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1. 发明申请

US20090053814A1 MICROFLUIDIC APPARATUS AND METHOD FOR SAMPLE PREPARATION AND ANALYSIS 审中-公开
标题翻译：微流化装置和样品制备和分析方法
公开(公告)号：US20090053814A1
公开(公告)日：2009-02-26
申请号：US11719513
申请日：2006-08-10
申请人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： G01N31/00 , B01J19/00 , G01N21/64
CPC分类号： G05D11/136 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0404 , B01F15/042 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , F04B19/006 , G01N2035/00158 , G05D7/0694 , Y10T436/10
摘要： The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and the reagents mixed to form a reaction product. The reaction product can be measured at one or more detection points defined in the chip. Concentration gradients are continuously varied by continuously varying the flow rates respectively produced by the pumps according to predetermined flow velocity profiles.
摘要翻译：操作泵（Pn）以低流速以非脉动，层流状态将各个试剂流输送到芯片中，允许以0.1nl / min的精度从0降至低至5nl / min。在芯片（MFC）中，将试剂流合并，将试剂混合形成反应产物。可以在芯片中定义的一个或多个检测点处测量反应产物。通过根据预定的流速分布连续改变由泵产生的流量，浓度梯度连续变化。

2. 发明授权

US08021130B2 Apparatus and method for handling fluids at nano-scale rates 有权
标题翻译：用于处理纳米级流体的装置和方法
公开(公告)号：US08021130B2
公开(公告)日：2011-09-20
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B17/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

3. 发明申请

US20090142198A1 APPARATUS AND METHOD FOR HANDLING FLUIDS AT NANO-SCALE RATES 有权
标题翻译：用于处理纳米尺度流体的装置和方法
公开(公告)号：US20090142198A1
公开(公告)日：2009-06-04
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B49/06 , F04B35/04 , A61M1/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

4. 发明申请

US20090145485A1 MICROFLUIDIC METHODS AND APPARATUSES FOR FLUID MIXING AND VALVING 审中-公开
标题翻译：用于流体混合和阀门的微流化方法和装置
公开(公告)号：US20090145485A1
公开(公告)日：2009-06-11
申请号：US11719521
申请日：2006-08-10
申请人： Gregory Fenton Smith , Dawn M. Schmidt , Sara Thrall , David G. Tew , Gregory A. Votaw , Hugh C. Crenshaw , Michael G. Pollack , Christopher David Bevan , Kelly Junge , Mehul Patel
发明人： Gregory Fenton Smith , Dawn M. Schmidt , Sara Thrall , David G. Tew , Gregory A. Votaw , Hugh C. Crenshaw , Michael G. Pollack , Christopher David Bevan , Kelly Junge , Mehul Patel
IPC分类号： G05D7/06 , G05D11/13 , F15C1/02 , F15C4/00 , B81B7/00
CPC分类号： B01F15/0404 , B01F5/0646 , B01F5/0647 , B01F5/0653 , B01F13/0059 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , B01L2300/1894 , B01L2400/0487 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K2099/0084 , G01N30/6095 , G01N35/1097 , Y10T137/0324 , Y10T137/0329 , Y10T137/0391 , Y10T137/218 , Y10T137/2196 , Y10T137/86131 , Y10T137/87652
摘要： According to one embodiment, an apparatus and method for delivering one or more fluids to a microfluidic channel is provided. A microfluidic channel is provided in communication with a first conduit for delivering fluids to the microfluidic channel. Further, the apparatus and method can include a first fluid freeze valve connected to the first conduit and operable to reduce the temperature of the first conduit for freezing fluid in the first conduit such that fluid is prevented from advancing through the first conduit.
摘要翻译：根据一个实施例，提供了将一种或多种流体输送到微流体通道的装置和方法。提供与第一导管连通以将流体输送到微流体通道的微流体通道。此外，该装置和方法可以包括连接到第一管道的第一流体冷冻阀，并可操作以降低第一管道的温度，以冷冻第一管道中的流体，以防止流体通过第一管道前进。

