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1. 发明申请

US20060014691A1 Mechanically activated channel blocker 有权
标题翻译：机械激活通道阻塞器
公开(公告)号：US20060014691A1
公开(公告)日：2006-01-19
申请号：US11176745
申请日：2005-07-07
申请人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
发明人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
IPC分类号： A61K38/54 , C07K14/47 , C12P21/06
CPC分类号： C07K14/43518 , A61K38/00 , Y10S530/858
摘要： The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alteartions in mechanical stress.
摘要翻译：本发明公开了SEQ ID NO：1的肽及其延伸活化离子通道的变体。该肽中的所有氨基酸都是D-氨基酸。称为D-GsMTx4的肽是存在于蜘蛛Grammostola spatulata的毒液中的肽GsMTX-4的对映异构体。本发明还公开了抑制细胞中拉伸活化离子通道的方法。该肽可用于治疗心律失常和其他涉及机械应激中的alteartions的病态。

2. 发明授权

US07259145B2 Mechanically activated channel blocker 有权
标题翻译：机械激活通道阻塞器
公开(公告)号：US07259145B2
公开(公告)日：2007-08-21
申请号：US11176745
申请日：2005-07-07
申请人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
发明人： Frederick Sachs , Thomas Suchyna , Phillip Gottlieb
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： C07K14/43518 , A61K38/00 , Y10S530/858
摘要： The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alterations in mechanical stress.
摘要翻译：本发明公开了SEQ ID NO：1的肽及其延伸活化离子通道的变体。该肽中的所有氨基酸都是D-氨基酸。称为D-GsMTx4的肽是存在于蜘蛛Grammostola spatulata的毒液中的肽GsMTX-4的对映异构体。本发明还公开了抑制细胞中拉伸活化离子通道的方法。该肽可用于治疗涉及机械应激改变的心律失常和其他病态。

3. 发明授权

US09211313B2 Methods and compound to inhibit Ca2+ permeable cation conductance 有权
标题翻译：抑制Ca2 +渗透性阳离子电导的方法和化合物
公开(公告)号：US09211313B2
公开(公告)日：2015-12-15
申请号：US13351611
申请日：2012-01-17
申请人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
发明人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
IPC分类号： A61K38/16 , A61K38/17
CPC分类号： A61K38/1767
摘要： The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
摘要翻译：本发明提供用于抑制患有镰状细胞性贫血的个体的红细胞的钙渗透性阳离子电导的方法和组合物。该方法包括将细胞暴露于肽GsMTx4和/或其变体。

4. 发明申请

US20120184491A1 Methods and Compound to Inhibit Ca2+ Permeable Cation Conductance 有权
标题翻译：方法和化合物抑制Ca2 +透过阳离子电导
公开(公告)号：US20120184491A1
公开(公告)日：2012-07-19
申请号：US13351611
申请日：2012-01-17
申请人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
发明人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
IPC分类号： A61K38/16 , C12N5/02 , A61P7/06
CPC分类号： A61K38/1767
摘要： The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
摘要翻译：本发明提供用于抑制患有镰状细胞性贫血的个体的红细胞的钙渗透性阳离子电导的方法和组合物。该方法包括将细胞暴露于肽GsMTx4和/或其变体。

5. 发明授权

US07125847B1 Mechanically activated channel blocker 有权
标题翻译：机械激活通道阻塞器
公开(公告)号：US07125847B1
公开(公告)日：2006-10-24
申请号：US10397595
申请日：2003-03-26
申请人： Frederick Sachs , Thomas Suchyna , Janice Johnson
发明人： Frederick Sachs , Thomas Suchyna , Janice Johnson
IPC分类号： A61K38/00 , A61K38/16 , C07K14/00 , C07K1/00
CPC分类号： C07K14/43518 , A61K38/00
摘要： The present invention discloses a peptide of SEQ ID NO:2 and its variants that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider Grammostola spatulata. The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. The cDNA sequence encoding the GsMTx-4 is also disclosed. This peptide and its variants can be used for the treatment of cardiac arrhythmias.
摘要翻译：本发明公开了SEQ ID NO：2的肽及其延伸激活离子通道的变体。称为GsMTx-4的肽存在于蜘蛛G the的毒液中。本发明还公开了一种从蜘蛛毒液中纯化肽GsMTx-4的方法和抑制细胞中拉伸活化离子通道的方法。还公开了编码GsMTx-4的cDNA序列。该肽及其变体可用于治疗心律失常。

