland , Raymond Spivey , Glen Harrelson
IPC分类号： B65D5/16 , B65D5/468 , B65D5/72 , B65D17/28 , B65D71/00 , B65D71/36 , B65D17/00 , B65D43/00
CPC分类号： B65D71/36 , B65D5/4608 , B65D5/725 , B65D2571/00141 , B65D2571/00154 , B65D2571/0045 , B65D2571/00574 , B65D2571/00592 , B65D2571/0066 , B65D2571/00728 , B65D2571/00753 , B65D2571/00851
摘要： A carton with a new type of dispenser that is placed midway between the ends of the carton adjacent a fold line between the top panel and adjoining side panel. The dispenser is designed so that it is slightly larger than the diameter of the bottom ends of from two to three containers. Said dispenser may have a push tab or starting flap to aid in commencing tearing the dispenser flap open. A coupon may be located on the inside or outside of the dispenser flap.
摘要翻译：一个装有新型分配器的纸箱，放置在纸板箱的两端之间的中间，与纸板和相邻的侧板之间的折叠线相邻。分配器被设计成使其略大于从两个到三个容器的底端的直径。所述分配器可以具有推动突片或起始挡板，以帮助开始撕开分配器挡板。优惠券可以位于分配器挡板的内部或外部。

5. 发明申请

US20050109641A1 Wrap around carrier for petaloid PET bottles 有权
标题翻译：卷绕PET瓶的载体
公开(公告)号：US20050109641A1
公开(公告)日：2005-05-26
申请号：US10985331
申请日：2004-11-09
申请人： Robert Sutherland
发明人： Robert Sutherland
IPC分类号： B65D71/00 , B65D71/20 , B65D75/00
CPC分类号： B65D71/20 , B65D2571/0016 , B65D2571/00172 , B65D2571/00277 , B65D2571/0029 , B65D2571/00444 , B65D2571/00543 , B65D2571/0066 , B65D2571/00716 , B65D2571/0087
摘要： A wrap around carrier for carrying bottle with a petaloid base having heel assemblies that have hinge doors with a vertical cut line in the bottom of each hinge with a horizontal cut line at the top of each cut line that extends inwardly towards the heel aperture formed by the door. This carton has a second cut line that is either at the bottom of the vertical cut line in each hinge or near the center of the door. None of these cut lines extend into the heel aperture. This combination of cut lines facilitates the control tearing of the cut line at the top of the vertical cut line into the heel aperture.
摘要翻译：用于携带具有花瓣状基部的瓶子的托架，其具有鞋跟组件，所述鞋底组件具有在每个铰链的底部具有垂直切割线的铰链门，每个切割线的顶部处的水平切割线向内延伸朝向由门。该纸箱具有位于每个铰链中的垂直切割线的底部或靠近门的中心的第二条切割线。这些切割线都不延伸到脚跟孔中。切割线的这种组合有助于将切割线在垂直切割线的顶部的撕裂控制到鞋跟孔中。

6. 发明授权

US08535712B2 Radiation sensitive liposomes 有权
公开(公告)号：US08535712B2
公开(公告)日：2013-09-17
申请号：US13609058
申请日：2012-09-10
申请人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
发明人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
IPC分类号： A61K9/127
CPC分类号： A61K9/0009 , A61K9/1273
摘要： The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

7. 发明申请

US20110217236A1 RADIATION SENSITIVE LIPOSOMES 审中-公开
标题翻译：辐射敏感性脂质体
公开(公告)号：US20110217236A1
公开(公告)日：2011-09-08
申请号：US12902059
申请日：2010-10-11
申请人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
发明人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
IPC分类号： A61K9/127 , A61K49/00 , A61K31/704 , A61P35/00 , B01J13/02
CPC分类号： A61K9/0009 , A61K9/1273
摘要： The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
摘要翻译：本发明涉及一种辐射敏感性脂质体，以及该脂质体作为治疗和诊断剂的载体的用途。特别地，本发明包括脂质体递送系统，其包含稳定的形成脂质体的脂质和可聚合的脂肪，其可聚合的脂肪酸在暴露于电离，辐射时聚合，从而使脂质体膜失稳。脂质体的不稳定性允许脂质体内容物的泄漏。本发明还考虑了诊断和治疗对脂质体包封或相关药物有反应的病症和疾病的方法。

8. 发明申请

US20090233286A1 Methods of diagnosis and prognosis of pancreatic cancer 审中-公开
标题翻译：胰腺癌的诊断和预后方法
公开(公告)号：US20090233286A1
公开(公告)日：2009-09-17
申请号：US12288676
申请日：2008-10-22
申请人： Davendra Segara , Andrew Biankin , Robert Sutherland , Susan Henshall
发明人： Davendra Segara , Andrew Biankin , Robert Sutherland , Susan Henshall
IPC分类号： C12Q1/68
CPC分类号： G01N33/57438 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N2800/52
摘要： Disclosed herein are methods of diagnosing pancreatic cancer in a subject. Also provided are methods of monitoring the efficacy of a therapeutic treatment of pancreatic cancer as well as methods of determining the likelihood that a subject having pancreatic cancer will survive, and methods of determining the suitability of a subject having pancreatic cancer for surgical resection therapy.
摘要翻译：本文公开了诊断受试者中胰腺癌的方法。还提供了监测胰腺癌治疗治疗效果的方法以及确定胰腺癌患者可能存活的可能性的方法以及确定具有胰腺癌的受试者适合手术切除治疗的方法。

9. 发明授权

US07394889B2 Contrast-enhanced cone beam X-ray imaging, evaluation, monitoring and treatment delivery 有权
标题翻译：对比增强锥束X射线成像，评估，监测和治疗交付
公开(公告)号：US07394889B2
公开(公告)日：2008-07-01
申请号：US11437076
申请日：2006-05-18
申请人： Larry D. Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
发明人： Larry D. Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
IPC分类号： A61B6/04
CPC分类号： A61B6/4241 , A61B6/032 , A61B6/4085 , A61B6/482 , A61B6/502 , A61B6/507
摘要： A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.
摘要翻译：使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集或至少两个正交方向。

10. 发明申请

US20070269000A1 Contrast-enhanced cone beam X-ray imaging, evaluation, monitoring and treatment delivery 有权
标题翻译：对比增强锥束X射线成像，评估，监测和治疗交付
公开(公告)号：US20070269000A1
公开(公告)日：2007-11-22
申请号：US11437076
申请日：2006-05-18
申请人： Larry Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
发明人： Larry Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
IPC分类号： A61B6/04
CPC分类号： A61B6/4241 , A61B6/032 , A61B6/4085 , A61B6/482 , A61B6/502 , A61B6/507
摘要： A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.
摘要翻译：使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集或至少两个正交方向。

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