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1. 发明授权

US06309650B1 Attenuated Japanese encephalitis virus adapted to Vero cell and a Japanese encephalitis vaccine 有权
标题翻译：减毒的日本脑炎病毒适应于Vero细胞和日本脑炎疫苗
公开(公告)号：US06309650B1
公开(公告)日：2001-10-30
申请号：US09486392
申请日：2000-06-15
申请人： Hyun Su Kim , Wang Don Yoo , Soo Ok Kim , Sung Hee Lee , Sang Bum Moon , Sun Pyo Hong , Yong Cheol Shin , Yong Ju Chung , Kenneth H. Eckels , Bruce Innis , Joseph R. Puniak , Leonard N. Binn , Ashok K. Srivastava , Doria R. Dubois
发明人： Hyun Su Kim , Wang Don Yoo , Soo Ok Kim , Sung Hee Lee , Sang Bum Moon , Sun Pyo Hong , Yong Cheol Shin , Yong Ju Chung , Kenneth H. Eckels , Bruce Innis , Joseph R. Puniak , Leonard N. Binn , Ashok K. Srivastava , Doria R. Dubois
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/55505 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , Y02A50/39
摘要： An attenuated Japanese encephalitis virus adapted to Vero cell by passages on Vero cell is disclosed. A Japanese encephalitis vaccine comprising said attenuated virus is also disclosed.
摘要翻译：公开了一种通过Vero细胞通过适应Vero细胞的减毒日本脑炎病毒。还公开了包含所述减毒病毒的日本脑炎疫苗。

2. 发明授权

US07371859B2 PNA monomer and precursor 有权
标题翻译： PNA单体和前体
公开(公告)号：US07371859B2
公开(公告)日：2008-05-13
申请号：US11182935
申请日：2005-07-15
申请人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
发明人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
IPC分类号： C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D239/54 , C07D241/18
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

3. 发明授权

US07211668B2 PNA monomer and precursor 有权
标题翻译： PNA单体和前体
公开(公告)号：US07211668B2
公开(公告)日：2007-05-01
申请号：US10819769
申请日：2004-04-06
申请人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Sung Hee Lee
发明人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Sung Hee Lee
IPC分类号： C07D473/34 , C07D473/30 , C07D473/18 , C07D239/47 , C07D239/54
CPC分类号： C07D271/113 , C07D263/46 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C—R′; R1, R′ is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A1, A2, A3, A4, A5, is independently selected from H, halogen such as F, Cl, Br or I, CF3, alkyl, preferably C1–C4 alkyl, nitro, nitrile, alkoxy, preferably C1–C4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C1–C4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C1–C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为硫或氧; J为氮或C-R'; R1，R'独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基或具有以下通式之一的官能团：其中A 1， A 3，A 4，A 5 H独立地选自H，卤素如F，Cl，Br或 I，CF 3，烷基，优选C 1 -C 4烷基，硝基，腈，烷氧基，优选C 1〜卤代（如F，Cl，Br和I）烷基，优选卤代C 1 -C 4烷基，C 1 -C 4烷基，，卤代（如F，Cl，Br和I）烷氧基，优选卤代C 1 -C 4烷氧基，苯基和卤代（如F，Cl，Br 和I苯基; R2是H或天然或非天然α-氨基酸的保护或未保护的侧链; B是天然或非天然核碱基，其中当所述核碱基具有外来氨基功能时，所述功能受保护基团不稳定酸，但稳定在硫醇存在下为弱至中等碱。

4. 发明授权

US08553902B2 Multi-channel broadcasting system using digital matrix amplifier and method of controlling the same 有权
标题翻译：使用数字矩阵放大器的多通道广播系统及其控制方法
公开(公告)号：US08553902B2
公开(公告)日：2013-10-08
申请号：US13499285
申请日：2011-11-16
申请人： Sung Hee Lee
发明人： Sung Hee Lee
IPC分类号： H04R27/00
CPC分类号： H04H20/61 , H04H60/04 , H04R3/12 , H04R27/00 , H04R29/007 , H04R29/008 , H04R2227/001 , H04R2227/005 , H04R2420/01 , H04R2420/03 , H04R2430/01
摘要： A multi-channel broadcasting system using a digital matrix amplifier performing the setting of respective equipment is provided to control the model equipment through a digital master controller. An 8-channel audio input unit 66 is electrically connected to a digital audio mixer. Sound source equipment connection terminals are electrically connected to the sound equipment. A data converter unit 46 converts each data and a contact point signal. An audio matrix IC 60 outputs an input sound source signal to an arbitrary channel. A pair of audio output terminals transmits the output signal of the audio matrix IC.
摘要翻译：提供了使用执行相应设备的设置的数字矩阵放大器的多声道广播系统，以通过数字主控制器来控制模型设备。 8声道音频输入单元66电连接到数字音频混合器。声源设备连接端子与声音设备电连接。数据转换器单元46转换每个数据和接触点信号。音频矩阵IC 60将输入声源信号输出到任意通道。一对音频输出端子发送音频矩阵IC的输出信号。

