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1. 发明授权

US07537935B2 System for providing biological materials 有权
标题翻译：提供生物材料的系统
公开(公告)号：US07537935B2
公开(公告)日：2009-05-26
申请号：US10694136
申请日：2003-10-27
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
IPC分类号： B01D15/08 , G01N33/53 , G01N1/18
CPC分类号： B01L3/50853 , B01L3/5025 , B01L3/50255 , B01L3/50825 , G01N2035/00752 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids in the lysis vessels into a matrix unit. The liquids in the matrix vessels of the matrix unit are extracted through outlet openings during which the liquids flow through matrices and the matrix unit is placed on a collecting unit with collecting vessels which are arranged such that at least the outlet openings of the matrix vessels extend into the collecting vessels. The matrix vessels are with elution fluid and elution fluids from the matrix vessels are extracted through their outlet openings during which the elution fluids flow through the matrices and the elution fluids which are enriched with biological material are collected in the collecting vessels.
摘要翻译：提供了一种用于分离纯化的生物材料的方法和封闭装置。该方法包括将生物材料放置在分离的裂解容器中，向裂解容器中的生物材料中加入裂解液，并将裂解容器中的液体转移到基质单元中。基质单元的基质容器中的液体通过出口开口被抽出，在此期间液体流过基质，矩阵单元被放置在具有收集容器的收集单元上，收集容器布置成使得至少矩阵容器的出口开口延伸进入收集船。基质容器具有洗脱液，来自基质容器的洗脱液通过其出口开口提取，在洗涤流体中流过基质，富集有生物材料的洗脱液被收集在收集容器中。

2. 发明授权

US6017698A Method of binding a biological material 失效
标题翻译：结合生物材料的方法
公开(公告)号：US6017698A
公开(公告)日：2000-01-25
申请号：US617698
申请日：1996-04-01
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： G01N33/48 , B01L3/14 , B65D39/16 , B65D51/16 , G01N1/00 , G01N1/28 , G01N1/34 , C12Q1/68 , G01N21/00 , G01N33/543 , G01N33/548
CPC分类号： G01N1/405 , B01L3/5082 , B01L3/50825 , B65D39/16 , B65D51/1616 , Y10S435/969 , Y10S436/807
摘要： Subject matter of the invention is a method of binding a biological material to a solid phase by providing a sample liquid containing the biological material in a sample vessel (A) having an inner contour (A17); then a hollow body (C) which has a contour (C12) that matches the inner contour (A17) is introduced into the sample vessel (A) while being closed with respect to the sample vessel by means of a porous matrix (C11); the sample liquid can enter the structural form (C) through the porous matrix (C11). This method is easy to automate and reduces the generation of aerosols.
摘要翻译：本发明的主题是通过在具有内轮廓（A17）的样品容器（A）中提供含有生物材料的样品液体将生物材料与固相结合的方法; 然后将具有与内部轮廓（A17）相匹配的轮廓（C12）的中空体（C）通过多孔基体（C11）相对于样品容器关闭而导入样品容器（A）中。样品液体可以通过多孔基质（C11）进入结构形式（C）。这种方法很容易自动化，减少了气溶胶的产生。

3. 发明授权

US06669910B1 System for providing biological materials 有权
标题翻译：提供生物材料的系统
公开(公告)号：US06669910B1
公开(公告)日：2003-12-30
申请号：US09485144
申请日：2000-10-02
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
IPC分类号： B01L300
CPC分类号： B01L3/50853 , B01L3/5025 , B01L3/50255 , B01L3/50825 , G01N2035/00752 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： System and process for isolating purified biological materials with a collecting unit which has collecting vessels that are accessible from above with a matrix unit in which matrix vessels are arranged in a holder as well as a closure unit which can be placed on the collecting unit to close the collecting vessel. In addition the invention also concerns a system having a collecting unit, a matrix unit, and a closure unit as well as a lysis unit and a waste unit. Moreover a new closure arrangement is disclosed which is suitable for closing vessels in which there is excess pressure.
摘要翻译：用收集单元分离纯化的生物材料的系统和方法，该收集单元具有可从上方接近的收集容器，其中基质容器布置在保持器中，矩形单元以及能够放置在收集单元上以封闭的封闭单元收集船。此外，本发明还涉及具有收集单元，矩阵单元和闭合单元以及裂解单元和废物单元的系统。此外，公开了一种新的封闭装置，其适用于封闭存在过压的容器。

