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1. 发明申请

US20100128839A1 Structure and Procedure for X-Ray CT Guided Cancer Treatment 审中-公开
标题翻译： X射线CT引导癌症治疗的结构和程序
公开(公告)号：US20100128839A1
公开(公告)日：2010-05-27
申请号：US12275819
申请日：2008-11-21
申请人： Larry D. Partain , Gary Virshup , Edward Seppi , David Humber
发明人： Larry D. Partain , Gary Virshup , Edward Seppi , David Humber
IPC分类号： A61N5/10 , H05G1/60
CPC分类号： A61N5/1048 , A61N2005/1061
摘要： A radiation apparatus includes a first radiation source configured to generate radiation suitable for therapeutic treatment, and a structure for supporting a body. The structure comprises a curved surface adapted to receive a body portion to be treated during a therapeutic treatment.
摘要翻译：辐射装置包括被配置为产生适于治疗性治疗的辐射的第一辐射源和用于支撑身体的结构。该结构包括适于在治疗性治疗期间接收待治疗的身体部分的弯曲表面。

2. 发明申请

US20080226018A1 CONTRAST-ENHANCED CONE BEAM X-RAY IMAGING, EVALUATION, MONITORING AND TREATMENT DELIVERY 有权
标题翻译：对比增强锥体X射线成像，评估，监测和处理交付
公开(公告)号：US20080226018A1
公开(公告)日：2008-09-18
申请号：US12126224
申请日：2008-05-23
申请人： Larry D. Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
发明人： Larry D. Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
IPC分类号： A61B6/00
CPC分类号： A61B6/4241 , A61B6/032 , A61B6/4085 , A61B6/482 , A61B6/502 , A61B6/507
摘要： A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.
摘要翻译：使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集或至少两个正交方向。

3. 发明授权

US5919819A Dihydropyran derivatives as viral neuraminidase inhibitors 有权
标题翻译：二氢吡喃衍生物作为病毒神经氨酸酶抑制剂
公开(公告)号：US5919819A
公开(公告)日：1999-07-06
申请号：US000149
申请日：1998-09-14
申请人： David Andrews , Paul Jones , David Humber
发明人： David Andrews , Paul Jones , David Humber
IPC分类号： A61K31/00 , A61K31/35 , A61K31/351 , A61P31/00 , C07D309/28 , C07D315/00
CPC分类号： C07D309/28
摘要： Compounds of formula (I), wherein R.sup.1 represents NR.sup.5 R.sup.6, wherein R.sup.5 represents H or a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF.sub.3, NR.sup.7 R.sup.8, CO.sub.2 R.sup.9, CONR.sup.7 R.sup.8, COR.sup.9, OR.sup.10 or SR.sup.10, or a heteroaromatic group; and R.sup.6 represents a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF.sub.3, NR.sup.7 R.sup.8, CO.sub.2 R.sup.9, CONR.sup.7 R.sup.8, COR.sup.9, OR.sup.10 or SR.sup.10, or a heteroaromatic group; R.sup.2 represents a group SO.sub.2 R.sup.9 or COR.sup.9 ; R.sup.3 represents H, C.sub.1-6 -alkyl or C(=NR.sup.11)NR.sup.12 R.sup.13 ; R.sup.4 represents H or C.sub.1-6 alkyl; R.sup.7 and R.sup.8 each independently represent H, C.sub.1-6 alkyl or COR.sup.9 ; R.sup.9 represents C.sub.1-6 alkyl optionally substituted by one or more halogen atoms; R.sup.10 represents H, C.sub.1-6 -alkyl or phenyl; R.sup.11, R.sup.12 and R.sup.13 each independently represent H, C.sub.1-6 alkyl, amino, hydroxy, cyano or nitro; and X represents O or S; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.
摘要翻译： PCT No.PCT / AU96 / 00495 Sec。 371日期：1998年9月14日 102（e）1998年9月14日PCT PCT 1996年8月7日PCT公布。公开号WO97 / 06157 日期：1997年2月20日，式（I）的化合物，其中R 1表示NR 5 R 6，其中R 5表示H或任选被Br，Cl，F，I，CF 3，NR 7 R 8，CO 2 R 9，CONR 7 R 8，COR 9， OR10或SR10，或杂芳族基团; 并且R 6表示任选被Br，Cl，F，I，CF 3，NR 7 R 8，CO 2 R 9，CONR 7 R 8，COR 9，OR 10或SR 10中的一个或多个取代的烃基或杂芳基; R2代表基团SO2R9或COR9; R 3表示H，C 1-6 - 烷基或C（= NR 11）NR 12 R 13; R4表示H或C1-6烷基; R 7和R 8各自独立地表示H，C 1-6烷基或COR 9; R9表示任选被一个或多个卤素原子取代的C 1-6烷基; R 10表示H，C 1-6 - 烷基或苯基; R 11，R 12和R 13各自独立地表示H，C 1-6烷基，氨基，羟基，氰基或硝基; X表示O或S; 其药学上可接受的衍生物是可用于治疗病毒感染的神经氨酸酶抑制剂。

