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1. 发明授权

US07959583B2 Integrated lancet and bodily fluid sensor 有权
标题翻译：集成的柳叶刀和体液传感器
公开(公告)号：US07959583B2
公开(公告)日：2011-06-14
申请号：US11704186
申请日：2007-02-09
申请人： John D. DeNuzzio , Steven Keith , Lawrence A. Monahan , Phyllis Palmer , Bill Stewart , Todd M. Chelak , Robert E. West , William Allen , Frederick Karl , Lee Griswold
发明人： John D. DeNuzzio , Steven Keith , Lawrence A. Monahan , Phyllis Palmer , Bill Stewart , Todd M. Chelak , Robert E. West , William Allen , Frederick Karl , Lee Griswold
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150618 , A61B5/150725 , A61B5/15107 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B2562/0295 , Y10T29/49002 , Y10T29/49826
摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.
摘要翻译：提供了与传感带集成的穿刺装置及其制造和使用方法。喷枪和分析物感测带组合在单个，优选一次性的装置中。在优选实施例中，在支撑构件中设置狭槽，使得喷枪可以由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

2. 发明授权

US07787923B2 Fiber optic device for sensing analytes and method of making same 有权
标题翻译：用于感测分析物的光纤设备及其制造方法
公开(公告)号：US07787923B2
公开(公告)日：2010-08-31
申请号：US10967220
申请日：2004-10-19
申请人： Javier Alarcon , Kristin Weidemaier , Terry J. Amis , John D. DeNuzzio , Christopher C. Herdman , Ross W. Jacobson , J. Bruce Pitner , Douglas B. Sherman , Steven Keith
发明人： Javier Alarcon , Kristin Weidemaier , Terry J. Amis , John D. DeNuzzio , Christopher C. Herdman , Ross W. Jacobson , J. Bruce Pitner , Douglas B. Sherman , Steven Keith
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1459 , A61B5/1495 , A61B5/4839 , A61B5/6848 , A61B2560/0223 , G01N21/274 , G01N21/7703 , G01N33/542 , G01N33/54373 , G01N2021/7786 , G01N2201/1211
摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.
摘要翻译：公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。感测元件连接到光学导管的远端，并且包含适于与至少一种靶分析物结合的至少一种结合蛋白。感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。可选地，光学导管和感测元件可以容纳在插管斜面内。

3. 发明授权

US07426408B2 Minimally-invasive system and method for monitoring analyte levels 有权
标题翻译：用于监测分析物水平的微创系统和方法
公开(公告)号：US07426408B2
公开(公告)日：2008-09-16
申请号：US10903640
申请日：2004-08-02
申请人： John D. DeNuzzio , William E. Strohben, Jr.
发明人： John D. DeNuzzio , William E. Strohben, Jr.
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61M5/158 , A61M5/1723 , A61M2005/1581
摘要： A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient's skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.
摘要翻译：一种微创分析物检测装置及其使用方法。该系统和方法采用具有可选地涂覆有物质的活性电极的器件和被配置为至少部分地围绕有源电极的对电极。辅助电极和有源电极的配置改善了通过器件的电流，提高了器件的灵敏度。当将装置放置在患者皮肤上时，活性电极适于通过患者的角质层进入深度小于神经末梢所在真皮层的深度。电位被施加到有源电极，并且基于流过器件的电流或电荷的量来确定分析物水平。

4. 发明授权

US06952604B2 Minimally-invasive system and method for monitoring analyte levels 有权
公开(公告)号：US06952604B2
公开(公告)日：2005-10-04
申请号：US10024506
申请日：2001-12-21
申请人： John D. DeNuzzio , William E. Strohben, Jr.
发明人： John D. DeNuzzio , William E. Strohben, Jr.
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1473 , A61M5/158 , A61M5/172 , G01N27/327 , G01N27/416
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61M5/158 , A61M5/1723 , A61M2005/1581
摘要： A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient's skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.

