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1. 发明申请

US20050106596A1 Nucleic acid analysis methods conducted in small reaction volumes 审中-公开
标题翻译：在小反应体积中进行核酸分析方法
公开(公告)号：US20050106596A1
公开(公告)日：2005-05-19
申请号：US10928965
申请日：2004-08-27
申请人： Zbigniev Skrzypczynski , Joerg Baier , Karl Nichols
发明人： Zbigniev Skrzypczynski , Joerg Baier , Karl Nichols
IPC分类号： C07H21/04 , C12M1/34 , C12N20060101 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6827
摘要： The present invention relates to reactions conducted on or in solid surface materials, including liquid phase reactions within capillary tubes and arrays of capillary tubes or open end reaction microchambers. A wide array of biomolecular and combinatorial synthesis reactions may be used with the present invention. For example, the present invention provides methods for forming and cleaving nucleic acid cleavage structures on or in solid surface materials.
摘要翻译：本发明涉及在固体表面材料上或固体表面材料中进行的反应，包括毛细管内的液相反应和毛细管阵列或开放端反应微室。本发明可以使用各种各样的生物分子和组合合成反应。例如，本发明提供了在固体表面材料上或固体表面材料中形成和切割核酸裂解结构的方法。

2. 发明授权

US06245518B1 Polynucleotide arrays and methods of making and using the same 失效
标题翻译：多核苷酸阵列及其制作和使用方法
公开(公告)号：US06245518B1
公开(公告)日：2001-06-12
申请号：US09454822
申请日：1999-12-06
申请人： Joerg Baier
发明人： Joerg Baier
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , B01J19/0046 , B01J2219/00387 , B01J2219/00515 , B01J2219/00533 , B01J2219/00572 , B01J2219/00576 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , C40B60/14 , C12Q2565/501 , C12Q2565/549
摘要： The present invention relates to methods of using labeled tracers to generate spatially addressable arrays of immobilized molecules, particularly polynucleotides, that can be normalized for differences in immobilization efficiencies at different addresses in the array. It also relates to the arrays generated by the method and to use of these arrays to enhance discrimination in array-based assays, particularly the discrimination between perfectly matched hybrids and hybrids containing a single mismatch in nucleic acid hybridization assays.
摘要翻译：本发明涉及使用标记的示踪剂来产生固定分子的空间可寻址阵列，特别是多核苷酸的方法，其可以对阵列中不同地址的固定效率的差异进行归一化。它还涉及通过该方法产生的阵列和使用这些阵列来增强基于阵列的测定中的区别，特别是在完全匹配的杂交体和在核酸杂交测定中含有单一错配的杂交体之间的区别。

3. 发明授权

US5882930A Reagent transfer device 失效
标题翻译：试剂转移装置
公开(公告)号：US5882930A
公开(公告)日：1999-03-16
申请号：US966893
申请日：1997-11-10
申请人： Joerg Baier
发明人： Joerg Baier
IPC分类号： B01J19/00 , C40B60/14 , G01N35/00 , G01N35/10
CPC分类号： G01N35/1074 , B01J19/0046 , B01J2219/00317 , B01J2219/00369 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L2300/0893 , C40B60/14 , G01N2035/00237 , G01N2035/1037 , G01N35/1065 , Y10T436/11 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： The present device is directed to a reagent transfer device for transferring a plurality of reagent samples from one location to another location having a deposit surface. The device includes a reagent tray having a top surface with a top surface area and a plurality of wells in the ratio of at least 1,000 wells per square centimeter of top surface area, and a transfer member having a transfer surface with a plurality of pins extending therefrom. Each of the pins is positioned to correspond to one of the wells so that when the transfer member is moved in the Z-direction the pins are simultaneously dipped into the corresponding wells. The device further includes a mechanism for moving the transfer member between a first position in which reagent from the wells is deposited onto the corresponding pins and a second position in which reagent on the pins is deposited on the deposit surface. The mechanism for moving is adapted to move the transfer member in the X-direction, the Y-direction and the Z-direction.
摘要翻译：本装置被引导到用于将多个试剂样品从一个位置转移到具有沉积表面的另一位置的试剂转移装置。该装置包括具有顶表面区域的顶表面和多于每平方厘米顶表面积至少1,000个孔的比例的多个孔的试剂托盘和具有多个销延伸的转移表面的转移构件由此。每个销定位成对应于其中一个井，使得当传送构件沿Z方向移动时，销同时浸入相应的井中。该装置还包括用于在第一位置和第二位置之间移动转移构件的机构，其中来自孔的试剂沉积到相应的引脚上，其中在引脚上的试剂沉积在沉积表面上的第二位置。移动机构适于在X方向，Y方向和Z方向上移动传送构件。

