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    • 2. 发明授权
    • Dry powder delivery system
    • 干粉输送系统
    • US5746227A
    • 1998-05-05
    • US483540
    • 1995-06-07
    • Jed E. RoseFrederique BehmJames Turner
    • Jed E. RoseFrederique BehmJames Turner
    • A24F47/00A61K9/00A61M15/00A61M15/06
    • A61K9/007A24F47/002A61M11/001A61M15/00A61M15/0006A61M15/0028A61M15/0036A61M15/0041A61M15/06A61M2202/062A61M2202/064Y10T137/5196
    • A method for delivering dry powder particles through the mouth of a user, in which a suction is created through an opening in a proximal end of an elongated housing for drawing air into a flow path in the housing from an opening in a distal end of the housing, the distal end including an opening in the housing with a ridge surrounding the housing, and through a resistance member in the housing for introducing a controlled pressure drop in the housing and a resistance to the drawing of air into the mouth of the user. A measured amount of dry powder particles having a therapeutic capability, is introduced into the housing so that the particles will travel downstream from the resistance member at a relatively low velocity in a non-agglomerated state, the dry powder particles being sized and coordinated with the controlled pressure drop so that the particles can be drawn into the mouth of the user and inhaled, with the resistance being sufficiently great that the particles are drawn into the mouth of the user to simulate the action of puffing on a cigarette so that at least some of the particles are deposited in the oral cavity and upper respiratory tract of the user after being drawn into the mouth.
    • 一种用于将干燥粉末颗粒输送通过使用者口腔的方法,其中通过细长壳体的近端中的开口产生吸力,用于从空腔的远端中的开口将空气吸入壳体中的流动路径 所述远端包括在所述壳体中的开口,所述开口具有围绕所述壳体的脊,并且通过所述壳体中的阻力构件,用于在所述壳体中引入受控的压降并且阻止将空气抽吸到所述使用者的口中。 将测量量的具有治疗能力的干粉颗粒引入壳体中,使得颗粒将以非聚集状态的相对较低的速度从阻力构件下游移动,干粉颗粒的尺寸和配合与 控制的压降使得颗粒可以被吸入使用者的嘴中并被吸入,其阻力足够大,使得颗粒被吸入使用者的口中以模拟在香烟上膨化的作用,使得至少一些 的颗粒在吸入口腔后沉积在使用者的口腔和上呼吸道中。