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1. 发明授权

US08252905B2 Anti-CD14 antibody fusion protein 失效
标题翻译：抗CD14抗体融合蛋白
公开(公告)号：US08252905B2
公开(公告)日：2012-08-28
申请号：US11791888
申请日：2006-06-05
申请人： Shoji Furusako , Kazuyuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
发明人： Shoji Furusako , Kazuyuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
IPC分类号： C07K16/24 , C07K16/46
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/39541 , A61K2039/505 , C07K14/81 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
摘要翻译：提供了包含（I）抗CD14抗体或其活性片段或其衍生物和（II）蛋白酶抑制剂或其活性片段或其衍生物的蛋白质。

2. 发明授权

US07977461B2 Anti-platelet membrane glycoprotein VI monoclonal antibody 有权
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US07977461B2
公开(公告)日：2011-07-12
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

3. 发明申请

US20080286290A1 Anti-Cd14 Antibody Fusion Protein 失效
标题翻译：抗Cd14抗体融合蛋白
公开(公告)号：US20080286290A1
公开(公告)日：2008-11-20
申请号：US11791888
申请日：2006-06-05
申请人： Shoji Furusako , Kazayuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
发明人： Shoji Furusako , Kazayuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/00 , A61P31/00 , C12P21/00 , A61K35/00 , A61K31/7088
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/39541 , A61K2039/505 , C07K14/81 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
摘要翻译：提供了包含（I）抗CD14抗体或其活性片段或其衍生物和（II）蛋白酶抑制剂或其活性片段或其衍生物的蛋白质。

4. 发明申请

US20070106067A1 Assay kit and antibody for human low molecular weight cd14 有权
标题翻译：人类低分子量cd14的测定试剂盒和抗体
公开(公告)号：US20070106067A1
公开(公告)日：2007-05-10
申请号：US10534257
申请日：2003-11-12
申请人： Shoji Furusako
发明人： Shoji Furusako
IPC分类号： C07K16/28 , G01N33/53
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N2800/26
摘要： The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid sequence at a position among the positions 1 to 68. An assay kit for human low-molecular-weight CD14 using the antibody and an assay method of the present invention, preferably a sandwich method, are able to quantitatively or qualitatively determine human low-molecular-weight CD14 with high sensitivity and specificity in a simple manner, so that they are useful for the diagnosis of a patient suffering from sepsis.
摘要翻译：本发明提供使用肽作为抗原制备的抗体，所述肽具有选自人高分子量CD14的1至68位的氨基酸序列的8至30个氨基酸残基或结合至在1至68位的位置具有特定氨基酸序列的肽。使用抗体的人类低分子量CD 14的测定试剂盒和本发明的测定方法，优选夹心法，能够以简单的方式以高灵敏度和特异性定量或定性地测定人类低分子量CD14，从而可用于诊断患有败血症的患者。

5. 发明授权

US08541565B2 Polynucleotide encoding anti-CD14 antibody fusion protein 失效
标题翻译：编码抗CD14抗体融合蛋白的多核苷酸
公开(公告)号：US08541565B2
公开(公告)日：2013-09-24
申请号：US13547548
申请日：2012-07-12
申请人： Shoji Furusako , Kazuyuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
发明人： Shoji Furusako , Kazuyuki Nakayama , Yoshitaka Hosaka , Tetsushi Kawahara , Masaki Nakamura , Takashi Takeuchi
IPC分类号： C07H21/04 , C12N15/00 , C12N5/00 , C12P21/00 , A61K48/00
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/39541 , A61K2039/505 , C07K14/81 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
摘要翻译：提供了包含（I）抗CD14抗体或其活性片段或其衍生物和（II）蛋白酶抑制剂或其活性片段或其衍生物的蛋白质。

6. 发明授权

US08389692B2 Anti-platelet membrane glycoprotein VI monoclonal antibody 失效
公开(公告)号：US08389692B2
公开(公告)日：2013-03-05
申请号：US13095098
申请日：2011-04-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.

7. 发明申请

US20060068445A1 Novel soluble CD14 antigen 有权
标题翻译：新型可溶性CD14抗原
公开(公告)号：US20060068445A1
公开(公告)日：2006-03-30
申请号：US11126344
申请日：2005-05-11
申请人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
发明人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N33/6893 , G01N2333/70596 , G01N2800/26
摘要： There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
摘要翻译：提供可溶性CD14抗原，其是用作诊断败血症的标志物的新型体内蛋白质，具有以下特征1）至3）：1）当通过SDS-PAGE测定时，分子量为13±2kDa 非还原条件; 2）其N末端存在SEQ ID NO：1的氨基酸序列的氨基酸序列; 和3）通过使用包含SEQ ID NO：2中所述的16个氨基酸残基的肽作为抗原而特异性结合抗体的能力; 和重组可溶性CD14片段。

8. 发明申请

US20110217318A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 失效
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US20110217318A1
公开(公告)日：2011-09-08
申请号：US13095098
申请日：2011-04-27
申请人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
发明人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
IPC分类号： A61K39/395 , C12N15/63 , C12N5/071 , C12P21/02 , C07K16/28 , C07H21/00 , A61P7/02 , C07K19/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

9. 发明申请

US20090203052A1 NOVEL SOLUBLE CD14 ANTIGEN 有权
标题翻译：新型可溶性CD14抗原
公开(公告)号：US20090203052A1
公开(公告)日：2009-08-13
申请号：US12395298
申请日：2009-02-27
申请人： Shoji FURUSAKO , Kamon Shirakawa , Jiro Hirose
发明人： Shoji FURUSAKO , Kamon Shirakawa , Jiro Hirose
IPC分类号： G01N33/53
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N33/6893 , G01N2333/70596 , G01N2800/26
摘要： There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
摘要翻译：提供可溶性CD14抗原，其是用作诊断败血症的标志物的新型体内蛋白质，具有以下特征1）至3）：1）当通过SDS-PAGE测定时，分子量为13±2kDa 非还原条件; 2）其N末端存在SEQ ID NO：1的氨基酸序列的氨基酸序列; 和3）通过使用包含SEQ ID NO：2中所述的16个氨基酸残基的肽作为抗原而特异性结合抗体的能力; 和重组可溶性CD14片段。

10. 发明申请

US20090041783A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 审中-公开
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US20090041783A1
公开(公告)日：2009-02-12
申请号：US11816233
申请日：2006-01-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C07K14/00 , A61P43/00 , G01N33/566 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

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