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1. 发明授权

US5726190A Agonist-antagonist combination to reduce the use of nicotine and other drugs 失效
标题翻译：激动剂 - 拮抗剂组合，以减少使用尼古丁和其他药物
公开(公告)号：US5726190A
公开(公告)日：1998-03-10
申请号：US554403
申请日：1995-11-06
申请人： Jed E. Rose , Edward D. Levin
发明人： Jed E. Rose , Edward D. Levin
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00 , A61K31/44 , A61K31/465 , A61K47/48 , A61K9/70
CPC分类号： B82Y5/00 , A24B15/16 , A24B15/165 , A24B15/18 , A24F47/008 , A61K47/48738 , Y10S514/81 , Y10S514/812 , Y10S514/813 , Y10S514/922 , Y10S514/947
摘要： A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine, or an agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or an agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or agonist while there is a substantial amount of the drug or agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or agonist thereof. In another embodiment, the drug or agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relies upon a combination of an agonist and an antagonist.
摘要翻译：提供了治疗和减少药物依赖性的方法，例如尼古丁依赖性。该方法包括首先向受试者施用一定量的药物，例如尼古丁或药物的激动剂，其量通常将提供所需的药理作用，并且至少部分地使用者对药物的需求饱和。该方法还包括向受试者施用足以至少部分阻断药物或激动剂的药理作用的量的药物拮抗剂或激动剂，同时存在大量药物或激动剂存在于该系统中的药物或激动剂用户。在本发明的一个实施方案中，药物和拮抗剂基本上同时施用，以便占据该药物用量的大部分受体，从而阻断或减弱任何进一步摄取药物或其激动剂的作用。在另一个实施方案中，首先施用药物或激动剂，并且受试者以模拟药物使用的方式自身施用拮抗剂，从而使药物使用者对药物正常施用相关的刺激进行反调节。本发明还提供治疗性治疗涉及神经元失调的心理生理疾病和病症的方法。该方法另外提供用于治疗和降低药物依赖性并且依赖于激动剂和拮抗剂的组合的药物组合物。

2. 发明授权

US5383478A Low tar and low nicotine cigarette adapted to provide enhanced smoking satisfaction 失效
标题翻译：低焦油和低尼古丁香烟适应提高吸烟满意度
公开(公告)号：US5383478A
公开(公告)日：1995-01-24
申请号：US3569
申请日：1993-01-12
申请人： Jed E. Rose , Frederique M. Behm
发明人： Jed E. Rose , Frederique M. Behm
IPC分类号： A24B15/30 , A24D1/18 , A24C1/18
CPC分类号： A24D1/18 , A24B15/30
摘要： A low tar cigarette product and method of use which enhances the sensory impact of low tar and low nicotine cigarettes in order to increase their acceptability and reduce the likelihood that smokers will exhibit compensatory smoking during use thereof. The novel cigarette utilizes an irritant selected from the group consisting of one or more constituents from black and/or red pepper, capsaicinoids, and mixtures of the foregoing in the tobacco thereof. Subsequent to igniting the tobacco and inhaling from the cigarette, the irritant creates respiratory tract sensations in a user substantively similar to those obtained by inhalation of tobacco smoke from a conventional cigarette.
摘要翻译：一种低焦油卷烟产品和使用方法，其增强了低焦油和低尼古丁香烟的感官影响，以增加其可接受性并降低吸烟者在使用期间显示补偿性吸烟的可能性。该新颖的香烟在其烟草中使用选自由黑色和/或红辣椒，辣椒素和上述混合物组成的组中的刺激剂。在点燃烟草并从香烟吸入之后，刺激物在用户中产生与通过从常规香烟吸入烟草烟雾获得的那些类似的呼吸道感觉。

3. 发明授权

US5316759A Agonist-antagonist combination to reduce the use of nicotine and other drugs 失效
标题翻译：激动剂 - 拮抗剂组合，以减少使用尼古丁和其他药物
公开(公告)号：US5316759A
公开(公告)日：1994-05-31
申请号：US855868
申请日：1992-03-23
申请人： Jed E. Rose , Edward D. Levin
发明人： Jed E. Rose , Edward D. Levin
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00 , A61K31/44 , A61K31/465 , A61K47/48 , A61K49/00 , A61K31/13
CPC分类号： B82Y5/00 , A24B15/16 , A24B15/165 , A24B15/18 , A24F47/008 , A61K47/48738 , Y10S514/81 , Y10S514/812 , Y10S514/813 , Y10S514/922 , Y10S514/947
摘要： A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist. In another embodiment, the drug or its other agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relies upon a combination of an agonist and an antagonist.
摘要翻译：提供了治疗和减少药物依赖性的方法，例如尼古丁依赖性。该方法包括首先向受试者施用一定量的药物，例如尼古丁或另一种药物激动剂，其量通常将提供所需的药理作用并且至少部分地满足使用者对药物的需要。该方法还包括以足以至少部分阻断药物或其其它激动剂的药理作用的量将药物或其它激动剂的拮抗剂施用给受试者，同时存在大量的药物或其它激动剂用户的系统。在本发明的一个实施方案中，基本上同时施用药物和拮抗剂，以占据该药物的使用者的大部分受体，从而阻断或减弱药物或其它激动剂的任何进一步摄入的影响。在另一个实施方案中，首先施用药物或其它激动剂，并且拮抗剂以模仿药物使用的方式由受试者自身给药，从而使药物使用者对与正常给药相关的刺激进行反调节药物。本发明还提供治疗性治疗涉及神经元失调的心理生理疾病和病症的方法。该方法另外提供用于治疗和降低药物依赖性并且依赖于激动剂和拮抗剂的组合的药物组合物。

