专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

US20240252619A1 Coronavirus Constructs and Vaccines 审中-公开
公开(公告)号：US20240252619A1
公开(公告)日：2024-08-01
申请号：US18560515
申请日：2022-05-20
申请人： The Regents of the University of California
发明人： Vaithilingaraja Arumugaswami , Gustavo Garcia Jr. , Kouki Morizono
IPC分类号： A61K39/215 , A61K39/00 , A61P31/14 , C12N7/00
CPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/5254 , C12N2770/20034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2830/50 , C12N2830/52
摘要： Disclosed herein are nucleic acid constructs comprising a replication defective Zika virus vector and one or more coronavirus sequences and compositions thereof. The constructs relates to compositions and methods for inducing an immune response against coronavirus antigens due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak. The results herein indicate that these coronavirus constructs are safe and will induce an immune response that may provide protection against coronaviruses.

2. 发明授权

US10058602B2 Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus 有权
公开(公告)号：US10058602B2
公开(公告)日：2018-08-28
申请号：US14305572
申请日：2014-06-16
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The United States of America, as Represented by The Secretary of The Army
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney
IPC分类号： A61K45/06 , C12N7/00 , A61K39/12 , C07K14/005 , C12N15/86 , C12Q1/6888 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , C12Q1/6888 , Y02A50/386 , Y02A50/394
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

3. 发明申请

US20170360916A9 METHOD FOR THE PRODUCTION OF RECOMBINANT VIRUS, DNA CONSTRUCTS, RECOMBINANT VIRUS AND VACCINE COMPOSITIONS 审中-公开
公开(公告)号：US20170360916A9
公开(公告)日：2017-12-21
申请号：US15378294
申请日：2016-12-14
申请人： Myrna Cristina Bonaldo , Ricardo Galler
发明人： Myrna Cristina Bonaldo , Ricardo Galler
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/5256 , A61K2039/575 , C07K14/005 , C07K2319/02 , C07K2319/03 , C07K2319/40 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24171 , Y02A50/386 , Y02A50/388
摘要： The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way they when cloned and expressed in the vector virus, the present in the 5′ region nucleotides present in the 5′ edge of the gene NS1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the steam and anchor of the protein E of this vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein E level and of constructural NS1 vector virus; (c) obtention of the non pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigene in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the Flavivirus and/or other patogens.

4. 发明授权

US09539317B2 Method for the production of recombinant virus, DNA constructs, recombinant virus and vaccine compositions 有权
标题翻译：生产重组病毒，DNA构建体，重组病毒和疫苗组合物的方法
公开(公告)号：US09539317B2
公开(公告)日：2017-01-10
申请号：US14304387
申请日：2014-06-13
申请人： Myrna Cristina Bonaldo , Ricardo Galler
发明人： Myrna Cristina Bonaldo , Ricardo Galler
IPC分类号： A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/5256 , A61K2039/575 , C07K14/005 , C07K2319/02 , C07K2319/03 , C07K2319/40 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24171 , Y02A50/386 , Y02A50/388
摘要： The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way that when cloned and expressed in the vector virus, they present in the 5′ region nucleotides present in the 5′ edge of the gene NS1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the stem and anchor of the protein E of this vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein E level and of nonstructural NS1 vector virus; (c) obtaining the non-pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigen in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the Flavivirus and/or other pathogens.
摘要翻译：本发明的目的是通过以下方法通过克隆和表达编码全部或部分异源蛋白质的核苷酸的序列来生产重组病毒：（a）修饰异源核苷酸序列，使得当在载体病毒中克隆并表达，它们存在于存在于该载体病毒或其他病毒或等效功能序列的NS1基因的5'边缘的5'区核苷酸中，并且在其3'区域中，相应的基因组区域在该载体病毒的蛋白质E的茎和锚的全部或部分球体或相当的功能序列中，不包括提及载体病毒的结构和复制; （b）在（a）中在修饰的异源序列插入结构蛋白E水平的基因间区域和非结构性NS1载体病毒; （c）根据（b）中描述的插入获得非致病性重组病毒和免疫学性质的所有者，其具有整合在病毒基因组中的杂种序列，并且像以下那样表达异源抗原，使得它可以诱导适当的免疫应答。本发明还涉及免疫黄病毒和/或其他病原体的疫苗组合物。

