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1. 发明申请

US20130071333A1 METHOD AND SYSTEM FOR IDENTIFYING, ASSESSING, AND MANAGING CANCER GROWTH RATES AND POTENTIAL METASTASIS 有权
标题翻译：识别，评估和管理癌症生长率和潜在的细胞因子的方法和系统
公开(公告)号：US20130071333A1
公开(公告)日：2013-03-21
申请号：US13623098
申请日：2012-09-19
申请人： Larry PARTAIN , Mingshan SUN , Edward J. SEPPI , Raisa PAVLYUCHKOVA , Arundhuti GANGULY , Stavros PRIONAS , James E. CLAYTON
发明人： Larry PARTAIN , Mingshan SUN , Edward J. SEPPI , Raisa PAVLYUCHKOVA , Arundhuti GANGULY , Stavros PRIONAS , James E. CLAYTON
IPC分类号： A61K49/04
CPC分类号： G06F19/3431 , G06F19/00 , G06K9/6277 , G06K2209/053 , G16H50/30
摘要： Techniques described herein generally relate to identifying, assessing, and managing cancer growth rates and potential metastasis. Some example methods may include constructing one or more quantitative metrics for the potential metastasis in a selected population of other patients, acquiring a first set of numeric biomarker data for the patient before having placed a biomarker in the patient, acquiring a second set of numeric biomarker data for the patient after having placed the biomarker in the patient, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, and predicting quantitative and objective risk for the cancer growth rates and potential metastasis and adjusting a treatment plan based on the biomarker surrogate values and at least one of the one or more quantitative metrics.
摘要翻译：本文描述的技术通常涉及鉴定，评估和管理癌症生长速度和潜在转移。一些示例性方法可以包括为所选择的其他患者群体中的潜在转移构建一个或多个定量度量，在将患者的生物标志物置于患者体内之前获取患者的第一组数值生物标志物数据，获取第二组数值生物标志物基于从第一组数字生物标志物数据和第二组数值生物标志物数据导出的平均数值生物标志物差异，确定用于微血管密度信息的生物标记替代值的集合，确定患者的数据;确定基于从第一组数值生物标志物数据和第二组数值生物标志物数据得出的平均数值生物标志物差异的微血管密度信息的一组生物标志物替代值，并预测癌症生长速率和潜在转移的定量和客观风险，根据生物标志物代理调整治疗计划值和至少一个一个或多个定量度量。

2. 发明授权

US10380736B1 MIP determination of solid cancer size and size changes based on contrast enhanced MRI and CT imaging 有权
公开(公告)号：US10380736B1
公开(公告)日：2019-08-13
申请号：US15290951
申请日：2016-10-11
申请人： Larry Partain , George Zentai , Stavros Prionas , Raisa Pavlyuchkova
发明人： Larry Partain , George Zentai , Stavros Prionas , Raisa Pavlyuchkova
IPC分类号： G06K9/00 , G06T7/00 , G06T17/20
摘要： Methods of obtaining a suspect nodules' sizes and/or growth rate are provided. In one embodiment, the method begins with at a first time: (i) obtaining a first three dimensional (3D) data set cube of voxels of a patient's anatomy including nodules; (ii) creating a second 3D data set cube of the same size as the first where all voxel values are set to zero; (iii) creating multiple Maximum-Intensity-Projection (MIP) images from the first 3D data set cube taken at different angles; (iv) replacing those voxels in the second 3D data set cube with corresponding voxels from the first 3D data set cube that provide non-zero values in the multiple MIP images; and (v) converting data in the second 3D data set cube into closed surface volumes, cross sectional areas or linear dimensions using image segmentation. Data from a second time can be used to determine growth rate.

3. 发明授权

US06969896B1 Photodetector biasing scheme 有权
标题翻译：光电检测器偏置方案
公开(公告)号：US06969896B1
公开(公告)日：2005-11-29
申请号：US10639931
申请日：2003-08-12
申请人： Larry Dean Partain , George Zentai , Raisa Pavlyuchkova
发明人： Larry Dean Partain , George Zentai , Raisa Pavlyuchkova
IPC分类号： H01L27/142 , H01L31/0224 , H01L31/08 , H01L31/115
CPC分类号： H01L31/0224 , H01L31/085 , H01L31/115
摘要： A photodetector having a semiconductor conversion layer is described. The photodetector is configured to receive x-rays incident on its substrate with the substrate-side contact biased so that the lowest mobility carrier in the semiconductor conversion layer is collected by the substrate side contact.
摘要翻译：描述具有半导体转换层的光电检测器。光电检测器被配置为接收入射在其衬底上的x射线，衬底侧接触被偏置，使得半导体转换层中的最低迁移率载流子被衬底侧接触收集。

4. 发明授权

US06409652B1 Device and method for delivery of uniform and controlled radiation dose to blood vessels 失效
标题翻译：用于将均匀和受控的辐射剂量递送到血管的装置和方法
公开(公告)号：US06409652B1
公开(公告)日：2002-06-25
申请号：US09665729
申请日：2000-09-20
申请人： Kirti P. Kamdar , Majid Leonard Riaziat , William K. Wheeler , Raisa Pavlyuchkova
发明人： Kirti P. Kamdar , Majid Leonard Riaziat , William K. Wheeler , Raisa Pavlyuchkova
IPC分类号： A61N500
CPC分类号： A61N5/1002 , A61M2025/1047 , A61N2005/1003
摘要： The present invention provides a device, system and method for uniformly delivering a radiation dose over the surface area of a stenosed vessel during or after a percutaneous transluminal angioplasty procedure. A helical balloon is inflated in the region to be treated, preferably in contact with the vessel wall, and a radiation source is drawn through the helical coils of the balloon to provide a uniform dosage. Alternatively, the helical balloon is disposed within a cylindrical balloon and the helical balloon containing a radiation source with at least one coil is drawn through the cylindrical balloon.
摘要翻译：本发明提供了一种用于在经皮腔内血管成形术过程中或之后均匀地递送在狭窄血管的表面区域上的辐射剂量的装置，系统和方法。在待处理的区域中，优选地与血管壁接触，螺旋状的气囊被膨胀，并且辐射源被吸入气球的螺旋线圈以提供均匀的剂量。或者，螺旋形气球设置在圆柱形球囊内，并且包含具有至少一个线圈的辐射源的螺旋形气球被抽吸通过圆柱形球囊。

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