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1. 发明授权

US07977461B2 Anti-platelet membrane glycoprotein VI monoclonal antibody 有权
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US07977461B2
公开(公告)日：2011-07-12
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

2. 发明授权

US6148660A Glow sensor-ceramic tip 失效
标题翻译：辉光传感器 - 陶瓷尖端
公开(公告)号：US6148660A
公开(公告)日：2000-11-21
申请号：US160396
申请日：1998-09-25
申请人： Randolph Kwok-Kin Chiu , Charles Dale Oakley , Russell Harmon Bosch , Magnus Glavmo , Hiroshi Takayama , Keisuke Okajima
发明人： Randolph Kwok-Kin Chiu , Charles Dale Oakley , Russell Harmon Bosch , Magnus Glavmo , Hiroshi Takayama , Keisuke Okajima
IPC分类号： F23Q7/00 , G01M15/00 , F02M39/00
CPC分类号： F02P19/028 , F23Q7/001 , F23Q2007/002
摘要： A glow sensor which combines functions of a diesel engine glow plug with an ion sensor for sensing engine combustion initiation and characteristics includes a ceramic rod retained in a supporting ceramic sleeve carried by a metal shell mountable in an engine cylinder head. The ceramic rod includes a heating element in a glow tip at the inner end of the rod which, in use, extends into an engine combustion chamber or pre-chamber. A conductive material such as platinum or palladium is coated on the lower end of the glow tip and connected by a conductor with a source of electric voltage. In use, the voltage produces a current carried by electrons generated by ionization of the combustion chamber gases during combustion. The current varies with the degree of ionization and the amount of electrons generated during various phases of the combustion event. The resulting information is usable in controlling engine operation or evaluating its operation for test purposes. Various construction features of disclosed embodiments include an internal conductor through the ceramic rod from the platinum or palladium material to a lead or an external conductor applied on the surface of the ceramic rod with which an insulating ceramic sleeve is utilized to mount the rod within its supporting shell. Grounding connections through an additional lead from the outer end of the ceramic rod or via metallic connections through the ceramic sleeve to the shell are alternatively disclosed.
摘要翻译：将柴油发动机预热塞与用于感测发动机燃烧起动和特性的离子传感器的功能组合的辉光传感器包括保持在由可安装在发动机气缸盖中的金属壳承载的支撑陶瓷套筒中的陶瓷棒。陶瓷棒包括在杆的内端处的辉光尖端中的加热元件，其在使用中延伸到发动机燃烧室或预制室中。诸如铂或钯的导电材料涂覆在辉光尖端的下端，并由具有电压源的导体连接。在使用中，电压产生由燃烧室内的燃烧室气体的电离产生的电子携带的电流。电流随着电离的程度和在燃烧事件的各个阶段期间产生的电子的量而变化。所得到的信息可用于控制发动机操作或评估其操作用于测试目的。所公开的实施例的各种结构特征包括通过陶瓷棒从铂或钯材料到引线或外部导体的内部导体，该导体或外部导体施加在陶瓷棒的表面上，通过该导体或外部导体使用绝缘陶瓷套管将杆安装在其支撑贝壳。可选地公开了通过陶瓷棒的外端的附加引线或经由穿过陶瓷套管的金属连接到壳体的接地连接。

3. 发明授权

US5897477A Developer carrier and developing apparatus comprising the same 失效
标题翻译：显影剂载体和包含其的显影装置
公开(公告)号：US5897477A
公开(公告)日：1999-04-27
申请号：US806931
申请日：1997-02-26
申请人： Kenji Nakatogawa , Shigeo Ohta , Hiroshi Takayama
发明人： Kenji Nakatogawa , Shigeo Ohta , Hiroshi Takayama
IPC分类号： G03G15/08 , G03G15/09
CPC分类号： G03G15/0928
摘要： A developer carrier comprising a cylindrical support having provided on the outer surface thereof a coating layer for retaining a developer, wherein the coating layer comprises electrically conductive fine particles and a binder resin comprising a phenolic resin having a weight-average molecular weight of from 3,000 to 5,000 as determined before being crosslinked. Also disclosed is a developing apparatus which comprises a developer carrier for retaining a developer on the surface thereof and for conveying the developer onto the position at which an electrostatic latent image formed on a latent image carrier is developed, wherein the developer carrier comprises a cylindrical support having provided on the outer surface thereof a coating layer for retaining a developer, wherein the coating layer comprises electrically conductive fine particles and a binder resin comprising a phenolic resin having a weight-average molecular weight of from 3,000 to 5,000 as determined before being crosslinked.
摘要翻译：一种显影剂载体，其包括在其外表面上设置有用于保持显影剂的涂层的圆柱形支撑体，其中所述涂层包含导电细颗粒和包含酚醛树脂的粘合剂树脂，所述酚醛树脂的重均分子量为3,000至交联前测定的5,000。还公开了一种显影装置，其包括用于将显影剂保持在其表面上并用于将显影剂输送到形成在潜像载体上的静电潜像显影的位置的显影剂载体，其中显影剂载体包括圆柱形支撑体在其外表面上设置有用于保持显影剂的涂层，其中所述涂层包含导电细颗粒和包含在交联之前测定的重均分子量为3,000至5,000的酚醛树脂的粘合剂树脂。

