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1. 发明申请

US20130192462A1 ELECTROSTATIC AEROSOL CONCENTRATOR 有权
标题翻译：静电空气浓缩器
公开(公告)号：US20130192462A1
公开(公告)日：2013-08-01
申请号：US13566297
申请日：2012-08-03
申请人： Kapil Pant , Shivshankar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshankar Sundaram , Yi Wang
IPC分类号： B03C3/68
CPC分类号： B03C3/68 , B03C3/025 , B03C3/06 , B03C3/41 , B03C3/49
摘要： Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.
摘要翻译：公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。集中器包括气流室，其包括交替地供电和接地的电极元件，其一起工作以向带电的气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。

2. 发明申请

US20100227312A1 Particle Adhesion Assay for Microfluidic Bifurcations 有权
标题翻译：微流控分岔的粒子粘附测定
公开(公告)号：US20100227312A1
公开(公告)日：2010-09-09
申请号：US12399606
申请日：2009-03-06
申请人： Kapil Pant , Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Angela Irene Rea-Ramsey
发明人： Kapil Pant , Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Angela Irene Rea-Ramsey
IPC分类号： C12Q1/70 , C12Q1/02 , G01N33/545
CPC分类号： B01L3/5027 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/086
摘要： A method for characterizing particle adhesion in microfluidic bifurcations and junctions comprises at least one idealized bifurcation or junction. Multiple bifurcations and/or junctions can be combined on a single microfluidic chip to create microfluidic networks configured for assays specifically to characterize particle interactions at junctions or to screen particles for desired interactions with microfluidic bifurcations and/or junctions.
摘要翻译：用于表征微流体分支和结中颗粒粘附的方法包括至少一个理想化的分叉或连接。多个分叉和/或结点可以组合在单个微流体芯片上以产生微流控网络，其被配置用于特异性地用于表征在结处的颗粒相互作用或筛选颗粒以用于与微流体分叉和/或结点的期望相互作用的测定。

3. 发明申请

US20100099136A1 Microfluidic Assay for Selection and Optimization of Drug Delivery Vehicles to Tumors 有权
标题翻译：用于选择和优化向药物递送载体到肿瘤的微流控测定
公开(公告)号：US20100099136A1
公开(公告)日：2010-04-22
申请号：US12648296
申请日：2009-12-28
申请人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram
发明人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/5082 , G01N33/5008
摘要： An apparatus and method for assaying a tumor drug delivery vehicle comprises a synthetic microvascular network of interconnected flow channels in fluid communication through a porous wall with a tissue space containing animal cells and means for quantifying drug delivery from the microvascular network to the animal cells.
摘要翻译：用于测定肿瘤药物递送载体的装置和方法包括通过多孔壁与包含动物细胞的组织空间流体连通的互连流动通道的合成微血管网络，以及用于定量从微血管网络向动物细胞递送药物的装置。

4. 发明授权

US08828715B2 Particle adhesion assay for microfluidic bifurcations 有权
标题翻译：微流体分支的颗粒粘附测定
公开(公告)号：US08828715B2
公开(公告)日：2014-09-09
申请号：US12399606
申请日：2009-03-06
申请人： Kapil Pant , Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Angela I. Rea-Ramsey
发明人： Kapil Pant , Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Angela I. Rea-Ramsey
IPC分类号： C12M1/34 , C12M3/00 , B01L3/00
CPC分类号： B01L3/5027 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/086
摘要： A method for characterizing particle adhesion in microfluidic bifurcations and junctions comprises at least one idealized bifurcation or junction. Multiple bifurcations and/or junctions can be combined on a single microfluidic chip to create microfluidic networks configured for assays specifically to characterize particle interactions at junctions or to screen particles for desired interactions with microfluidic bifurcations and/or junctions.
摘要翻译：用于表征微流体分支和结中颗粒粘附的方法包括至少一个理想化的分叉或连接。多个分叉和/或结点可以组合在单个微流体芯片上以产生微流控网络，其被配置用于特异性地用于表征在结处的颗粒相互作用或筛选颗粒以用于与微流体分叉和/或结点的期望相互作用的测定。

5. 发明授权

US08778160B2 Method and apparatus for separating particles by dielectrophoresis 有权
标题翻译：通过介电电泳分离颗粒的方法和装置
公开(公告)号：US08778160B2
公开(公告)日：2014-07-15
申请号：US13190882
申请日：2011-07-26
申请人： Kapil Pant , Yi Wang , Ketan Bhatt , Balabhasker Prabhakarpandian
发明人： Kapil Pant , Yi Wang , Ketan Bhatt , Balabhasker Prabhakarpandian
IPC分类号： B03C5/02 , B03C5/00
CPC分类号： B03C5/02 , B01L2400/0424 , B03C5/005 , B03C5/022 , B03C5/026
摘要： Particle separation apparatus separate particles and particle populations using dielectrophoretic (DEP) forces generated by one or more pairs of electrically coupled electrodes separated by a gap. Particles suspended in a fluid are separated by DEP forces generated by the at least one electrode pair at the gap as they travel over a separation zone comprising the electrode pair. Selected particles are deflected relative to the flow of incoming particles by DEP forces that are affected by controlling applied potential, gap width, and the angle linear gaps with respect to fluid flow. The gap between an electrode pair may be a single, linear gap of constant gap, a single linear gap having variable width, or a be in the form of two or more linear gaps having constant or variable gap width having different angles with respect to one another and to the flow.
摘要翻译：颗粒分离装置使用由间隙分开的一对或多对电耦合电极产生的介电泳（DEP）力分离颗粒和颗粒群。悬浮在流体中的颗粒在由间隙中由至少一个电极对产生的DEP力分离，因为它们在包括电极对的分离区域上移动。所选择的颗粒相对于进入的颗粒的流动通过受到施加的电势，间隙宽度和相对于流体流动的角度线性间隙的影响的DEP力而偏转。电极对之间的间隙可以是恒定间隙的单个线性间隙，具有可变宽度的单个线性间隙，或者具有两个或更多个线性间隙的形式，具有相对于一个具有不同角度的不同角度的恒定或可变间隙宽度另一个和流。