5. 发明授权

US5817044A User activated iontophoertic device 失效
标题翻译：用户激活离子电位器
公开(公告)号：US5817044A
公开(公告)日：1998-10-06
申请号：US282100
申请日：1994-07-28
申请人： Hans Christer Arvid Evers , Bernt Fredrick Julius Broberg , John D. DeNuzzio , Randal A. Hoke
发明人： Hans Christer Arvid Evers , Bernt Fredrick Julius Broberg , John D. DeNuzzio , Randal A. Hoke
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/0448
摘要： A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. In one embodiment, the two portions are each contained in separate compartments of a pouch. In another embodiment, the portions are contained in a single compartment and divided by a barrier. A method of activating the device includes causing the two portions to come into electrical conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished, for example, by either folding the device to bring the two portions into contact with one another or simply by removing the barrier dividing the two portions. In the alternative, the device may include two separate portions which can be brought together to activate the device. In this way, the device is suitable for use to deliver a high dose efficiency, while providing a commercially suitable shelf-life.
摘要翻译：本发明的用户激活的离子电渗疗法装置包括电极组件，电极储存器和至少一个药物贮存器。该装置被分割或以其他方式分离成至少两部分，其中一部分包含电极储存器，另一部分包含药物储存器，其可包括干燥形式的药物。在一个实施例中，两个部分各自包含在袋的独立隔室中。在另一个实施例中，这些部分被包含在单个隔室中并且被屏障隔开。激活装置的方法包括使两部分彼此进行导电接触以至少部分地水合其中一个储存器。这可以通过例如折叠装置来使两个部分彼此接触或简单地通过去除划分两个部分的屏障来实现。在替代方案中，该装置可以包括两个分开的部分，这些部分可以组合在一起以启动装置。以这种方式，该装置适合用于提供高剂量效率，同时提供商业上合适的保质期。

6. 发明申请

US20120011705A1 Integrated lancet and bodily fluid sensor 有权
标题翻译：集成的柳叶刀和体液传感器
公开(公告)号：US20120011705A1
公开(公告)日：2012-01-19
申请号：US12929261
申请日：2011-01-11
申请人： John D. DeNuzzio , Steven Keith , Lawrence A. Monahan , Phyllis Palmer , Bill Stewart , Todd M. Chelak , Robert E. West , William Allen , Frederick Karl , Lee Griswold
发明人： John D. DeNuzzio , Steven Keith , Lawrence A. Monahan , Phyllis Palmer , Bill Stewart , Todd M. Chelak , Robert E. West , William Allen , Frederick Karl , Lee Griswold
IPC分类号： H05K13/00 , B23P11/00
CPC分类号： A61B5/1486 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150618 , A61B5/150725 , A61B5/15107 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B2562/0295 , Y10T29/49002 , Y10T29/49826
摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.
摘要翻译：提供了与传感带集成的穿刺装置及其制造和使用方法。喷枪和分析物感测带组合在单个，优选一次性的装置中。在优选实施例中，在支撑构件中设置狭槽，使得喷枪可以由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

7. 发明授权

US07792561B2 Fiber optic device for sensing analytes 有权
标题翻译：用于感测分析物的光纤设备
公开(公告)号：US07792561B2
公开(公告)日：2010-09-07
申请号：US11840069
申请日：2007-08-16
申请人： Javier Alarcon , Kristin Weidemaier , Terry J. Amiss , John D. Denuzzio , Christopher C. Herdman , Ross Wayne Jacobson , J. Bruce Pitner , Douglas B. Sherman
发明人： Javier Alarcon , Kristin Weidemaier , Terry J. Amiss , John D. Denuzzio , Christopher C. Herdman , Ross Wayne Jacobson , J. Bruce Pitner , Douglas B. Sherman
IPC分类号： A61B5/145
CPC分类号： G01N21/7703 , G01N33/542 , G01N33/54373
摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.
摘要翻译：公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。光导管，优选地，光导纤维在光导管的近端具有光学系统。感测元件连接到光学导管的远端，并且包括适于与至少一种靶分析物结合的至少一种结合蛋白。感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。可选地，感测元件包括具有通过分析物浓度的变化基本上不变的发光特性的参考组。