4. 发明授权

US5839029A Charging device 失效
标题翻译：充电装置
公开(公告)号：US5839029A
公开(公告)日：1998-11-17
申请号：US802106
申请日：1997-02-19
申请人： Hiroyuki Kataoka , Eiko Tanaka , Hiroshi Takayama
发明人： Hiroyuki Kataoka , Eiko Tanaka , Hiroshi Takayama
IPC分类号： F16C13/00 , G03G15/02 , G03G15/16 , G03G21/18
CPC分类号： G03G15/0233 , Y10S430/102
摘要： The present invention describes a charging device pressed against the surface of a body to be charged in a state of being applied with a voltage so as to charge the body. The charging device includes an electrically conductive support to which a voltage is to be applied; an electrically conductive elastic body layer fixed on the electrically conductive support; a resistance regulation layer covering the electrically conductive elastic body layer; and a protective layer laminated on the resistance regulation layer, having hardness of 6 H or more in pencil hardness, and made from a silicon compound.
摘要翻译：本发明描述了一种在施加电压以对身体充电的状态下按压被充电体的表面的充电装置。充电装置包括一个导电支架，电压被施加到该导电支架上; 固定在导电支撑体上的导电弹性体层; 覆盖导电性弹性体层的电阻调节层; 以及层叠在电阻调节层上的保护层，硬度为铅笔硬度以上6H以上，并由硅化合物制成。

5. 发明授权

US5614935A Ink transfer medium for toner, ink transfer process and re-inking process for the same 失效
标题翻译：用于调色剂的墨水转印介质，墨水转印过程和再次上墨过程相同
公开(公告)号：US5614935A
公开(公告)日：1997-03-25
申请号：US447212
申请日：1995-05-22
申请人： Kenji Ogi , Hiroshi Takayama , Yasuo Yamamoto , Kazuo Maruyama , Eiichi Akutsu
发明人： Kenji Ogi , Hiroshi Takayama , Yasuo Yamamoto , Kazuo Maruyama , Eiichi Akutsu
IPC分类号： B41J2/325 , B41J31/00 , B41J31/14 , B41M5/30 , B41M5/392 , G03G15/34 , B41J2/315
CPC分类号： B41J2/325 , G03G15/344 , Y10S428/913 , Y10S428/914 , Y10T428/24802 , Y10T428/24901 , Y10T428/25 , Y10T428/254 , Y10T428/31504 , Y10T428/31786
摘要： An ink transfer medium for toner is disclosed, comprising the following layers, in this order: a heat-generating resistive layer heated by input of electrical signal, a conductive layer, and an ink release layer having a toner layer on it, an adhesion from 0.2 g/mm to 40 g/mm as measured by the 90.degree. peeling off method and consisting of a viscoelastomer having a critical surface tension of 35 dyne/cm or less. It can be re-inked by attaching toner to the portions of the ink transfer medium from which the ink has been removed, using toner held in a toner holding means.An ink transfer process for toner is also disclosed, wherein an ink transfer medium having toner layer formed on the above described ink release layer is used and the toner layer contacts the recording medium under pressure, while a recording head contacts the anisotropic conductive layer of the ink transfer medium, so that an electrical signal is input and then toner fused by heat generated by the heat-generating resistive layer is transferred to the recording medium.
摘要翻译：公开了一种用于调色剂的油墨转印介质，包括以下层：通过电信号输入加热的发热电阻层，导电层和在其上具有调色剂层的油墨释放层， 0.2g / mm至40g / mm，通过90°剥离法测量，并由粘弹性体组成，其临界表面张力为35达因/厘米或更小。通过使用保持在调色剂保持装置中的调色剂将调色剂附着到已经从中除去油墨的油墨转印介质的部分上，可以再次进行再墨。还公开了一种用于调色剂的油墨转印方法，其中使用在上述油墨释放层上形成有调色剂层的油墨转印介质，并且调色剂层在压力下与记录介质接触，而记录头接触到油墨转印介质，从而输入电信号，然后通过发热电阻层产生的热量将调色剂转印到记录介质上。

6. 发明授权

US4265992A Coated magnetic developer particles for electrophotography containing vinyl and olefin resins 失效
标题翻译：包含乙烯基和烯烃树脂的电子照相用涂覆磁性显影剂颗粒
公开(公告)号：US4265992A
公开(公告)日：1981-05-05
申请号：US929411
申请日：1978-07-31
申请人： Toshihiro Kouchi , Hiroshi Takayama , Tatsuo Aizawa
发明人： Toshihiro Kouchi , Hiroshi Takayama , Tatsuo Aizawa
IPC分类号： G03G9/08 , G03G9/083 , G03G9/087 , G03G9/14
CPC分类号： G03G9/0839 , G03G9/0833 , G03G9/08704 , G03G9/08706 , G03G9/08748 , G03G9/08775
摘要： In a one-component type developer for electrophotography consisting essentially of a dry blend of fixing magneto-sensitive particles and flowability- and electric resistance-controlling fine particles, when an aromatic vinyl resin and/or an acrylic resin is used as a binder resin for the magneto-sensitive particles in combination with a low molecular weight olefin resin, the magneto-sensitive particles are much improved in the property of holding the flowability- and electric resistance-controlling fine particles on the surfaces thereof. Accordingly, these fine particles cannot be substantially separated from the magneto-sensitive particles under agitation conditions, development conditions and fixing conditions. As a result, contamination of the interior of a copying machine, especially an optical system, can be completely prevented, and also contamination of the background can be completely prevented. Further, the resulting fixed images have a very high resistance to friction and abrasion, and troubles such as blurring and flow of the image are not caused at all.