4. 发明授权

US08350226B2 Methods and systems for treating cancer using external beam radiation 有权
标题翻译：使用外部束辐射治疗癌症的方法和系统
公开(公告)号：US08350226B2
公开(公告)日：2013-01-08
申请号：US12572265
申请日：2009-10-01
申请人： George Zdasiuk , James Clayton , Josh Star-Lack , David Humber , Gary Virshup , Michael C. Green
发明人： George Zdasiuk , James Clayton , Josh Star-Lack , David Humber , Gary Virshup , Michael C. Green
IPC分类号： H01J1/50
CPC分类号： H05H7/04 , A61N5/1043 , A61N5/1081 , A61N2005/1087 , A61N2005/1089 , G21K1/093 , G21K5/00 , H01J37/1475 , H05G2/00
摘要： A radiation system employs magnetic field to move particle beams and radiation sources. The radiation system includes a source operable to produce a particle beam, a scanning magnet operable to scan the particle beam, and a target configured to be impinged by at least a portion of the scanned particle beam to produce radiation.
摘要翻译：辐射系统采用磁场来移动粒子束和辐射源。辐射系统包括可操作以产生粒子束的源，可操作以扫描粒子束的扫描磁体以及被配置为被扫描的粒子束的至少一部分撞击以产生辐射的目标。

5. 发明申请

US20100102244A1 Methods and Systems for Treating Cancer Using External Beam Radiation 有权
标题翻译：使用外部光束辐射治疗癌症的方法和系统
公开(公告)号：US20100102244A1
公开(公告)日：2010-04-29
申请号：US12572265
申请日：2009-10-01
申请人： George Zdasiuk , James Clayton , Josh Star-Lack , David Humber , Gary Virshup , Michael C. Green
发明人： George Zdasiuk , James Clayton , Josh Star-Lack , David Humber , Gary Virshup , Michael C. Green
IPC分类号： H01J1/50 , G21G4/00 , A61N5/10
CPC分类号： H05H7/04 , A61N5/1043 , A61N5/1081 , A61N2005/1087 , A61N2005/1089 , G21K1/093 , G21K5/00 , H01J37/1475 , H05G2/00
摘要： A radiation system employs magnetic field to move particle beams and radiation sources. The radiation system includes a source operable to produce a particle beam, a scanning magnet operable to scan the particle beam, and a target configured to be impinged by at least a portion of the scanned particle beam to produce radiation.
摘要翻译：辐射系统采用磁场来移动粒子束和辐射源。辐射系统包括可操作以产生粒子束的源，可操作以扫描粒子束的扫描磁体以及被配置为被扫描的粒子束的至少一部分撞击以产生辐射的目标。

6. 发明申请

US20100098214A1 Methods and Systems for Treating Breast Cancer Using External Beam Radiation 有权
标题翻译：使用外部束辐射治疗乳腺癌的方法和系统
公开(公告)号：US20100098214A1
公开(公告)日：2010-04-22
申请号：US12256461
申请日：2008-10-22
申请人： Josh Star-Lack , David Humber , Karla Knott , Corey Zankowski , Michael C. Green , Gary Virshup , James Clayton , Michelle M. Svatos
发明人： Josh Star-Lack , David Humber , Karla Knott , Corey Zankowski , Michael C. Green , Gary Virshup , James Clayton , Michelle M. Svatos
IPC分类号： A61N5/10 , A61B6/04
CPC分类号： A61N5/1042 , A61B6/04 , A61B6/0435 , A61B6/4071 , A61B6/4458 , A61B6/4488 , A61B6/502 , A61B6/583
摘要： A radiation apparatus includes a radiation source movable in translational and/or rotational degrees of freedom, and a structure adapted to support a body. The structure is provided with an opening to allow a portion of the body passing through to be exposed to at least a portion of the therapeutic radiation while in use.
摘要翻译：辐射装置包括可平移和/或旋转自由度移动的辐射源，以及适于支撑身体的结构。该结构设置有开口，以允许身体通过的一部分在使用中暴露于治疗辐射的至少一部分。

7. 发明申请

US20090129550A1 FILAMENT ASSEMBLY HAVING REDUCED ELECTRON BEAM TIME CONSTANT 有权
标题翻译：具有减少电子束时间的薄膜组件
公开(公告)号：US20090129550A1
公开(公告)日：2009-05-21
申请号：US11942656
申请日：2007-11-19
申请人： Steve G. Bandy , Gary F. Virshup , Michael Curzon Green , James Russell Boye , Dennis Runnoe , Robert Clark Treseder , David Humber
发明人： Steve G. Bandy , Gary F. Virshup , Michael Curzon Green , James Russell Boye , Dennis Runnoe , Robert Clark Treseder , David Humber
IPC分类号： H01J35/12
CPC分类号： H01J1/16 , H01J1/135 , H01J1/15 , H01J35/06 , H01J2201/2803 , H01J2201/281 , H01J2201/2867 , H01J2235/1212
摘要： A filament assembly for use in an x-ray emitting device or other filament-containing device is disclosed. In one embodiment, an x-ray tube is disclosed, including a vacuum enclosure that houses both an anode having a target surface, and a cathode positioned with respect to the anode. The cathode includes a filament assembly for emitting a beam of electrons during tube operation. The filament assembly comprises a heat sink and a plurality of filament segments. The filament segments are configured for simultaneous emission of an electron beam for impingement on the target surface of the anode, and are electrically connected in series. Each filament segment includes first and second end portions that are thermally connected to the heat sink, and a central portion that can be configured with a modified work function for preferential electron emission.
摘要翻译：公开了一种用于x射线发射装置或其它含灯丝装置的灯丝组件。在一个实施例中，公开了一种X射线管，其包括容纳具有目标表面的阳极和相对于阳极定位的阴极的真空外壳。阴极包括在管操作期间发射电子束的灯丝组件。灯丝组件包括散热器和多个灯丝段。灯丝段被配置为同时发射用于冲击阳极的靶表面的电子束，并且串联电连接。每个细丝段包括热连接到散热器的第一和第二端部，以及可以配置有用于优先电子发射的修改功函数的中心部分。

