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1. 发明授权

US08021130B2 Apparatus and method for handling fluids at nano-scale rates 有权
标题翻译：用于处理纳米级流体的装置和方法
公开(公告)号：US08021130B2
公开(公告)日：2011-09-20
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B17/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

2. 发明授权

US07933012B2 Microfluidic chip apparatuses, systems and methods having fluidic and fiber optic interconnections 有权
标题翻译：具有流体和光纤互连的微流控芯片装置，系统和方法
公开(公告)号：US07933012B2
公开(公告)日：2011-04-26
申请号：US11719527
申请日：2006-08-10
申请人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
发明人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
IPC分类号： G01N1/10
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , G01N2021/0346 , G02B6/10 , G02B6/1228 , G02B6/305 , G02B6/3636 , G02B6/3644 , G02B6/3652 , G02B6/3688 , G02B6/3692 , G02B6/3696 , Y10T29/49885
摘要： According to one embodiment, apparatuses and methods are provided for connecting a light-guiding conduit to a microfluidic channel. First and second substrates with first surfaces can be provided, wherein the first surfaces of the first and second substrates form a microfluidic channel and a connection channel when the first surfaces are positioned together, and wherein the connection channel extends from an edge of the first surface of the first or second substrate to the microfluidic channel. The apparatus and method can also include bonding the first surfaces of the first and second substrates to form the microfluidic channel and the connection channel. A light-guiding conduit can be inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel and filling an area between the light-guiding conduit and the connection channel for forming a liquid-tight seal between the light-guiding conduit and the connection channel.
摘要翻译：根据一个实施例，提供了用于将导光管连接到微流体通道的装置和方法。可以提供具有第一表面的第一和第二基底，其中第一和第二基底的第一表面在第一表面位于一起时形成微流体通道和连接通道，并且其中连接通道从第一表面的边缘延伸的第一或第二基底到微流体通道。该装置和方法还可以包括粘合第一和第二基底的第一表面以形成微流体通道和连接通道。导光管可以插入连接通道中，使得导光管连接到微流体通道并且填充导光管和连接通道之间的区域，以在导光管之间形成液密密封导管和连接通道。

3. 发明申请

US20090146380A1 METHODS AND APPARATUSES FOR GENERATING A SEAL BETWEEN A CONDUIT AND A RESERVOIR WELL 审中-公开
标题翻译：用于产生管道和储藏室之间的密封的方法和装置
公开(公告)号：US20090146380A1
公开(公告)日：2009-06-11
申请号：US11719522
申请日：2006-08-10
申请人： Gregory A. Votaw , Kelly Junge , Michael G. Pollack , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Kelly Junge , Michael G. Pollack , Hugh C. Crenshaw
IPC分类号： F16L21/02 , F16J15/00
CPC分类号： F04B19/006 , B01F5/0471 , B01F5/0646 , B01F5/0653 , B01F13/0059 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L2300/044 , B01L2300/0816 , B01L2300/1822 , B01L2300/1883 , B01L2300/1894 , B01L2400/0487 , B01L2400/0677
摘要： Methods and Apparatuses for Generating a Seal Between a Conduit and a Reservoir Well. According to one embodiment, an apparatus is provided for generating a seal between a conduit and a reservoir well. The apparatus can include a mount including a first and second end. The mount can also include a first aperture extending between the first and second ends. The apparatus can also include a tube including a first end engaging the first end of the mount, and operable to hold a conduit having an end such that the conduit extends through the first aperture of the mount and the end of the conduit communicates with a reservoir well. Further, the apparatus can include a nut operable to engage the mount and tube and seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount.
摘要翻译：在管道和储层之间产生密封的方法和装置。根据一个实施例，提供了用于在导管和储存器井之间产生密封的装置。该装置可以包括包括第一端和第二端的安装件。安装件还可以包括在第一和第二端之间延伸的第一孔。该装置还可以包括管，其包括接合安装件的第一端的第一端，并且可操作地保持具有端部的导管，使得导管延伸穿过安装件的第一孔，并且导管的端部与储存器好。此外，该装置可以包括可操作以接合安装件和管并且将导管密封到安装件的第一孔的螺母，使得空气不能从储存器穿过安装件的第一孔而连通。

