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1. 发明授权

US4994553A Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies 失效
标题翻译：人白细胞介素-1的免疫原性肽和相应的抗肽抗体
公开(公告)号：US4994553A
公开(公告)日：1991-02-19
申请号：US208954
申请日：1988-06-17
申请人： John A. Schmidt , Joshua S. Boger , Ellen B. K. Bayne
发明人： John A. Schmidt , Joshua S. Boger , Ellen B. K. Bayne
IPC分类号： C07K7/08 , C07K14/545 , C07K16/24 , G01N33/68
CPC分类号： C07K7/08 , C07K14/545 , C07K16/245 , G01N33/6869 , Y10S514/885 , Y10S530/806 , Y10S530/81 , Y10S530/812
摘要： Several distinct peptide regions of the secreted form of purified human interleukin-1 species pI 6.8 have been found to exhibit characteristics associated with highly immunogenic protein moieties and are used to produce specific anti-peptide antibodies. The antibodies raised against the individual peptides are specific for the peptide used for their production and for IL-1, pI 6.8. The individual antibodies bind to both the precursor of IL-1, pI 6.8 and the mature or extracellular IL-1, pI 6.8.
摘要翻译：已经发现分泌形式的纯化的人白细胞介素-1物质pI 6.8的几个不同的肽区域表现出与高度免疫原性蛋白质部分相关的特征，并且用于产生特异性抗肽抗体。对各种肽产生的抗体对于用于其生产的肽和IL-1，pI 6.8是特异性的。单个抗体结合IL-1，pI 6.8的前体和成熟或细胞外IL-1，pI 6.8两者。

2. 发明授权

US3614606A Capacitive-coupled probe for measuring potentials in a plasma 失效
标题翻译：用于测量等离子体中的电位的电容耦合探针
公开(公告)号：US3614606A
公开(公告)日：1971-10-19
申请号：US3614606D
申请日：1969-04-04
申请人： JOHN A SCHMIDT , DONALD W KERST
发明人： SCHMIDT JOHN A , KERST DONALD W
IPC分类号： G01R29/24
CPC分类号： G01R29/24
摘要： A capacitive-coupled probe includes an elongated glass tube closed at one end thereof and an electrode mounted within the glass tube at the closed end. A conductor extends within the tube along the length thereof to contact the electrode and a shield is disposed about the conductor with a dielectric material interposed of the shield and the conductor for insulation purposes. The conductor and electrode are sized with respect to the interior of the tube to restrain relative motion therebetween.

3. 发明授权

US06643546B2 Multi-electrode apparatus and method for treatment of congestive heart failure 失效
公开(公告)号：US06643546B2
公开(公告)日：2003-11-04
申请号：US10075808
申请日：2002-02-13
申请人： Scott Mathis , John K. Prentice , John A. Schmidt , William B. Rottenberg
发明人： Scott Mathis , John K. Prentice , John A. Schmidt , William B. Rottenberg
IPC分类号： A61N118
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3686
摘要： An apparatus and method for treatment of congestive heart failure from the right side of the heart. An implantable cardiac stimulation system with a multi-electrode lead having three or more selectable electrodes, together with apparatus for identifying an optimal subset of electrodes, apparatus for shaping a propagating wave front, and apparatus for modifying the intrinsic ventricular cardiac activation sequence, or generating simultaneous or near simultaneous pacing pulses to the septum or right ventricular outflow tract during ventricular systole in order to improve left ventricular cardiac efficiency and reduce mitral regurgitation in patients with dilated cardiomyopathy. A three dimensional map of electrode placement may be calculated. A sub set of the available electrodes in the right side of the heart is selected for stimulation such that septal motion during systole is reduced or the mitral valve area is stiffened to reduce mitral regurgitation.

4. 发明授权

US06240320B1 Cardiac lead with zone insulated electrodes 失效
标题翻译：心脏导联带区域绝缘电极
公开(公告)号：US06240320B1
公开(公告)日：2001-05-29
申请号：US09092106
申请日：1998-06-05
申请人： Paul R. Spehr , James E. Machek , David R. Erickson , John A. Schmidt
发明人： Paul R. Spehr , James E. Machek , David R. Erickson , John A. Schmidt
IPC分类号： A61N105
CPC分类号： A61N1/0565
摘要： An electrode for a cardiac lead and method of making the same are provided. The electrode includes an electrode member and a coating applied to the electrode member. The coating is composed of an electrically insulating material and covers a first portion of the exterior of the electrode member while leaving a preselected second portion thereof exposed. The second or exposed portion enhances the impedance of the electrode, resulting in power savings and extended life spans for implantable stimulation and sensing devices. Exemplary materials for the coating includes diamond-like carbon and sapphire.
摘要翻译：提供了一种用于心脏导联的电极及其制造方法。电极包括电极部件和施加到电极部件的涂层。涂层由电绝缘材料构成，并且覆盖电极构件的外部的第一部分，同时使其预选的第二部分露出。第二或暴露的部分增强电极的阻抗，导致功率节省并延长可植入的刺激和感测装置的寿命。用于涂层的示例性材料包括类金刚石碳和蓝宝石。