4. 发明申请

US20080293930A1 3' end tagged oligonucleotides 失效
标题翻译： 3'末端标记的寡核苷酸
公开(公告)号：US20080293930A1
公开(公告)日：2008-11-27
申请号：US11787843
申请日：2007-04-18
申请人： Jeff G. Hall , Zbigniev Skrzypczynski , Sarah Wayland , Ned D. Reimer , Luis P. Reynaldo , Joerg Baier , Victor Lyamichev , Bruce P. Neri
发明人： Jeff G. Hall , Zbigniev Skrzypczynski , Sarah Wayland , Ned D. Reimer , Luis P. Reynaldo , Joerg Baier , Victor Lyamichev , Bruce P. Neri
IPC分类号： C07H1/00
CPC分类号： C12Q1/6823 , C12Q1/6806 , C12Q1/6853 , C12Q2561/109 , C12Q2525/197
摘要： The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3′ end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
摘要翻译：本发明提供了包含具有3'端基（例如亲脂部分）的寡核苷酸的组合物，其可用于浸润性切割反应，例如INVADER测定。具体而言，本发明提供含有3'末端基团的寡核苷酸的组合物，其配置用于在具有高信号与背景比的侵入性切割分析中产生可检测信号，以及产生这种组合物的方法。

5. 发明申请

US20080053901A1 Continuous Isocratic Affinity Chromatography 有权
标题翻译：连续等度亲和层析
公开(公告)号：US20080053901A1
公开(公告)日：2008-03-06
申请号：US11847983
申请日：2007-08-30
申请人： Robert Mierendorf , Herbert Paaren , Anthony Grabski , Andrew Wilke , Joerg Baier , Anil Oroskar
发明人： Robert Mierendorf , Herbert Paaren , Anthony Grabski , Andrew Wilke , Joerg Baier , Anil Oroskar
IPC分类号： B01D15/18 , F16K11/02
CPC分类号： F16K11/022 , B01D15/1842 , B01D15/3804 , Y10T137/86533 , Y10T137/86654
摘要： The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.
摘要翻译：本发明提供用于连续制备分析量高的目标分子的高纯度级分的微尺度模拟移动床层析（SMB）的装置和方法。本发明的本发明的装置和方法在优选实施方案中适用于通过亲和层析分离，涉及三个不连续的液体流动循环。亲和层析的另一个实施方案利用在等度条件下操作的标准SMB。

6. 发明申请

US20080053543A1 Valve Module And Methods For Simulated Moving Bed Chromatography 有权
标题翻译：模拟移动床色谱的阀门模块和方法
公开(公告)号：US20080053543A1
公开(公告)日：2008-03-06
申请号：US11847971
申请日：2007-08-30
申请人： Joerg Baier , Robert Mierendorf , Anthony Grabski , Andrew Wilke , Anil Oroskar
发明人： Joerg Baier , Robert Mierendorf , Anthony Grabski , Andrew Wilke , Anil Oroskar
IPC分类号： F16K11/078
CPC分类号： G01N30/44 , B01D15/1821 , B01D15/1842 , B01D15/3804 , G01N30/20 , G01N2030/202 , Y10T137/86509 , Y10T137/86533 , Y10T137/86549 , Y10T137/8667 , Y10T137/87249 , Y10T137/87885
摘要： The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.
摘要翻译：本发明提供用于连续制备分析量高的目标分子的高纯度级分的微尺度模拟移动床层析（SMB）的装置和方法。本发明的本发明的装置和方法在优选实施方案中适用于通过亲和层析分离，涉及三个不连续的液体流动循环。亲和层析的另一个实施方案利用在等度条件下操作的标准SMB。

