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1. 发明申请

US20170173105A1 AUTOASSEMBLING PEPTIDES FOR THE TREATMENT OF PULMONARY LEAKAGE 审中-公开
公开(公告)号：US20170173105A1
公开(公告)日：2017-06-22
申请号：US15124638
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
发明人： Manav Mehta , Hisashi Tsukada , Eun Seok Gil , Karl Patrick Gilbert , Satoru Kobayashi
IPC分类号： A61K38/07 , A61L26/00
CPC分类号： A61K38/07 , A61K2121/00 , A61L26/0047 , A61L26/008 , A61L2400/06
摘要： Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.

2. 发明申请

US20170072008A1 AUTOASSEMBLING PEPTIDES FOR THE TREATMENT OF PULMONARY BULLA 审中-公开
标题翻译：用于治疗肺栓塞的自动化用途
公开(公告)号：US20170072008A1
公开(公告)日：2017-03-16
申请号：US15124636
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
发明人： Manav Mehta , Hisashi Tsukada , Eun Seok Gil , Karl Patrick Gilbert , Satoru Kobayashi
IPC分类号： A61K38/16 , A61B17/34 , A61M16/04 , A61K38/08 , A61K38/10
CPC分类号： A61K38/16 , A61B17/34 , A61K38/08 , A61K38/10 , A61M16/0463
摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
摘要翻译：提供了治疗肺泡的材料和方法。在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。可以在目标部位提供水凝胶屏障以便治疗肺大疱。

3. 发明授权

US08009297B2 Optical image measuring apparatus 有权
标题翻译：光学图像测量装置
公开(公告)号：US08009297B2
公开(公告)日：2011-08-30
申请号：US12086280
申请日：2006-11-07
申请人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hisashi Tsukada
发明人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hisashi Tsukada
IPC分类号： G01B9/02
CPC分类号： G01B9/02067 , G01B9/02014 , G01B9/02069 , G01B9/02081 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/70 , G01N21/21 , G01N21/4795
摘要： Provided is an optical image measuring apparatus capable of obtaining a high-accuracy image without being influenced by a movement of an object to be measured. Flash light is emitted from a xenon lamp (2) and converted into broad band light by an optical filter (2A). A polarization characteristic of the flash light is converted into linear polarization by a polarizing plate (3). Then, the flash light is divided into signal light (S) and reference light (R) by a half mirror (6). A polarization characteristic of the reference light (R) is converted into circular polarization by a wavelength plate (7). The signal light (S) and the reference light (R) are superimposed on each other by the half mirror (6) to produce interference light (L). A CCD (23) detects interference light having the same characteristic as that of the produced interference light (L). The produced interference light (L) is divided into an S-polarized light component (L1) and a P-polarized light component (L2) by a polarization beam splitter (11). The polarized light components are detected by CCDs (21 and 22). A signal processing section (20) of a computer (30) forms an image of the object to be measured (O) based on detection signals from the CCDs (21, 22, and 23).
摘要翻译：本发明提供能够得到高精度图像而不受被测定物的移动影响的光学图像测定装置。闪光灯从氙灯（2）发射并通过滤光器（2A）转换成宽带光。闪光的偏振特性由偏光板（3）转换成线偏振光。然后，闪光被半反射镜（6）分为信号光（S）和参考光（R）。参考光（R）的偏振特性由波片（7）转换成圆偏振。信号光（S）和参考光（R）通过半反射镜（6）彼此重叠以产生干涉光（L）。 CCD（23）检测与产生的干涉光（L）的特性相同的干涉光。所产生的干涉光（L）被偏振分束器（11）分为S偏振光分量（L1）和P偏振光分量（L2）。偏振光分量由CCD（21和22）检测。计算机（30）的信号处理部（20）基于来自CCD（21,22,23）的检测信号，形成被测量物体（O）的图像。