5. 发明授权

US5861078A Method and apparatus for detecting a seal on a plastic bag 失效
标题翻译：用于检测塑料袋上的密封的方法和装置
公开(公告)号：US5861078A
公开(公告)日：1999-01-19
申请号：US749158
申请日：1996-11-14
申请人： John J. Huben , John A. Schmidt , Charles H. Sauder , Kevin O. Heindel , Thomas C. Jansen , Stephen A. Saindon
发明人： John J. Huben , John A. Schmidt , Charles H. Sauder , Kevin O. Heindel , Thomas C. Jansen , Stephen A. Saindon
IPC分类号： B26D5/20 , B26D5/22 , B26D5/34 , B29C65/00 , B29C65/18 , B31B1/74 , B31B19/74 , B31B23/00 , G01N21/89 , B32B31/00
CPC分类号： B29C66/4312 , B26D5/007 , B26D5/20 , B26D5/22 , B26D5/34 , B29C65/18 , B29C66/83421 , B29C66/83511 , B29C66/961 , B29C66/9672 , B29C66/98 , B31B1/00 , B31B23/00 , G01N21/89 , B29C66/932 , B31B2201/95 , B31B2219/028 , B31B2219/95 , B31B2237/10
摘要： A method and apparatus for registration of a seal to a perforation on a plastic bag include a drum for forming a seal on a continuous plastic film and a downstream perforator/cutting station for forming a perforation on the film with respect to the location of the seal. The perforation is properly registered to the seal by sensing the seal location directly, with a seal sensor located near the perforator/cutting station.
摘要翻译：用于将密封件注册到塑料袋上的穿孔的方法和装置包括用于在连续塑料膜上形成密封的滚筒和用于在薄膜上相对于密封件的位置形成穿孔的下游穿孔/切割台。通过直接检测密封位置，密封传感器位于穿孔/切割站附近，将穿孔适当地注册到密封件上。

6. 发明授权

US5527026A Auto compensating paper feeder 失效
标题翻译：自动补偿进纸器
公开(公告)号：US5527026A
公开(公告)日：1996-06-18
申请号：US406233
申请日：1995-03-17
申请人： Martin J. Padget , John A. Schmidt , Scott S. Williams
发明人： Martin J. Padget , John A. Schmidt , Scott S. Williams
IPC分类号： B65H1/08 , B65H3/06 , B65H3/30
CPC分类号： B65H1/08 , B65H3/0669
摘要： A gear train (1) pivoted (11) around its drive gear (3) rotates a drive roller (13) with increasing pressure until the top sheet of paper (15) is moved. The corner buckler (19) is moved around a pivot (25) under the paper tray to drive the buckler into the paper stack. A bottom roller (27) permits the drive roller to rotate when the tray is empty. To reduce the angular variation of the gear train, its pivot point may be lowered by positioning it to the side of the tray. The assembly adjusts automatically to correct feeding variations.
摘要翻译：围绕其驱动齿轮（3）枢转（11）的齿轮系（1）以增加的压力旋转驱动辊（13）直到顶片纸（15）移动。拐角扣环（19）围绕纸盘下方的枢轴（25）移动，以将扣环驱动到纸叠中。当底盘为空时，底辊（27）允许驱动辊旋转。为了减小齿轮系的角度变化，其枢轴点可以通过将其定位在托盘的侧面而降低。组件自动调整以校正进给变化。

7. 发明授权

US4772685A Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies 失效
标题翻译：人白细胞介素-1的免疫原性肽和相应的抗肽抗体
公开(公告)号：US4772685A
公开(公告)日：1988-09-20
申请号：US782847
申请日：1985-10-02
申请人： John A. Schmidt , Joshua S. Boger , Ellen B. K. Bayne
发明人： John A. Schmidt , Joshua S. Boger , Ellen B. K. Bayne
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C07K16/00 , C07K16/24 , C07K19/00 , G01N33/68 , C07K7/10
CPC分类号： G01N33/6869 , C07K14/545 , C07K16/245 , Y10S514/885 , Y10S530/806 , Y10S530/81 , Y10S530/812 , Y10S930/141
摘要： Several distinct peptide regions of the secreted form of purified human interleukin-1 species pI 6.8 have been found to exhibit characteristics associated with highly immunogenic protein moieties and are used to produce specific anti-peptide antibodies. The antibodies raised against the individual peptides are specific for the peptide used for their production and for IL-1, pI 6.8. The individual antibodies bind to both the precursor of IL-1, pI 6.8 and the mature or extracellular IL-1, pI 6.8.
摘要翻译：已经发现分泌形式的纯化的人白细胞介素-1物质pI 6.8的几个不同的肽区域表现出与高度免疫原性蛋白质部分相关的特征，并且用于产生特异性抗肽抗体。对各种肽产生的抗体对于用于其生产的肽和IL-1，pI 6.8是特异性的。单个抗体结合IL-1，pI 6.8的前体和成熟或细胞外IL-1，pI 6.8两者。

