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1. 发明授权

US07178780B2 Composite coating for mold insert and method for making a coated mold insert 有权
标题翻译：用于模具插入件的复合涂层和用于制造涂覆模具插件的方法
公开(公告)号：US07178780B2
公开(公告)日：2007-02-20
申请号：US10815073
申请日：2004-03-31
申请人： Paul F. Mastro , Christopher D. Blair , Jennifer R. Wagner , Jay Schneider
发明人： Paul F. Mastro , Christopher D. Blair , Jennifer R. Wagner , Jay Schneider
IPC分类号： B29C33/38
CPC分类号： H01F7/0268 , B29C33/56 , B29C45/37 , H01F41/0266
摘要： A mold used to form a magnetic member includes a mold body having a mold opening, a mold support that supports the mold cavity, and a mold insert. The mold insert is disposed in the mold opening of the mold body to form a mold cavity. The mold insert is coated with a coating to protect the mold body from chemical attack and abrasive wear of the mold material. The coating comprises an electroless nickel layer formed on or over the mold insert, and a chromium nitride layer formed on or over the electroless nickel layer. The mold insert can be formed of beryllium-copper (Be—Cu).
摘要翻译：用于形成磁性构件的模具包括具有模具开口的模具主体，支撑模腔的模具支撑件和模具插入件。模具插入件设置在模具主体的模具开口中以形成模腔。模具插入件涂覆有涂层以保护模具体免受模具材料的化学侵蚀和磨损磨损。涂层包括形成在模具插入件上或上方的无电镍层，以及形成在无电镀镍层上或之上的氮化铬层。模具插入件可以由铍铜（Be-Cu）形成。

2. 发明申请

US20050020530A1 Treatment of parkinson's disease with oligonucleotides 有权
标题翻译：用寡核苷酸治疗帕金森病
公开(公告)号：US20050020530A1
公开(公告)日：2005-01-27
申请号：US10937824
申请日：2004-09-09
申请人： Jay Schneider
发明人： Jay Schneider
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P25/16 , C12N15/113
CPC分类号： A61K31/711 , A61K38/00 , C12N15/1137 , C12N2310/152 , C12N2310/315
摘要： The present invention relates to a method of treatment of Parkinson's disease, and to the use of antisense oligonucleotides or triplex oligonucleotides introduced into targeted brain structures to decrease the function of brain circuits known to be overactive in the Parkinsonian brain. Antisense or triplex oligonucleotides are targeted to the internal globus pallidus and/or substantia nigra pars reticulata (SNr) where the expression of glutamic acid decarboxylase (GAD67, GAD65, or a combination of the two isoforms) is downregulated. The present invention also relates to a method of treatment of Parkinson's disease where antisense or triplex oligonucleotides are targeted to the internal globus pallidus and/or substantia nigra pars reticulata for the downregulation of glutamate receptors. The present invention further relates to a method of treatment of Parkinson's disease where antisense or triplex oligonucleotides are targeted to the thalamic motor nuclei for the downregulation of GABA receptors.
摘要翻译：本发明涉及治疗帕金森病的方法，以及引入靶向脑结构中的反义寡核苷酸或三链寡核苷酸的用途，以降低已知在帕金森病脑中过度活跃的脑电路的功能。反义或三重寡核苷酸靶向内部苍白球和/或黑质浆果（SNr），其中谷氨酸脱羧酶（GAD67，GAD65或两种同种型的组合）的表达下调。本发明还涉及一种治疗帕金森病的方法，其中反义或三重寡核苷酸针对内部苍白球和/或黑质黑质对谷氨酸受体的下调。本发明还涉及治疗帕金森病的方法，其中反义或三重寡核苷酸靶向用于下调GABA受体的丘脑运动核。

