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1. 发明授权

US07699788B2 Noninvasive effective lung volume estimation 有权
标题翻译：无创有效肺容量估计
公开(公告)号：US07699788B2
公开(公告)日：2010-04-20
申请号：US10973815
申请日：2004-10-25
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/00
CPC分类号： A61B5/0836 , A61B5/091
摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.
摘要翻译：用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。还公开了用于有效的这种方法的装置。

2. 发明申请

US20060111749A1 System for providing emergency medical care with real-time instructions and associated methods 有权
标题翻译：提供紧急医疗护理的实时指导和相关方法的系统
公开(公告)号：US20060111749A1
公开(公告)日：2006-05-25
申请号：US11157218
申请日：2005-06-20
申请人： Dwayne Westenskow , Joseph Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutta , Santosh Balakrishnan , Kai Kuck , Lara Brewer
发明人： Dwayne Westenskow , Joseph Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutta , Santosh Balakrishnan , Kai Kuck , Lara Brewer
IPC分类号： A61N1/39
CPC分类号： G09B19/00 , A61M16/0051 , A61M16/024 , A61M16/1055 , A61M16/106 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2230/04 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61N1/39 , A61N1/3993 , G09B23/288
摘要： A basic life support system (BLSS) includes a processing element and an output element, such as a display screen or an audio output element, for providing an individual with real-time instructions on providing emergency medical care to a patient until paramedics or other healthcare professionals arrive to take over care for the patient. The instructions may be provided as graphics, including animations, as text, audibly, or as a combination of visible and audible elements. The BLSS may be configured for providing emergency medical care to individuals who have suffered from ventricular fibrillation. Accordingly, the BLSS may also include a defibrillation apparatus, an air or oxygen supply, a respiratory interface, one or more sensors, or a combination thereof.
摘要翻译：基本生命支持系统（BLSS）包括处理元件和诸如显示屏或音频输出元件的输出元件，用于向个人提供关于向患者提供紧急医疗护理的实时指令，直到护理人员或其他保健专业人员到医院接受治疗。指令可以作为图形，包括动画，文本，听觉地或作为可见和可听元素的组合来提供。 BLSS可能被配置为为患有心室颤动的个人提供紧急医疗。因此，BLSS还可以包括除颤装置，空气或氧气供应，呼吸界面，一个或多个传感器或其组合。

3. 发明申请

US20060004297A1 Lung model-based cardiopulmonary performance determination 审中-公开
标题翻译：肺型心肺功能测定
公开(公告)号：US20060004297A1
公开(公告)日：2006-01-05
申请号：US11150378
申请日：2005-06-10
申请人： Joseph Orr , Kai Kuck , Lara Brewer
发明人： Joseph Orr , Kai Kuck , Lara Brewer
IPC分类号： A61B5/08
CPC分类号： A61B5/029 , A61B5/082 , A61B5/083 , A61B5/0836 , A61B5/087 , A61B5/091 , G01N33/497
摘要： Methods for noninvasively evaluating indicators of cardio-pulmonary performance of a subject, such as cardiac output, pulmonary capillary blood flow, and blood carbon dioxide content, include obtaining data of an expiratory carbon dioxide signal and comparing data generated by an algorithmic lung model to the data of the expiratory carbon dioxide signal of a subject. The variables that are input into the algorithmic lung model are adjusted until the data generated thereby reflects that of the measured expiratory carbon dioxide signal with a desired degree of accuracy. Once the algorithmic lung model replicates the data of the measured expiratory carbon dioxide signal with the desired degree of accuracy, one or more of the input values may be used to determine one or more of the cardiac output, pulmonary capillary blood flow, or a blood gas content of the subject from which the expiratory carbon dioxide signal was obtained.
摘要翻译：用于非侵入性评估受试者的心肺功能指标（如心输出量，肺毛细血管血流量和血二氧化碳含量）的方法包括获得呼气二氧化碳信号的数据，并将算法肺模型产生的数据与受检者呼气二氧化碳信号的数据。调整输入到算法肺模型中的变量，直到由此产生的数据以所需的准确程度反映测量的呼气二氧化碳信号的数据。一旦算法肺模型以期望的准确度复制测量的呼气二氧化碳信号的数据，则一个或多个输入值可用于确定心输出量，肺毛细血管血流量或血液中的一个或多个获得呼气二氧化碳信号的对象的气体含量。