5. 发明授权

US08282990B2 Method for preparing a biodegradable polymer microsphere containing a glucose-regulating peptide 失效
标题翻译：制备含有葡萄糖调节肽的可生物降解聚合物微球的方法
公开(公告)号：US08282990B2
公开(公告)日：2012-10-09
申请号：US12595434
申请日：2008-04-18
申请人： Hyun Hee Kwak , Ghun II Lee , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
发明人： Hyun Hee Kwak , Ghun II Lee , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
IPC分类号： A61K38/17 , A61K9/14 , B05D7/00 , B01J13/00
CPC分类号： A61K9/1647 , A61K38/26 , Y02A50/465
摘要： Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose -regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero -order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.
摘要翻译：公开了能够以受控方式释放葡萄糖调节肽的生物可降解微球，其包含其中包封有葡萄糖调节肽的生物可降解聚合物载体及其制备方法。除了确保包封药物的高封装效率和高稳定性之外，微球体既不显示初始爆发效应也不显示不完全释放，并允许药物在一段较长时间内零次释放，从而改善药物的治疗效果。

6. 发明授权

US08085745B2 Method for improving energy efficiency in wireless mesh network 有权
标题翻译：提高无线网状网络能效的方法
公开(公告)号：US08085745B2
公开(公告)日：2011-12-27
申请号：US12535199
申请日：2009-08-04
申请人： Sang Joon Park , Young Bag Moon , Young Bae Ko , Sung Hee Lee , Seung Mok Yoo
发明人： Sang Joon Park , Young Bag Moon , Young Bae Ko , Sung Hee Lee , Seung Mok Yoo
IPC分类号： H04W4/00
CPC分类号： H04W40/24 , H04L43/0852 , H04W40/10 , H04W40/244 , H04W84/18 , Y02D70/142 , Y02D70/22 , Y02D70/326
摘要： A method for effectively using power resource in a wireless mesh network is disclosed to select and change a level of a power saving mode according to terminal and network situations to increase the duration of the network's existence as well as improve the power consumption of each mesh terminal. After active mesh terminals that are to perform a data relay function and super-saving mesh terminals that are not to perform the data relay function are selected in consideration of a network topology at certain periods, the level of a power saving mode of the mesh terminals selected as the super-saving mesh terminals is higher than that of the mesh terminals selected as the active mesh terminals. And then, a routing path in a tree form is formed along the mesh terminals selected as the active mesh terminals to transmit data.
摘要翻译：公开了一种在无线网状网络中有效利用电力资源的方法，根据终端和网络情况选择和改变节电模式的水平，以增加网络存在的持续时间，并提高每个网状终端的功耗。在特定时段考虑到网络拓扑结构，选择要执行数据中继功能的活动网状终端和不执行数据中继功能的超级节点网状终端，网状终端节电模式的级别作为超级节省网状终端选择的网络终端比选择为活动网状终端的网状终端高。然后，沿着选择为活动网状终端的网状终端形成树形路由路由，以发送数据。

7. 发明申请

US20100129459A1 BIODEGRADABLE MICROSPHERE COMPOSITION SUITABLE FOR THE CONTROLLED RELEASE OF GLUCOSE CONTROLLING PEPTIDE AND FORMULATION THEREOF 失效
标题翻译：生物可降解微生物组合物，适用于控制葡萄糖控制肽及其制剂的释放
公开(公告)号：US20100129459A1
公开(公告)日：2010-05-27
申请号：US12595434
申请日：2008-04-18
申请人： Hyun Hee Kwak , Ghun Lee, II , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
发明人： Hyun Hee Kwak , Ghun Lee, II , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
IPC分类号： A61K38/17 , A61P3/10 , A61P3/04 , A61K9/14
CPC分类号： A61K9/1647 , A61K38/26 , Y02A50/465
摘要： Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose-regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero-order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.
摘要翻译：公开了能够以受控方式释放葡萄糖调节肽的生物可降解微球，其包含其中包含葡萄糖调节肽的生物可降解聚合物载体及其制备方法。除了确保包封药物的高封装效率和高稳定性之外，微球体既不显示初始爆发效应也不显示不完全释放，并允许药物在较长时间内零次释放，从而改善药物的治疗效果。

