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1. 发明申请

US20090227949A1 BALLOON CATHETER DEVICES WITH FOLDED BALLOONS 有权
标题翻译：具有折叠气球的气缸导管装置
公开(公告)号：US20090227949A1
公开(公告)日：2009-09-10
申请号：US12399548
申请日：2009-03-06
申请人： David Knapp , Timothy J. Mickley , John Chen , Derek Sutermeister , Toby Freyman , Gordon Kocur , Daniel Horn , Jim Anderson , Ben Arcand , Jay Rassat , Raed Rizq , Irina Nazarova , Dan Quillin , Jan Weber , Torsten Scheuermann
发明人： David Knapp , Timothy J. Mickley , John Chen , Derek Sutermeister , Toby Freyman , Gordon Kocur , Daniel Horn , Jim Anderson , Ben Arcand , Jay Rassat , Raed Rizq , Irina Nazarova , Dan Quillin , Jan Weber , Torsten Scheuermann
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. The balloon has one or more folds which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊的导管装置。气囊具有一个或多个折叠，其用作容纳治疗剂的储存器。折叠可以具有保持治疗剂的各种构造中的任何一种。在一些情况下，气囊包括形成褶皱的一个或多个凸起。治疗剂可以以各种方式提供。例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

2. 发明授权

US08439961B2 Stent retaining mechanisms 有权
标题翻译：支架保持机构
公开(公告)号：US08439961B2
公开(公告)日：2013-05-14
申请号：US11496249
申请日：2006-07-31
申请人： Karl A. Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
发明人： Karl A. Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system comprises a catheter comprising a distal portion, a proximal portion and an inner shaft. The inner shaft comprises a medical device receiving region for receiving and carrying a medical device. The retaining device is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical device receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the activated state and the inactivated state.
摘要翻译：导管系统包括导管，其包括远侧部分，近端部分和内部轴。内轴包括用于接收和携带医疗装置的医疗装置接收区域。保持装置至少部分地由电活性聚合物构成。保持装置位于或邻近医疗装置接收区域。保持装置的电活性聚合物具有活化状态和失活状态。保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换而将医疗装置从导管释放。

3. 发明申请

US20080027528A1 Stent retaining mechanisms 有权
标题翻译：支架保持机构
公开(公告)号：US20080027528A1
公开(公告)日：2008-01-31
申请号：US11496249
申请日：2006-07-31
申请人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
发明人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system comprises a catheter comprising a distal portion, a proximal portion and an inner shaft. The inner shaft comprises a medical device receiving region for receiving and carrying a medical device. The retaining device is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical device receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the activated state and the inactivated state.
摘要翻译：导管系统包括导管，其包括远侧部分，近端部分和内部轴。内轴包括用于接收和携带医疗装置的医疗装置接收区域。保持装置至少部分地由电活性聚合物构成。保持装置位于或邻近医疗装置接收区域。保持装置的电活性聚合物具有活化状态和失活状态。保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换而将医疗装置从导管释放。

4. 发明授权

US08740844B2 Medical device with drug delivery member 失效
标题翻译：医疗器械配药
公开(公告)号：US08740844B2
公开(公告)日：2014-06-03
申请号：US10645653
申请日：2003-08-20
申请人： Toby Freyman , Timothy J. Mickley , Maria J. Palasis , Wendy Naimark
发明人： Toby Freyman , Timothy J. Mickley , Maria J. Palasis , Wendy Naimark
IPC分类号： A61M31/00 , A61M29/02
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/0057 , A61M2025/105
摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。还可以设置保持构件以选择性地折叠输送构件。

5. 发明申请

US20120010589A1 LOCAL DELIVERY OF THERAPEUTIC AGENT TO HEART VALVES 有权
标题翻译：将治疗剂局部输送到心脏瓣膜
公开(公告)号：US20120010589A1
公开(公告)日：2012-01-12
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
IPC分类号： A61M5/00
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译：本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。在一个实施例中，提供了包括身体的医疗装置。身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。然后释放的治疗剂可以被递送到心脏瓣膜。

