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1. 发明申请

US20120215303A1 REPLACEMENT HEART VALVE AND METHOD 有权
标题翻译：更换心瓣和方法
公开(公告)号：US20120215303A1
公开(公告)日：2012-08-23
申请号：US13403929
申请日：2012-02-23
申请人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
发明人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2427 , A61F2/2439 , A61F2210/0014 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/0071
摘要： A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.
摘要翻译：替换心脏瓣膜具有被构造成接合天然瓣膜环的可膨胀框架和安装到可扩张框架的阀体。阀体可以具有多个阀单元，其构造成打开以允许在第一方向上流动并且彼此接合，以便关闭并防止在第二方向上流动，第二方向与第一方向相反。

2. 发明申请

US20120078353A1 REPLACEMENT HEART VALVES, DELIVERY DEVICES AND METHODS 有权
标题翻译：更换心阀，输送装置和方法
公开(公告)号：US20120078353A1
公开(公告)日：2012-03-29
申请号：US13244080
申请日：2011-09-23
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

3. 发明申请

US20160135948A1 DELIVERY SYSTEM FOR VASCULAR IMPLANT 有权
公开(公告)号：US20160135948A1
公开(公告)日：2016-05-19
申请号：US15004823
申请日：2016-01-22
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24 , A61F2/95
CPC分类号： A61F2/246 , A61F2/2418 , A61F2/243 , A61F2/2439 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067
摘要： A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.

4. 发明申请

US20120083828A1 Apparatus and method for delivery of biological sealant 审中-公开
标题翻译：用于输送生物密封剂的装置和方法
公开(公告)号：US20120083828A1
公开(公告)日：2012-04-05
申请号：US13200060
申请日：2011-09-16
申请人： John L. Wheeler , Gary Whipple , A. David Boccuti , Thomas T. Washburn , Andrew Nicholas Gentile , J. Brent Ratz , John Spiridigliozzi
发明人： John L. Wheeler , Gary Whipple , A. David Boccuti , Thomas T. Washburn , Andrew Nicholas Gentile , J. Brent Ratz , John Spiridigliozzi
IPC分类号： A61B17/03 , B23P17/04
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61K38/363 , A61K38/482 , A61K45/06 , A61L24/106 , A61L27/225 , A61L27/50 , A61L27/54 , A61L2300/00 , A61L2400/06 , A61L2430/38 , B05C17/00553 , B05C17/0116 , Y10T29/49826 , A61K2300/00
摘要： A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.
摘要翻译：一种用于输送生物材料的装置，包括：具有用于待输送流体的至少两个气缸孔的筒，其中每个气缸包括用于流体的出口，用于将流体推出气缸的每个气缸内的柱塞，壳体，其适于接收所述盒，其中所述壳体或盒包括用于容纳和锁定歧管的适配器，所述歧管可操作地连接到所述药筒的出口，至少两个齿状的公柱，其中每个齿状的压头至少部分地在汽缸孔内触发器，其连接到所述壳体，其中所述触发器包括齿形驱动齿条，与所述齿形驱动齿条和所述齿状凸起协作的齿轮组件，以及制造所述装置的方法，使用所述装置的方法来治疗光盘，套件，包括设备。

5. 发明授权

US09730790B2 Replacement valve and method 有权
公开(公告)号：US09730790B2
公开(公告)日：2017-08-15
申请号：US13403929
申请日：2012-02-23
申请人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
发明人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2427 , A61F2/2439 , A61F2210/0014 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/0071
摘要： A replacement valve has an expandable frame configured to engage a native valve and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

6. 发明授权

US08414644B2 Vascular implant and delivery system 有权
标题翻译：血管植入和输送系统
公开(公告)号：US08414644B2
公开(公告)日：2013-04-09
申请号：US12761349
申请日：2010-04-15
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A compacted vascular implant can be delivered to a target location within a delivery device. During delivery, the implant can be partially released from the delivery device before full deployment. The delivery device can include an elongated support tube, a locking mechanism, and a sheath. The locking mechanism can be provided on the support tube. The sheath can be configured to slide over the elongated support tube and can be configured to cover the locking mechanism and to restrain at least a portion of the implant.
摘要翻译：压实的血管植入物可以递送到输送装置内的目标位置。在输送期间，在完全展开之前，植入物可以从输送装置部分地释放。输送装置可以包括细长支撑管，锁定机构和护套。锁定机构可以设置在支撑管上。护套可以被配置成在细长支撑管上滑动，并且可以构造成覆盖锁定机构并且限制植入物的至少一部分。

7. 发明授权

US08337541B2 Delivery system for vascular implant 有权
标题翻译：输血系统用于血管植入
公开(公告)号：US08337541B2
公开(公告)日：2012-12-25
申请号：US12572180
申请日：2009-10-01
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/84
CPC分类号： A61F2/246 , A61F2/2418 , A61F2/243 , A61F2/2439 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067
摘要： A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.
摘要翻译：描述了一种治疗系统和治疗方法，其具有能够定位和展开的植入物，然后去除部署以允许植入物的重新定位。该系统包括自动扩张的医用植入物，其在从径向压实状态径向膨胀时纵向缩短，构造成将植入物附接到输送装置的远端安装件的远端界面，以及被配置为将植入物附接到近端输送装置的安装。将远端安装件纵向远离近侧安装件移动，对植入物施加纵向张力，使得植入物纵向膨胀并径向收缩，并使远端安装件向近端安装件移动，减小了植入物中的纵向张力，使植入物径向扩张一个完全扩张的状态。

8. 发明申请

US20100298931A1 VASCULAR IMPLANT AND DELIVERY SYSTEM 有权
标题翻译：血管植入和输送系统
公开(公告)号：US20100298931A1
公开(公告)日：2010-11-25
申请号：US12761349
申请日：2010-04-15
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant is verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

9. 发明授权

US08403983B2 Heart valve 有权
标题翻译：心脏瓣膜
公开(公告)号：US08403983B2
公开(公告)日：2013-03-26
申请号：US12569856
申请日：2009-09-29
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/848 , A61F2002/8483 , A61F2002/8486 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , Y10T29/49426
摘要： A replacement heart valve can comprise a valve body and an elongate frame. The valve body can define a plurality of leaflets adapted to move between an open state and a coapted state. The elongate frame can be configured to move between a radially compacted state and a radially expanded state, the frame comprising a plurality of struts. Stitches attach the valve body to the plurality of struts. At least one of the stitches can be a loose stitch configured to freely slide over the corresponding strut when the frame is moved between the radially compacted and radially expanded states.
摘要翻译：替换心脏瓣膜可包括阀体和细长框架。阀体可以限定适于在打开状态和受压状态之间移动的多个传单。细长框架可构造成在径向压实状态和径向膨胀状态之间移动，框架包括多个支柱。接头将阀体附接到多个支柱。当框架在径向压实和径向膨胀状态之间移动时，至少一个线圈可以是构造成在相应的支柱上自由滑动的松线圈。

10. 发明授权

US08652203B2 Replacement heart valves, delivery devices and methods 有权
标题翻译：更换心脏瓣膜，输送装置和方法
公开(公告)号：US08652203B2
公开(公告)日：2014-02-18
申请号：US13244080
申请日：2011-09-23
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

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