4. 发明授权

US6024235A Container seal with a sealing body which can be punctured 失效
标题翻译：集装箱密封带有可以刺破的密封体
公开(公告)号：US6024235A
公开(公告)日：2000-02-15
申请号：US347201
申请日：1994-11-21
申请人： Jurgen Schwab
发明人： Jurgen Schwab
IPC分类号： B65D39/04 , A61M5/162 , B65D41/58 , B65D47/36 , B65D51/00 , B65D51/18 , B65D39/00
CPC分类号： B65D51/002
摘要： The invention relates to a container seal with a sealing body which can be punctured for supplying or removing liquids to or from a container (3) by means of a blunt hollow needle (10), this sealing body consisting at least partially of a highly elastic material in which a cut is made at the puncture point (23) through at least 75% of its thickness. The seal can in this case be designed independently in the form of a stopper or as a small insert plate for a seal.
摘要翻译：本发明涉及一种具有密封体的容器密封件，该密封体可以被刺穿，用于通过钝的中空针（10）向容器（3）供应或从容器（3）移除或移除液体，该密封体至少部分地由高弹性通过其厚度的至少75％在穿刺点（23）上形成切口的材料。在这种情况下，密封件可以以止动器的形式独立地设计，或者作为用于密封件的小的插入板。

5. 发明授权

US5855852A Vessel for reducing contamination in the treatment of liquids 失效
标题翻译：用于减少液体处理污染的容器
公开(公告)号：US5855852A
公开(公告)日：1999-01-05
申请号：US623798
申请日：1996-03-29
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： G01N1/00 , B01L3/14 , B65D39/16 , B65D51/16 , G01N1/34 , B01L3/00
CPC分类号： G01N1/405 , B01L3/5082 , B01L3/50825 , B65D39/16 , B65D51/1616 , Y10T436/2575
摘要： A vessel for reducing contamination of liquids is formed of a vessel body with an inlet opening and an outlet opening therein. A closing device is attached to the vessel body adjacent the outlet opening. The closing device closes the outlet opening, and includes a normally closed one-way valve which is openable by a predetermined pressure from within the vessel body.
摘要翻译：用于减少液体污染的容器由其中具有入口开口和出口开口的容器主体形成。关闭装置在出口开口附近附接到容器主体。关闭装置关闭出口开口，并且包括可从容器主体内的预定压力打开的常闭单向阀。

6. 发明授权

US06619248B1 Device for altering the control timing of gas exchange valves of an internal combustion engine, especially an apparatus for hydraulic rotational angle adjustment of a camshaft relative to a crankshaft 有权
标题翻译：用于改变内燃机的气体交换阀的控制时间的装置，特别是用于凸轮轴相对于曲轴的液压旋转角度调节装置
公开(公告)号：US06619248B1
公开(公告)日：2003-09-16
申请号：US10194760
申请日：2002-07-12
申请人： Thomas Bertelshofer , Gerd Wiessner , Jurgen Schwab , Thomas Kleiber
发明人： Thomas Bertelshofer , Gerd Wiessner , Jurgen Schwab , Thomas Kleiber
IPC分类号： F01L134
CPC分类号： F01L1/022 , F01L1/026 , F01L2001/34479 , F01L2001/34483 , F01L2101/00
摘要： A device (1) for hydraulic rotational angle adjustment of a camshaft relative to a crankshaft of an internal combustion engine including a drive unit (4) connected with the crankshaft and an output unit (5) non-rotatably connected with the camshaft. The drive unit (4) stands in power transmitting connection with the output unit (5) through at least two pressure chambers (6, 7) formed inside the device (1) which bring about, under action by pressure under continuous compensation for external pressure leakages, a relative rotation or a hydraulic clamping of the output unit (5) in relation to the drive unit (4). In addition, the device (1) has a coil spring (8) arranged outside the device which is provided for adaptation of its adjustment speeds in both adjustment directions. The coil spring (8) is arranged via enclosure in an additional housing (11) in a closed annular space which is completely fillable with the external pressure medium leakages of the device (1), whereby the hydraulic pressure medium acts at the same time as a damping agent against sympathetic resonant vibrations of the spring turns (13) of the coil spring (8) resulting from vibrations of the internal combustion engine.
摘要翻译：一种用于凸轮轴相对于包括与曲轴连接的驱动单元（4）的内燃机的曲轴的液压旋转角度调节装置（1）和与凸轮轴不可旋转地连接的输出单元（5）。驱动单元（4）通过形成在装置（1）内部的至少两个压力室（6,7）与输出单元（5）保持动力传递连接，该压力室在连续补偿的作用下产生外部压力泄漏，输出单元（5）相对于驱动单元（4）的相对旋转或液压夹紧。另外，装置（1）具有布置在装置外部的螺旋弹簧（8），其设置成用于在两个调节方向上适应其调节速度。螺旋弹簧（8）经由外壳设置在封闭的环形空间中的附加壳体（11）中，该空间可完全与外部压力介质泄漏装置（1）填充，由此液压介质与由内燃机的振动引起的螺旋弹簧（8）的弹簧圈（13）的交感共振振动的阻尼剂。

