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1. 发明申请

US20090170888A1 Antipruritic Agent for Pruritus Caused by Multiple Sclerosis 有权
标题翻译：多发性硬化引起的瘙痒止痒剂
公开(公告)号：US20090170888A1
公开(公告)日：2009-07-02
申请号：US11885946
申请日：2006-03-09
申请人： Hideo Umeuchi , Koki Ueno , Hiroshi Miyakawa
发明人： Hideo Umeuchi , Koki Ueno , Hiroshi Miyakawa
IPC分类号： A61K31/439 , C07D489/06 , A61P25/28
CPC分类号： C07D491/10 , A61K31/485
摘要： An antipruritic against pruritus caused by multiple sclerosis is disclosed. The antipruritic comprises as an effective ingredient an κ opioid receptor agonist compound having a 4,5-epoxymorphinan skeleton and having a specific chemical structure, such as Compound 1 having the following structure:
摘要翻译：公开了针对多发性硬化引起的瘙痒的止痒药。止痒剂包含具有4,5-环氧吗啡喃骨架并具有特定化学结构的κ阿片受体激动剂化合物作为有效成分，例如具有以下结构的化合物1：

2. 发明申请

US20060188606A1 Process for producing cheese 审中-公开
标题翻译：生产奶酪的方法
公开(公告)号：US20060188606A1
公开(公告)日：2006-08-24
申请号：US10548927
申请日：2004-04-27
申请人： Kiyotaka Takahashi , Kiyotaka Miyauchi , Rei Mizuno , Hiroshi Miyakawa , Hiroshi Ochi
发明人： Kiyotaka Takahashi , Kiyotaka Miyauchi , Rei Mizuno , Hiroshi Miyakawa , Hiroshi Ochi
IPC分类号： A23C9/12
CPC分类号： A23C19/0684 , A23C19/06 , A23C19/08 , A23C19/0912 , A23C2250/052 , A23C2250/054
摘要： A cheese production process of the present invention includes stretching cheese curds in hot water and contacting the cheese curds and a texture modifier capable of binding or adsorbing calcium either before or simultaneously with the stretching so as to enable the obtaining of cheese having a preferable rice cake-like elastic texture by improving the gum-like adhesive texture, hard rubber-like chewiness, and residual particles in the mouth when eating after baking, of cheese that is produced by going through a step of stretching cheese curds in hot water.
摘要翻译：本发明的奶酪生产方法包括在热水中拉伸干酪凝乳并使奶酪凝乳和能够在拉伸之前或同时结合或吸附钙的纹理调节剂接触，以便获得具有优选米糕的奶酪通过改善胶状粘合剂质地，硬橡胶状咀嚼性和在烘烤后进食时口中残留颗粒的类似弹性织构，通过在热水中拉伸干酪凝乳的步骤产生的奶酪。

3. 发明授权

US07022676B2 Peptide having angiotensin converting enzyme inhibitory effect 有权
标题翻译：肽具有血管紧张素转换酶的抑制作用
公开(公告)号：US07022676B2
公开(公告)日：2006-04-04
申请号：US10496200
申请日：2002-11-21
申请人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
发明人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
IPC分类号： A61K38/00
CPC分类号： C07K14/4732 , A61K38/00 , C07K5/081
摘要： A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
摘要翻译：用酪蛋白水解化学合成获得的肽Met-Lys-Pro作为血管紧张素转换酶抑制剂或降血压药物的有效成分。

