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1. 发明授权

US08518994B2 Arginine derivative and cosmetic containing the same 有权
标题翻译：精氨酸衍生物和含有其的化妆品
公开(公告)号：US08518994B2
公开(公告)日：2013-08-27
申请号：US13140468
申请日：2009-12-25
申请人： Kazuaki Wakita , Susumu Tanaka , Kei-ichi Maruyama
发明人： Kazuaki Wakita , Susumu Tanaka , Kei-ichi Maruyama
IPC分类号： A61K8/44 , C07C279/14 , C07C277/08 , A61Q19/00
CPC分类号： C07C279/14 , A61K8/44 , A61Q19/00 , C07C277/08
摘要： An object of the invention is to provide a novel arginine derivative and a cosmetic satisfactory in compatibility with the skin and hair, excellent in skin softening effect and skin-conditioning effect, and satisfactory in use feeling with little sticky feeling and tense feeling.Such present invention relates to an arginine derivative represented by the following general formula (1): wherein R1 and R2 are a hydrogen atom or a linear or branched monohydroxyalkyl group having 2 to 3 carbon atoms and at least one of R1 and R2 represents a linear or branched monohydroxyalkyl group having 2 to 3 carbon atoms; and R3 represents a hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and a cosmetic containing the same mixed therein.
摘要翻译：本发明的目的是提供一种新颖的精氨酸衍生物和与皮肤和头发的相容性令人满意的化妆品，具有优异的皮肤柔软效果和皮肤调理效果，并且使用感好，粘着感和紧张感少。本发明涉及由以下通式（1）表示的精氨酸衍生物：其中R 1和R 2是氢原子或具有2至3个碳原子的直链或支链单羟基烷基，并且R 1和R 2中的至少一个表示直链或具有2〜3个碳原子的支链单羟基烷基; 并且R 3表示氢原子，碱金属原子，铵或有机铵，以及含有它们的化妆品。

2. 发明申请

US20100190864A1 Alkylene Oxide Derivative And Skin External Preparation Containing The Same 有权
标题翻译：含氧化烯衍生物和皮肤外用制剂
公开(公告)号：US20100190864A1
公开(公告)日：2010-07-29
申请号：US12670181
申请日：2008-07-25
申请人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
发明人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
IPC分类号： A61K8/86 , C07C43/15 , A61Q5/12 , A61Q1/00 , A61Q1/14 , A61Q19/10 , A61Q5/02
CPC分类号： A61Q1/02 , A61K8/86 , A61Q19/00 , C08G65/2609 , C08G65/2615 , C08G65/337 , C08L71/02
摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z-{O-[(AO)a-(EO)b]-R}2 (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
摘要翻译：本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I）式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

3. 发明申请

US20070280897A1 Cosmetic Bases And Cosmetics Containing The Same 有权
标题翻译：化妆品基地和化妆品含有它
公开(公告)号：US20070280897A1
公开(公告)日：2007-12-06
申请号：US11664512
申请日：2005-10-06
申请人： Kei-ichi Maruyama , Yoji Tezuka
发明人： Kei-ichi Maruyama , Yoji Tezuka
IPC分类号： A61K8/39 , A61K8/30
CPC分类号： C07C43/11 , A61K8/86 , A61K8/90 , A61Q19/00 , A61Q19/007
摘要： A basic agent for use in cosmetics comprising an alkylene oxide derivative represented by the following formula (I) is provided: Z-{O(AO)l(EO)m-(BO)nH}a (I) (where Z represents a residue of a compound having 3 to 9 hydroxyl groups with the hydroxyl groups removed, a is from 3 to 9, AO represents an oxyalkylene group of 3 to 4 carbon atoms, EO represents oxyethylene group, l and m represent average additional mol numbers of the oxyalkylene groups of 3 to 4 carbon atoms and the oxyethylene groups, respectively, and 1≦l=50, 1≦m≦50, the weight ratio (AO/EO) of AO to EO is from 1/5 to 5/1, AO and EO may be added in a random form or may be added in a lock form. BO represents oxyalkylene group with a number of carbon atoms of 4, and n is an average additional mol number and 0.5≦n≦5).
摘要翻译：提供了包含下式（I）表示的氧化烯衍生物的化妆品中使用的碱性试剂：<？在线式说明=“在线式”末端=“铅”→Z- {O（（I）（I） line-formula description =“In-line Formulas”end =“tail”？>（其中Z表示除去羟基的具有3〜9个羟基的化合物的残基，a为3〜9，AO为氧化烯 3〜4个碳原子的基团，EO表示氧化乙烯基，l和m分别表示3〜4个碳原子的氧化烯基和氧化乙烯基的平均附加摩尔数，1≤i= 50,1 AO = EO，EO与EO的重量比（AO / EO）为1/5至5/1，AO和EO可以以随机形式加入，也可以以锁形式加入，BO表示氧化烯基，多个碳原子数为4，n为平均附加摩尔数，0.5 <= n <5）。