4. 发明授权

US4846199A Smoking of regenerated tobacco smoke 失效
标题翻译：吸烟再生烟草烟雾
公开(公告)号：US4846199A
公开(公告)日：1989-07-11
申请号：US840072
申请日：1986-03-17
申请人： Jed E. Rose
发明人： Jed E. Rose
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00
CPC分类号： B82Y5/00 , A24B15/165 , A24B15/18 , A24F47/008
摘要： A method and an apparatus for regenerating tobacco smoke separation of the gaseous constituents from the condensed constituents. The gaseous constituents which contain many of the harmful substances in tobacco smoke are eliminated and the residue of the condensed constituents is collected. For purposes of smoking the condensate, an aerosol is produced from this condensate for inhalation by the smoker. Heating is an effective means to produce the aerosol and since the heating occurs at low temperature, there is no re-combustion of tobacco and the attendant production of harmful constituents.
摘要翻译：一种用于从浓缩组分再生气态组分的烟草烟雾分离的方法和装置。消除了烟草烟雾中含有许多有害物质的气体成分，收集浓缩成分的残留物。为了吸收冷凝物，由该冷凝物产生气雾剂以吸引吸烟者。加热是产生气溶胶的有效手段，由于加热是在低温下进行的，因此不会再次燃烧烟草和伴随产生有害成分。

5. 发明授权

US10668058B2 Device and method for delivery of a medicament 审中-公开
公开(公告)号：US10668058B2
公开(公告)日：2020-06-02
申请号：US12054883
申请日：2008-03-25
申请人： Jed E. Rose , Seth D. Rose , James Edward Turner , Thangaraju Murugesan
发明人： Jed E. Rose , Seth D. Rose , James Edward Turner , Thangaraju Murugesan
IPC分类号： A61K31/465 , A61K31/4439 , A61M15/06 , A61M11/04 , A24F47/00 , A24B15/167 , A24B15/16 , A61K9/00 , A61K9/16 , A61M15/00
摘要： The disclosure relates to a method of enhancing nicotine or other medicament concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine or other medicaments for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.

6. 发明申请

US20130210783A1 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译：神经性甾体组合物及其使用方法
公开(公告)号：US20130210783A1
公开(公告)日：2013-08-15
申请号：US13600417
申请日：2012-08-31
申请人： Christine E. Marx , Jed E. Rose
发明人： Christine E. Marx , Jed E. Rose
IPC分类号： A61K31/57 , A61K45/06 , A61K31/5685
CPC分类号： A61K31/57 , A61K31/5685 , A61K45/06 , G01N33/6896 , G01N33/94 , G01N2800/304
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder. Also provided are methods for ameliorating at least one symptom resulting from tobacco cessation; and for ameliorating a symptom of Alzheimer's disease or other cognitive disorder; of schizophrenia, schizoaffective disorder, or other psychotic disorder; of a depressive disorder; of bipolar disorder; of post-traumatic stress disorder or other anxiety disorder; of a pain disorder; or of traumatic brain injury. Also provided are methods for ameliorating a sleep disorder; for improving cognitive functioning; for predicting a predisposition to suicide, suicidal ideation, and/or suicidal behavior; and for ameliorating a neurodegenerative disorder. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
摘要翻译：提供了改善神经精神障碍症状的方法。还提供了用于改善由戒烟导致的至少一种症状的方法; 并改善阿尔茨海默病或其他认知障碍的症状; 的精神分裂症，分裂情感障碍或其他精神障碍; 的抑郁症; 双相情感障碍; 的创伤后应激障碍或其他焦虑症; 的一种疼痛障碍或创伤性脑损伤。还提供了改善睡眠障碍的方法; 用于改善认知功能; 预测自杀，自杀意念和/或自杀行为的倾向; 并用于改善神经变性疾病。在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其药学上可接受的盐，其衍生物或其组合。