6. 发明授权

US07607344B2 Factory-alignable compact cantilever probe 失效
标题翻译：工厂可对齐的紧凑型悬臂式探头
公开(公告)号：US07607344B2
公开(公告)日：2009-10-27
申请号：US11789044
申请日：2007-04-23
申请人： Frederick Sachs
发明人： Frederick Sachs
IPC分类号： G01B5/28 , G01N13/16
CPC分类号： G01Q10/04 , G01Q20/02 , G01Q60/38
摘要： A scanner which includes a gradient index lens for passing and focusing beams from a radiation emitter to a cantilevered member reflective surface of a probe and from the reflective surface to a radiation detector. The lens also serves as a mechanical support for attachment of the radiation emitter and the radiation detector and is also attached to a support for the cantilevered member. The resulting fixed positions of the radiation emitter and the radiation detector relative to the reflective cantilevered member surface allows the scanner to be compact and factory focally alignable.
摘要翻译：一种扫描仪，其包括用于将来自辐射发射器的光束传递到聚焦到探针的悬臂构件反射表面并且从反射表面到辐射探测器的梯度折射率透镜。透镜还用作用于附接辐射发射器和辐射探测器的机械支撑件，并且还附接到用于悬臂构件的支撑件。辐射发射器和辐射检测器相对于反射悬臂构件表面的最终固定位置允许扫描仪紧凑并且工厂可以对准。

7. 发明授权

US5756663A Antiarrhythmic peptide from venom of spider Grammostola spatulata 失效
公开(公告)号：US5756663A
公开(公告)日：1998-05-26
申请号：US775477
申请日：1996-12-30
申请人： Richard Alexander Lampe , Frederick Sachs
发明人： Richard Alexander Lampe , Frederick Sachs
IPC分类号： A61K38/00 , C07K14/435 , A61K38/16 , C07K14/00
CPC分类号： C07K14/43518 , A61K38/00
摘要： The invention provides a novel peptide isolated from the venom of the spider Grammostola spatulata which peptide has antiarrhthymic activity. The invention also provides methods of treating arrhthymia comprising administering to a patient in need of such treatment an effective amount of the peptide. The invention further provides pharmaceutical compositions and methods of mediating hypotonic cell swelling induced calcium increase in cells.

8. 发明申请

US20100188101A1 Method And System For Synchronous Rectification 有权
标题翻译：同步整流方法与系统
公开(公告)号：US20100188101A1
公开(公告)日：2010-07-29
申请号：US12602884
申请日：2008-06-05
申请人： Stephen Besch , Frederick Sachs
发明人： Stephen Besch , Frederick Sachs
IPC分类号： G01R35/00
CPC分类号： G01D3/036 , G01D18/002
摘要： The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited with an AC voltage or current, or in which the signal can be modulated with an AC voltage or current.
摘要翻译：本发明的方法和系统使用同步整流和频域分析来消除对A / D和D / A组件校准的需要。它适用于任何基于传感器的测量，其中传感器可以用交流电压或电流激励，或者可以用交流电压或电流调制信号。

9. 发明授权

US4828599A Method for producing glass tubing of a narrowed diameter 失效
标题翻译：生产窄径玻璃管的方法
公开(公告)号：US4828599A
公开(公告)日：1989-05-09
申请号：US229905
申请日：1988-08-08
申请人： Frederick Sachs , Victor Demjanenko
发明人： Frederick Sachs , Victor Demjanenko
IPC分类号： C03B23/043 , C03B23/045 , C03B23/047
CPC分类号： C03B23/0473 , C03B23/043 , C03B23/045
摘要： The method of the present invention consists of the steps of heating an area along the length of a small diameter glass tube while the tube is being rotated, pulling the heated tube using an unidirectional force to rapidly extend the heated area while mechanically maintaining the heat source centrally located along the portion of the tubing being extended. The extended tubing is subsequently cooled and separated at the narrowed portion to produce two capillary tubes.
摘要翻译：本发明的方法包括以下步骤：当管旋转时沿着小直径玻璃管的长度加热区域，使用单向力拉动加热的管以快速延伸加热区域，同时机械地保持热源沿着被延伸的管道的部分位于中心。随后将扩展的管冷却并在狭窄部分分离，以产生两个毛细管。

10. 发明授权

US4452249A Microelectrodes and process for shielding same 失效
标题翻译：微电极和屏蔽过程
公开(公告)号：US4452249A
公开(公告)日：1984-06-05
申请号：US326388
申请日：1981-12-01
申请人： Frederick Sachs , Richard G. McGarrigle
发明人： Frederick Sachs , Richard G. McGarrigle
IPC分类号： A61B5/0408 , A61N1/04 , A61B5/04
CPC分类号： A61N1/044 , A61B5/0408
摘要： A shielded microelectrode process and product wherein the microelectrode is coated by vacuum evaporation techniques with a thin layer of silver; the silver from the microelectrode tip region is removed to a depth of no greater than substantially 20 micrometers by contact with memory; and the microelectrode is dipped into a thermosetting wax in liquid form whereby as the wax solidifies the silver is coated thereby below the tip region.
摘要翻译：一种屏蔽微电极工艺和产品，其中微电极通过真空蒸发技术用薄层银涂覆; 来自微电极尖端区域的银通过与记忆体的接触除去至不大于基本上20微米的深度; 并且将微电极浸入液态的热固性蜡中，由此当蜡固化时，银被涂覆在其顶部区域下方。

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