8. 发明申请

US20080317202A1 System and Method for Imaging and Treatment of Tumorous Tissue in Breasts Using Computed Tomography and Radiotherapy 有权
标题翻译：使用计算机断层扫描和放射治疗乳腺肿瘤组织成像和治疗的系统和方法
公开(公告)号：US20080317202A1
公开(公告)日：2008-12-25
申请号：US12197510
申请日：2008-09-09
申请人： Larry D. Partain , David Humber
发明人： Larry D. Partain , David Humber
IPC分类号： A61B6/04 , A61N5/10
CPC分类号： A61B6/482 , A61B6/032 , A61B6/0414 , A61B6/107 , A61B6/405 , A61B6/4441 , A61B6/466 , A61B6/502 , A61B6/541 , A61N5/10 , A61N5/1081 , A61N2005/1097
摘要： The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.
摘要翻译：本发明提供一种用于照射患者22的乳房20的系统10.系统10包括可围绕水平轴线14旋转的台架12，其包括用于产生辐射束18的辐射源16和与放射线隔开的检测器24 源16和设置在患者22和台架12之间的阻挡层26.阻挡层26设置有适于允许穿过其中的乳房20暴露于辐射束18的开口30.在一些实施例中，阻挡层26 设置有开口30，其适于允许乳房20和从乳房到达腋窝的组织和穿过其中的相邻胸壁的肌肉组织暴露于辐射束18。

9. 发明授权

US07940891B2 Methods and systems for treating breast cancer using external beam radiation 有权
标题翻译：使用外部束辐射治疗乳腺癌的方法和系统
公开(公告)号：US07940891B2
公开(公告)日：2011-05-10
申请号：US12256461
申请日：2008-10-22
申请人： Josh Star-Lack , David Humber , Karla Knott , Corey Zankowski , Michael C. Green , Gary Virshup , James Clayton , Michelle M. Svatos
发明人： Josh Star-Lack , David Humber , Karla Knott , Corey Zankowski , Michael C. Green , Gary Virshup , James Clayton , Michelle M. Svatos
IPC分类号： A61N5/00
CPC分类号： A61N5/1042 , A61B6/04 , A61B6/0435 , A61B6/4071 , A61B6/4458 , A61B6/4488 , A61B6/502 , A61B6/583
摘要： A radiation apparatus includes a radiation source movable in translational and/or rotational degrees of freedom, and a structure adapted to support a body. The structure is provided with an opening to allow a portion of the body passing through to be exposed to at least a portion of the therapeutic radiation while in use.
摘要翻译：辐射装置包括可平移和/或旋转自由度移动的辐射源，以及适于支撑身体的结构。该结构设置有开口，以允许身体通过的一部分在使用中暴露于治疗辐射的至少一部分。

10. 发明授权

US07817774B2 System and method for imaging and treatment of tumorous tissue in breasts using computed tomography and radiotherapy 有权
标题翻译：使用计算机断层扫描和放射治疗乳腺肿瘤组织成像和治疗的系统和方法
公开(公告)号：US07817774B2
公开(公告)日：2010-10-19
申请号：US12197510
申请日：2008-09-09
申请人： Larry D. Partain , David Humber
发明人： Larry D. Partain , David Humber
IPC分类号： A61B6/04 , A61N5/10 , G21K5/08
CPC分类号： A61B6/482 , A61B6/032 , A61B6/0414 , A61B6/107 , A61B6/405 , A61B6/4441 , A61B6/466 , A61B6/502 , A61B6/541 , A61N5/10 , A61N5/1081 , A61N2005/1097
摘要： The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.
摘要翻译：本发明提供一种用于照射患者22的乳房20的系统10.系统10包括可围绕水平轴线14旋转的台架12，其包括用于产生辐射束18的辐射源16和与放射线隔开的检测器24 源16和设置在患者22和台架12之间的阻挡层26.阻挡层26设置有适于允许穿过其中的乳房20暴露于辐射束18的开口30.在一些实施例中，阻挡层26 设置有开口30，其适于允许乳房20和从乳房到达腋窝的组织和穿过其中的相邻胸壁的肌肉组织暴露于辐射束18。

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