4. 发明授权

US10285596B2 Apparatus and system for measuring volume of blood loss 有权
公开(公告)号：US10285596B2
公开(公告)日：2019-05-14
申请号：US15485070
申请日：2017-04-11
申请人： Alfred Akerman , Stephen W. Allison , Matthew B. Scudiere , Michael R. Cates , David L. Beshears , Lara Brewer , Adan James Akerman
发明人： Alfred Akerman , Stephen W. Allison , Matthew B. Scudiere , Michael R. Cates , David L. Beshears , Lara Brewer , Adan James Akerman
IPC分类号： A61B5/02 , G01N21/31 , G01N33/49
摘要： A system for measuring the blood loss comprises a measuring device that determines a hemoglobin concentration of fluid within a container utilizing a light source and a light detector. The container receives blood and other fluids from a patient during a medical procedure. Light from the light source is passed through the blood and other fluids in the container and is detected by the light detector. Based upon a magnitude of light detected, a hemoglobin concentration of the fluid in the container can be determined. A volume-measuring device determines the volume of blood and fluid in the container. Knowing the hemoglobin concentration and volume of fluid in the container, the volume of patient blood loss in the container can be determined. The blood loss measuring device in combination with infusion systems maintains a real-blood volume status so that proper infusion of blood, crystalloid and/or colloid solutions occurs.

5. 发明申请

US20170290518A1 APPARATUS AND SYSTEM FOR MEASURING VOLUME OF BLOOD LOSS 审中-公开
公开(公告)号：US20170290518A1
公开(公告)日：2017-10-12
申请号：US15485070
申请日：2017-04-11
申请人： Alfred Akerman , Stephen W. Allison , Matthew B. Scudiere , Michael R. Cates , David L. Beshears , Lara Brewer , Adan James Akerman
发明人： Alfred Akerman , Stephen W. Allison , Matthew B. Scudiere , Michael R. Cates , David L. Beshears , Lara Brewer , Adan James Akerman
IPC分类号： A61B5/02 , G01N21/31 , G01N33/49
CPC分类号： A61B5/02042 , G01N21/314 , G01N21/3151 , G01N21/8507 , G01N33/49 , G01N2021/3181 , G01N2021/8528
摘要： A system for measuring the blood loss comprises a measuring device that determines a hemoglobin concentration of fluid within a container utilizing a light source and a light detector. The container receives blood and other fluids from a patient during a medical procedure. Light from the light source is passed through the blood and other fluids in the container and is detected by the light detector. Based upon a magnitude of light detected, a hemoglobin concentration of the fluid in the container can be determined. A volume-measuring device determines the volume of blood and fluid in the container. Knowing the hemoglobin concentration and volume of fluid in the container, the volume of patient blood loss in the container can be determined. The blood loss measuring device in combination with infusion systems maintains a real-blood volume status so that proper infusion of blood, crystalloid and/or colloid solutions occurs.

6. 发明申请

US20130013281A1 DETERMINING COMPONENTS OF TOTAL CARBON DIOXIDE EXCRETED BY A SUBJECT 有权
标题翻译：确定主体二氧化碳的组分
公开(公告)号：US20130013281A1
公开(公告)日：2013-01-10
申请号：US13636526
申请日：2011-03-17
申请人： Joseph Allen Orr , Lara Brewer
发明人： Joseph Allen Orr , Lara Brewer
IPC分类号： G06G7/60
CPC分类号： A61B5/0836 , A61B5/412 , A61M16/0003
摘要： Values of components of total carbon dioxide excreted by a subject can be provided. One or more signals may be received conveying information related to a rate of total carbon dioxide excreted by the subject. Based at least in part on the received one or more signals, a first capnometric component and/or a second capnometric component may be determined. The first capnometric component may indicate a rate of metabolic carbon dioxide production. The second capnometric component may indicate a rate of carbon dioxide transfer to or from body compartments of the subject that store carbon dioxide. The first capnometric component and/or the second capnometric component may be presented to a user.
摘要翻译：可以提供受试者排出的总二氧化碳的成分的值。可以接收一个或多个信号，其传送与被摄体排出的总二氧化碳的速率有关的信息。至少部分地基于所接收的一个或多个信号，可以确定第一测量分量和/或第二测量分量。第一个测量组分可能表示代谢二氧化碳产生的速率。第二测量组分可以指示存储二氧化碳的物体的二氧化碳转移到或来自身体隔室的速率。可以向用户呈现第一测量分量和/或第二测量分量。