4. 发明申请

US20090053814A1 MICROFLUIDIC APPARATUS AND METHOD FOR SAMPLE PREPARATION AND ANALYSIS 审中-公开
标题翻译：微流化装置和样品制备和分析方法
公开(公告)号：US20090053814A1
公开(公告)日：2009-02-26
申请号：US11719513
申请日：2006-08-10
申请人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： G01N31/00 , B01J19/00 , G01N21/64
CPC分类号： G05D11/136 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0404 , B01F15/042 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , F04B19/006 , G01N2035/00158 , G05D7/0694 , Y10T436/10
摘要： The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and the reagents mixed to form a reaction product. The reaction product can be measured at one or more detection points defined in the chip. Concentration gradients are continuously varied by continuously varying the flow rates respectively produced by the pumps according to predetermined flow velocity profiles.
摘要翻译：操作泵（Pn）以低流速以非脉动，层流状态将各个试剂流输送到芯片中，允许以0.1nl / min的精度从0降至低至5nl / min。在芯片（MFC）中，将试剂流合并，将试剂混合形成反应产物。可以在芯片中定义的一个或多个检测点处测量反应产物。通过根据预定的流速分布连续改变由泵产生的流量，浓度梯度连续变化。

5. 发明申请

US20090142846A1 METHODS FOR MEASURING BIOCHEMICAL REACTIONS 审中-公开
标题翻译：测量生物化学反应的方法
公开(公告)号：US20090142846A1
公开(公告)日：2009-06-04
申请号：US11719529
申请日：2006-08-10
申请人： Hugh C. Crenshaw , Jennifer Colonell
发明人： Hugh C. Crenshaw , Jennifer Colonell
IPC分类号： G01N33/00 , B01J19/00
CPC分类号： C12Q1/32 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F5/0655 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00885 , B01J2219/00889 , B01J2219/00894 , B01J2219/00896 , B01J2219/00936 , B01J2219/00959 , B01J2219/0097 , B01J2219/00986 , B01L3/5027 , B01L3/565 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K2099/0084 , G01N35/085
摘要： Methods for measuring biochemical reactions and analysis of reaction products by controlling dispersion of reagents within fluid streams such that the measuring of the biochemical reaction is substantially free of a measurable dispersion artifact. Controlling dispersion of reagents within fluid streams can include flowing multiple fluid streams each including reaction reagents into contact through a mixing region to laterally mix the fluid streams and then passing the merged, laterally mixed fluid stream through a controlled dispersion element to axially disperse the reaction reagents merged fluid stream. Controlling dispersion of reagents within fluid streams can include controlling flow rates of multiple fluid streams each including reaction reagents to create a concentration gradient that is substantially free of a measurable dispersion artifact. The biochemical reaction can occur in a microfluidic chip.
摘要翻译：用于通过控制试剂在流体流中的分散来测量生化反应和分析反应产物的方法，使得生物化学反应的测量基本上没有可测量的分散假象。控制试剂在流体流中的分散可以包括使多个流体流流动，每个流体流包括反应试剂通过混合区域接触以横向混合流体流，然后将合并的横向混合的流体流通过受控的分散体，以使反应试剂合并流体流。控制流体流中试剂的分散可以包括控制多个流体流的流速，每个流体流包括反应试剂以产生基本上没有可测量的分散伪影的浓度梯度。生化反应可能发生在微流控芯片中。

6. 发明申请

US20090142198A1 APPARATUS AND METHOD FOR HANDLING FLUIDS AT NANO-SCALE RATES 有权
标题翻译：用于处理纳米尺度流体的装置和方法
公开(公告)号：US20090142198A1
公开(公告)日：2009-06-04
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B49/06 , F04B35/04 , A61M1/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

