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1. 发明申请

US20180021426A1 Combination Purified Inactivated Vaccine for Flaviviruses 审中-公开
公开(公告)号：US20180021426A1
公开(公告)日：2018-01-25
申请号：US15550433
申请日：2016-03-10
申请人： Stephen J. THOMAS , Kenneth H. ECKELS , Joseph R. PUTNAK , The United States of America, as represented by the Secretary, on behalf of the Walter Reed Army
发明人： Stephen J. Thomas , Kenneth H. Eckels , Joseph R. Putnak
IPC分类号： A61K39/12 , A61K39/395
CPC分类号： A61K39/12 , A61K39/395 , A61K2039/5252 , A61K2039/545 , A61K2039/70 , C12N7/00 , C12N2770/24034 , C12N2770/24051 , C12N2770/24134 , C12N2770/24151 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392 , Y02A50/394
摘要： Disclosed herein are immunogenic compositions comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses and methods of making and using thereof.

2. 发明授权

US06309650B1 Attenuated Japanese encephalitis virus adapted to Vero cell and a Japanese encephalitis vaccine 有权
标题翻译：减毒的日本脑炎病毒适应于Vero细胞和日本脑炎疫苗
公开(公告)号：US06309650B1
公开(公告)日：2001-10-30
申请号：US09486392
申请日：2000-06-15
申请人： Hyun Su Kim , Wang Don Yoo , Soo Ok Kim , Sung Hee Lee , Sang Bum Moon , Sun Pyo Hong , Yong Cheol Shin , Yong Ju Chung , Kenneth H. Eckels , Bruce Innis , Joseph R. Puniak , Leonard N. Binn , Ashok K. Srivastava , Doria R. Dubois
发明人： Hyun Su Kim , Wang Don Yoo , Soo Ok Kim , Sung Hee Lee , Sang Bum Moon , Sun Pyo Hong , Yong Cheol Shin , Yong Ju Chung , Kenneth H. Eckels , Bruce Innis , Joseph R. Puniak , Leonard N. Binn , Ashok K. Srivastava , Doria R. Dubois
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/55505 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , Y02A50/39
摘要： An attenuated Japanese encephalitis virus adapted to Vero cell by passages on Vero cell is disclosed. A Japanese encephalitis vaccine comprising said attenuated virus is also disclosed.
摘要翻译：公开了一种通过Vero细胞通过适应Vero细胞的减毒日本脑炎病毒。还公开了包含所述减毒病毒的日本脑炎疫苗。

3. 发明授权

US06184024B2 Chimeric and/or growth-restricted flaviviruses 失效
标题翻译：嵌合和/或生长受限的黄病毒
公开(公告)号：US06184024B2
公开(公告)日：2001-02-06
申请号：US08250802
申请日：1994-05-27
申请人： Ching-Juh Lai , Michael Bray , Alexander G. Pletnev , Ruhe Men , Yi-Ming Zhang , Kenneth H. Eckels , Robert M. Chanock
发明人： Ching-Juh Lai , Michael Bray , Alexander G. Pletnev , Ruhe Men , Yi-Ming Zhang , Kenneth H. Eckels , Robert M. Chanock
IPC分类号： C12N704
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要： The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus. The invention also includes a baculovirus having a recombinant dengue cDNA sequence which encodes: (1) dengue virus capsid protein, pre-matrix protein, envelope glycoprotein and NS1 and NS2a nonstructural proteins or (2) dengue envelope glycoprotein or (3) dengue non-structural proteins NS1 and NS2a. The invention further includes a baculovirus having a recombinant Japanese B encephalitis virus cDNA sequence which encodes the Japanese B encephalitis virus capsid protein, pre-matrix protein, envelope glycoprotein and non-structural proteins NS1 and NS2a. The invention further includes a vaccine and a method to produce that vaccine.
摘要翻译：本发明包括用于疫苗制剂的嵌合病毒，其具有包含编码来自一种黄病毒的至少一种结构蛋白的核酸序列的基因组和来自另一种黄病毒的编码非结构蛋白的核酸序列。基因组优选包括在病毒基因组内的减少病毒毒力的突变，并且在特别优选的实施方案中，这些疫苗针对黄病毒例如登革热病毒，蜱传脑炎病毒和日本脑炎病毒。本发明还包括具有重组登革热cDNA序列的杆状病毒，其编码：（1）登革热病毒衣壳蛋白，前基质蛋白，包膜糖蛋白和NS1和NS2a非结构蛋白或（2）登革热包膜糖蛋白或（3）结构蛋白NS1和NS2a。本发明还包括具有编码日本B型脑炎病毒衣壳蛋白，前基质蛋白，包膜糖蛋白和非结构蛋白NS1和NS2a的重组日本B脑炎病毒cDNA序列的杆状病毒。本发明还包括疫苗和生产该疫苗的方法。

