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    • 1. 发明申请
    • External Skin Preparation And Skin Cleanser
    • 外用皮肤准备和皮肤清洁剂
    • US20100075882A1
    • 2010-03-25
    • US12443050
    • 2007-09-28
    • Takashi OhmoriAkira IshikuboTakashi TeshigawaraYuki SugiyamaEiichiro YagiKei-ichi MaruyamaSue TaguchiYogi Tezuka
    • Takashi OhmoriAkira IshikuboTakashi TeshigawaraYuki SugiyamaEiichiro YagiKei-ichi MaruyamaSue TaguchiYogi Tezuka
    • A61K8/86C08L71/02A61Q19/10
    • A61Q19/00A61K8/90A61Q1/14A61Q19/10
    • The present invention was made in view of the above-described circumstances, and an object of the invention is to provide an external skin preparation having a rough skin improving effect, excellent in texture in use, especially excellent in smoothness, free of sticky feeling, and excellent in stability. Another object is to provide a skin cleanser excellent especially in usability and a cosmetic removing effect. That is, the external skin preparation of the present invention is characterized by comprising a block-type alkylene oxide derivative represented by the below-described formula (I). [formula 1] Y—[O(EO)a-(AO)b-(EO)c-R]k  (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 6 carbon atoms, and they are attached in a block-type, respectively. The products, a×k, b×k, and c×k, are the average addition mole numbers of the oxyethylene group, the oxyalkylene group having 3 to 6 carbon atoms, and the oxyethylene group, respectively, and 0≦a×k≦100, 1≦b×k≦100, and 0≦c×k≦100, however, (a+c)×k>1. The percentage of all oxyethylene groups in formula (I) with respect to the sum of all oxyethylene groups and oxyalkylene groups having 3 to 6 carbon atoms in formula (I) is 10 to 80 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups with 1 to 4 carbon atoms.) The skin cleanser of present invention is characterized by comprising 0.01 to 70 mass % of a block-type alkylene oxide derivative represented by the above-described formula (I) and 0.1 to 20 mass % of a moisturizer.
    • 本发明是鉴于上述情况而完成的,其目的在于提供一种具有粗糙的皮肤改善效果,使用性质优异,平滑性优异,无粘性的外用皮肤剂, 稳定性好。 另一个目的是提供一种特别优异的可用性和美容消除效果的皮肤清洁剂。 也就是说,本发明的外用皮肤制剂的特征在于包含由下述式(I)表示的嵌段型烯化氧衍生物。 [式1] Y- [O(EO)a-(AO)b-(EO)cR] k(I)(式中,Y是通过从具有3至6个羟基的多元醇除去羟基而得到的残基 基团,k为多元醇的羟基数,EO为氧化乙烯基,AO为碳原子数为3〜6的氧化烯基,分别以嵌段型连接,产物a× k,b×k,c×k分别为氧化乙烯基,碳原子数3〜6的氧化烯基和氧化乙烯基的平均加成摩尔数,0< nlE; a×k≦̸ 100,1≦̸ 式(I)中所有氧化乙烯基相对于所有氧化乙烯基和氧化烯基的总和的百分比(b + k≦̸ 100,0和nlE; c×k≦̸ 100,(a + c)×k> 式(I)中的碳原子数为3〜6个碳原子数为10〜80质量%,Rs可以相同也可以不同,为碳原子数1〜4的烃基。)本发明的皮肤清洁剂 其特征在于,含有0.01〜70质量%的由上述式(I)表示的嵌段型烯化氧衍生物和0.1〜20质量%的保湿剂。