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1. 发明授权

US08652784B2 DNA recombination junction detection 有权
标题翻译： DNA重组结检测
公开(公告)号：US08652784B2
公开(公告)日：2014-02-18
申请号：US13455875
申请日：2012-04-25
申请人： Jian Ping Zhang , Ernest Jay Friedlander , Robert Ruhfel , David Douglas Swenson , Alan Thomas Wortman
发明人： Jian Ping Zhang , Ernest Jay Friedlander , Robert Ruhfel , David Douglas Swenson , Alan Thomas Wortman
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6858 , C12Q2537/162 , C12Q2537/161
摘要： The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.
摘要翻译：本发明提供用于检测整合的插入多核苷酸的存在或不存在的方法，组合物和试剂盒。

2. 发明授权

US08394324B2 Microchip large-volume PCR with integrated real-time CE detection 有权
标题翻译： Microchip大容量PCR，集成实时CE检测
公开(公告)号：US08394324B2
公开(公告)日：2013-03-12
申请号：US12664018
申请日：2008-06-11
申请人： Luc Bousse , Jian-ping Zhang
发明人： Luc Bousse , Jian-ping Zhang
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/68 , C12P19/34 , C12M1/36 , C12M1/38 , C12M3/00 , C12M1/34
CPC分类号： G01N27/44791 , B01L3/502746 , B01L3/502753 , B01L7/52 , B01L2300/0816 , B01L2400/0421 , G01N27/44721
摘要： A microfluidic device is provided with appropriate integrated structures to conduct large volume PCR and end-point or real-time capillary electrophoresis detection. The microfluidic device includes a substrate having an amplification chamber of a volume of nucleic acid, wells disposed on the substrate, flow channels connecting the wells and the chamber in the substrate to allow for solution flow through the chamber, and one or more separation channels provided in the substrate and connected to the chamber for separating and detecting a fraction of the amplified nucleic acid. The chamber, the flow channels, and the one or more separation channels are configured such that the hydrodynamic flow resistance of the chambers and the flow channels combined is at least 10Λ3 times smaller than the hydrodynamic flow resistance in the one or more separation channels. The microfluidic device can achieve a very high sensitivity in detection while being highly cost effective.
摘要翻译：微流体装置具有适当的整合结构，可进行大容量PCR和终点或实时毛细管电泳检测。微流体装置包括具有一定体积的核酸的扩增室的衬底，设置在衬底上的阱，连通阱的流动通道和衬底中的室，以允许溶液流过腔室，以及提供一个或多个分离通道在底物中并连接到室以分离和检测一部分扩增的核酸。腔室，流动通道和一个或多个分离通道被构造成使得腔室和流动通道组合的流体动力学流动阻力比一个或多个分离通道中的流体动力流动阻力小至少10 ^ 3倍。微流体装置在检测中可以获得非常高的灵敏度，同时具有高成本效益。

3. 发明申请

US20110223382A1 HOUSING STRUCTURE 审中-公开
标题翻译：住房结构
公开(公告)号：US20110223382A1
公开(公告)日：2011-09-15
申请号：US12910938
申请日：2010-10-25
申请人： CHANG-HAI GU , JIAN-PING ZHANG , PO-FENG HO , JIA-HONG QU
发明人： CHANG-HAI GU , JIAN-PING ZHANG , PO-FENG HO , JIA-HONG QU
IPC分类号： B32B7/04 , B32B3/24 , B32B3/26 , B32B15/08
CPC分类号： B29C70/78 , B29C70/885 , B29L2031/712 , Y10T428/24314 , Y10T428/24339
摘要： A housing includes a metal member and a plastic member integrally formed with the metal member. The metal member defines a number of stepped holes. The stepped holes are filled with the plastic member. The plastic member and the metal member cooperatively define a flat surface of the housing.
摘要翻译：壳体包括与金属构件一体形成的金属构件和塑料构件。金属构件限定多个阶梯孔。阶梯孔填充有塑料构件。塑料构件和金属构件协作地限定壳体的平坦表面。

