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    • 1. 发明申请
    • FLEXIBLE, MULTI-CHANNEL MICROELECTRODE FOR RECORDING LABORATORY ANIMAL EEG AND METHOD FOR RECORDING LABORATORY ANIMAL EEG USING THE SAME
    • 用于记录实验动物脑的灵活的多通道微电解器和使用该实验室的实验动物脑的记录方法
    • US20110224528A1
    • 2011-09-15
    • US13123217
    • 2008-12-24
    • Ji Hyun ChoiHee Sup ShinKlaus Peter Koch
    • Ji Hyun ChoiHee Sup ShinKlaus Peter Koch
    • A61B5/0478
    • A61B5/0478A61B5/4094A61B2503/40A61B2562/0209A61B2562/046
    • Disclosed are a novel, elastic, biocompatible, micro-sized, polyimide-based multi-channel microelectrode for recording of electroencephalography (EEG) from a laboratory animal including mouse, and a method for recording of laboratory animal EEG using the microelectrode. The microelectrode may include 2 grounding electrodes and 32 recording electrodes. A connector for signal transmission easily connects the microelectrode to a signal acquiring apparatus. The total weight of the microelectrode, including the connector, does not exceed 150 mg. Laboratory animal EEG, including that of mouse, provides the advantage of monitoring the brain state of a freely moving animal following a genetic or pharmaceutical manipulation. The microelectrode can be implanted without surgery and may be detached from wires while EEG is not recorded from the laboratory animal. The microelectrode can successfully acquire broadband EEG signals from the skull of the laboratory animal and is effective in monitoring spatial and temporal pattern of brain activities of the laboratory animal.
    • 公开了一种用于从包括小鼠的实验室动物记录脑电图(EEG)的新型,弹性的,生物相容的,微尺寸的基于聚酰亚胺的多通道微电极,以及使用微电极记录实验动物脑电图的方法。 微电极可以包括2个接地电极和32个记录电极。 用于信号传输的连接器容易地将微电极连接到信号获取装置。 包括连接器的微电极的总重量不超过150mg。 包括小鼠在内的实验动物脑电图提供了在遗传或药物操作后监测自由移动的动物的脑状态的优点。 微电极可以手术植入,并且可能从电线上脱离,而EEG未从实验室动物记录。 微电极可以从实验室动物的头骨中成功获得宽带脑电信号,有效监测实验动物大脑活动的时空格局。
    • 3. 发明授权
    • Method and apparatus for non-contact measurement of object surfaces
    • 用于非接触式测量物体表面的方法和装置
    • US5251156A
    • 1993-10-05
    • US728557
    • 1991-07-11
    • Helmut HeierKlaus-Peter KochKarl-Hermann Breyer
    • Helmut HeierKlaus-Peter KochKarl-Hermann Breyer
    • G01B11/00G01B11/24
    • G01B11/005
    • Pictures of an object to be measured are taken from several different positions or aspects by a video camera which is mounted via a two-axis articulating head to the measurement arm of a coordinate-measuring machine. The pictures taken from the different positions or aspects are stored and are evaluated with respect to the coordinates of characteristic points of interest on the surface of the object by the method of space intersection, known from photogrammetry. And, in this connection, the position-measurement values supplied by the scales of the coordinate-measuring machine and the angle-measurement values supplied by the articulating head are used for a calculated determination of the coordinates for each of the points of interest on the surface of the object.