4. 发明授权

US07980697B2 Fundus oculi observation device and ophthalmic image display device 有权
标题翻译：眼底观察装置和眼科图像显示装置
公开(公告)号：US07980697B2
公开(公告)日：2011-07-19
申请号：US12051981
申请日：2008-03-20
申请人： Hisashi Tsukada , Yasufumi Fukuma
发明人： Hisashi Tsukada , Yasufumi Fukuma
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/102
摘要： A fundus oculi observation device comprises: a first image forming part configured to form a 2-dimensional image of a surface of a fundus oculi of an eye; a second image forming part configured to form a tomographic image having a cross-sectional position in a measurement region of the fundus oculi corresponding to a partial region of the 2-dimensional image; a display; a storage configured to store imaging condition information including characteristic information showing a characteristic of the eye; and a controller configured to match display sizes of the formed 2-dimensional image and a measurement range image showing a range of the measurement region with each other, based on the stored imaging condition information, and cause the display to display the 2-dimensional image and the measurement range image whose display sizes are matched.
摘要翻译：眼底观察装置包括：构造成形成眼睛眼底表面的二维图像的第一图像形成部; 第二图像形成部，被配置为形成具有对应于所述二维图像的部分区域的眼底的测量区域中的横截面位置的断层图像; 一个显示器存储器，被配置为存储包括表示眼睛特征的特征信息的成像条件信息; 以及控制器，其被配置为基于所存储的成像条件信息来匹配形成的二维图像的显示尺寸和示出测量区域的范围的测量范围图像，并且使显示器显示二维图像和显示尺寸匹配的测量范围图像。

5. 发明申请

US20090190092A1 FUNDUS OCULI OBSERVATION DEVICE AND OPHTHALMIC IMAGE DISPLAY DEVICE 有权
标题翻译： FUNDUS OCULI观察装置和视觉图像显示装置
公开(公告)号：US20090190092A1
公开(公告)日：2009-07-30
申请号：US12051981
申请日：2008-03-20
申请人： Hisashi Tsukada , Yasufumi Fukuma
发明人： Hisashi Tsukada , Yasufumi Fukuma
IPC分类号： A61B3/12 , A61B3/15
CPC分类号： A61B3/102
摘要： A fundus oculi observation device comprises: a first image forming part configured to form a 2-dimensional image of a surface of a fundus oculi of an eye; a second image forming part configured to form a tomographic image having a cross-sectional position in a measurement region of the fundus oculi corresponding to a partial region of the 2-dimensional image; a display; a storage configured to store imaging condition information including characteristic information showing a characteristic of the eye; and a controller configured to match display sizes of the formed 2-dimensional image and a measurement range image showing a range of the measurement region with each other, based on the stored imaging condition information, and cause the display to display the 2-dimensional image and the measurement range image whose display sizes are matched.
摘要翻译：眼底观察装置包括：构造成形成眼睛眼底表面的二维图像的第一图像形成部; 第二图像形成部，被配置为形成具有对应于所述二维图像的部分区域的眼底的测量区域中的横截面位置的断层图像; 一个显示器存储器，被配置为存储包括表示眼睛特征的特征信息的成像条件信息; 以及控制器，被配置为基于所存储的成像条件信息来匹配形成的二维图像的显示尺寸和示出测量区域的范围的测量范围图像，并且使显示器显示二维图像和显示尺寸匹配的测量范围图像。

6. 发明申请

US20080259275A1 EYE MOVEMENT MEASURING APPARATUS, EYE MOVEMENT MEASURING METHOD AND RECORDING MEDIUM 有权
标题翻译：眼睛运动测量装置，眼动运动测量方法和记录介质
公开(公告)号：US20080259275A1
公开(公告)日：2008-10-23
申请号：US11845358
申请日：2007-08-27
申请人： Hiroyuki AOKI , Takashi FUJIMURA , Hisashi TSUKADA , Tsutomu KIKAWA , Yasufumi FUKUMA
发明人： Hiroyuki AOKI , Takashi FUJIMURA , Hisashi TSUKADA , Tsutomu KIKAWA , Yasufumi FUKUMA
IPC分类号： A61B3/113
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/113 , G06T7/246 , G06T2207/10101 , G06T2207/30041
摘要： An eye movement measuring apparatus comprises: an image forming part configured to obtain data optically to form a fundus oculi image of an eye based on the obtained data; and an image analysis part configured to analyze the formed fundus oculi image to determine eye movement of the eye.
摘要翻译：眼动测量装置包括：图像形成部，被配置为基于获得的数据光学地获得眼睛的眼底图像; 以及图像分析部，被配置为分析形成的眼底图像以确定眼睛的眼睛运动。