7. 发明授权

US4108786A Magnetic dry developer for electrostatic photography and process for preparation thereof 失效
标题翻译：用于静电摄影的磁性干燥显影剂及其制备方法
公开(公告)号：US4108786A
公开(公告)日：1978-08-22
申请号：US641285
申请日：1975-12-16
申请人： Hiroshi Takayama , Tatsuo Aizawa
发明人： Hiroshi Takayama , Tatsuo Aizawa
IPC分类号： G03G9/08 , G03G9/083 , G03G9/14
CPC分类号： G03G9/0825 , G03G9/0827 , G03G9/083 , G03G9/0838 , Y10S430/104
摘要： A magnetic toner for electrostatic photography consisting essentially of spherical particles of a composition comprising a fine powder of a magnetic material having an average particle size not exceeding 1000 m.mu. and being dispersed in a binder resin, said powdery magnetic material being present in an amount of 25 to 75% by weight based on the composition, spherical particles of said composition having such a particle size distribution that particles having a particle size larger than 44 .mu. occupy up to 10% of the total particles and particles having a particle size smaller than 2 .mu. occupy up to 10% of the total particles, wherein said fine powder of the magnetic material is distributed predominantly in the surface layer portion of each spherical particle and said spherical particles have a volume resistivity not higher than 1 .times. 10.sup.11 .OMEGA.-cm as measured in a magnetic field of about 680 gauss under a voltage of 1000 V.
摘要翻译：一种用于静电摄影的磁性调色剂，其基本上由包括平均粒度不超过1000μm的磁性材料的细粉末并分散在粘合剂树脂中的组合物的球形颗粒组成，所述粉末状磁性材料以基于组合物为25〜75重量％，所述组合物的球形粒子具有粒径分布，粒径大于44μm的粒子占总粒子的10％，粒径小于2的粒子 mu占总粒子的10％，其中所述磁性材料的细粉末主要分布在每个球形颗粒的表面层部分中，并且所测量的球形颗粒的体积电阻率不高于1×1011欧姆 - 厘米在1000V的电压下在约680高斯的磁场中。

8. 发明申请

US20110217318A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 失效
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US20110217318A1
公开(公告)日：2011-09-08
申请号：US13095098
申请日：2011-04-27
申请人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
发明人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
IPC分类号： A61K39/395 , C12N15/63 , C12N5/071 , C12P21/02 , C07K16/28 , C07H21/00 , A61P7/02 , C07K19/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

9. 发明申请

US20090041783A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 审中-公开
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US20090041783A1
公开(公告)日：2009-02-12
申请号：US11816233
申请日：2006-01-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C07K14/00 , A61P43/00 , G01N33/566 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

10. 发明授权

US06259875B1 Charging member and charging device 失效
标题翻译：充电器和充电器
公开(公告)号：US06259875B1
公开(公告)日：2001-07-10
申请号：US09373208
申请日：1999-08-12
申请人： Hiroyuki Miura , Hiroyuki Kataoka , Hiroshi Takayama
发明人： Hiroyuki Miura , Hiroyuki Kataoka , Hiroshi Takayama
IPC分类号： B03B1502
CPC分类号： G03G15/0233 , Y10T428/25
摘要： A charging member has a conductive core, a conductive elastic layer formed on the surface of the conductive core, and a wearing surface layer to be used also as a resistance controlling layer formed on the surface of the conductive elastic layer, and comprising a surface layer-forming resin and a resistance controlling conductive filler, developing conductivity by electron conduction and having a specific wearing amount of 5.0×10−4 (mm3/N·km) or more, the charging member capable of preventing deterioration of the charging performance of a charging member caused by contamination of the surface layer of the charging member, and maintaining stable and satisfactory uniform charging property and image quality for a long period of time, and always keeping the surface clean by positively wearing the surface layer of the charging member.
摘要翻译：充电构件具有导电芯，形成在导电芯的表面上的导电弹性层和用作形成在导电弹性层的表面上的电阻控制层的磨损表面层，并且包括表面层形成树脂和电阻控制导电填料，通过电子传导显影导电性，并且具有5.0×10 -4（mm 3 / N.km）以上的特定磨损量，该充电构件能够防止充电的充电性能的劣化由充电构件的表面层的污染引起的构件，并且长时间保持稳定和令人满意的均匀充电性能和图像质量，并且通过正面地佩戴充电构件的表面层来始终保持表面清洁。

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