8. 发明授权

US06667007B1 System and method of applying energetic ions for sterilization 失效
公开(公告)号：US06667007B1
公开(公告)日：2003-12-23
申请号：US10164838
申请日：2002-06-07
申请人： John A. Schmidt
发明人： John A. Schmidt
IPC分类号： A61L214
CPC分类号： B65B55/04 , A23L3/26 , A61L2/14
摘要： A method of sterilization of a container is provided whereby a cold plasma is caused to be disposed near a surface to be sterilized, and the cold plasma is then subjected to a pulsed voltage differential for producing energized ions in the plasma. Those energized ions then operate to achieve spore destruction on the surface to be sterilized. Further, a system for sterilization of a container which includes a conductive or non-conductive container, a cold plasma in proximity to the container, and a high voltage source for delivering a pulsed voltage differential between an electrode and the container and across the cold plasma, is provided.

9. 发明授权

US06500303B1 Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives 失效
公开(公告)号：US06500303B1
公开(公告)日：2002-12-31
申请号：US09573401
申请日：2000-05-18
申请人： Raymond R. Seltzer , Jean-Pierre Wolf , Cyril Heitner , John A. Schmidt , Peter F. McGarry , Glen T. Cunkle , Randall B. Nelson
发明人： Raymond R. Seltzer , Jean-Pierre Wolf , Cyril Heitner , John A. Schmidt , Peter F. McGarry , Glen T. Cunkle , Randall B. Nelson
IPC分类号： D21C712
CPC分类号： C07D405/12 , C07D211/94 , C08K5/3435 , D21C9/005 , D21H21/143 , C08L97/00
摘要： Pulps or papers, especially chemimechanical or thermomechanical pulps or papers, which still contain lignin, have enhanced resistance to yellowing when they contain an effective stabilizing amount of a hindered amine compound which preferably is a nitroxide, a hydroxylamine or an ammonium salt thereof. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents, metal chelating agents, sulfur containing stabilizers, metal salts and diene compounds. Combinations of nitroxides, hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective. Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-piperidin-4-ol and selected hydroxylamine salts are novel compounds and are surprisingly effective for this purpose.

10. 发明授权

US5605072A Load-isolated, single-cycle mechanism 失效
标题翻译：负载隔离，单循环机制
公开(公告)号：US5605072A
公开(公告)日：1997-02-25
申请号：US528068
申请日：1995-09-14
申请人： John A. Schmidt , Kevin D. Schoedinger
发明人： John A. Schmidt , Kevin D. Schoedinger
IPC分类号： B41J23/02 , B65H3/06 , F16H27/08 , F16H55/17 , F16H29/12
CPC分类号： F16H27/08 , B41J23/02 , B65H3/0669 , Y10T74/1503 , Y10T74/18528 , Y10T74/19874
摘要： A driven gear (3a), a gear (11a) to a rotary solenoid (15a) and an output drive gear (19a) are mounted to rotate together, preferably as one part turning on a stationary shaft (7a). The driven gear and the output drive gear have disengagement sectors (5a and 20a). Activation of the solenoid turns the driven gear into engagement with a normally turning drive gear (1a). Shortly after the sector on the output gear is cleared, and the load (27) is driven through engagement with driven gear (23a). After one cycle, the detent force of the solenoid positions the sector 5a so that engagement is terminated. Because the rotary solenoid need only move the gears 3a, 11a and 19a, the size of the load is immaterial to the physical requirements for the solenoid and its reliability of operation.
摘要翻译：从动齿轮（3a），齿轮（11a）到旋转螺线管（15a）和输出驱动齿轮（19a）安装成一起旋转，优选地作为转动固定轴（7a）的一部分。从动齿轮和输出驱动齿轮具有分离扇区（5a和20a）。螺线管的激活使从动齿轮与正常转动的驱动齿轮（1a）接合。在输出齿轮上的扇区被清除之后不久，负载（27）通过与从动齿轮（23a）的啮合而被驱动。在一个周期之后，螺线管的止动力使扇形部分5a位于接合终止状态。由于旋转电磁铁只需要移动齿轮3a，11a和19a，负载的大小对于螺线管的物理要求和操作的可靠性是无关紧要的。

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