7. 发明申请

US20090140170A1 MICROFLUIDIC SYSTEMS, DEVICES AND METHODS FOR REDUCING BACKGROUND AUTOFLUORESCENCE AND THE EFFECTS THEREOF 审中-公开
标题翻译：微流体系统，减少背景自动化的装置和方法及其效果
公开(公告)号：US20090140170A1
公开(公告)日：2009-06-04
申请号：US11719526
申请日：2006-08-10
申请人： Joshua T. Nevill , Eric T. Espenhahn , Daniel M. Hartmann , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Joshua T. Nevill , Eric T. Espenhahn , Daniel M. Hartmann , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： H05B33/00 , G01J1/58
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/0816 , B01L2300/0822 , B01L2300/0887 , B01L2300/12 , G01N21/6428 , G01N21/6458
摘要： According to one embodiment, a microfluidic system and method is disclosed for reducing autofluorescence. The microfluidic system can include a light source for generating an excitation light. The microfluidic system can also include a microscope having an objective for focusing the excitation light on a fluid inside a microfluidic channel of a microfluidic chip. Further, the microfluidic system can include a detector for rejecting out-of-focus light emitted from the microfluidic chip.
摘要翻译：根据一个实施方案，公开了用于减少自发荧光的微流体系统和方法。微流体系统可以包括用于产生激发光的光源。微流体系统还可以包括具有将激发光聚焦在微流体芯片的微流体通道内的流体的目的的显微镜。此外，微流体系统可以包括用于拒绝从微流控芯片发射的离焦光的检测器。

8. 发明授权

US06378801B1 Devices and methods for orienting and steering in three-dimensional space 失效
标题翻译：三维空间定向和转向的装置和方法
公开(公告)号：US06378801B1
公开(公告)日：2002-04-30
申请号：US09371485
申请日：1999-08-10
申请人： Charles A. Pell , Hugh C. Crenshaw , Jason Janet , Mathieu Kemp
发明人： Charles A. Pell , Hugh C. Crenshaw , Jason Janet , Mathieu Kemp
IPC分类号： F41G700
CPC分类号： G05D1/108
摘要： A self-orienting device comprises: a housing; a sensor mounted to the housing that is sensitive to a signal field and configured to produce a signal responsive to the signal field; a translation-inducing unit associated with the housing; rotation-inducing unit attached to the housing, wherein the translation-inducing unit and the rotation-inducing unit are configured such that the housing travels along a helical trajectory having an axis and is free to rotate about the axis; and a controller operably associated with the sensor for controlling the output of at least one of the translation-inducing unit and the rotation-inducing unit, wherein the controller is configured such that it receives the signal from the sensor and, responsive to the signal, controls the output of at least one of the translation-inducing unit and said rotation-inducing unit. A device so configured can automatically orient to a signal. In this configuration, orientation is robust—wide variance in the parameters relating &ohgr; to signal intensity are tolerated. In fact, if &ohgr; changes as a function of signal intensity, then orientation to the signal is the only stable outcome. Exemplary signal fields for the device include light, magnetic fields, and gradients of temperature, chemical concentration and depth. The devices can be employed to perform such tasks as locating lost objects, identifying foreign objects, performing transect sampling, guiding munitions, disabling mines, delivering chemical agents, and the like.
摘要翻译：自动定向装置包括：壳体; 安装到壳体的传感器，其对信号场敏感并且被配置为产生响应于信号场的信号; 与壳体相关联的翻译感应单元; 附接到壳体的旋转诱导单元，其中，所述平移感应单元和所述旋转感应单元被构造成使得所述壳体沿着具有轴线的螺旋轨迹行进并且围绕所述轴线自由旋转; 以及与所述传感器可操作地相关联的控制器，用于控制所述转换感应单元和所述旋转感应单元中的至少一个的输出，其中所述控制器被配置为使得所述控制器从所述传感器接收所述信号，并且响应于所述信号，控制转换感应单元和旋转感应单元中的至少一个的输出。如此配置的设备可以自动地定向到信号。在这种配置中，相对于信号强度相关参数的方位是稳健的方差。事实上，如果欧米茄随着信号强度的变化而变化，那么信号的方向是唯一稳定的结果。器件的示例性信号场包括光，磁场和温度梯度，化学浓度和深度。可以使用这些装置执行诸如定位丢失的物体，识别异物，执行横断面取样，引导弹药，禁止地雷，输送化学试剂等的任务。