4. 发明申请

US20110151577A1 DISPOSABLE DEVICE FOR AUTOMATED BIOLOGICAL SAMPLE PREPARATION 审中-公开
标题翻译：用于自动生物样品制备的不可替代的装置
公开(公告)号：US20110151577A1
公开(公告)日：2011-06-23
申请号：US13060433
申请日：2009-08-26
申请人： Jian-Ping Zhang , Samuel D. Chan , Daisuke Eto , Takatoshi Hamada
发明人： Jian-Ping Zhang , Samuel D. Chan , Daisuke Eto , Takatoshi Hamada
IPC分类号： G01N1/28 , B67D7/06 , G01N33/48
CPC分类号： B01L3/5023 , B01L3/0275 , B01L3/508 , B01L3/5082 , B01L3/5635 , B01L2200/026 , B01L2200/0631 , B01L2300/044 , B01L2300/06 , B01L2300/0672 , B01L2300/069 , B01L2400/0433 , C12N15/1017 , C12Q1/6806 , G01N1/4077 , G01N35/1079 , G01N2001/4088 , G01N2001/4094 , Y10T436/25125
摘要： A device and a process for preparing biological test samples are presented. The device has a disposable device with a connection mechanism for connecting to a closed sonication tube together with a filter capture unit to capture samples and to handle the samples without requiring additional tubes. With the device and/or method, samples are sonicated in the closed sonication tube that prevents aerosol contamination.
摘要翻译：提出了一种用于制备生物测试样品的装置和方法。该装置具有一次性装置，其具有连接机构，用于连接到封闭的超声处理管以及过滤器捕获单元以捕获样品并处理样品而不需要额外的管。使用装置和/或方法，将样品在封闭的超声处理管中超声处理，防止气溶胶污染。

5. 发明申请

US20060177844A1 Closed-system multi-stage nucleic acid amplification reactions 有权
标题翻译：封闭系统多级核酸扩增反应
公开(公告)号：US20060177844A1
公开(公告)日：2006-08-10
申请号：US11262523
申请日：2005-10-27
申请人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Wang , Wendy Wong , Kendra Paul , Reuel Van Atta
发明人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Wang , Wendy Wong , Kendra Paul , Reuel Van Atta
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
摘要： The invention is directed to systems, methods, and apparatus for carrying out multi-stage amplification reactions, especially under fluidly closed conditions. In one aspect, methods of the invention are carried out in a fluidly closed reaction system that permits the isolation of a portion of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In this aspect, systems, methods, and apparatus of the invention may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
摘要翻译：本发明涉及用于进行多级扩增反应的系统，方法和装置，特别是在流体封闭的条件下。在一个方面，本发明的方法在流体封闭的反应体系中进行，其允许分离第一（或先前）反应混合物的一部分，并将其用作第二（或后续）反应混合物中的样品或样品，从而基本上避免了如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中可能具有干扰效应。在这方面，本发明的系统，方法和装置可以与基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。

6. 发明授权

US5825799A Microcavity semiconductor laser 失效
标题翻译：微腔半导体激光器
公开(公告)号：US5825799A
公开(公告)日：1998-10-20
申请号：US450284
申请日：1995-05-25
申请人： Seng-Tiong Ho , Daniel Yen Chu , Jian-Ping Zhang , Shengli Wu
发明人： Seng-Tiong Ho , Daniel Yen Chu , Jian-Ping Zhang , Shengli Wu
IPC分类号： H01S5/00 , G02F1/01 , H01S3/091 , H01S5/026 , H01S5/10 , H01S5/343 , H01S3/05
CPC分类号： B82Y20/00 , G02F1/011 , H01S5/10 , H01S5/1075 , G02F2203/055 , H01S3/091 , H01S5/026 , H01S5/1032 , H01S5/1042 , H01S5/105 , H01S5/34306 , H01S5/34326 , H01S5/3434
摘要： Laser comprising a first lasing microdisk, microcylinder or microannulus defining a microcavity having a circular cross-sectional periphery and a second waveguiding micromember spaced from the first lasing micromember in a different plane and optically coupled by resonant photon tunneling. The second waveguiding micromember includes a light output coupling for providing light output from the laser without adversely affecting the Q value and low lasing threshold of the microcavity.
摘要翻译：激光器包括限定具有圆形横截面周边的微腔的第一激光微盘，微圆柱体或微通道，以及在不同平面中与第一激光微型部件间隔开的第二波导微型组件，并通过共振光子隧道光学耦合。第二波导微元件包括光输出耦合器，用于提供来自激光器的光输出，而不会不利地影响微腔的Q值和低激光阈值。

