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1. 发明申请

US20080257022A1 Factory-alignable compact cantilever probe 失效
标题翻译：工厂可对齐的紧凑型悬臂式探头
公开(公告)号：US20080257022A1
公开(公告)日：2008-10-23
申请号：US11789044
申请日：2007-04-23
申请人： Frederick Sachs
发明人： Frederick Sachs
IPC分类号： G01B5/28
CPC分类号： G01Q10/04 , G01Q20/02 , G01Q60/38
摘要： A scanner which includes a gradient index lens for passing and focusing beams from a radiation emitter to a cantilevered member reflective surface of a probe and from the reflective surface to a radiation detector. The lens also serves as a mechanical support for attachment of the radiation emitter and the radiation detector and is also attached to a support for the cantilevered member. The resulting fixed positions of the radiation emitter and the radiation detector relative to the reflective cantilevered member surface allows the scanner to be compact and factory focally alignable.
摘要翻译：一种扫描仪，其包括用于将来自辐射发射器的光束传递到聚焦到探针的悬臂构件反射表面并且从反射表面到辐射探测器的梯度折射率透镜。透镜还用作用于附接辐射发射器和辐射探测器的机械支撑件，并且还附接到用于悬臂构件的支撑件。辐射发射器和辐射检测器相对于反射悬臂构件表面的最终固定位置允许扫描仪紧凑并且工厂可以对准。

2. 发明申请

US20080128385A1 Oscillator and method of making for atomic force microscope and other applications 审中-公开
标题翻译：振荡器和制造原子力显微镜等应用的方法
公开(公告)号：US20080128385A1
公开(公告)日：2008-06-05
申请号：US12008127
申请日：2008-01-09
申请人： Arthur Beyder , Frederick Sachs
发明人： Arthur Beyder , Frederick Sachs
IPC分类号： B29D11/00
CPC分类号： G01Q10/045 , G01Q60/38 , Y10T29/49 , Y10T29/49007 , Y10T74/10
摘要： A method for making a device which includes an oscillator, which includes depositing on silicon or other first material a layer of silicon nitride or other second material, forming in the first material a support structure and the oscillator, including applying an etchant which is selective for the first material to etch all the way through the first material and leave the second material substantially unetched to thereby form the at least one flexible hinge of the second material.
摘要翻译：一种用于制造包括振荡器的装置的方法，该振荡器包括在硅或其它第一材料上沉积氮化硅或其它第二材料层，在第一材料中形成支撑结构和振荡器，包括施加蚀刻剂，所述蚀刻剂对于所述第一材料一直蚀刻通过所述第一材料并且使所述第二材料基本上未被蚀刻，从而形成所述第二材料的所述至少一个柔性铰链。

3. 发明授权

US07340944B2 Oscillator and method of making for atomic force microscope and other applications 失效
标题翻译：振荡器和制造原子力显微镜等应用的方法
公开(公告)号：US07340944B2
公开(公告)日：2008-03-11
申请号：US11506970
申请日：2006-08-18
申请人： Arthur Beyder , Frederick Sachs
发明人： Arthur Beyder , Frederick Sachs
IPC分类号： G01B5/28
CPC分类号： G01Q10/045 , G01Q60/38 , Y10T29/49 , Y10T29/49007 , Y10T74/10
摘要： A device having an oscillator such as a sensor for use in an atomic force microscope. A pair of co-axial members interconnect support structure and the oscillator for torsionally suspending the oscillator. The co-axial members are portions of a layer of silicon nitride or other material that is connected to the oscillator and support structure, which are composed of silicon or other material.A process for making a device which includes an oscillator, which includes depositing on silicon or other first material a layer of silicon nitride or other second material, forming in the first material a support structure and the oscillator, including applying an etchant which is selective for the first material to etch all the way through the first material and leave the second material substantially unetched to thereby form the at least one flexible hinge of the second material.
摘要翻译：具有诸如用于原子力显微镜的传感器的振荡器的装置。一对同轴构件互连支撑结构和振荡器，用于扭转振荡器的悬挂。共轴构件是连接到由硅或其它材料构成的振荡器和支撑结构的氮化硅或其它材料层的部分。一种制造包括振荡器的方法，该振荡器包括在硅或其它第一材料上沉积氮化硅或其它第二材料层，在第一材料中形成支撑结构和振荡器，包括施加选择性的蚀刻剂所述第一材料一直蚀刻通过所述第一材料并且使所述第二材料基本上未被蚀刻，从而形成所述第二材料的所述至少一个柔性铰链。