7. 发明授权

US07774060B2 System for providing emergency medical care with real-time instructions and associated methods 有权
标题翻译：提供紧急医疗护理的实时指导和相关方法的系统
公开(公告)号：US07774060B2
公开(公告)日：2010-08-10
申请号：US11157218
申请日：2005-06-20
申请人： Dwayne R. Westenskow , Joseph A. Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutla , Santosh Balakrishnan , Kai Kuck , Lara Brewer
发明人： Dwayne R. Westenskow , Joseph A. Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutla , Santosh Balakrishnan , Kai Kuck , Lara Brewer
IPC分类号： A61N1/39
CPC分类号： G09B19/00 , A61M16/0051 , A61M16/024 , A61M16/1055 , A61M16/106 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2230/04 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61N1/39 , A61N1/3993 , G09B23/288
摘要： A basic life support system (BLSS) includes a processing element and an output element, such as a display screen or an audio output element, for providing an individual with real-time instructions on providing emergency medical care to a patient until paramedics or other healthcare professionals arrive to take over care for the patient. The instructions may be provided as graphics, including animations, as text, audibly, or as a combination of visible and audible elements. The BLSS may be configured for providing emergency medical care to individuals who have suffered from ventricular fibrillation. Accordingly, the BLSS may also include a defibrillation apparatus, an air or oxygen supply, a respiratory interface, one or more sensors, or a combination thereof.
摘要翻译：基本生命支持系统（BLSS）包括处理元件和诸如显示屏或音频输出元件的输出元件，用于向个人提供关于向患者提供紧急医疗护理的实时指令，直到护理人员或其他保健专业人员到医院接受治疗。指令可以作为图形，包括动画，文本，听觉地或作为可见和可听元素的组合来提供。 BLSS可能被配置为为患有心室颤动的个人提供紧急医疗。因此，BLSS还可以包括除颤装置，空气或氧气供应，呼吸界面，一个或多个传感器或其组合。

8. 发明申请

US20050177055A1 Algorithms, systems, and methods for estimating carbon dioxide stores, transforming respiratory gas measurements, and obtaining accurate noninvasive pulmonary capillary blood flow and cardiac output measurements 有权
标题翻译：用于估算二氧化碳储存，转化呼吸气体测量和获得准确无创肺毛细血管血流量和心输出量测量的算法，系统和方法
公开(公告)号：US20050177055A1
公开(公告)日：2005-08-11
申请号：US11102072
申请日：2005-04-08
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/026 , A61B5/08 , A61B5/083 , A61B5/087 , G01N1/22 , A61M15/00 , A61M16/10
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.
摘要翻译：用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化。还公开了转换或滤波算法，以及可以使用方法和算法的系统。方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

9. 发明授权

US08398559B2 Methods and apparatus for improving time domain relationships between signals obtained from respiration 有权
标题翻译：改善从呼吸获得的信号之间的时域关系的方法和装置
公开(公告)号：US08398559B2
公开(公告)日：2013-03-19
申请号：US11483460
申请日：2006-07-10
申请人： Kai Kück , Joseph A. Orr , Lara Brewer
发明人： Kai Kück , Joseph A. Orr , Lara Brewer
IPC分类号： A61B5/08
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.
摘要翻译：用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化。还公开了转换或滤波算法，以及可以使用方法和算法的系统。方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

10. 发明授权

US07135001B2 Rebreathing methods including oscillating, substantially equal rebreathing and nonrebreathing periods 有权
标题翻译：呼吸方法包括振荡，基本相等的呼吸和非呼吸期
公开(公告)号：US07135001B2
公开(公告)日：2006-11-14
申请号：US09813225
申请日：2001-03-20
申请人： Joseph A. Orr , Kai Kuck , Lara Brewer
发明人： Joseph A. Orr , Kai Kuck , Lara Brewer
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0836 , A61B5/029 , A61M16/0045 , A61M2016/0036 , A61M2230/432 , G06F19/00
摘要： A differential Fick technique including a first phase in which baseline breathing parameters may be established and a second phase in which a change in the effective ventilation of a patient is induced. The durations of the first and second phases may be substantially the same and may be abbreviated relative to the durations of comparable phases of previously known differential Fick techniques. The disclosed differential Fick technique also lacks a recovery period in which the respiratory parameters of a patient are permitted to return to “normal” levels.
摘要翻译：一种差分Fick技术，包括其中可以建立基线呼吸参数的第一阶段和诱导患者有效通气变化的第二阶段。第一和第二阶段的持续时间可以基本上相同并且可以相对于先前已知的差分Fick技术的相似阶段的持续时间来缩写。所公开的差分Fick技术还缺乏允许患者的呼吸参数恢复到“正常”水平的恢复期。

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