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1. 发明申请

US20050177055A1 Algorithms, systems, and methods for estimating carbon dioxide stores, transforming respiratory gas measurements, and obtaining accurate noninvasive pulmonary capillary blood flow and cardiac output measurements 有权
标题翻译：用于估算二氧化碳储存，转化呼吸气体测量和获得准确无创肺毛细血管血流量和心输出量测量的算法，系统和方法
公开(公告)号：US20050177055A1
公开(公告)日：2005-08-11
申请号：US11102072
申请日：2005-04-08
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/026 , A61B5/08 , A61B5/083 , A61B5/087 , G01N1/22 , A61M15/00 , A61M16/10
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.
摘要翻译：用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化。还公开了转换或滤波算法，以及可以使用方法和算法的系统。方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

2. 发明授权

US07699788B2 Noninvasive effective lung volume estimation 有权
标题翻译：无创有效肺容量估计
公开(公告)号：US07699788B2
公开(公告)日：2010-04-20
申请号：US10973815
申请日：2004-10-25
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/00
CPC分类号： A61B5/0836 , A61B5/091
摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.
摘要翻译：用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。还公开了用于有效的这种方法的装置。

3. 发明申请

US20060111749A1 System for providing emergency medical care with real-time instructions and associated methods 有权
标题翻译：提供紧急医疗护理的实时指导和相关方法的系统
公开(公告)号：US20060111749A1
公开(公告)日：2006-05-25
申请号：US11157218
申请日：2005-06-20
申请人： Dwayne Westenskow , Joseph Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutta , Santosh Balakrishnan , Kai Kuck , Lara Brewer
发明人： Dwayne Westenskow , Joseph Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutta , Santosh Balakrishnan , Kai Kuck , Lara Brewer
IPC分类号： A61N1/39
CPC分类号： G09B19/00 , A61M16/0051 , A61M16/024 , A61M16/1055 , A61M16/106 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2230/04 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61N1/39 , A61N1/3993 , G09B23/288
摘要： A basic life support system (BLSS) includes a processing element and an output element, such as a display screen or an audio output element, for providing an individual with real-time instructions on providing emergency medical care to a patient until paramedics or other healthcare professionals arrive to take over care for the patient. The instructions may be provided as graphics, including animations, as text, audibly, or as a combination of visible and audible elements. The BLSS may be configured for providing emergency medical care to individuals who have suffered from ventricular fibrillation. Accordingly, the BLSS may also include a defibrillation apparatus, an air or oxygen supply, a respiratory interface, one or more sensors, or a combination thereof.
摘要翻译：基本生命支持系统（BLSS）包括处理元件和诸如显示屏或音频输出元件的输出元件，用于向个人提供关于向患者提供紧急医疗护理的实时指令，直到护理人员或其他保健专业人员到医院接受治疗。指令可以作为图形，包括动画，文本，听觉地或作为可见和可听元素的组合来提供。 BLSS可能被配置为为患有心室颤动的个人提供紧急医疗。因此，BLSS还可以包括除颤装置，空气或氧气供应，呼吸界面，一个或多个传感器或其组合。

