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1. 发明申请

US20100022942A1 DEVICE FOR PERCUTANEOUS ABSORPTION PREPARATION 有权
标题翻译：用于经皮吸收制备的装置
公开(公告)号：US20100022942A1
公开(公告)日：2010-01-28
申请号：US12441842
申请日：2007-08-31
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
IPC分类号： A61N1/30 , A61M35/00
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).
摘要翻译：本发明提供了一种用于经皮吸收制剂的装置，其具有能够独立于力水平显示良好的溶液迁移的溶液储存容器。用于经皮吸收制剂的装置包括：电极膜，包括基底部件（1）和电极层（2），并具有溶解液体通过孔（9）;药物浸渍部件（3），安装在电极层）侧，以及通过覆盖所述溶液通孔（9）的盖部件（7）与所述电极膜的基材（1）侧接合的溶解液收容容器（5）。溶解液储存容器（5）包括底部和侧壁。在底部的中心设有面向溶解液通路孔（9）的突起（5b），侧壁设有垂直折叠部（5c）。

2. 发明授权

US07883504B2 Device for percutaneous absorption preparation 有权
标题翻译：经皮吸收制剂装置
公开(公告)号：US07883504B2
公开(公告)日：2011-02-08
申请号：US12441842
申请日：2007-08-31
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
IPC分类号： A61K9/22
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).
摘要翻译：本发明提供了一种用于经皮吸收制剂的装置，其具有能够独立于力水平显示良好的溶液迁移的溶液储存容器。用于经皮吸收制剂的装置包括：电极膜，包括基底部件（1）和电极层（2），并具有溶解液体通过孔（9）;药物浸渍部件（3），安装在电极层）侧，以及通过覆盖所述溶液通孔（9）的盖部件（7）与所述电极膜的基材（1）侧接合的溶解液收容容器（5）。溶解液储存容器（5）包括底部和侧壁。在底部的中心设有面向溶解液通路孔（9）的突起（5b），侧壁设有垂直折叠部（5c）。

3. 发明申请

US20090318845A1 Iontophoresis Device and Method for Producing Same 审中-公开
标题翻译：离子渗透装置及其制造方法
公开(公告)号：US20090318845A1
公开(公告)日：2009-12-24
申请号：US12087054
申请日：2006-12-25
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via an aluminum lid member (7) which covers the dissolution liquid passing hole (9), and the aluminum lid member (7) is arranged within the flange outer diameter of the dissolution liquid-storing container.
摘要翻译：为了提供容易生产的批量生产型离子电渗疗法装置，其具有溶解液储存容器与离子电渗电极结合的结构，溶解液和药物可以通过简单的操作混合，并且没有泄漏的风险的电力。该装置包括具有形成在基底（1）上的电极层（2）和布置在电极膜的电极层形成侧的药物负载构件（3）的电极膜和溶解液储存容器（5），设置在电极膜的非电极层形成侧，其中电极膜设置有溶解液通过孔（9），溶解液储存容器（5）的凸缘（5a）通过覆盖溶解液通过孔（9）的铝盖构件（7）与电极膜接合，铝盖构件（7）配置在溶解液储存容器的凸缘外径内。

4. 发明申请

US20090221952A1 Device for Transdermal Preparation 审中-公开
标题翻译：透皮制剂装置
公开(公告)号：US20090221952A1
公开(公告)日：2009-09-03
申请号：US12087055
申请日：2006-12-25
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： To provide an easily producible mass-production type transdermal drug device having a structure that a dissolution liquid and a drug can be mixed by simple operations. The device comprises an electrode holder (1) having an electrode layer (1b) formed on a substrate (1a), a drug-loaded member (2) provided on a surface of the electrode holder (1) for forming the electrode layer (1b), and a dissolution liquid-storing container (5) provided on a surface of the electrode holder (1) for not forming the electrode layer (1b), wherein a dissolution liquid passing hole (8) is formed in the electrode holder (1), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode holder (1) via a lid material (6) covering the dissolution liquid passing hole (8), the dissolution liquid-storing container (5) has a protrusion (5b) opposing the dissolution liquid passing hole (8), and the protrusion (5b) has a recessed surface at the tip.
摘要翻译：提供一种易于生产的批量生产型透皮药物装置，其具有可以通过简单的操作混合溶解液体和药物的结构。该装置包括具有形成在基板（1a）上的电极层（1b）的电极保持器（1），设置在用于形成电极层（1b）的电极保持器（1）的表面上的药物负载部件）和设置在不形成电极层（1b）的电极保持件（1）的表面上的溶解液储存容器（5），其中在电极保持器（1）中形成溶解液通孔（8）），溶解液储存容器（5）的凸缘（5a）通过覆盖溶解液通过孔（8）的盖材料（6），溶解液储存容器（ 5）具有与溶解液通过孔（8）相对的突起（5b），突起（5b）在尖端具有凹陷表面。