8. 发明授权

US07125994B2 PNA monomer and precursor 有权
公开(公告)号：US07125994B2
公开(公告)日：2006-10-24
申请号：US11182672
申请日：2005-07-15
申请人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
发明人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
IPC分类号： C07D473/34 , C07D473/18 , C07D247/02 , C07D417/12 , C07D413/12
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

9. 发明申请

US20060223144A1 Method for mass production of human pollicle stimulating hormone 审中-公开
标题翻译：大量生产人类激素激素的方法
公开(公告)号：US20060223144A1
公开(公告)日：2006-10-05
申请号：US10595200
申请日：2004-09-24
申请人： Se Hwan Yang , Young Chul Sung , Kyu-Heum Na , Sung Hee Lee , Won Bae Kim
发明人： Se Hwan Yang , Young Chul Sung , Kyu-Heum Na , Sung Hee Lee , Won Bae Kim
IPC分类号： C12P21/06 , C07H21/04 , C12N15/09 , C12N5/06 , C07K14/59
CPC分类号： A61K38/44 , A61K38/00 , A61K48/00 , C07K14/59 , C12N15/85 , C12N2840/203 , C12Y105/01003
摘要： The present invention relates to a method for mass-production of human follicle stimulating hormone, more precisely, to an expression vector containing human follicle stimulating hormone gene, a transformant transfected with the expression vector and a method for mass-production of human follicle stimulating hormone by using the same. Human follicle stimulating hormone can be produced largely by using an expression vector and a transformant of the present invention. Therefore the expression vector and the transformant of the present invention can be effectively used for the treatment of infertility.
摘要翻译：本发明涉及一种批量生产人卵泡刺激素的方法，更确切地说，涉及含有人促卵泡激素基因的表达载体，用表达载体转染的转化体和大量生产人卵泡刺激素的方法通过使用相同。可以通过使用本发明的表达载体和转化体大量产生人类促卵泡激素。因此，本发明的表达载体和转化体可以有效地用于治疗不育症。

10. 发明授权

US08681620B2 Method for notifying about/avoiding congestion situation of data transmission in wireless mesh network, and mesh node for the same 失效
标题翻译：无线网状网络数据传输通知/避免拥塞情况的方法，网状节点相同
公开(公告)号：US08681620B2
公开(公告)日：2014-03-25
申请号：US13213613
申请日：2011-08-19
申请人： Sang Joon Park , Yoo Seung Song , Young Bae Ko , Sung Hee Lee , Keun Woo Lim
发明人： Sang Joon Park , Yoo Seung Song , Young Bae Ko , Sung Hee Lee , Keun Woo Lim
IPC分类号： H04L12/26 , H04J1/16 , H04J3/14
CPC分类号： H04W40/22 , G06F19/00 , H04L45/125 , H04L45/26
摘要： Provided is a multi-route routing scheme that supports Quality of Service (QoS) in the wireless mesh network. A method of notifying about and avoiding congestion situation in data transmission in a wireless mesh network and a mesh node may also be provided. Data may be differentially transmitted to multiple routes by obtaining a route congestion level existing in a current multi-hop route and thus, data providing a real-time service, such as a video streaming service, may avoid congested routes and may be promptly transmitted. Multiple queues in a mesh node may be divided into divided queues based on a congestion situation of a transmission route in a network and the divided queues may be transmitted through multiple routes and thus, an efficiency of the overall network may increase.
摘要翻译：提供了一种支持无线网状网络中的服务质量（QoS）的多路由路由方案。还可以提供通知和避免无线网状网络和网状节点中的数据传输中的拥塞情况的方法。可以通过获得当前多跳路由中存在的路由拥塞级别将数据差分地传送到多个路由，并且因此，提供诸如视频流服务的实时服务的数据可以避免拥塞路由并且可以被迅速地发送。网状节点中的多个队列可以基于网络中的传输路由的拥塞情况被划分成划分的队列，并且可以通过多个路由发送划分的队列，从而整体网络的效率可能增加。

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