4. 发明申请

US20200179506A1 ZIKA VIRUS VACCINE AND METHODS OF PRODUCTION 审中-公开
公开(公告)号：US20200179506A1
公开(公告)日：2020-06-11
申请号：US16304793
申请日：2017-05-30
申请人： Stephen J. THOMAS , Timothy ENDY , Kenneth H. ECKELS , J. Robert PUTNAK , Richard JARMAN , Rafael DE LA BARRERA
发明人： Stephen J. THOMAS , Timothy ENDY , Kenneth H. ECKELS , J. Robert PUTNAK , Richard JARMAN , Rafael DE LA BARRERA
IPC分类号： A61K39/12 , C12N7/00
摘要： The invention generally relates to a purified inactivated Zika virus (ZIKV), methods for producing the purified inactivated ZIKV, immunogenic compositions and vaccines comprising the purified inactivated ZIKV and methods for the prevention and/or treatment of infection by ZIKV.

5. 发明授权

US06511667B1 Attenuated dengue-2 virus vaccine 有权
标题翻译：登革2病毒疫苗减毒
公开(公告)号：US06511667B1
公开(公告)日：2003-01-28
申请号：US09534725
申请日：2000-03-24
申请人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , David Vaughn , Erik A. Henchai , Niranian Kanesa-thasan
发明人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , David Vaughn , Erik A. Henchai , Niranian Kanesa-thasan
IPC分类号： A61K39193
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/70 , C12N2770/24134 , C12N2770/24161 , Y02A50/386
摘要： The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.
摘要翻译：本发明提供了减毒登革热-2病毒的疫苗组合物。更具体地说，减毒病毒是通过PDK细胞中连续传代产生的。本发明还提供刺激个体的免疫系统以通过施用减毒登革热-2诱导针对登革热-2病毒的保护的方法。

6. 发明授权

US07217418B2 Multivalent dengue virus vaccine 失效
标题翻译：多价登革热病毒疫苗
公开(公告)号：US07217418B2
公开(公告)日：2007-05-15
申请号：US10626315
申请日：2003-07-24
申请人： Kenneth H. Eckels , Joseph B. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , Wellington Sun , Niranjan Kanesa-Thasan
发明人： Kenneth H. Eckels , Joseph B. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , Wellington Sun , Niranjan Kanesa-Thasan
IPC分类号： A61K39/295
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/70 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
摘要翻译：本发明提供了减毒登革热病毒的疫苗组合物。更具体地说，减毒病毒是通过在PDK细胞中连续传代产生的。本发明还提供了通过施用减毒登革热-1，登革热2，登革热-3和登革热-4病毒刺激个体的免疫系统以诱导针对所有四种登革热病毒血清型的保护的方法。

