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1. 发明授权

US08318951B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US08318951B2
公开(公告)日：2012-11-27
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D405/14 , C07D413/04 , A61K31/4155 , A61K31/422 , A61P29/00 , C12N5/0775 , C12N5/0797
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

2. 发明申请

US20120029200A1 Stem Cell Differentiating Agents and Uses Therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US20120029200A1
公开(公告)日：2012-02-02
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

3. 发明授权

US08778940B2 Chemical inducers of neurogenesis 有权
标题翻译：化学诱导剂的神经发生
公开(公告)号：US08778940B2
公开(公告)日：2014-07-15
申请号：US13487963
申请日：2012-06-04
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/415 , A61K31/4155 , A61K31/42
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

4. 发明授权

US08193225B2 Isoxazole amides, derivatives and methods of chemical induction of neurogenesis 有权
标题翻译：异恶唑酰胺，衍生物和化学诱导神经发生的方法
公开(公告)号：US08193225B2
公开(公告)日：2012-06-05
申请号：US11974479
申请日：2007-10-12
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , C07D261/18
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。化合物是异恶唑酰胺及其衍生物。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

5. 发明申请

US20090076103A1 STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR 有权
标题翻译：干细胞分化试剂及其用途
公开(公告)号：US20090076103A1
公开(公告)日：2009-03-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C12N5/06 , C12Q1/66 , C12Q1/68 , A01K67/027 , C07C311/15 , A61P35/00 , C07D413/04 , C07D405/06 , C07D409/06 , A61K31/422 , A61K31/4155
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

6. 发明申请

US20130143885A1 CHEMICAL INDUCERS OF NEUROGENESIS 有权
标题翻译：化学发现神经细胞
公开(公告)号：US20130143885A1
公开(公告)日：2013-06-06
申请号：US13487963
申请日：2012-06-04
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/04 , C07D403/14 , A61K31/496 , C07D413/14
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

7. 发明授权

US07981935B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US07981935B2
公开(公告)日：2011-07-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C07C311/49 , C12N5/074
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

8. 发明申请

US20090036451A1 Chemical inducers of neurogenesis 有权
标题翻译：化学诱导剂的神经发生
公开(公告)号：US20090036451A1
公开(公告)日：2009-02-05
申请号：US11974479
申请日：2007-10-12
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , C07D261/18 , C07D249/10 , C07D271/06 , A61P35/00 , C12N1/38 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

9. 发明申请

US20050148069A1 IGF-1 instructs multipotent adult CNS neural stem cells to an oligodendroglial lineage 审中-公开
标题翻译： IGF-1指导多能成人CNS神经干细胞向少突胶质细胞谱系
公开(公告)号：US20050148069A1
公开(公告)日：2005-07-07
申请号：US10949017
申请日：2004-09-24
申请人： Fred Gage , Jenny Hsieh
发明人： Fred Gage , Jenny Hsieh
IPC分类号： C12N20060101 , C12N5/079 , C12N5/08
CPC分类号： C12N5/0622 , C12N2501/105
摘要： Adult neural stem cells differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian CNS, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor-I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural stem cells. Here we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of BMP signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.
摘要翻译：成年神经干细胞在哺乳动物CNS中分化为神经元，星形胶质细胞和少突胶质细胞，但是控制其分化的分子机制尚未明了。胰岛素样生长因子-I（IGF-I）可以促进在发育期间已经致力于少突胶质细胞谱系的细胞的分化。然而，IGF-I是否影响多能神经干细胞是不清楚的。在这里我们显示IGF-I刺激多能成年大鼠海马源神经祖细胞分化为少突胶质细胞。建模分析表明IGF-I的作用是有启发性的。通过IGF-I的少突胶质细胞分化似乎通过抑制BMP信号传导。此外，IGF-I在海马中的过表达导致少突胶质细胞标志物的增加。这些数据表明存在可以影响多能成年神经祖细胞对少突神经胶质谱系的命运选择的单分子IGF-I。

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