7. 发明授权

US09410975B2 Pressure manifold to equalize pressure in integration PCR-CE microfluidic devices 有权
标题翻译：集成PCR-CE微流体装置的压力歧管以均衡压力
公开(公告)号：US09410975B2
公开(公告)日：2016-08-09
申请号：US12600171
申请日：2008-05-15
申请人： Chen Li , Samuel Chan , Jian Ping Zhang
发明人： Chen Li , Samuel Chan , Jian Ping Zhang
IPC分类号： B01L3/00 , G01N27/26 , G01N35/10 , C12P19/34 , G01N35/00
CPC分类号： G01N35/1095 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L2200/027 , B01L2200/0684 , B01L2300/0645 , B01L2300/0819 , B01L2400/0487 , B01L2400/049 , G01N2035/00158 , G01N2035/00237
摘要： A device is presented that includes a chip having a plurality of wells that are optionally connected by capillary channels, and a manifold member configured to be disposed over the chip for equalizing pressure over the wells and capillary channels.
摘要翻译：提出了一种装置，其包括具有可选地通过毛细管通道连接的多个阱的芯片，以及配置成设置在芯片上方以均衡孔和毛细通道上的压力的歧管构件。

8. 发明申请

US20120244534A1 CLOSED-SYSTEM MULTI-STAGE NUCLEIC ACID AMPLIFICATION REACTIONS 有权
标题翻译：封闭系统多级核酸放大反应
公开(公告)号：US20120244534A1
公开(公告)日：2012-09-27
申请号：US13397416
申请日：2012-02-15
申请人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wingkei Wong , Kendra Lara Paul , Reuel Van Atta
发明人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wingkei Wong , Kendra Lara Paul , Reuel Van Atta
IPC分类号： G01N21/64 , C12P19/34 , C12Q1/68
CPC分类号： G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
摘要： The invention is directed to systems, methods, and apparatus for carrying out multi-stage amplification reactions, especially under fluidly closed conditions. In one aspect, methods of the invention are carried out in a fluidly closed reaction system that permits the isolation of a portion of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In this aspect, systems, methods, and apparatus of the invention may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
摘要翻译：本发明涉及用于进行多级扩增反应的系统，方法和装置，特别是在流体封闭的条件下。在一个方面，本发明的方法在流体封闭的反应体系中进行，其允许分离第一（或先前）反应混合物的一部分，并将其用作第二（或后续）反应混合物中的样品或样品，从而基本上避免了如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中可能具有干扰效应。在这方面，本发明的系统，方法和装置可以与基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。

9. 发明授权

US08728765B2 Closed-system multi-stage nucleic acid amplification reactions 有权
标题翻译：封闭系统多级核酸扩增反应
公开(公告)号：US08728765B2
公开(公告)日：2014-05-20
申请号：US13397416
申请日：2012-02-15
申请人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wong , Kendra Lara Paul , Reuel Van Atta
发明人： Jesus Ching , Ronald Chang , Douglas Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wong , Kendra Lara Paul , Reuel Van Atta
IPC分类号： C12P19/34
CPC分类号： G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
摘要： The invention is directed to systems, methods, and apparatus for carrying out multi-stage amplification reactions, especially under fluidly closed conditions. In one aspect, methods of the invention are carried out in a fluidly closed reaction system that permits the isolation of a portion of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In this aspect, systems, methods, and apparatus of the invention may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
摘要翻译：本发明涉及用于进行多级扩增反应的系统，方法和装置，特别是在流体封闭的条件下。在一个方面，本发明的方法在流体封闭的反应体系中进行，其允许分离第一（或先前）反应混合物的一部分，并将其用作第二（或后续）反应混合物中的样品或样品，从而基本上避免了如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中可能具有干扰效应。在这方面，本发明的系统，方法和装置可以与基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。

10. 发明申请

US20130065774A1 DNA RECOMBINATION JUNCTION DETECTION 有权
标题翻译： DNA重组接头检测
公开(公告)号：US20130065774A1
公开(公告)日：2013-03-14
申请号：US13455875
申请日：2012-04-25
申请人： Jian Ping Zhang , Ernest Jay Friedlander , Robert Ruhfel , David Douglas Swenson , Alan Thomas Wortman
发明人： Jian Ping Zhang , Ernest Jay Friedlander , Robert Ruhfel , David Douglas Swenson , Alan Thomas Wortman
IPC分类号： C12Q1/68 , C40B30/04
CPC分类号： C12Q1/689 , C12Q1/6858 , C12Q2537/162 , C12Q2537/161
摘要： The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.
摘要翻译：本发明提供用于检测整合的插入多核苷酸的存在或不存在的方法，组合物和试剂盒。

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