5. 发明授权

US08753648B2 Modified poxviruses, including modified smallpox virus vaccine based on recombinant drug-sensitive vaccinia virus, and new selection methods 有权
标题翻译：改良痘病毒，包括基于重组药物敏感性痘苗病毒的改良天花病毒疫苗，以及新的选择方法
公开(公告)号：US08753648B2
公开(公告)日：2014-06-17
申请号：US11304578
申请日：2005-12-16
申请人： Falko-Guenter Falkner , Georg Holzer , Sogue Coulibaly , Josef Mayrhofer
发明人： Falko-Guenter Falkner , Georg Holzer , Sogue Coulibaly , Josef Mayrhofer
IPC分类号： A61K48/00 , A61K39/42 , A61K39/12 , A61K39/275 , C12N7/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/275 , A61K2039/525 , A61K2039/5256 , C07K2319/00 , C12N9/1211 , C12N2710/24143 , C12N2770/24143
摘要： The present invention provides recombinant poxviruses, such as vaccinia virus, that contain an integrated exogenous sequence, such as a foreign gene, encoding a prodrug converting polypeptide that can convert a prodrug to a drug that prevents virus replication or is otherwise toxic to the virus. The recombinant poxviruses can be suitable for use as vaccines. The invention also provides, among other things, methods of inhibiting virus replication, methods of vaccination and methods of treating vaccinated subjects showing signs or otherwise at risk for of vaccination-induced disease.
摘要翻译：本发明提供了重组痘病毒，例如痘苗病毒，其含有整合的外源序列，例如外源基因，其编码可以将前药转化成药物的前体药物转化多肽，所述药物可以防止病毒复制或对病毒有毒性。重组痘病毒可适用于疫苗。本发明还提供了抑制病毒复制的方法，接种方法和治疗接种疫苗的受试者的方法，这些受试者显示出接种疫苗引起的疾病的风险。

6. 发明申请

US20130295134A1 RECOMBINANT BICISTRONIC FLAVIVIRUS VECTORS 有权
标题翻译：重组双歧杆菌FLAVIVIRUS矢量
公开(公告)号：US20130295134A1
公开(公告)日：2013-11-07
申请号：US13942064
申请日：2013-07-15
申请人： Sanofi Pasteur Biologics, LLC
发明人： Simon DELAGRAVE , Nathan Brown , Harold Kleanthous , Farshad Guirakhoo , Alexander A. Rumyantsev
IPC分类号： C12N15/86 , A61K39/00 , A61K39/145
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/16134 , C12N2770/24143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要： This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
摘要翻译：本发明涉及双顺反子黄病毒载体，在预防和治疗疾病中使用这些载体的方法，以及制备此类载体的方法。

7. 发明授权

US08048427B2 Subgenomic replicons of the flavivirus dengue 有权
标题翻译：黄病毒登革热的亚基因组复制子
公开(公告)号：US08048427B2
公开(公告)日：2011-11-01
申请号：US12394822
申请日：2009-02-27
申请人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
IPC分类号： A61K39/12 , C12N7/01 , C12N15/86
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要： The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译：本发明公开了在基因组结构域（C-preM-E）中含有大缺失的登革热病毒亚基因组复制子的构建，该复制子可用作防止登革热病毒感染的疫苗。

8. 发明申请

US20110014229A1 Chimeric flavivirus vectors 审中-公开
标题翻译：嵌合黄病毒载体
公开(公告)号：US20110014229A1
公开(公告)日：2011-01-20
申请号：US12460110
申请日：2009-07-14
申请人： Harold Kleanthous , Charles Miller , Larisa Oros
发明人： Harold Kleanthous , Charles Miller , Larisa Oros
IPC分类号： A61K39/145 , C12Q1/70 , C12N15/63 , A61K39/29 , C07H21/00 , A61P31/16 , A61P31/14
CPC分类号： C12N15/86 , C12N2770/24143
摘要： The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
摘要翻译：本发明提供嵌合黄病毒载体，包括插入到载体的包膜蛋白中的外源肽和使用这些载体的方法。

9. 发明申请

US20100255028A1 Flavivirus Vaccine Vector Against Influenza Virus 失效
标题翻译：针对流感病毒的黄病毒疫苗载体
公开(公告)号：US20100255028A1
公开(公告)日：2010-10-07
申请号：US12525168
申请日：2008-01-31
申请人： Simon Delagrave , Farshad Guirakhoo , Caroline Maier , Alexander A. Rumyantsev
发明人： Simon Delagrave , Farshad Guirakhoo , Caroline Maier , Alexander A. Rumyantsev
IPC分类号： A61K39/12 , C07H21/02 , A61P31/16 , A61P31/14 , C12N7/01
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2770/24143 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要： This invention relates to chimeric flavivirus vectors that can be used, for example, in the prevention and treatment of influenza virus infection, compositions including such viral vectors, and methods employing the vectors.
摘要翻译：本发明涉及可用于例如预防和治疗流感病毒感染的嵌合黄病毒载体，包括这种病毒载体的组合物以及使用载体的方法。

10. 发明授权

US07494813B2 VAC-BAC shuttle vector system 有权
标题翻译： VAC-BAC穿梭载体系统
公开(公告)号：US07494813B2
公开(公告)日：2009-02-24
申请号：US10959392
申请日：2004-10-05
申请人： Bernard Moss , Arban Domi
发明人： Bernard Moss , Arban Domi
IPC分类号： C12N15/10 , C12N15/63 , C12N15/64 , C12N15/70 , C12N15/863 , C12N1/21 , A61K48/00
CPC分类号： C12N15/86 , C12N15/70 , C12N2710/14143 , C12N2710/24043 , C12N2710/24143 , C12N2770/24143 , C12N2800/204
摘要： The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
摘要翻译：本发明涉及一种用于从克隆在细菌人造染色体中的DNA产生重组痘病毒的VAC-BAC穿梭载体系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式