5. 发明授权

US07897330B2 Methods for characterizing enzyme inhibitors 有权
标题翻译：表征酶抑制剂的方法
公开(公告)号：US07897330B2
公开(公告)日：2011-03-01
申请号：US11719528
申请日：2006-08-10
申请人： Mehul Patel , Dawn M. Schmidt , Sara H. Thrall , David G. Tew
发明人： Mehul Patel , Dawn M. Schmidt , Sara H. Thrall , David G. Tew
IPC分类号： C12Q1/00
CPC分类号： C12Q1/25 , B01L3/50273 , B01L2300/16 , B01L2300/1827 , B01L2400/0478 , G01N33/53 , G01N33/54393 , G01N2500/02
摘要： Methods for characterizing a biochemical reaction and analysis of reaction products by establishing continuously variable concentration gradients of one or more reagents of the biochemical reaction are provided. Methods for determining mechanism of inhibition or activation, potency of inhibition or activation, or both of an enzyme inhibitor or activator, respectively, are also provided. The continuously variable concentration gradients can be established in a microfluidic chip.
摘要翻译：提供了通过建立生化反应的一种或多种试剂的连续可变浓度梯度来表征生物化学反应和反应产物分析的方法。还提供了用于分别确定抑制或活化机制，抑制或活化能力或酶抑制剂或活化剂两者的方法。可以在微流控芯片中建立连续可变的浓度梯度。

6. 发明申请

US20090148858A1 METHODS FOR CHARACTERIZING BIOLOGICAL MOLECULE MODULATORS 有权
标题翻译：表征生物分子调节剂的方法
公开(公告)号：US20090148858A1
公开(公告)日：2009-06-11
申请号：US11719528
申请日：2006-08-10
申请人： Mehul Patel , Dawn M. Schmidt , Sara H. Thrall , David G. Tew
发明人： Mehul Patel , Dawn M. Schmidt , Sara H. Thrall , David G. Tew
IPC分类号： G01N33/53
CPC分类号： C12Q1/25 , B01L3/50273 , B01L2300/16 , B01L2300/1827 , B01L2400/0478 , G01N33/53 , G01N33/54393 , G01N2500/02
摘要： Methods for characterizing a biochemical reaction and analysis of reaction products by establishing continuously variable concentration gradients of one or more reagents of the biochemical reaction are provided. Methods for determining mechanism of inhibition or activation, potency of inhibition or activation, or both of an enzyme inhibitor or activator, respectively, are also provided. The continuously variable concentration gradients can be established in a microfluidic chip.
摘要翻译：提供了通过建立生化反应的一种或多种试剂的连续可变浓度梯度来表征生物化学反应和反应产物分析的方法。还提供了用于分别确定抑制或活化机制，抑制或活化能力或酶抑制剂或活化剂两者的方法。可以在微流控芯片中建立连续可变的浓度梯度。

7. 发明授权

US10161742B2 Range finder 有权
公开(公告)号：US10161742B2
公开(公告)日：2018-12-25
申请号：US12963466
申请日：2010-12-08
申请人： Mehul Patel , Edward Douglas Hatton , Xinping Liu , Paul R. Poloniewicz
发明人： Mehul Patel , Edward Douglas Hatton , Xinping Liu , Paul R. Poloniewicz
IPC分类号： G01B11/06 , G01B11/25
摘要： A system and method for measuring a height of objects on a moving surface comprising providing a linear image sensor positioned transverse to a direction of travel of the moving surface, and at least one light source positioned collinear to the linear image sensor and proximate to an edge of the moving surface so that the light source projects a unique patterned light sequence across a width of the moving surface, detecting a transverse shift in a portion of the unique patterned light sequence with respect to the direction of travel of the moving surface as an object passes through the unique patterned light sequence, determining an amount of shift of the portion of the unique patterned light sequence, and determining a height of the object based on the portion of the unique patterned light sequence shift.