    • 要被测量的物体的照片是通过摄像机从几个不同的位置或方面拍摄的,摄像机通过两轴铰接头安装在坐标测量机的测量臂上。 通过摄影测量学已知的从不同位置拍摄的图像被存储并且通过空间交叉的方法相对于对象表面上的感兴趣特征点的坐标进行评估。 并且,在这方面,由坐标测量机的刻度提供的位置测量值和由铰接头提供的角度测量值用于计算每个感兴趣点的坐标的确定 物体的表面。
    • 4. 发明授权
    • Flexible, multi-channel microelectrode for recording laboratory animal EEG and method for recording laboratory animal EEG using the same
    • 用于记录实验室动物脑电的灵活的多通道微电极和使用该实验室动物脑电图记录实验动物脑电图的方法
    • US08798707B2
    • 2014-08-05
    • US13123217
    • 2008-12-24
    • Ji Hyun ChoiHee Sup ShinKlaus Peter Koch
    • Ji Hyun ChoiHee Sup ShinKlaus Peter Koch
    • A61B5/0478
    • A61B5/0478A61B5/4094A61B2503/40A61B2562/0209A61B2562/046
    • Disclosed are a novel, elastic, biocompatible, micro-sized, polyimide-based multi-channel microelectrode for recording of electroencephalography (EEG) from a laboratory animal including mouse, and a method for recording of laboratory animal EEG using the microelectrode. The microelectrode may include 2 grounding electrodes and 32 recording electrodes. A connector for signal transmission easily connects the microelectrode to a signal acquiring apparatus. The total weight of the microelectrode, including the connector, does not exceed 150 mg. Laboratory animal EEG, including that of mouse, provides the advantage of monitoring the brain state of a freely moving animal following a genetic or pharmaceutical manipulation. The microelectrode can be implanted without surgery and may be detached from wires while EEG is not recorded from the laboratory animal. The microelectrode can successfully acquire broadband EEG signals from the skull of the laboratory animal and is effective in monitoring spatial and temporal pattern of brain activities of the laboratory animal.
    • 公开了一种用于从包括小鼠的实验室动物记录脑电图(EEG)的新型,弹性的,生物相容的,微尺寸的基于聚酰亚胺的多通道微电极,以及使用微电极记录实验动物脑电图的方法。 微电极可以包括2个接地电极和32个记录电极。 用于信号传输的连接器容易地将微电极连接到信号获取装置。 包括连接器的微电极的总重量不超过150mg。 包括小鼠在内的实验动物脑电图提供了在遗传或药物操作后监测自由移动的动物的脑状态的优点。 微电极可以手术植入,并且可能从电线上脱离,而EEG未从实验室动物记录。 微电极可以从实验室动物的头骨中成功获得宽带脑电信号,有效监测实验动物大脑活动的时空格局。
    • 5. 发明授权
    • Coordinate-measuring machine for non-contact measurement of objects
    • 坐标测量机用于非接触式测量物体
    • US5285397A
    • 1994-02-08
    • US616627
    • 1990-11-21
    • Helmut HeierKlaus-Peter KochKarl-Hermann Breyer
    • Helmut HeierKlaus-Peter KochKarl-Hermann Breyer
    • G01B11/00G01B11/02G01B11/03
    • G01B11/002G01B11/024Y10S367/907
    • A plurality of video cameras (7a-d) are mounted on a table which is adapted support a workpiece or other object to be measured, and the mounting of each camera to the table provides for controlled universal orientation of each camera via an articulating head having provision for selective rotation about each of two orthogonally related axes. The table is provided with vibration damping, whereby both the measured object, and the cameras which provide triangulation data for each measurement, can operate from the same rigid base, isolated from external sources of mechanical shock. The video signals of the cameras are fed, along with instantaneous optical-axis orientation data for each camera, to the computer of a coordinate-measuring machine. The computer relies upon stored calibration data and angular-position data sensed about each of the rotary axes of the articulating heads to derive the orientation data; and the computer additionally relies on video-image analysis to calculate the coordinates of each measured point on the object.