4. 发明授权

US06455639B1 Oxirane derivative and process for the preparation thereof 有权
标题翻译：环氧乙烷衍生物及其制备方法
公开(公告)号：US06455639B1
公开(公告)日：2002-09-24
申请号：US09367642
申请日：1999-08-19
申请人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
发明人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
IPC分类号： C08G6528
CPC分类号： C08G65/2609 , C08G65/30 , G01N30/90
摘要： An oxirane derivative and process for preparation of the same, having a high purity characterized in terms of gel permeation chromatography and thin layer chromatography. The oxirane derivative is useful as a starting material for medical purposes, and mainly drug delivery systems.
摘要翻译：一种环氧乙烷衍生物及其制备方法，具有以凝胶渗透色谱和薄层色谱为特征的高纯度。环氧乙烷衍生物可用作医疗用途的原料，主要用于药物输送系统。

5. 发明授权

US5767284A Process for producing a polyoxyalkylene derivative substituted with succinimidyl group 失效
标题翻译：用琥珀酰亚胺基取代的聚氧化烯衍生物的制造方法
公开(公告)号：US5767284A
公开(公告)日：1998-06-16
申请号：US868261
申请日：1997-06-03
申请人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
发明人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
IPC分类号： C08G65/32 , A61K47/48 , C07D207/46 , C08G65/30 , C08G65/329 , C08G65/332 , C08G65/333 , C07D207/12
CPC分类号： A61K47/48215 , C08G65/30 , C08G65/329 , C08G65/33337
摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; filtering an obtained reaction product; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding isopropyl alcohol to a filtrate obtained by the filtration, an amount by weight of isopropyl alcohol being 1 to 100 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends. Materials can be handled with safety in the process of the present invention, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.
摘要翻译：一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 过滤得到的反应产物; 并将通过过滤得到的滤液中加入异丙醇使用琥珀酰亚胺基取代的聚氧化烯衍生物结晶，异丙醇的重量比在末端具有羧基的聚氧化烯化合物的重量的1〜100倍。可以在本发明的方法中安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

6. 发明申请

US20110245344A1 ARGININE DERIVATIVE AND COSMETIC CONTAINING THE SAME 有权
标题翻译：含有衍生物和化妆品的ARGININE衍生物和化妆品
公开(公告)号：US20110245344A1
公开(公告)日：2011-10-06
申请号：US13140468
申请日：2009-12-25
申请人： Kazuaki Wakita , Susumu Tanaka , Kei-ichi Maruyama
发明人： Kazuaki Wakita , Susumu Tanaka , Kei-ichi Maruyama
IPC分类号： A61K8/44 , C07C279/14 , C07C277/08 , A61Q19/00
CPC分类号： C07C279/14 , A61K8/44 , A61Q19/00 , C07C277/08
摘要： An object of the invention is to provide a novel arginine derivative and a cosmetic satisfactory in compatibility with the skin and hair, excellent in skin softening effect and skin-conditioning effect, and satisfactory in use feeling with little sticky feeling and tense feeling.Such present invention relates to an arginine derivative represented by the following general formula (1): wherein R1 and R2 are a hydrogen atom or a linear or branched monohydroxyalkyl group having 2 to 3 carbon atoms and at least one of R1 and R2 represents a linear or branched monohydroxyalkyl group having 2 to 3 carbon atoms; and R3 represents a hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and a cosmetic containing the same mixed therein.
摘要翻译：本发明的目的是提供一种新颖的精氨酸衍生物和与皮肤和头发的相容性令人满意的化妆品，具有优异的皮肤柔软效果和皮肤调理效果，并且使用感好，粘着感和紧张感少。本发明涉及由以下通式（1）表示的精氨酸衍生物：其中R 1和R 2是氢原子或具有2至3个碳原子的直链或支链单羟基烷基，并且R 1和R 2中的至少一个表示直链或具有2〜3个碳原子的支链单羟基烷基; 并且R 3表示氢原子，碱金属原子，铵或有机铵，以及含有它们的化妆品。

