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    • 8. 发明授权
    • Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces
    • 用于离子迁移的中性粒子的离子化oTOFMS鉴定从表面解吸的分子和元素
    • US08384023B2
    • 2013-02-26
    • US12692604
    • 2010-01-23
    • J. Albert SchultzThomas F. EganKelley L. WatersErnest K. Lewis
    • J. Albert SchultzThomas F. EganKelley L. WatersErnest K. Lewis
    • H01J49/00
    • H01J49/40G01N27/622H01J49/0027H01J49/0045H01J49/107
    • The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
    • 本发明涉及一种用于离子化中性MALDI解吸羽流的方法和装置,特别是当电离后技术与中压MALDI-IM-OTOFMS仪器结合时,用于有效测量电离的MALDI解吸羽流。 此外,本公开提供了一种方法和装置,其通过IM-oTOFMS根据其化学族同时分离组织样品MALDI离子。 分离后,将MALDI离子直接与通过用第二激光离子化共解吸的中性分子产生的离子进行比较,其中第二激光器延迟几百微秒。 本公开进一步提供了增强离子分析的新方法,包括使用巨富勒烯内标来提高质量精度,以及紫外(UV)去聚簇激光以产生完整的肽和蛋白质,其中之一可以是VUV柱 产生可识别的结构碎片。
    • 10. 发明申请
    • POST-IONIZATION OF NEUTRALS FOR ION MOBILITY OTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES
    • 离子移动物质中和离子的离子化鉴定从表面脱落的分子和元素
    • US20100200742A1
    • 2010-08-12
    • US12692604
    • 2010-01-23
    • J. Albert SchultzThomas F. EganKelley L. WatersErnest K. Lewis
    • J. Albert SchultzThomas F. EganKelley L. WatersErnest K. Lewis
    • H01J49/40H01J49/04G12B13/00
    • H01J49/40G01N27/622H01J49/0027H01J49/0045H01J49/107
    • The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
    • 本发明涉及一种用于离子化中性MALDI解吸羽流的方法和装置,特别是当电离后技术与中压MALDI-IM-OTOFMS仪器结合时,用于有效测量电离的MALDI解吸羽流。 此外,本公开提供了一种方法和装置,其通过IM-oTOFMS根据其化学族同时分离组织样品MALDI离子。 分离后,将MALDI离子直接与通过用第二激光离子化共解吸的中性分子产生的离子进行比较,其中第二激光器延迟几百微秒。 本公开进一步提供了增强离子分析的新方法,包括使用巨富勒烯内标来提高质量精度,以及紫外(UV)去聚簇激光以产生完整的肽和蛋白质,其中之一可以是VUV柱 产生可识别的结构碎片。