    • 多个摄像机(7a-d)安装在适于支撑待测量的工件或其他物体的工作台上,并且将每个摄像机安装到桌子上,通过铰接头提供每个摄像机的受控通用定向, 提供用于围绕两个正交相关轴中的每一个进行选择性旋转。 该台具有减震功能,由此可以测量物体和为每次测量提供三角测量数据的摄像机,可以从与机械冲击外部隔离的同一刚性基座上操作。 摄像机的视频信号与每个摄像机的瞬时光轴取向数据一起馈送到坐标测量机的计算机。 计算机依赖于存储的校准数据和关于铰接头的每个旋转轴的感测角位置数据以导出取向数据; 并且计算机另外依靠视频图像分析来计算对象上每个测量点的坐标。
    • 6. 发明授权
    • Coordinate measuring apparatus having an optical sensing head
    • 具有光学感测头的坐标测量装置
    • US4963728A
    • 1990-10-16
    • US417551
    • 1989-10-05
    • Albrecht HofWilhelm UlrichLothar RublKlaus-Peter Koch
    • Albrecht HofWilhelm UlrichLothar RublKlaus-Peter Koch
    • G01B11/00G01B11/03
    • G01B11/007
    • The invention is directed to a coordinate measuring apparatus having an optical sensing head. The optical sensing head is held on the measuring arm of the coordinate measuring apparatus. The optical sensing head includes a holder and a plurality of detachable front optic units which can be exchanged as required. Each of the front optic units has its own objective and its own illuminating optic arrangement adapted to the objective. The illuminating optic is supplied via light conductors with the light conductors being guided over a change interface where the front optic unit is attached to the holder of the sensing head in a reproducible manner. The light conducting ends for the illumination are coupled in the change interface by means of a coupling device which achieves this coupling with low losses. This device includes, for example, self-centering sleeves which enable flexible supply light conductors to be centrally seated on the end faces of half-rigid plastic light conductors. Interface losses are avoided in this manner.
    • 本发明涉及一种具有光学感测头的坐标测量装置。 光学传感头保持在坐标测量装置的测量臂上。 光学传感头包括一个保持器和多个可拆卸的前光学单元,可根据需要进行更换。 每个前光学单元具有其自己的目标,并且其自身的照明光学装置适合于该目的。 照明光学器件通过光导体提供,其中光导体被导引在改变接口上,其中前光学单元以可再现的方式附接到感测头的保持器。 用于照明的导光端通过耦合装置耦合在改变界面中,该耦合装置以低损耗实现该耦合。 该装置包括例如自对中套筒,其使得柔性供应光导体能够集中位于半刚性塑料光导体的端面上。 以这种方式避免接口损耗。
    • 8. 发明授权
    • Illuminating arrangement for illuminating an object with incident light
    • 用入射光照射物体的照明装置
    • US5038258A
    • 1991-08-06
    • US484890
    • 1990-02-26
    • Klaus-Peter KochReinhard Prinz
    • Klaus-Peter KochReinhard Prinz
    • G02B21/06G01B11/00G01J3/10G02B17/00G02B21/08G02B25/02
    • G02B25/02G01B11/00G01J3/10G02B21/082
    • The invention relates to an illuminating arrangement for illuminating an object with incident light wherein the angle of the incident light is selectable. The illuminating arrangement includes a plurality of individual light sources which can be switched on and off. The light sources are advantageously arranged in several concentric circles in different planes from which the light can be radiated along different beam axes. An illumination at different selectable angles is possible without a mechanical adjustment of the light sources or the imaging elements. The light sources can be advantageously mounted in a hemispherically-shaped carrier. The illuminating arrangement can be a component of a closed control loop and be controlled quickly and completely automatically via an image processing unit or by manual instructions of desired values via a control console.
    • 本发明涉及用入射光照射物体的照明装置,其中入射光的角度是可选择的。 照明装置包括可以打开和关闭的多个单独的光源。 光源有利地布置在不同平面中的几个同心圆中,光可以沿着不同的平面轴轴辐射。 不需要对光源或成像元件进行机械调整就可以在不同的可选角度进行照明。 光源可以有利地安装在半球形的载体中。 照明装置可以是闭合控制环路的一个组成部分,并且经由图像处理单元或通过控制台通过手动指令来达到期望值的快速和完全自动控制。