8. 发明申请

US20170173015A1 PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS 有权
公开(公告)号：US20170173015A1
公开(公告)日：2017-06-22
申请号：US15300405
申请日：2015-03-27
申请人： Christopher S. BURGEY , Jeffrey F. FRITZEN , Jaume BALSELLS , Mehul PATEL , Merck Sharp & Dohme Corp.
发明人： Christopher S. Burgey , Jeffrey F. Fritzen , Jaume Balsells , Mehul Patel
IPC分类号： A61K31/506 , C07D403/06 , A61K45/06
CPC分类号： A61K31/506 , A61K31/501 , A61K31/513 , A61K45/06 , C07D237/22 , C07D239/47 , C07D403/06
摘要： Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

9. 发明授权

US09541106B1 Plasma optimized aerostructures for efficient flow control 有权
标题翻译：等离子体优化航空结构，实现有效的流量控制
公开(公告)号：US09541106B1
公开(公告)日：2017-01-10
申请号：US11710750
申请日：2007-02-26
申请人： Mehul Patel , Thomas Corke , Alan B. Cain
发明人： Mehul Patel , Thomas Corke , Alan B. Cain
IPC分类号： B64C29/00 , F15D1/00 , B64C21/00
CPC分类号： F15D1/0065 , B64C15/14 , B64C21/00 , B64C2230/12 , F15D1/0075 , Y02T50/166
摘要： The present invention relates to a method of designing or optimizing a control surface for use with plasma actuators for controlling an aircraft, missile, munition or automobile, and more particularly to controlling fluid flow across their surfaces or other surfaces using plasma actuators, which would benefit from such a method. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and automobiles. The method of flow control also provides a means for reducing aircraft, missile's, munition's and automobile's power requirements. These methods also provide alternate means for aerodynamic control using low-power hingeless plasma actuator devices.
摘要翻译：本发明涉及一种设计或优化用于控制飞机，导弹，弹药或汽车的等离子体致动器的控制表面的方法，更具体地涉及使用等离子致动器来控制流过其表面或其它表面的流体，这将有利于从这样的方法。各种实施例提供了增加飞机，导弹，弹药和汽车的效率的步骤。流量控制方法还为减少飞机，导弹，弹药和汽车的电力需求提供了手段。这些方法还提供了使用低功率无铰链等离子体致动器装置的空气动力学控制的替代方法。

10. 发明授权

US08267355B1 Method of controlling aircraft, missiles, munitions and ground vehicles with plasma actuators 有权
标题翻译：用等离子执行器控制飞机，导弹，弹药和地面车辆的方法
公开(公告)号：US08267355B1
公开(公告)日：2012-09-18
申请号：US13094872
申请日：2011-04-27
申请人： Mehul Patel , Thomas C. Corke
发明人： Mehul Patel , Thomas C. Corke
IPC分类号： B64C23/00 , B64C21/00 , F42B15/01
CPC分类号： B64C23/005 , B62D35/007 , B64C2230/12 , F42B10/38 , F42B10/40 , F42B10/668 , Y02T50/166
摘要： A method of controlling an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly of controlling fluid flow across their surfaces or other surfaces which would benefit from such a method, includes the design of an aerodynamic plasma actuator for the purpose of controlling airflow separation over a control surface of a aircraft, missile, or a ground vehicle, and a method of determining a modulation frequency for the plasma actuator for the purpose of fluid flow control over these vehicles. Various embodiments provide steps to increase the efficiency of aircraft, missiles, munitions and ground vehicles. The method of flow control reduces the power requirements of the aircraft, missile, munition and or ground vehicle. These methods also provide alternative aerodynamic control using low-power hingeless plasma actuator devices.
摘要翻译：使用等离子体致动器控制飞机，导弹，弹药或地面车辆的方法，更具体地说是控制流过其表面或将受益于这种方法的其它表面的流体流动的方法包括设计空气动力学等离子体致动器，目的在于控制飞机，导弹或地面车辆的控制表面上的气流分离，以及为了在这些车辆上进行流体流动控制的目的，确定等离子体致动器的调制频率的方法。各种实施例提供了增加飞机，导弹，弹药和地面车辆的效率的步骤。流量控制的方法降低了飞机，导弹，弹药和地面车辆的电力需求。这些方法还提供使用低功率无铰链等离子体致动器装置的替代空气动力学控制。

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