7. 发明申请

US20090203658A1 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译：神经性甾体组合物及其使用方法
公开(公告)号：US20090203658A1
公开(公告)日：2009-08-13
申请号：US12404886
申请日：2009-03-16
申请人： Christine E. Marx , Jed E. Rose
发明人： Christine E. Marx , Jed E. Rose
IPC分类号： A61K31/57 , A61P25/00
CPC分类号： A61K31/57 , A61K31/5685 , A61K45/06 , G01N33/6896 , G01N33/94 , G01N2800/304
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
摘要翻译：提供了改善受试者神经精神障碍症状的方法。还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法用于改善受试者的创伤性脑损伤的症状，改善sl的方法受试者的睡眠障碍以及用于改善受试者的认知功能的方法。在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢表雄酮（DHEA），孕酮（PROG），其前体，其代谢物，其可接受的盐，其衍生物或其组合。

8. 发明申请

US20080241255A1 DEVICE AND METHOD FOR DELIVERY OF A MEDICAMENT 审中-公开
标题翻译：用于递送药物的装置和方法
公开(公告)号：US20080241255A1
公开(公告)日：2008-10-02
申请号：US12054883
申请日：2008-03-25
申请人： JED E. ROSE , Seth D. Rose , James E. Turner , Thangaraju Murugesan
发明人： JED E. ROSE , Seth D. Rose , James E. Turner , Thangaraju Murugesan
IPC分类号： A61K9/14 , A61K31/4439 , A61P25/34 , A61M15/06
摘要： The disclosure relates to a method of enhancing nicotine or other medicament concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine or other medicaments for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.
摘要翻译：本公开涉及一种在气态载体中增强尼古丁或其他药物浓度的方法。该方法适用于尼古丁或其他药物的递送，用于各种疾病中的治疗效果，特别是用于烟草制品停止，替代和/或伤害减少的尼古丁。本公开进一步涉及用于实施这些方法的各种设备和设备设计原理。

9. 发明授权

US06595209B1 Dry powder delivery system 失效
标题翻译：干粉输送系统
公开(公告)号：US06595209B1
公开(公告)日：2003-07-22
申请号：US09016262
申请日：1998-01-30
申请人： Jed E. Rose , Frederique Behm , James Turner
发明人： Jed E. Rose , Frederique Behm , James Turner
IPC分类号： A61M1500
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system and method for use, the system having an elongated tube containing a matrix having a measured amount of dry particles of a therapeutic compound and a porous element having a desiccant therein. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
摘要翻译：一种干粉输送系统和使用方法，该系统具有细长管，该细管包含具有测量量的治疗化合物干燥颗粒的基质和在其中具有干燥剂的多孔元件。具有干燥剂的多孔元件可以与含粉末的基质组合，或者它可以是两个分开的元素。吸入使用者引起的压降导致空气流过管并与干粉颗粒接触，用于排出用户吸入的颗粒。

10. 发明授权

US5861422A Agonist-antagonist combination to reduce the use of nicotine and other drugs 失效
标题翻译：激动剂 - 拮抗剂组合，以减少使用尼古丁和其他药物
公开(公告)号：US5861422A
公开(公告)日：1999-01-19
申请号：US722675
申请日：1996-09-30
申请人： Jed E. Rose , Edward D. Levin
发明人： Jed E. Rose , Edward D. Levin
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00 , A61K31/44 , A61K31/465 , A61K47/48
CPC分类号： B82Y5/00 , A24B15/16 , A24B15/165 , A24B15/18 , A24F47/008 , A61K47/48738 , Y10S514/81 , Y10S514/812 , Y10S514/813 , Y10S514/922 , Y10S514/947
摘要： A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially, simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist. In another embodiment, the drug or its other agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence.
摘要翻译：提供了治疗和减少药物依赖性的方法，例如尼古丁依赖性。该方法包括首先向受试者施用一定量的药物，例如尼古丁或另一种药物激动剂，其量通常将提供所需的药理作用并且至少部分地满足使用者对药物的需要。该方法还包括以足以至少部分阻断药物或其其它激动剂的药理作用的量将药物或其它激动剂的拮抗剂施用给受试者，同时存在大量的药物或其它激动剂用户的系统。在本发明的一个实施方案中，药物和拮抗剂基本上同时施用以便占据该药物用量的大部分受体，从而阻断或减弱药物或其它激动剂的任何进一步摄入的影响。在另一个实施方案中，首先施用药物或其它激动剂，并且拮抗剂以模仿药物使用的方式由受试者自身给药，从而使药物使用者对与正常给药相关的刺激进行反调节药物。本发明还提供治疗性治疗涉及神经元失调的心理生理疾病和病症的方法。该方法另外提供用于治疗和减少药物依赖性的药理学组合物。

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