4. 发明申请

US20060004297A1 Lung model-based cardiopulmonary performance determination 审中-公开
标题翻译：肺型心肺功能测定
公开(公告)号：US20060004297A1
公开(公告)日：2006-01-05
申请号：US11150378
申请日：2005-06-10
申请人： Joseph Orr , Kai Kuck , Lara Brewer
发明人： Joseph Orr , Kai Kuck , Lara Brewer
IPC分类号： A61B5/08
CPC分类号： A61B5/029 , A61B5/082 , A61B5/083 , A61B5/0836 , A61B5/087 , A61B5/091 , G01N33/497
摘要： Methods for noninvasively evaluating indicators of cardio-pulmonary performance of a subject, such as cardiac output, pulmonary capillary blood flow, and blood carbon dioxide content, include obtaining data of an expiratory carbon dioxide signal and comparing data generated by an algorithmic lung model to the data of the expiratory carbon dioxide signal of a subject. The variables that are input into the algorithmic lung model are adjusted until the data generated thereby reflects that of the measured expiratory carbon dioxide signal with a desired degree of accuracy. Once the algorithmic lung model replicates the data of the measured expiratory carbon dioxide signal with the desired degree of accuracy, one or more of the input values may be used to determine one or more of the cardiac output, pulmonary capillary blood flow, or a blood gas content of the subject from which the expiratory carbon dioxide signal was obtained.
摘要翻译：用于非侵入性评估受试者的心肺功能指标（如心输出量，肺毛细血管血流量和血二氧化碳含量）的方法包括获得呼气二氧化碳信号的数据，并将算法肺模型产生的数据与受检者呼气二氧化碳信号的数据。调整输入到算法肺模型中的变量，直到由此产生的数据以所需的准确程度反映测量的呼气二氧化碳信号的数据。一旦算法肺模型以期望的准确度复制测量的呼气二氧化碳信号的数据，则一个或多个输入值可用于确定心输出量，肺毛细血管血流量或血液中的一个或多个获得呼气二氧化碳信号的对象的气体含量。

5. 发明申请

US20060253038A1 Methods and apparatus for improving time domain relationships between signals obtained from respiration 有权
公开(公告)号：US20060253038A1
公开(公告)日：2006-11-09
申请号：US11483460
申请日：2006-07-10
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/02 , G01N33/497 , A61B5/08
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

6. 发明申请

US20050124907A1 Noninvasive effective lung volume estimation 有权
标题翻译：无创有效肺容量估计
公开(公告)号：US20050124907A1
公开(公告)日：2005-06-09
申请号：US10973815
申请日：2004-10-25
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/083 , A61B5/091 , G01N1/22 , A61B5/08 , B32B5/02 , G01N31/00 , G01N33/497
CPC分类号： A61B5/0836 , A61B5/091
摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.
摘要翻译：用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。还公开了用于有效的这种方法的装置。

7. 发明授权

US07774060B2 System for providing emergency medical care with real-time instructions and associated methods 有权
标题翻译：提供紧急医疗护理的实时指导和相关方法的系统
公开(公告)号：US07774060B2
公开(公告)日：2010-08-10
申请号：US11157218
申请日：2005-06-20
申请人： Dwayne R. Westenskow , Joseph A. Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutla , Santosh Balakrishnan , Kai Kuck , Lara Brewer
发明人： Dwayne R. Westenskow , Joseph A. Orr , Noah Syroid , Daniel Snell , James Agutter , Frank Drews , Srinath Lingutla , Santosh Balakrishnan , Kai Kuck , Lara Brewer
IPC分类号： A61N1/39
CPC分类号： G09B19/00 , A61M16/0051 , A61M16/024 , A61M16/1055 , A61M16/106 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2230/04 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61N1/39 , A61N1/3993 , G09B23/288
摘要： A basic life support system (BLSS) includes a processing element and an output element, such as a display screen or an audio output element, for providing an individual with real-time instructions on providing emergency medical care to a patient until paramedics or other healthcare professionals arrive to take over care for the patient. The instructions may be provided as graphics, including animations, as text, audibly, or as a combination of visible and audible elements. The BLSS may be configured for providing emergency medical care to individuals who have suffered from ventricular fibrillation. Accordingly, the BLSS may also include a defibrillation apparatus, an air or oxygen supply, a respiratory interface, one or more sensors, or a combination thereof.
摘要翻译：基本生命支持系统（BLSS）包括处理元件和诸如显示屏或音频输出元件的输出元件，用于向个人提供关于向患者提供紧急医疗护理的实时指令，直到护理人员或其他保健专业人员到医院接受治疗。指令可以作为图形，包括动画，文本，听觉地或作为可见和可听元素的组合来提供。 BLSS可能被配置为为患有心室颤动的个人提供紧急医疗。因此，BLSS还可以包括除颤装置，空气或氧气供应，呼吸界面，一个或多个传感器或其组合。