4. 发明授权

US06908633B2 Protein hydrolyzates, process for producing the same and drinks and foods containing the protein hydrolyzates 失效
标题翻译：蛋白质水解物，其制备方法以及含有蛋白质水解产物的饮料和食品
公开(公告)号：US06908633B2
公开(公告)日：2005-06-21
申请号：US10148274
申请日：2001-03-12
申请人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Toshikazu Shichino , Yasushi Kawaguchi , Hirokatsu Kanehara
发明人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Toshikazu Shichino , Yasushi Kawaguchi , Hirokatsu Kanehara
IPC分类号： A23C9/152 , A23C11/04 , A23J3/30 , A23J3/34 , A23L1/305 , C07K1/12 , C07K1/20 , A23C9/12 , A23J1/00
CPC分类号： C07K1/20 , A23C9/1526 , A23C11/04 , A23J3/30 , A23J3/343 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , C07K1/12 , A23V2300/30
摘要： A protein hydrolysate comprising at least two types of peptides, characterized in that the rate of hydrolysis of protein is from 30 to 45%, the number average molecular weight is 300 or less, and the ratio of a weight average molecular weight to the number average molecular weight is greater than 1 and 2 or less, has excellent emulsifiability, and antigenicity thereof is low enough to be used for people who has predisposition to allergic diseases. This protein hydrolysate is obtained by hydrolysis of a protein starting material to a rate of hydrolysis in the range of 30 to 45%, and then bringing it into contact simultaneously or separately with two types of porous synthetic adsorbent respectively having an average pore radius of 2 to 8 nm and an average pore radius of 20 to 30 nm, the total surface area of the two porous synthetic adsorbents being in a range of 300 to 3000 m2 per 1 g (protein equivalent) of the obtained protein hydrolysate, and recovering the non-adsorbed component.
摘要翻译：一种蛋白质水解物，其包含至少两种类型的肽，其特征在于蛋白质的水解速率为30〜45％，数均分子量为300以下，重均分子量与数均分子量的比例分子量大于1和2以下，具有优异的乳化性，其抗原性低到足以用于具有过敏性疾病倾向的人。该蛋白质水解物是通过将蛋白原料水解至30〜45％范围内的水解速率而获得的，然后使其与平均孔半径为2的两种类型的多孔合成吸附剂同时或分开地接触至8nm，平均孔半径为20至30nm，两个多孔合成吸附剂的总表面积在每1000克（蛋白质当量）的300至3000微米2范围内得到的蛋白质水解物，回收未吸附成分。

5. 发明授权

US5340924A Method for heat treatment of lactoferrin without losing physiological activities thereof 失效
标题翻译：乳铁蛋白的热处理方法，而不会失去其生理活性
公开(公告)号：US5340924A
公开(公告)日：1994-08-23
申请号：US860224
申请日：1992-03-27
申请人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
发明人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
IPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , C07K3/12 , C07K15/00 , C07K15/14 , C07K15/22
CPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , Y10S530/832
摘要： A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.
摘要翻译：一种处理含有保湿或液化的乳铁蛋白的物质的方法，其已从哺乳动物乳，加工的哺乳动物乳和哺乳动物乳加工中的副产物中分离出来，而不损失乳铁蛋白的生理活性，其包括调节所述保湿或当所述保湿或液化的乳铁蛋白的pH在所述pH范围之外时，通过加入酸或酸的水溶液，在所述物质中含有的液化乳铁蛋白在2.0至6.0之间的酸性范围内，并且将所述物质加热到60℃ 在130℃下，可以确保乳铁蛋白的未饱和化率达到60％以上。

6. 发明授权

US5219838A Method for inhibiting tyrosinase activity in treatment of skin 失效
标题翻译：抑制皮肤治疗中酪氨酸酶活性的方法
公开(公告)号：US5219838A
公开(公告)日：1993-06-15
申请号：US884051
申请日：1992-05-15
申请人： Mamoru Tomita , Seiichi Shimamura , Hiroshi Miyakawa , Susumu Kobayashi
发明人： Mamoru Tomita , Seiichi Shimamura , Hiroshi Miyakawa , Susumu Kobayashi
IPC分类号： A23J3/34 , A61K8/64 , A61K38/00 , A61K38/01 , A61Q19/02
CPC分类号： A61K38/005 , A23J3/343 , A61K38/018 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： An agent for tyrosinase inhibition which contains the effective quantity of enzymatic hydrolyzates of milk proteins, having a decomposition rate from 6% to 55% as expressed by the percentage of formol nitrogen to total nitrogen.
摘要翻译：酪氨酸酶抑制剂，其含有有效量的乳蛋白质的酶水解产物，其分解速率由甲醛氮与总氮的百分比表示为6％至55％。

7. 发明授权

US5389611A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译：乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。

8. 发明授权

US07424391B2 Period division statistics device, method, and program product 有权
标题翻译：期间统计设备，方法和程序产品
公开(公告)号：US07424391B2
公开(公告)日：2008-09-09
申请号：US11603621
申请日：2006-11-21
申请人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
发明人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
IPC分类号： G06F17/18
CPC分类号： G06Q10/10
摘要： A statistics system stores inputted statistical target information into storage. When each unit time period defined in a statistical calculation rule expires, the statistics system reads all pieces of statistical target information whose occurrence times are contained in the unit time period from storage, executes statistical calculation, and registers the statistical result to the statistical information in storage. When statistical target information is inputted, the statistics system sets a re-calculation flag to a unit time period including the occurrence time shown by the statistical target information among the respective unit time periods whose statistical results are registered in the statistical information. The statistics system reads all pieces of the statistical target information whose occurrence times are contained in the unit time period from storage for each of the flagged unit time periods, re-executing the statistical calculation, and overwrites the statistical result onto the information in storage.
摘要翻译：统计系统将输入的统计目标信息存储到存储器中。当统计计算规则中定义的每个单位时间段到期时，统计系统从存储单元读取单位时间内包含发生次数的所有统计目标信息，执行统计计算，并将统计结果登记到统计信息中存储。当输入统计目标信息时，统计系统将统计结果登记在统计信息中的各个单位时间段内的统计目标信息所显示的发生时间设定为单位时间。统计系统从每个标记单位时间段的存储单位时间内读出其发生次数所包含的所有统计目标信息，重新执行统计计算，并将统计结果重写到存储信息中。