4. 发明申请

US20070062265A1 Oscillator for atomic force microscope and other applications 失效
标题翻译：振荡器用于原子力显微镜等应用
公开(公告)号：US20070062265A1
公开(公告)日：2007-03-22
申请号：US11506757
申请日：2006-08-18
申请人： Arthur Beyder , Frederick Sachs
发明人： Arthur Beyder , Frederick Sachs
IPC分类号： G12B21/00 , G12B21/08
CPC分类号： G01Q10/045 , G01Q60/38 , Y10T29/49 , Y10T29/49007 , Y10T74/10
摘要： A device such as a sensor for use in an atomic force microscope. The device comprises a first oscillator, a second oscillator, a pair of first co-axial members interconnecting the first and second oscillators for torsionally suspending the first oscillator, a support structure, and a pair of second co-axial members whose axis is orthogonal to an axis of the first co-axial members and which interconnect the second oscillator and the support structure for torsionally suspending the second oscillator.
摘要翻译：用于原子力显微镜的诸如传感器的装置。该装置包括第一振荡器，第二振荡器，互连第一振荡器和第二振荡器的一对第一同轴构件，用于扭转地悬挂第一振荡器，支撑结构和一对第二同轴构件，其轴线正交于第一同轴构件的轴线，并且连接第二振荡器和支撑结构，用于扭转地悬挂第二振荡器。

5. 发明授权

US4818266A Apparatus for producing glass tubing of a narrowed diameter 失效
标题翻译：用于生产窄径玻璃管的设备
公开(公告)号：US4818266A
公开(公告)日：1989-04-04
申请号：US863119
申请日：1986-05-14
申请人： Frederick Sachs , Victor Demjanenko
发明人： Frederick Sachs , Victor Demjanenko
IPC分类号： C03B23/043 , C03B23/045 , C03B23/047 , C03B23/11
CPC分类号： C03B23/045 , C03B23/043 , C03B23/0473
摘要： The method of the present invention consists of the steps of heating an area along the length of a small diameter glass tube while the tube is being rotated, pulling the heated tube using an unidirectional force to rapidly extend the heated area while mechanically maintaining the heat source centrally located along the portion of the tubing being extended. The extended tubing is subsequently cooled and separated at the narrowed portion to produce two capillary tubes. The apparatus of the present invention consists of two independently rotatable, co-axially aligned chucks. The chucks rotate in an essentially simultaneous manner, that is, the speed of rotation of each chuck is essentially the same. Each of the chucks has an adjustable collet thereon adapted to receive and hold a section of glass tubing aligned therebetween. A means of moving one of said chucks away from the other is provided. A moveable heating means is positioned intermediate the chucks. The moveable heating means is adapted to start at the same time and to move in the same direction as the movable chuck, but half the distance that the chuck moves. The moveable heating means provides longitudinal symmetry while the rotational means provides axial symmetry.
摘要翻译：本发明的方法包括以下步骤：当管旋转时沿着小直径玻璃管的长度加热区域，使用单向力拉动加热的管以快速延伸加热区域，同时机械地保持热源沿着被延伸的管道的部分位于中心。随后将扩展的管冷却并在狭窄部分分离，以产生两个毛细管。本发明的装置由两个可独立旋转的同轴对准的卡盘组成。卡盘以基本上同时的方式旋转，即每个卡盘的旋转速度基本相同。每个卡盘上都有一个可调节的夹头，适用于容纳和保持与其间对准的一段玻璃管。提供将所述卡盘中的一个移动远离另一个的装置。可移动加热装置位于卡盘之间。可移动加热装置适于同时启动并沿与可移动卡盘相同的方向移动，但是卡盘移动的距离的一半。可移动加热装置提供纵向对称，而旋转装置提供轴向对称。

6. 发明授权

US4427483A Microelectrode fabricting apparatus 失效
标题翻译：微电极制造设备
公开(公告)号：US4427483A
公开(公告)日：1984-01-24
申请号：US371550
申请日：1982-04-26
申请人： Frederick Sachs , Richard G. McGarrigle
发明人： Frederick Sachs , Richard G. McGarrigle
IPC分类号： A61N1/04 , C23F4/04 , G01N27/28 , C23F1/02 , B44C1/22 , C23F1/00 , C23F3/00
CPC分类号： A61N1/044 , C23F4/04 , G01N27/28
摘要： Apparatus for controlled removal of silver from the tip of a silver coated microelectrode including a mercury bath aligned with the microelectrode; a motor driven micromanipulator for moving the microelectrode into contact with the mercury; and circuits to deenergize and control the angular momentum of the micromanipulator motor whereby the depth of penetration of the electrode into the mercury can be accurately controlled.
摘要翻译：用于从包括与微电极对准的汞浴的镀银微电极的尖端控制去除银的装置; 用于移动微电极与汞接触的电机驱动的微操纵器; 以及断开和控制显微操纵器电动机的角动量的电路，从而可以精确地控制电极进入汞的深度。