8. 发明授权

US5738647A User activated iontophoretic device and method for activating same 失效
标题翻译：用户激活的离子电渗装置及其激活方法
公开(公告)号：US5738647A
公开(公告)日：1998-04-14
申请号：US722813
申请日：1996-09-27
申请人： Michael I. Bernhard , John D. DeNuzzio
发明人： Michael I. Bernhard , John D. DeNuzzio
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. The electrode reservoir and the drug reservoir are sealingly separated by a barrier, which can be removed to bring the reservoirs into fluid conducting contact with one another. A method of activating the device includes causing the two portions to come into fluid conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished by removing the barrier dividing the two portions. In this way, the device is suitable for use to deliver a drug which has limited stability in an aqueous solution.
摘要翻译：本发明的用户激活的离子电渗疗法装置包括电极组件，电极储存器和至少一个药物贮存器。该装置被分割或以其他方式分离成至少两部分，其中一部分包含电极储存器，另一部分包含药物储存器，其可包括干燥形式的药物。电极储存器和药物贮存器通过屏障密封地隔开，可以将其移除以使储存器彼此流体导电接触。启动装置的方法包括使两部分彼此进行流体导电接触以至少部分地水合其中一个储存器。这可以通过去除分隔两个部分的屏障来实现。以这种方式，该装置适用于递送在水溶液中具有有限稳定性的药物。

9. 发明授权

US5713846A Iontophoretic drug delivery system, including method for activating same for attachment to patient 失效
标题翻译：离子电渗药物递送系统，包括用于激活其以用于附着于患者的方法
公开(公告)号：US5713846A
公开(公告)日：1998-02-03
申请号：US722814
申请日：1996-09-27
申请人： Michael I. Bernhard , John D. DeNuzzio
发明人： Michael I. Bernhard , John D. DeNuzzio
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0448
摘要： An iontophoretic drug delivery system including a patch, a controller and a magazine. The patch may be secured in a compartment formed in the magazine so that upon insertion of the controller along the magazine to fasten the controller to the patch, a dry drug contained in the patch is hydrated and the patch and controller can be removed from the magazine for attachment to the skin of a patient.
摘要翻译：包括贴片，控制器和杂志的离子电渗药物递送系统。贴片可以固定在形成在盒子中的隔室中，使得当沿着盒子插入控制器以将控制器紧固到贴片时，补片中包含的干燥药物被水合，并且可以将药片和控制器从盒子中取出用于附着于患者的皮肤。

10. 发明申请

US20110184259A1 Fiber Optic Device for Sensing Analytes and Method of Making Same 审中-公开
标题翻译：用于感应分析物的光纤装置及其制作方法
公开(公告)号：US20110184259A1
公开(公告)日：2011-07-28
申请号：US12861202
申请日：2010-08-23
申请人： Javier Alarcon , Kristin Weidemaier , Terry J. Amiss , John D. DeNuzzio , Christopher C. Herdman , Ross W. Jacobson , J. Bruce Pitner , Douglas B. Sherman , Steven Keith
发明人： Javier Alarcon , Kristin Weidemaier , Terry J. Amiss , John D. DeNuzzio , Christopher C. Herdman , Ross W. Jacobson , J. Bruce Pitner , Douglas B. Sherman , Steven Keith
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1459 , A61B5/1495 , A61B5/4839 , A61B5/6848 , A61B2560/0223 , G01N21/274 , G01N21/7703 , G01N33/542 , G01N33/54373 , G01N2021/7786 , G01N2201/1211
摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.
摘要翻译：公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。感测元件连接到光学导管的远端，并且包含适于与至少一种靶分析物结合的至少一种结合蛋白。感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。可选地，光学导管和感测元件可以容纳在插管斜面内。

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