3. 发明授权

US08753194B2 Escrow accounts for use in distributing payouts with minimal interruption to game play 有权
标题翻译：托管账户用于分发付款，游戏玩法中断
公开(公告)号：US08753194B2
公开(公告)日：2014-06-17
申请号：US12944261
申请日：2010-11-11
申请人： Richard Jay Schneider , Thomas O. Mikulich
发明人： Richard Jay Schneider , Thomas O. Mikulich
IPC分类号： A63F9/24 , G06F17/00
CPC分类号： G07F17/3225 , G06Q40/123
摘要： A gaming machine includes configured to communicate with a remote server, and further configured to detect a reportable event during play of a game by a player, wherein the reportable event is associated with a winning outcome having an associated award amount. The processor also receives an acknowledgement of the reportable event from the player, and transmits the acknowledgement of the reportable event and the award amount to the remote server for use in generating a taxable accrual log.
摘要翻译：游戏机包括被配置为与远程服务器进行通信，并且还被配置为在玩家玩游戏期间检测可报告事件，其中所述可报告事件与具有相关联的奖励量的获胜结果相关联。处理器还从播放器接收到可报告事件的确认，并将可报告事件的确认和裁决量发送到远程服务器，以用于生成应税应计制日志。

4. 发明申请

US20130143885A1 CHEMICAL INDUCERS OF NEUROGENESIS 有权
标题翻译：化学发现神经细胞
公开(公告)号：US20130143885A1
公开(公告)日：2013-06-06
申请号：US13487963
申请日：2012-06-04
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/04 , C07D403/14 , A61K31/496 , C07D413/14
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

5. 发明授权

US08318951B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US08318951B2
公开(公告)日：2012-11-27
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D405/14 , C07D413/04 , A61K31/4155 , A61K31/422 , A61P29/00 , C12N5/0775 , C12N5/0797
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

6. 发明申请

US20120029200A1 Stem Cell Differentiating Agents and Uses Therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US20120029200A1
公开(公告)日：2012-02-02
申请号：US13116574
申请日：2011-05-26
申请人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

7. 发明授权

US07981935B2 Stem cell differentiating agents and uses therefor 有权
标题翻译：干细胞分化剂及其用途
公开(公告)号：US07981935B2
公开(公告)日：2011-07-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C07C311/49 , C12N5/074
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译：本发明涉及可诱导干细胞分化的化合物的筛选。此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

8. 发明申请

US20090036451A1 Chemical inducers of neurogenesis 有权
标题翻译：化学诱导剂的神经发生
公开(公告)号：US20090036451A1
公开(公告)日：2009-02-05
申请号：US11974479
申请日：2007-10-12
申请人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
发明人： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC分类号： A61K31/422 , C07D261/18 , C07D249/10 , C07D271/06 , A61P35/00 , C12N1/38 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译：本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

9. 发明授权

US6068101A Gaming machine currency apparatus and method therefore 失效
标题翻译：因此，游戏机货币装置和方法
公开(公告)号：US6068101A
公开(公告)日：2000-05-30
申请号：US729602
申请日：1996-10-11
申请人： Robert M. Dickenson , Richard Jay Schneider , Joseph Wesley Cole , Linn A. McKay
发明人： Robert M. Dickenson , Richard Jay Schneider , Joseph Wesley Cole , Linn A. McKay
IPC分类号： G07F9/06 , G07F17/32 , G07F7/04 , G07F17/34
CPC分类号： G07F9/06 , G07F17/32
摘要： A gaming machine and method including a housing having a door which exposes a currency mechanism along a medial portion thereof and located between a side wall and a monitor. This strategic location of the currency mechanism allows clearance for an underlying coin hopper so as to minimize the need for an external currency mechanism and to provide access to the coin hopper in a much more maintenance friendly manner for tending to the coin hopper and currency mechanisms, e.g. for filling, etc.
摘要翻译：一种游戏机和方法，包括具有门的壳体，所述门沿着其中间部分暴露货币机构并且位于侧壁和监视器之间。这种货币机制的这一战略位置允许对下一个硬币漏斗进行清除，以便最小化对外部货币机制的需求，并以更加维护的方式提供对硬币漏斗的接近以便向硬币漏斗和货币机制转移，例如填充等

10. 外观设计

USD424122S Electronic game housing 失效
公开(公告)号：USD424122S
公开(公告)日：2000-05-02
申请号：US52216
申请日：1996-03-25
申请人： Robert M. Dickenson , Richard Jay Schneider , Joseph Wesley Cole , Linn A. McKay
设计人： Robert M. Dickenson , Richard Jay Schneider , Joseph Wesley Cole , Linn A. McKay

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