6. 发明授权

US07998328B2 Method and apparatus for separating particles by dielectrophoresis 有权
标题翻译：通过介电电泳分离颗粒的方法和装置
公开(公告)号：US07998328B2
公开(公告)日：2011-08-16
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B03C5/026
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译：提供微尺度，介电泳分离颗粒的方法和装置。颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。间隙距离和施加电位可用于控制所产生的介电电泳力。使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。

7. 发明申请

US20110104658A1 Synthetic Microfluidic Blood-Brain Barrier 有权
标题翻译：合成微流体血脑屏障
公开(公告)号：US20110104658A1
公开(公告)日：2011-05-05
申请号：US12726140
申请日：2010-03-17
申请人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Bhatt
发明人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Bhatt
IPC分类号： C12Q1/70 , C12Q1/02 , C12M1/00 , C12M1/34
CPC分类号： G01N33/5082 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/56972
摘要： An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
摘要翻译：用于测定用于药物和药物递送载体筛选的血脑屏障性质的装置和方法，包括具有分隔内腔和组织空间的间隙的微流体装置，从而能够形成类似于使用内皮细胞和脑细胞的体内条件的紧密连接。

8. 发明申请

US20080119780A1 Thrombectomy Microcatheter 有权
标题翻译：血栓切除术
公开(公告)号：US20080119780A1
公开(公告)日：2008-05-22
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译：本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

9. 发明申请

US20070231783A1 Synthetic microfluidic microvasculature network 有权
标题翻译：合成微流体微血管网络
公开(公告)号：US20070231783A1
公开(公告)日：2007-10-04
申请号：US11393715
申请日：2006-03-31
申请人： Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Kapil Pant
发明人： Balabhaskar Prabhakarpandian , Shivshankar Sundaram , Kapil Pant
IPC分类号： C12Q1/00 , G06F19/00 , C12M3/00
CPC分类号： G01N33/54346
摘要： The present invention is a synthetic microfluidic microvasculature network and associated methods. The synthetic microfluidic microvasculature network mimics the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are also described. The invention has many uses including the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature such as inflammation, diabetes and hypertension.
摘要翻译：本发明是合成微流控微血管网络及其相关方法。合成微流体微血管网络模拟生理微血管网络的结构，流体流动特性和生理行为。还描述了用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法。本发明具有许多用途，包括优化药物递送和微血管治疗，并描述影响微血管的疾病机制，如炎症，糖尿病和高血压。

10. 发明授权

US08663374B2 Electrostatic aerosol concentrator 有权
标题翻译：静电雾化浓缩机
公开(公告)号：US08663374B2
公开(公告)日：2014-03-04
申请号：US13566297
申请日：2012-08-03
申请人： Kapil Pant , Shivshankar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshankar Sundaram , Yi Wang
IPC分类号： B03C3/06 , B03C3/49
CPC分类号： B03C3/68 , B03C3/025 , B03C3/06 , B03C3/41 , B03C3/49
摘要： An apparatus for concentrating aerosol particles can include: a sample air inlet; an enriched aerosol outlet; an aerosol lean outlet; a flow path connecting the air inlet and aerosol rich and aerosol lean outlets; and a plurality of alternately energized and grounded electrode pairs along the flow path. The aerosol rich outlet can be in fluid communication with an aerosol particle capture device. The apparatus can include a sheath air inlet providing a flow of aerosol free air over surfaces of the alternately energized and grounded electrode pairs. The apparatus can include an elongate focusing chamber having a cylindrical shape containing the alternately energized and grounded electrode pairs that are configured as circular rings. The apparatus can include one or more structures configured to impart tangential, spiral or helical flow to a stream entering through the sample air inlet.
摘要翻译：用于浓缩气溶胶颗粒的装置可以包括：样品空气入口; 浓缩气溶胶出口; 气雾瘦出口; 连接空气入口和富含气溶胶的气流通道的流路; 以及沿着流动路径的多个交替供电和接地的电极对。气溶胶富集出口可与气溶胶颗粒捕获装置流体连通。该设备可以包括护套空气入口，其在交替供电和接地的电极对的表面上提供无气溶胶的空气流。该装置可以包括具有圆柱形形状的细长聚焦腔，其包含被配置为圆形环的交替激励和接地的电极对。该装置可以包括一个或多个结构，其构造成向通过样品空气入口进入的流赋予切向，螺旋或螺旋流。

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