8. 发明授权

US07135001B2 Rebreathing methods including oscillating, substantially equal rebreathing and nonrebreathing periods 有权
标题翻译：呼吸方法包括振荡，基本相等的呼吸和非呼吸期
公开(公告)号：US07135001B2
公开(公告)日：2006-11-14
申请号：US09813225
申请日：2001-03-20
申请人： Joseph A. Orr , Kai Kuck , Lara Brewer
发明人： Joseph A. Orr , Kai Kuck , Lara Brewer
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0836 , A61B5/029 , A61M16/0045 , A61M2016/0036 , A61M2230/432 , G06F19/00
摘要： A differential Fick technique including a first phase in which baseline breathing parameters may be established and a second phase in which a change in the effective ventilation of a patient is induced. The durations of the first and second phases may be substantially the same and may be abbreviated relative to the durations of comparable phases of previously known differential Fick techniques. The disclosed differential Fick technique also lacks a recovery period in which the respiratory parameters of a patient are permitted to return to “normal” levels.
摘要翻译：一种差分Fick技术，包括其中可以建立基线呼吸参数的第一阶段和诱导患者有效通气变化的第二阶段。第一和第二阶段的持续时间可以基本上相同并且可以相对于先前已知的差分Fick技术的相似阶段的持续时间来缩写。所公开的差分Fick技术还缺乏允许患者的呼吸参数恢复到“正常”水平的恢复期。

9. 发明申请

US20060129055A1 Systems and methods for accurately, substantially noninvasivelydetermining pulmonary capillary blood flow or cardiac output 有权
标题翻译：用于准确，基本上非侵入性确定肺毛细血管血流量或心输出量的系统和方法
公开(公告)号：US20060129055A1
公开(公告)日：2006-06-15
申请号：US11347611
申请日：2006-02-03
申请人： Joseph Orr , Kai Kuck
发明人： Joseph Orr , Kai Kuck
IPC分类号： A61B5/08 , G01N33/497 , G01N1/22
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for noninvasively determining a pulmonary capillary blood flow or a cardiac output of a subject include determining data of the amount of gas exchanged between blood and gas in lungs of the subject, as well as data of an indicator of the content of the gas in blood of the subject. Such a determination may be made during two or more different states of ventilation. A geometric relationship is identified between data points, with any data points outlying the geometric relationship being disregarded. The remaining data points may be used to estimate or calculate a measure of pulmonary capillary blood flow or cardiac output. Systems that include elements that are configured to effect such methods are also disclosed.
摘要翻译：用于非侵入性地确定受试者的肺毛细血管血流量或心输出量的方法包括确定受试者肺中血液和气体之间交换的气体量的数据，以及血液中气体含量指标的数据的主题。这种确定可以在两个或更多个不同的通气状态下进行。在数据点之间识别出几何关系，并且忽略几何关系的任何数据点。剩余的数据点可用于估计或计算肺毛细血管血流量或心输出量的量度。还公开了包括被配置为实现这些方法的元素的系统。

10. 发明授权

US6042550A Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output 有权
$Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output$
标题翻译：非侵入性评估肺内分流分数和测量心输出量的方法
公开(公告)号：US6042550A
公开(公告)日：2000-03-28
申请号：US150450
申请日：1998-09-09
申请人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kuck , Michael B. Jaffe
发明人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kuck , Michael B. Jaffe
IPC分类号： A61B5/00 , A61B5/029 , A61B5/083 , A61B5/02
CPC分类号： A61B5/14551 , A61B5/0836 , A61B5/029 , A61B5/083
摘要： A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow and carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.
摘要翻译：一种非侵入性估计患者肺内分流的方法。该方法包括非侵入性地测量呼吸流量，呼吸二氧化碳含量和动脉血氧含量。采用呼吸过程来促进对患者肺毛细血管血流的估计。校正动脉血氧含量的任何不准确性，以提供基本上精确的动脉血氧含量测量。使用呼吸流量和二氧化碳含量和动脉血氧含量测量以及肺毛细血管血流估计来估计患者的肺内分流。本发明还包括确定考虑到估计的肺内分流的患者的总心输出量的方法。

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