7. 发明申请

US20070188704A1 Fundus Observation Device 有权
标题翻译：眼底观察装置
公开(公告)号：US20070188704A1
公开(公告)日：2007-08-16
申请号：US11675657
申请日：2007-02-16
申请人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/10
CPC分类号： A61B3/102
摘要： Technology is provided, capable of easily acquiring high precision tomographic images of the desired observation site of the fundus oculi. A fundus observation device 1 is provided, comprising: an interferometer that generates interference light LC from a reference light LR via a reference mirror 174 and a signal light LS that reaches the fundus oculi Ef after low-coherence light L0 is split into that signal light LS and reference light LR; a CCD 184 that detects interference light LC; an image forming part 220 that forms image data G of a tomographic image based on detection results of the CCD 184; a display part 240A; an operation part 240B for specifying an observation mode (observation site); and a reference mirror drive mechanism 243. The image data G of a tomographic image includes image data of a normal image G (Re) and an inverse image G (Im). A controlling part 210 that displays the selected normal image G (Re) or inverse image G (Im) on the display part 240A along with moving the reference mirror 174 by controlling the reference mirror drive mechanism 243 based on the selected observation mode.
摘要翻译：提供技术，能够容易地获取眼底的所需观察部位的高精度断层图像。提供了一种眼底观察装置1，其包括：干涉仪，其经由参考镜174产生来自参考光LR的干涉光LC和在低相干光L 0被分割成该信号之后到达眼底Ef的信号光LS 光LS和参考光LR; 检测干涉光LC的CCD184; 基于CCD 184的检测结果形成断层图像的图像数据G的图像形成部220; 显示部分240A; 用于指定观察模式（观察部位）的操作部240B; 和参考镜驱动机构243。断层图像的图像数据G包括正常图像G（Re）和逆图像G（Im）的图像数据。控制部210，通过基于所选择的观察模式控制参考镜驱动机构243，在显示部240A上显示所选择的正常图像G（Re）或反转图像G（Im）。

8. 发明申请

US20050219544A1 Optical image measuring apparatus 失效
标题翻译：光学图像测量装置
公开(公告)号：US20050219544A1
公开(公告)日：2005-10-06
申请号：US11091478
申请日：2005-03-29
申请人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hiroyuki Otsuka , Hisashi Tsukada
发明人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hiroyuki Otsuka , Hisashi Tsukada
IPC分类号： G01B11/00 , A61B3/12 , A61B5/00 , G01B9/02 , G01N21/17 , G01N21/47
CPC分类号： A61B3/1225 , A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02003 , G01B9/02007 , G01B9/02012 , G01B9/02028 , G01B9/02091 , G01B2290/45
摘要： Provided is an optical image measuring apparatus capable of taking images of an object to be measured in plural depth regions in parallel. An optical image measuring apparatus of the present invention includes: a beam splitter (4) for dividing a light beam into signal light (S) and reference light (R); beam splitters (5-1 to 5-(n−1)) for dividing the reference light (R) into plural reference light beams (R1 to Rn); frequency shifters (6-1 to 6-n) for shifting frequencies of the reference light beams (R-1 to Rn) by different amounts; and reflector plates (7-1 to 7-n) arranged at different distances from an object to be measured (O). The reference light beams (R1 to Rn) and the signal light (S) reflected by the object to be measured in depth regions (D1 to Dn) are superimposed on each other to thereby produce interference light (L). Shutters (9-1 to 9-3) extract interference light components (L1 to Ln) from the reference light (L), and CCD cameras (10-1 to 10-3) receive the interference light component and convert the interference light component into electrical signals to output the signals. A computer (20) forms images in depth regions corresponding to the interference light components based on the electrical signals.
摘要翻译：本发明提供一种能够并行地在多个深度区域拍摄被测量物体的图像的光学图像测量装置。本发明的光学图像测量装置包括：用于将光束分成信号光（S）和参考光（R）的分束器（4）; 用于将参考光（R）分成多个参考光束（R 1至R n）的分束器（5-1-1至（n-1））; 用于将参考光束（R-1至Rn）的频率移动不同量的频移器（6-1至6-n）; 以及布置在与被测量物体（O）不同的距离处的反射板（7-1至7-n）。在深度区域（D 1〜D n）中被测量对象物反射的基准光束（R 1〜R n）和信号光（S）彼此叠加，从而产生干涉光（L）。百叶窗（9-1至9-3）从参考光（L）中提取干涉光分量（L 1至Ln），CCD相机（10-1至10-3）接收干涉光分量并转换干涉光组成电信号输出信号。计算机（20）基于电信号在与干涉光分量对应的深度区域中形成图像。