7. 发明申请

US20100075882A1 External Skin Preparation And Skin Cleanser 审中-公开
标题翻译：外用皮肤准备和皮肤清洁剂
公开(公告)号：US20100075882A1
公开(公告)日：2010-03-25
申请号：US12443050
申请日：2007-09-28
申请人： Takashi Ohmori , Akira Ishikubo , Takashi Teshigawara , Yuki Sugiyama , Eiichiro Yagi , Kei-ichi Maruyama , Sue Taguchi , Yogi Tezuka
发明人： Takashi Ohmori , Akira Ishikubo , Takashi Teshigawara , Yuki Sugiyama , Eiichiro Yagi , Kei-ichi Maruyama , Sue Taguchi , Yogi Tezuka
IPC分类号： A61K8/86 , C08L71/02 , A61Q19/10
CPC分类号： A61Q19/00 , A61K8/90 , A61Q1/14 , A61Q19/10
摘要： The present invention was made in view of the above-described circumstances, and an object of the invention is to provide an external skin preparation having a rough skin improving effect, excellent in texture in use, especially excellent in smoothness, free of sticky feeling, and excellent in stability. Another object is to provide a skin cleanser excellent especially in usability and a cosmetic removing effect. That is, the external skin preparation of the present invention is characterized by comprising a block-type alkylene oxide derivative represented by the below-described formula (I). [formula 1] Y—[O(EO)a-(AO)b-(EO)c-R]k (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 6 carbon atoms, and they are attached in a block-type, respectively. The products, a×k, b×k, and c×k, are the average addition mole numbers of the oxyethylene group, the oxyalkylene group having 3 to 6 carbon atoms, and the oxyethylene group, respectively, and 0≦a×k≦100, 1≦b×k≦100, and 0≦c×k≦100, however, (a+c)×k>1. The percentage of all oxyethylene groups in formula (I) with respect to the sum of all oxyethylene groups and oxyalkylene groups having 3 to 6 carbon atoms in formula (I) is 10 to 80 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups with 1 to 4 carbon atoms.) The skin cleanser of present invention is characterized by comprising 0.01 to 70 mass % of a block-type alkylene oxide derivative represented by the above-described formula (I) and 0.1 to 20 mass % of a moisturizer.
摘要翻译：本发明是鉴于上述情况而完成的，其目的在于提供一种具有粗糙的皮肤改善效果，使用性质优异，平滑性优异，无粘性的外用皮肤剂，稳定性好。另一个目的是提供一种特别优异的可用性和美容消除效果的皮肤清洁剂。也就是说，本发明的外用皮肤制剂的特征在于包含由下述式（I）表示的嵌段型烯化氧衍生物。 [式1] Y- [O（EO）a-（AO）b-（EO）cR] k（I）（式中，Y是通过从具有3至6个羟基的多元醇除去羟基而得到的残基基团，k为多元醇的羟基数，EO为氧化乙烯基，AO为碳原子数为3〜6的氧化烯基，分别以嵌段型连接，产物a× k，b×k，c×k分别为氧化乙烯基，碳原子数3〜6的氧化烯基和氧化乙烯基的平均加成摩尔数，0＆lt; nlE; a×k＆nlE; 100,1＆nlE; 式（I）中所有氧化乙烯基相对于所有氧化乙烯基和氧化烯基的总和的百分比（b + k＆nlE; 100,0和nlE; c×k＆nlE; 100，（a + c）×k> 式（I）中的碳原子数为3〜6个碳原子数为10〜80质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基。）本发明的皮肤清洁剂其特征在于，含有0.01〜70质量％的由上述式（I）表示的嵌段型烯化氧衍生物和0.1〜20质量％的保湿剂。