7. 发明授权

US06268210B1 Sandwich arrays of biological compounds 失效
标题翻译：三明治阵列的生物化合物
公开(公告)号：US06268210B1
公开(公告)日：2001-07-31
申请号：US09251303
申请日：1999-02-17
申请人： Joerg Baier , Brian Hauser , Radoje T. Drmanac
发明人： Joerg Baier , Brian Hauser , Radoje T. Drmanac
IPC分类号： C12M134
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00542 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/508 , B01L3/5085 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0887 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B70/00
摘要： The present invention relates to spatially-addressable sandwich arrays of compounds, particularly biological compounds such as peptides and polynucleotide probes, and methods of making and using the same. The present invention also relates to a method and device for holding together the substrates of the sandwich array, more particularly, a clamping device for securely yet safely holding substrates of a sandwich array together during assembly, use, storage, and/or transport of the sandwich array.
摘要翻译：本发明涉及化合物，特别是生物化合物如肽和多核苷酸探针的空间可寻址三明治阵列，以及制备和使用它们的方法。本发明还涉及一种用于将三明治阵列的基板保持在一起的方法和装置，更具体地说，涉及一种夹紧装置，用于在组装，使用，储存和/或运输三明治阵列。

8. 发明授权

US07582436B2 3′ end tagged oligonucleotides 失效
标题翻译： 3'末端标记的寡核苷酸
公开(公告)号：US07582436B2
公开(公告)日：2009-09-01
申请号：US11787843
申请日：2007-04-18
申请人： Jeff G. Hall , Zbigniev Skrzypczynski , Sarah Wayland , Ned D. Reimer , Luis P. Reynaldo , Joerg Baier , Victor Lyamichev , Bruce P. Neri
发明人： Jeff G. Hall , Zbigniev Skrzypczynski , Sarah Wayland , Ned D. Reimer , Luis P. Reynaldo , Joerg Baier , Victor Lyamichev , Bruce P. Neri
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6823 , C12Q1/6806 , C12Q1/6853 , C12Q2561/109 , C12Q2525/197
摘要： The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3′ end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
摘要翻译：本发明提供了包含具有3'端基（例如亲脂部分）的寡核苷酸的组合物，其可用于浸润性切割反应，例如INVADER测定。具体而言，本发明提供含有3'末端基团的寡核苷酸的组合物，其配置用于在具有高信号与背景比的侵入性切割分析中产生可检测信号，以及产生这种组合物的方法。

9. 发明授权

US06255119B1 Reagent transfer device 失效
标题翻译：试剂转移装置
公开(公告)号：US06255119B1
公开(公告)日：2001-07-03
申请号：US09161155
申请日：1998-09-25
申请人： Joerg Baier
发明人： Joerg Baier
IPC分类号： B01L302
CPC分类号： G01N35/1074 , B01J19/0046 , B01J2219/00317 , B01J2219/00369 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L2300/0893 , C40B60/14 , G01N35/1065 , G01N2035/00237 , G01N2035/1037 , Y10T436/11 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： The present device is directed to a reagent transfer device for transferring a plurality of reagent samples from one location to another. A transfer plate has a top surface with reservoirs, a bottom surface with orifices, and channels connecting the reservoirs and orifices. Fluid is moved from the reservoirs, through the channels and out of the orifices to form samples on the bottom surface about the orifices. A movement apparatus is provided for bringing the samples into contact with deposit surfaces at various deposition positions. Arrays of at least 100 orifices per square centimeter are provided.
摘要翻译：本装置被引导到用于将多个试剂样品从一个位置转移到另一个位置的试剂转移装置。转印板具有带有储存器的顶表面，具有孔的底表面和连接储存器和孔的通道。流体从储存器通过通道移出孔口，以在孔的底部表面上形成样品。提供移动装置，用于使样品与各种沉积位置的沉积物接触。提供每平方厘米至少100个孔的阵列。

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