9. 发明申请

US20090268548A1 MICROFLUIDIC SYSTEMS, DEVICES AND METHODS FOR REDUCING DIFFUSION AND COMPLIANCE EFFECTS AT A FLUID MIXING REGION 审中-公开
标题翻译：微流体系统，用于减少流体混合区域的扩散和合并效应的装置和方法
公开(公告)号：US20090268548A1
公开(公告)日：2009-10-29
申请号：US11719523
申请日：2006-08-10
申请人： Daniel M. Hartmann , Joshua T. Nevill , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Daniel M. Hartmann , Joshua T. Nevill , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： B01F15/02 , B21D51/16
CPC分类号： B01F13/0059 , B01F5/0646 , B01F5/0647 , Y10T29/494
摘要： Microfluidic Systems, Devices and Methods for Reducing Diffusion and Compliance Effects at a Fluid Mixing Region. According to one embodiment, a microfluidic device is provided for combining fluids in a mixing region. The microfluidic device can include a fluid mixing region connected to a first and second microscale channel. The microscale channels can advance fluids to the fluid mixing region. The microscale channels can include constricted flow portions. According to another embodiment, the microscale channels can be connected to waste channels for removing fluid diffused into one of the channels from the other channel. According to yet another embodiment, a microfluidic system is provided for controlling the flow of fluids through the microscale channels for reducing or eliminating diffusion between the channels.
摘要翻译：微流体系统，用于减少流体混合区域的扩散和依从性效应的装置和方法。根据一个实施例，提供了用于在混合区域中组合流体的微流体装置。微流体装置可以包括连接到第一和第二微量通道的流体混合区域。微量通道可以将流体推进到流体混合区域。微型通道可以包括收缩的流动部分。根据另一个实施例，微型通道可以连接到废物通道，用于从另一个通道去除扩散到一个通道中的流体。根据又一个实施例，提供了一种微流体系统，用于控制流经微量通道的流体，以减少或消除通道之间的扩散。

10. 发明申请

US20090145485A1 MICROFLUIDIC METHODS AND APPARATUSES FOR FLUID MIXING AND VALVING 审中-公开
标题翻译：用于流体混合和阀门的微流化方法和装置
公开(公告)号：US20090145485A1
公开(公告)日：2009-06-11
申请号：US11719521
申请日：2006-08-10
申请人： Gregory Fenton Smith , Dawn M. Schmidt , Sara Thrall , David G. Tew , Gregory A. Votaw , Hugh C. Crenshaw , Michael G. Pollack , Christopher David Bevan , Kelly Junge , Mehul Patel
发明人： Gregory Fenton Smith , Dawn M. Schmidt , Sara Thrall , David G. Tew , Gregory A. Votaw , Hugh C. Crenshaw , Michael G. Pollack , Christopher David Bevan , Kelly Junge , Mehul Patel
IPC分类号： G05D7/06 , G05D11/13 , F15C1/02 , F15C4/00 , B81B7/00
CPC分类号： B01F15/0404 , B01F5/0646 , B01F5/0647 , B01F5/0653 , B01F13/0059 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , B01L2300/1894 , B01L2400/0487 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K2099/0084 , G01N30/6095 , G01N35/1097 , Y10T137/0324 , Y10T137/0329 , Y10T137/0391 , Y10T137/218 , Y10T137/2196 , Y10T137/86131 , Y10T137/87652
摘要： According to one embodiment, an apparatus and method for delivering one or more fluids to a microfluidic channel is provided. A microfluidic channel is provided in communication with a first conduit for delivering fluids to the microfluidic channel. Further, the apparatus and method can include a first fluid freeze valve connected to the first conduit and operable to reduce the temperature of the first conduit for freezing fluid in the first conduit such that fluid is prevented from advancing through the first conduit.
摘要翻译：根据一个实施例，提供了将一种或多种流体输送到微流体通道的装置和方法。提供与第一导管连通以将流体输送到微流体通道的微流体通道。此外，该装置和方法可以包括连接到第一管道的第一流体冷冻阀，并可操作以降低第一管道的温度，以冷冻第一管道中的流体，以防止流体通过第一管道前进。

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