9. 发明申请

US20070223522A1 Period division statistics device, method, and program product 有权
标题翻译：期间统计设备，方法和程序产品
公开(公告)号：US20070223522A1
公开(公告)日：2007-09-27
申请号：US11603621
申请日：2006-11-21
申请人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
发明人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
IPC分类号： H04J3/22
CPC分类号： G06Q10/10
摘要： A statistics system stores inputted statistical target information into storage. When each unit time period defined in a statistical calculation rule expires, the statistics system reads all pieces of statistical target information whose occurrence times are contained in the unit time period from the storage, executes statistical calculation, and registers the statistical result to the statistical information in the storage. When statistical target information is inputted, the statistics system sets a re-calculation flag to a unit time period including the occurrence time shown by the statistical target information among the respective unit time periods whose statistical results are registered in the statistical information. The statistics system reads all pieces of the statistical target information whose occurrence times are contained in the unit time period from the storage for each of the flagged unit time periods, re-executing the statistical calculation, and overwrites the statistical result onto the information in the storage.
摘要翻译：统计系统将输入的统计目标信息存储到存储器中。当统计计算规则中定义的每个单位时间段到期时，统计系统从存储单元读取单位时间内包含发生次数的所有统计目标信息，执行统计计算，并将统计结果登记到统计信息在存储中。当输入统计目标信息时，统计系统将统计结果登记在统计信息中的各个单位时间段内的统计目标信息所显示的发生时间设定为单位时间。统计系统从针对每个标记单位时间段的存储中读出在单位时间段内包含发生次数的所有统计目标信息，重新执行统计计算，并将统计结果重写为存储。

10. 发明授权

US06299928B1 Fine granular feeds for fry 有权
标题翻译：细粒饲料用于油炸
公开(公告)号：US06299928B1
公开(公告)日：2001-10-09
申请号：US09623503
申请日：2000-09-19
申请人： Toshio Takeuchi , Hirotoshi Hayasawa , Tsutomu Kudo , Hiroshi Miyakawa , Akio Yamada , Naomichi Okuma , Waichi Ishizuka , Shuzo Ishida
发明人： Toshio Takeuchi , Hirotoshi Hayasawa , Tsutomu Kudo , Hiroshi Miyakawa , Akio Yamada , Naomichi Okuma , Waichi Ishizuka , Shuzo Ishida
IPC分类号： A23J300
CPC分类号： A23K50/80 , A23K10/33 , A23K20/142 , A23K20/147 , A23K20/158 , A23K40/10 , Y02P60/871 , Y10S426/805
摘要： Fine granular feeds for fry of fishes and shellfishes capable of remarkably elevating the survival rate of fry, improving the cultivation efficiency, and causing little elution of nitrogen sources therefrom into seawater or water in feeding, which are characterized by containing at least three active components, i.e., (a) a long-chain unsaturated fatty acid calcium salt blend comprising 80% by weight or more of long-chain unsaturated fatty acid calcium salt(s) having at least 18 carbon atoms, (b) 20% by weight or less of a browned matter formed by heating molasses or saccharides, a browned matter formed by heating saccharides with amino acids or a mixture thereof at an arbitrary ratio, and (c) a mixture of peptides obtained by hydrolyzing animal protein, and being in the form of fine grains.
摘要翻译：用于鱼类和贝类的鱼粒和贝类的细粒状饲料能够显着提高鱼苗的存活率，提高培养效率，并且使得氮源从其中进入海水或进料中的水几乎不被洗脱，其特征在于含有至少三种活性成分，即（a）包含80重量％以上具有至少18个碳原子的长链不饱和脂肪酸钙盐的长链不饱和脂肪酸钙盐混合物，（b）20重量％以下通过加热糖蜜或糖形成的褐变物质，通过以任意比例用氨基酸或其混合物加热糖形成的褐变物质，和（c）通过水解动物蛋白质获得的肽的混合物，并且以细粒。

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