7. 发明授权

US6024138A Dispensing device for dispensing small quantities of fluid 失效
标题翻译：用于分配少量流体的分配装置
公开(公告)号：US6024138A
公开(公告)日：2000-02-15
申请号：US61960
申请日：1998-04-17
申请人： Michael Fritz , Heinz Macho , Helmut Rinkel , Jurgen Schwab , Georg Arras , Klaus Oswald , Alfred Schaffner
发明人： Michael Fritz , Heinz Macho , Helmut Rinkel , Jurgen Schwab , Georg Arras , Klaus Oswald , Alfred Schaffner
IPC分类号： B67D99/00 , B01L3/02 , B65D51/32 , G01N1/38 , B65B1/04
CPC分类号： B01L3/0282 , A61B5/150022 , A61B5/150343 , G01N1/38
摘要： Dispensing device for dispensing small quantities of fluid comprising a compressible balloon with an end-to-end capillary inserted within the walls of the balloon in such a way that the one end of the capillary communicates with the interior of the balloon and the other end of the capillary communicates with the exterior space. The balloon has at least one opening through which the interior space of the balloon communicates with the exterior space. The at least one opening has a flow resistance that is designed so that a fluid contained in the capillary is expelled when the balloon is compressed. The present invention also comprises a system and method for the metered dispensing of fluids.
摘要翻译：用于分配少量流体的分配装置，包括可压缩气囊，其中插入在球囊壁内的端对端毛细管，使毛细管的一端与球囊的内部连通，另一端毛细管与外部空间连通。气球具有至少一个开口，气囊的内部空间通过该开口与外部空间连通。所述至少一个开口具有流动阻力，其被设计成使得当气囊被压缩时包含在毛细管中的流体被排出。本发明还包括用于计量分配流体的系统和方法。

8. 发明授权

US5957822A Lid for closing vessels 失效
标题翻译：盖封船
公开(公告)号：US5957822A
公开(公告)日：1999-09-28
申请号：US617657
申请日：1996-04-01
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： G01N35/02 , B01L3/14 , B65D39/16 , B65D51/16 , B65D51/24 , G01N1/34 , B31B1/74
CPC分类号： G01N1/405 , B01L3/5082 , B01L3/50825 , B65D39/16 , B65D51/1616 , B65D51/24 , Y10T29/49876
摘要： A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed on an outer portion of the lid, with the handling element extending in parallel with an axis of the vessel. The handling element is for handling the lid for opening and closing the vessel.
摘要翻译：用于关闭容器的开口的盖包括构造成接合开口的盖体，容器具有限定的形状。盖体包括与容器的相应表面接合的接合部分，从而封闭开口。处理元件设置在盖的外部部分上，处理元件与容器的轴线平行延伸。处理元件用于处理用于打开和关闭容器的盖子。

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