8. 发明授权

US5872191A Process for producing a polyoxyalkylene derivatives substituted with succinimidyl group 失效
标题翻译：用琥珀酰亚胺基取代的聚氧化烯衍生物的制造方法
公开(公告)号：US5872191A
公开(公告)日：1999-02-16
申请号：US867985
申请日：1997-06-03
申请人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
发明人： Kouzoh Sanchika , Tohru Yasukohchi , Kei-ichi Maruyama , Syunsuke Ohhashi
IPC分类号： C07D207/46 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/333 , C08L71/02
CPC分类号： C08G65/329 , C08G65/33337
摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; dissolving an obtained reaction product into chloroform, an amount by weight of chloroform being 0.5 to 10 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding an aliphatic hydrocarbon having 5 to 8 carbon atoms to a resultant solution, an amount by weight of the aliphatic hydrocarbon being 2 to 10 times as much as an amount by weight of chloroform. Materials can be handled with safety, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.
摘要翻译：一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 将得到的反应产物溶解在氯仿中，氯仿的重量为末端具有羧基的聚氧化烯化合物的重量的0.5〜10倍; 并通过向所得溶液中加入碳原子数为5〜8的脂肪族烃而使被琥珀酰亚胺基取代的聚氧化烯衍生物结晶化，所述脂肪族烃的重量比为氯仿的2〜10倍。可以安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

9. 发明授权

US5840973A Process for producing a polyoxyalkylenecarboxylic acid 失效
标题翻译：聚氧亚烷基羧酸的制造方法
公开(公告)号：US5840973A
公开(公告)日：1998-11-24
申请号：US917824
申请日：1997-08-27
申请人： Tohru Yasukohchi , Kei-ichi Maruyama , Tsunekatsu Maruyama
发明人： Tohru Yasukohchi , Kei-ichi Maruyama , Tsunekatsu Maruyama
IPC分类号： C07C51/367 , C07C59/125
CPC分类号： C07C51/367
摘要： A process for producing a polyoxyalkylenecarboxylic acid which comprises: (A) a step of obtaining a salt of a polyoxyalkylenecarboxylic acid by reacting a polyoxyalkylene compound having hydroxyl group at one or both ends of the molecule with a salt of a halogenated acetic acid or a salt of a halogenated propionic acid in an amount of 4 to 50 mol per 1 mol of the polyoxyalkylene compound and an alkali metal hydroxide in an amount of 8 to 70 mol per 1 mol of the polyoxyalkylene compound in the presence of an organic solvent at 80.degree. to 150.degree. C.; (B) a step of converting the obtained salt of a polyoxyalkylenecarboxylic acid into the polyoxyalkylenecarboxylic acid by adjusting pH of the reaction mixture obtained in step (A) to 3 or less by adding an inorganic acid; (C) a step of removing byproducts and the like by washing the obtained solution containing the polyoxyalkylenecarboxylic acid with an aqueous solution of an inorganic salt; and (D) a step of removing the organic solvent and water at a decreased pressure at 50.degree. to 120.degree. C. and removing precipitated salts by filtration. A high purity, high molecular weight polyoxyalkylenecarboxylic acid which contains only small amounts of unreacted starting materials or byproducts can easily be obtained.
摘要翻译：一种制备聚氧亚烷基羧酸的方法，其包括：（A）通过使分子的一端或两端具有羟基的聚氧化烯化合物与卤代乙酸或盐的盐反应获得聚氧亚烷基羧酸的盐的步骤的相对于1摩尔聚氧化烯化合物为4〜50摩尔的卤代丙酸和相对于1摩尔聚氧化烯化合物为8〜70摩尔的碱金属氢氧化物，在80℃的有机溶剂存在下，至150℃。（B）通过添加无机酸，将得到的工序（A）中得到的反应混合物的pH调节至3以下，从而将得到的聚氧亚烷基羧酸的盐转化为聚氧亚烷基羧酸的工序; （C）通过用无机盐的水溶液洗涤所得到的含有聚氧亚烷基羧酸的溶液来除去副产物等的工序; 和（D）在50〜120℃的减压下除去有机溶剂和水的步骤，并通过过滤除去沉淀的盐。可以容易地获得仅含少量未反应的原料或副产物的高纯度，高分子量的聚氧亚烷基羧酸。

10. 发明授权

US08232321B2 Alkylene oxide derivative and skin external preparation containing the same 有权
标题翻译：环氧丙烷衍生物和皮肤外用制剂含有
公开(公告)号：US08232321B2
公开(公告)日：2012-07-31
申请号：US12670181
申请日：2008-07-25
申请人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
发明人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
IPC分类号： C08G65/28 , A61K31/77 , A61K8/86 , A61Q1/02 , A61Q19/00 , A61P17/16
CPC分类号： A61Q1/02 , A61K8/86 , A61Q19/00 , C08G65/2609 , C08G65/2615 , C08G65/337 , C08L71/02
摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z—{O-[(AO)a-(EO)b]-R}2 (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
摘要翻译：本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I）式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

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