9. 发明申请

US20050219469A1 Optical image transmitting system, optical image transmitting apparatus, optical image receiving apparatus, and optical image transmitting method 有权
标题翻译：光学图像传输系统，光学图像发送装置，光学图像接收装置和光学图像发送方法
公开(公告)号：US20050219469A1
公开(公告)日：2005-10-06
申请号：US11092709
申请日：2005-03-30
申请人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hiroyuki Otsuka , Hisashi Tsukada
发明人： Kinpui Chan , Masahiro Akiba , Yasufumi Fukuma , Hiroyuki Otsuka , Hisashi Tsukada
IPC分类号： H04N7/22 , H04B10/00 , H04B10/112 , H04B10/516 , H04B10/54 , H04B10/548 , H04B10/61 , H04N21/647 , G03B21/00
CPC分类号： H04B10/61 , H04B10/50
摘要： Provided is an optical image transmitting system capable of producing signal light including plural image information and emitting the signal light, and in addition, receiving the signal light and selectively extracting target image information. An optical image transmitting system of the present invention includes an optical image transmitting apparatus (100) for producing plural optical image information beams (S1 to Sn) representing plural optical image information and including light beams of different frequencies, superimposing the plural optical image information beams (S1 to Sn) into signal light (S) and emitting the signal light (S) through free space or an optical waveguide such as an image fiber, and an optical image receiving apparatus (200) for receiving the emitted signal light (S) and selectively detecting the optical image information beams (S1 to Sn) based on the frequency difference.
摘要翻译：提供了一种能够产生包括多个图像信息并发射信号光的信号光的光学图像传输系统，此外，接收信号光并选择性地提取目标图像信息。本发明的光学图像传输系统包括：一个光学图像发送装置，用于产生多个光学图像信息光束（S 1至Sn），该光学图像信息光束表示多个光学图像信息，并包括不同频率的光束，将多个光学图像信息光束（S 1至Sn）转换成信号光（S）并通过自由空间发射信号光（S）或诸如图像光纤的光波导，以及用于接收发射信号光的光学图像接收装置（200） S），并且基于频率差选择性地检测光学图像信息光束（S 1至Sn）。

10. 发明授权

US08348426B2 Optical image measurement device and image processing device 有权
标题翻译：光学图像测量装置和图像处理装置
公开(公告)号：US08348426B2
公开(公告)日：2013-01-08
申请号：US12052187
申请日：2008-03-20
申请人： Hisashi Tsukada , Hiroyuki Aoki , Yasufumi Fukuma , Tsutomu Kikawa
发明人： Hisashi Tsukada , Hiroyuki Aoki , Yasufumi Fukuma , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02085 , G01B9/02087 , G01B9/02091 , G01B2290/65 , G06T3/4007
摘要： An optical image measurement device is configured to form a tomographic image at each of a plurality of cross sections of a measurement object, and the optical image measurement device comprises: an image processor configured to execute an arithmetic operation based on a tomographic image at one cross section of the plurality of cross sections and another tomographic image at each of one or more cross sections other than the one cross section, thereby forming a new tomographic image at the one cross section.
摘要翻译：光学图像测量装置被配置为在测量对象的多个横截面中的每一个处形成断层图像，并且所述光学图像测量装置包括：图像处理器，被配置为在一个十字交叉处执行基于断层图像的算术运算所述多个横截面的截面和在所述一个横截面以外的一个或多个横截面中的每一个处的另一断层图像，从而在所述一个横截面处形成新的断层图像。

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