7. 发明授权

US06676936B1 Chimeric and/or growth-restricted flaviviruses 有权
标题翻译：嵌合和/或生长受限的黄病毒
公开(公告)号：US06676936B1
公开(公告)日：2004-01-13
申请号：US09643217
申请日：2000-08-18
申请人： Ching-Juh Lai , Michael Bray , Alexander G. Pletnev , Ruhe Men , Yi-Ming Zhang , Kenneth H. Eckels , Robert M. Chanock
发明人： Ching-Juh Lai , Michael Bray , Alexander G. Pletnev , Ruhe Men , Yi-Ming Zhang , Kenneth H. Eckels , Robert M. Chanock
IPC分类号： A01N6300
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/14143 , C12N2770/24122 , C12N2770/24162 , Y02A50/386 , Y02A50/39 , Y02A50/396
摘要： The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus. The invention also includes a baculovirus having a recombinant dengue cDNA sequence which encodes: (1) dengue virus capsid protein, pre-matrix protein, envelope glycoprotein and NS1 and NS2a nonstructural proteins or (2) dengue envelope glycoprotein or (3) dengue non-structural proteins NS1 and NS2a. The invention further includes a baculovirus having a recombinant Japanese B encephalitis virus cDNA sequence which encodes the Japanese B encephalitis virus capsid protein, pre-matrix protein, envelope glycoprotein and non-structural proteins NS1 and NS2a. The invention further includes a vaccine and a method to produce that vaccine.
摘要翻译：本发明包括用于疫苗制剂的嵌合病毒，其具有包含编码来自一种黄病毒的至少一种结构蛋白的核酸序列的基因组和来自另一种黄病毒的编码非结构蛋白的核酸序列。基因组优选包括在病毒基因组内的减少病毒毒力的突变，并且在特别优选的实施方案中，这些疫苗针对黄病毒例如登革热病毒，蜱传脑炎病毒和日本脑炎病毒。本发明还包括具有重组登革热cDNA序列的杆状病毒，其编码：（1）登革热病毒衣壳蛋白，前基质蛋白，包膜糖蛋白和NS1和NS2a非结构蛋白或（2）登革热包膜糖蛋白或（3）结构蛋白NS1和NS2a。本发明还包括具有编码日本B型脑炎病毒衣壳蛋白，前基质蛋白，包膜糖蛋白和非结构蛋白NS1和NS2a的重组日本B脑炎病毒cDNA序列的杆状病毒。本发明还包括疫苗和生产该疫苗的方法。

8. 发明授权

US06638514B1 Multivalent dengue virus vaccine 有权
标题翻译：多价登革热病毒疫苗
公开(公告)号：US06638514B1
公开(公告)日：2003-10-28
申请号：US09535117
申请日：2000-03-24
申请人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , Sun Wellington , Niranjan Kanessa-thasan
发明人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , Sun Wellington , Niranjan Kanessa-thasan
IPC分类号： A61K39193
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/70 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
摘要翻译：本发明提供了减毒登革热病毒的疫苗组合物。更具体地说，减毒病毒是通过PDK细胞中连续传代产生的。本发明还提供了通过施用减毒登革热-1，登革热2，登革热-3和登革热-4病毒刺激个体的免疫系统以诱导针对所有四种登革热病毒血清型的保护的方法。

9. 发明授权

US06613556B1 Adaptation of virus to vertebrate cells 有权
标题翻译：病毒适应脊椎动物细胞
公开(公告)号：US06613556B1
公开(公告)日：2003-09-02
申请号：US09534724
申请日：2000-03-24
申请人： Kenneth H. Eckels , Joseph R. Putnak , Bruce L. Innis
发明人： Kenneth H. Eckels , Joseph R. Putnak , Bruce L. Innis
IPC分类号： C12N700
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.
摘要翻译：本发明提供了通过用高滴度病毒株感染哺乳动物细胞以获得感染细胞，特别是血清型1,2,3和4的减毒登革热病毒株，在培养的哺乳动物细胞中复制病毒至高效价的方法。所产生的复制病毒适用于本发明也提供的疫苗和疫苗接种方法。

10. 发明授权

US06537557B1 Attenuated dengue-4 virus vaccine 有权
标题翻译：登革4病毒疫苗减毒
公开(公告)号：US06537557B1
公开(公告)日：2003-03-25
申请号：US09534726
申请日：2000-03-24
申请人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , David Vaughn
发明人： Kenneth H. Eckels , Joseph R. Putnak , Doria R. Dubois , Bruce L. Innis , Charles H. Hoke , David Vaughn
IPC分类号： A61K39193
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The present invention provides vaccine compositions of attenuated dengue-4 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-4 virus by administration of attenuated dengue-4 virus.
摘要翻译：本发明提供了减毒登革热-4病毒的疫苗组合物。更具体地说，减毒病毒是通过PDK细胞中连续传代产生的。本发明还提供刺激个体的免疫系统以通过施用减毒登革热-4病毒诱导针对登革热-4病毒的保护的方法。

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