6. 发明授权

US07758587B2 Medical device guidance from an anatomical reference 有权
标题翻译：医疗设备指导从解剖参考
公开(公告)号：US07758587B2
公开(公告)日：2010-07-20
申请号：US10680288
申请日：2003-10-08
申请人： Toby Freyman , Timothy J. Mickley
发明人： Toby Freyman , Timothy J. Mickley
IPC分类号： A61F4/00
CPC分类号： A61M25/01 , A61B5/061 , A61M25/0105
摘要： A system and method for simply and reliably determining the location and orientation of a medical device within a patient's body. A medical device, such as a catheter, has bending indicators on or imbedded in its wall, and passes through an anatomical reference of known orientation relative to a target site within the patient. Information from the tube bending indicators permits determination of the orientation of a feature, such as an orifice, at the distal end of the medical device relative to the anatomical reference. From the known orientation of the anatomical reference, and information on the location and orientation of the distal end of the medical device obtained from fluoroscopic imaging from a single direction, the physician may reliably determine the orientation of the distal feature relative to the target site, eliminating the need for imaging from multiple directions.
摘要翻译：一种用于简单且可靠地确定患者体内的医疗装置的位置和方向的系统和方法。诸如导管的医疗装置在其壁上具有或嵌入其中的弯曲指示器，并且相对于患者内的目标部位通过已知取向的解剖参考。来自管弯曲指示器的信息允许在医疗装置的远端处相对于解剖参考确定诸如孔的特征的取向。从已知的解剖学参考方向，以及关于从单一方向从透视成像获得的医疗装置的远端的位置和方位的信息，医师可以可靠地确定远侧特征相对于目标部位的方向，消除了从多个方向进行成像的需要。

7. 发明授权

US07686788B2 Catheter having a distal drug delivery unit and method of using same 失效
标题翻译：具有远端药物递送单元的导管及其使用方法
公开(公告)号：US07686788B2
公开(公告)日：2010-03-30
申请号：US11070190
申请日：2005-03-03
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , Timothy J. Mickley
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , Timothy J. Mickley
IPC分类号： A61M5/00
CPC分类号： A61M25/0082 , A61M5/14526 , A61M5/14593 , A61M5/148 , A61M5/1483 , A61M25/0074 , A61M25/0084 , A61M2025/0091
摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
摘要翻译：一种在其远端具有药物输送单元的导管。药物递送单元包括能够承受激活和非活化构型的致动器。药物递送单元还包括能够接受治疗剂的容器。致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

8. 发明申请

US20090131906A1 METHOD, SYSTEM, APPARATUS, AND KIT FOR REMOTE THERAPEUTIC DELIVERY 审中-公开
标题翻译：方法，系统，设备和远程治疗手段
公开(公告)号：US20090131906A1
公开(公告)日：2009-05-21
申请号：US12358337
申请日：2009-01-23
申请人： Toby FREYMAN , Maria Palasis , Timothy J. Mickley
发明人： Toby FREYMAN , Maria Palasis , Timothy J. Mickley
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61B17/12136 , A61B2017/22067 , A61M25/0032 , A61M25/0045 , A61M25/1002 , A61M2025/0004 , A61M2025/0034 , A61M2025/0076 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052
摘要： A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic.
摘要翻译：提供了用于将治疗剂递送到目标位置的治疗性递送导管系统方法或试剂盒。在本发明的各种实施例中，本发明可以包括具有治疗性输送腔和治疗性输送孔的导管。管腔和孔可以彼此流体连通，并且可以被配置成使得通过其传递的治疗可以在模拟接收治疗剂的目标位置处存在或以其他方式正常的压力下进行。在一些实施例中，导管可以是套件的一部分，其可以包括关于导管的适当操作方式的指令。这些说明书可以包括用于治疗性递送以及递送时间的建议目标压力，以及设备在递送之后驻留在目标区域的建议时间长度，以允许治疗剂的适当摄取。

9. 发明授权

US08808364B2 Local delivery of therapeutic agent to heart valves 有权
标题翻译：局部向心脏瓣膜递送治疗剂
公开(公告)号：US08808364B2
公开(公告)日：2014-08-19
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译：本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。在一个实施例中，提供了包括身体的医疗装置。身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。然后释放的治疗剂可以被递送到心脏瓣膜。

10. 发明授权

US07938799B2 Medical device for vessel compatibility during high pressure infusion 失效
标题翻译：用于高压输注期间血管相容性的医疗装置
公开(公告)号：US07938799B2
公开(公告)日：2011-05-10
申请号：US11780885
申请日：2007-07-20
申请人： Samuel J. Epstein , Toby Freyman , Chad G. Harris , Timothy J. Mickley
发明人： Samuel J. Epstein , Toby Freyman , Chad G. Harris , Timothy J. Mickley
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M29/02 , A61B17/12022 , A61B17/1204 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B2017/1205 , A61M2025/0024 , A61M2025/1052 , A61M2025/1081 , A61M2025/1095
摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.
摘要翻译：本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。这允许递送具有降低治疗部位损伤风险的治疗剂。本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

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