7. 发明申请

US20100188101A1 Method And System For Synchronous Rectification 有权
标题翻译：同步整流方法与系统
公开(公告)号：US20100188101A1
公开(公告)日：2010-07-29
申请号：US12602884
申请日：2008-06-05
申请人： Stephen Besch , Frederick Sachs
发明人： Stephen Besch , Frederick Sachs
IPC分类号： G01R35/00
CPC分类号： G01D3/036 , G01D18/002
摘要： The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited with an AC voltage or current, or in which the signal can be modulated with an AC voltage or current.
摘要翻译：本发明的方法和系统使用同步整流和频域分析来消除对A / D和D / A组件校准的需要。它适用于任何基于传感器的测量，其中传感器可以用交流电压或电流激励，或者可以用交流电压或电流调制信号。

8. 发明申请

US20060014691A1 Mechanically activated channel blocker 有权
标题翻译：机械激活通道阻塞器
公开(公告)号：US20060014691A1
公开(公告)日：2006-01-19
申请号：US11176745
申请日：2005-07-07
申请人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
发明人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
IPC分类号： A61K38/54 , C07K14/47 , C12P21/06
CPC分类号： C07K14/43518 , A61K38/00 , Y10S530/858
摘要： The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alteartions in mechanical stress.
摘要翻译：本发明公开了SEQ ID NO：1的肽及其延伸活化离子通道的变体。该肽中的所有氨基酸都是D-氨基酸。称为D-GsMTx4的肽是存在于蜘蛛Grammostola spatulata的毒液中的肽GsMTX-4的对映异构体。本发明还公开了抑制细胞中拉伸活化离子通道的方法。该肽可用于治疗心律失常和其他涉及机械应激中的alteartions的病态。

9. 发明授权

US4828599A Method for producing glass tubing of a narrowed diameter 失效
标题翻译：生产窄径玻璃管的方法
公开(公告)号：US4828599A
公开(公告)日：1989-05-09
申请号：US229905
申请日：1988-08-08
申请人： Frederick Sachs , Victor Demjanenko
发明人： Frederick Sachs , Victor Demjanenko
IPC分类号： C03B23/043 , C03B23/045 , C03B23/047
CPC分类号： C03B23/0473 , C03B23/043 , C03B23/045
摘要： The method of the present invention consists of the steps of heating an area along the length of a small diameter glass tube while the tube is being rotated, pulling the heated tube using an unidirectional force to rapidly extend the heated area while mechanically maintaining the heat source centrally located along the portion of the tubing being extended. The extended tubing is subsequently cooled and separated at the narrowed portion to produce two capillary tubes.
摘要翻译：本发明的方法包括以下步骤：当管旋转时沿着小直径玻璃管的长度加热区域，使用单向力拉动加热的管以快速延伸加热区域，同时机械地保持热源沿着被延伸的管道的部分位于中心。随后将扩展的管冷却并在狭窄部分分离，以产生两个毛细管。

10. 发明授权

US4452249A Microelectrodes and process for shielding same 失效
标题翻译：微电极和屏蔽过程
公开(公告)号：US4452249A
公开(公告)日：1984-06-05
申请号：US326388
申请日：1981-12-01
申请人： Frederick Sachs , Richard G. McGarrigle
发明人： Frederick Sachs , Richard G. McGarrigle
IPC分类号： A61B5/0408 , A61N1/04 , A61B5/04
CPC分类号： A61N1/044 , A61B5/0408
摘要： A shielded microelectrode process and product wherein the microelectrode is coated by vacuum evaporation techniques with a thin layer of silver; the silver from the microelectrode tip region is removed to a depth of no greater than substantially 20 micrometers by contact with memory; and the microelectrode is dipped into a thermosetting wax in liquid form whereby as the wax solidifies the silver is coated thereby below the tip region.
摘要翻译：一种屏蔽微电极工艺和产品，其中微电极通过真空蒸发技术用薄层银涂覆; 来自微电极尖端区域的银通过与记忆体的接触除去至不大于基本上20微米的深度; 并且将微电极浸入液态的热固性蜡中，由此当蜡固化时，银被涂覆在其顶部区域下方。

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