5. 发明申请

US20090240190A1 Iontophoresis Device and Method for Producing Same 审中-公开
标题翻译：离子渗透装置及其制造方法
公开(公告)号：US20090240190A1
公开(公告)日：2009-09-24
申请号：US12087056
申请日：2006-12-25
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
IPC分类号： A61N1/30 , B32B37/12
CPC分类号： A61N1/0448 , A61N1/044 , Y10T156/1056
摘要： To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a resin lid member (7) is bonded to the electrode film via a thermoplastic resin layer (10) or an adhesive layer to cover the dissolution liquid passing hole, and a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via the resin lid member (7).
摘要翻译：为了提供容易生产的批量生产型离子电渗疗法装置，其具有溶解液储存容器与离子电渗电极结合的结构，溶解液和药物可以通过简单的操作混合，并且没有泄漏的风险的电力。该装置包括具有形成在基底（1）上的电极层（2）和布置在电极膜的电极层形成侧的药物负载构件（3）的电极膜和溶解液储存容器（5），设置在所述电极膜的非电极层形成侧，其中，所述电极膜设置有溶解液通过孔（9），树脂盖构件（7）经由热塑性树脂层（10）或覆盖溶解液通过孔的粘合剂层，并且溶解储液容器（5）的凸缘（5a）经由树脂盖构件（7）接合到电极膜。

6. 发明申请

US20050131336A1 Electrode structure 审中-公开
标题翻译：电极结构
公开(公告)号：US20050131336A1
公开(公告)日：2005-06-16
申请号：US10501948
申请日：2003-01-23
申请人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
发明人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0492 , A61N1/0412 , A61N1/0428 , A61N1/0496
摘要： An electrode structure is provided which is capable of efficiently using a material that can be a non-polarized electrode component, allowing the material to fully demonstrate the effect as the non-polarized electrode and maintaining the performance. This electrode structure comprises an insulating base (13), a polarized component layer (first layer) (12) laminated on the insulating base so as not to penetrate the insulating base, the polarized component layer comprising a conductive paste or metallic foil which is predominantly made of a component that can be a polarized electrode, and a non-polarized component layer (second layer) (11) provided on the polarized component layer, the non-polarized component layer comprising a conductive paste which is predominantly made of a component that can be a non-polarized electrode.
摘要翻译：提供一种电极结构，其能够有效地使用可以是非极化电极组分的材料，从而允许材料充分显示作为非极化电极的作用并保持性能。该电极结构包括绝缘基底（13），层叠在绝缘基底上的极化部件层（第一层）（12），以便不穿透绝缘基底，所述偏振构件层包括导电膏或金属箔，其主要是由可以是极化电极的部件和设置在偏振部件层上的非偏振部件层（第二层）（11）构成，非极化部件层包括主要由以下部件构成的导电膏可以是非极化电极。

7. 发明授权

US07502654B2 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US07502654B2
公开(公告)日：2009-03-10
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

8. 发明申请

US20060206186A1 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US20060206186A1
公开(公告)日：2006-09-14
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/04
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有突出部（70），该突起部（70）在除了通过模制形成的凹部（60）之外的向外的凸缘部分（110f）的一部分中向上突出。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中的翘曲（沿着周向的翘曲）发生。因此，突起（70）还可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，并防止电极层（30）断开。

9. 发明申请

US20070129664A1 Electrode chip for biological application and its using method 有权
标题翻译：用于生物应用的电极芯片及其使用方法
公开(公告)号：US20070129664A1
公开(公告)日：2007-06-07
申请号：US10579287
申请日：2004-10-22
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Mitsuru Kuribayashi , Naruhito Higo
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Mitsuru Kuribayashi , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： This invention relates to a technology for preventing leakage of liquid from gel (70). The electrode chip (10) comprises a cup-like support (20) including a cup part (210), and a sheet-like support (30) attached with an electrode layer (40). The gel (70) in the cup part (210) delivers liquid (700) containing water confined at the time of crosslinking. The liquid (700) moves by capillarity from the gel (70) side through a narrow gap between the outer flange (220) of the cup-like support (20) and the outside part (310o) of the sheet-like support (30) in a direction away from the gel (70). Since a groove (80) exists in the vicinity of the cup part (210) and the gap is large at that part, capillarity is broken thereat.
摘要翻译：本发明涉及防止液体从凝胶（70）泄漏的技术。电极芯片（10）包括一个包括一个杯形部分（210）的杯状支撑件（20）和一个安装有电极层（40）的片状支撑件（30）。杯部（210）中的凝胶（70）输送含有交联时限制的水的液体（700）。液体（700）通过毛细管作用从凝胶（70）侧通过杯形支撑件（20）的外凸缘（220）与片状支撑件（310）的外部（310o）之间的窄间隙移动 30）沿远离凝胶（70）的方向。由于在杯部（210）附近存在凹槽（80），并且在该部分处间隙大，所以毛细管损坏。

10. 发明申请

US20050113738A1 Iontophoresis electrode device 审中-公开
标题翻译：离子电渗电极装置
公开(公告)号：US20050113738A1
公开(公告)日：2005-05-26
申请号：US10500537
申请日：2003-01-09
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.
摘要翻译：提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。片材（50）具有使凝胶（70）渗透到其中的性质。由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

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