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1. 发明申请

US20170181972A1 Microfluidic Liposome Synthesis, Purification and Active Drug Loading 审中-公开
公开(公告)号：US20170181972A1
公开(公告)日：2017-06-29
申请号：US15456111
申请日：2017-03-10
申请人： Renee Hood , Donald Lad DeVoe
发明人： Renee Hood , Donald Lad DeVoe
IPC分类号： A61K9/127 , B01J13/08 , B01J19/00 , A61K31/704
CPC分类号： A61K9/1277 , A61K9/1278 , A61K31/00 , A61K31/5415 , A61K31/704 , A61K31/7048 , A61K31/7068 , B01J13/08 , B01J19/0093 , B01J2219/00783 , B01J2219/00792 , B01J2219/00795 , B01J2219/0086 , B01J2219/00894 , B01J2219/00905
摘要： Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

2. 发明申请

US20150368098A1 METHOD FOR FABRICATING THERMOPLASTIC FLUIDIC DEVICES BY OROGENIC GROWTH AND FLUIDIC DEVICES MANUFACTURED THEREBY 有权
标题翻译：通过生物生长制造热塑性流体装置的方法和制造的流体装置
公开(公告)号：US20150368098A1
公开(公告)日：2015-12-24
申请号：US14109711
申请日：2013-12-17
申请人： Omid Rahmanian , Chien-Fu Chen , Donald Lad Devoe
发明人： Omid Rahmanian , Chien-Fu Chen , Donald Lad Devoe
IPC分类号： B81C1/00 , B81B1/00 , B81C3/00
CPC分类号： B81C1/00119 , B81B2201/058 , B81C3/001 , B81C2203/032 , B82Y40/00 , Y10T428/24331
摘要： A new process enabling rapid and efficient desktop manufacturing of microfluidic devices fabricated from thermoplastic substrates utilizing the selective irreversible swelling of thermoplastic polymer when exposed to suitable solvent makes it possible to produce micro- or nano-fluidic devices with outstanding bonding and collapse free micro- or nano-structures.
摘要翻译：利用热塑性聚合物的选择性不可逆膨胀暴露于合适的溶剂时，能够快速高效地制造由热塑性基材制成的微流体装置的新方法使得有可能生产具有突出粘结和无崩溃微观或微观结构的微流体或纳米流体装置，纳米结构。

3. 发明授权

US06929730B2 Two dimensional microfluidic gene scanner 失效
标题翻译：二维微流体基因扫描仪
公开(公告)号：US06929730B2
公开(公告)日：2005-08-16
申请号：US10135385
申请日：2002-05-01
申请人： Cheng Sheng Lee , Donald Lad DeVoe
发明人： Cheng Sheng Lee , Donald Lad DeVoe
IPC分类号： B01L3/00 , B01L7/00 , B81B1/00 , G01N27/447 , G01N27/453
CPC分类号： G01N27/44773 , B01L3/5027 , B01L7/54 , G01N27/44791
摘要： One embodiment of the invention relates to a microfluidic apparatus for performing two dimensional biomolecular separations. According to one aspect of the invention, after a first dimension separation in a first microchannel, the sample material is electrokinetically and simultaneously transferred to an array of microchannels in the second dimension (e.g., by changing the electric potentials at the reservoirs connected to the microchannels). Preferably any separation accomplished in the first dimension is completely retained upon transfer to the second dimension. According to another aspect of the invention, the separation in the second dimension is performed using a temperature gradient (e.g., a spatial or temporal temperature gradient). According to one embodiment of the invention, the biomolecular material comprises DNA and the first dimension separation is a sized-based separation and the second dimension separation is a sequence-based separation.
摘要翻译：本发明的一个实施方案涉及用于进行二维生物分子分离的微流体装置。根据本发明的一个方面，在第一微通道中的第一维分离之后，将样品材料电动地同时转移到第二维度中的微通道阵列（例如，通过改变连接到微通道的储存器的电位）。优选地，在第一维度上完成的任何分离在转移到第二维度时完全保留。根据本发明的另一方面，使用温度梯度（例如，空间或时间温度梯度）来执行第二维度中的分离。根据本发明的一个实施方案，生物分子材料包含DNA，第一维分离是基于大小的分离，第二维分离是基于序列的分离。

4. 发明授权

US10434065B2 Microfluidic liposome synthesis, purification and active drug loading 有权
公开(公告)号：US10434065B2
公开(公告)日：2019-10-08
申请号：US15456111
申请日：2017-03-10
申请人： Renee Hood , Donald Lad DeVoe
发明人： Renee Hood , Donald Lad DeVoe
IPC分类号： A61K9/127 , B01J13/08 , B01J19/00 , A61K31/704 , A61K31/00 , A61K31/5415 , A61K31/7048 , A61K31/7068
摘要： Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

5. 发明申请

US20090227755A1 Low Temperature Polymer Bonding Using UV/Ozone Surface Treatment 有权
标题翻译：使用UV /臭氧表面处理的低温聚合物粘合
公开(公告)号：US20090227755A1
公开(公告)日：2009-09-10
申请号：US12399178
申请日：2009-03-06
申请人： Donald Lad DeVoe , Chia-Wen Tsao
发明人： Donald Lad DeVoe , Chia-Wen Tsao
IPC分类号： C08F120/10 , C08F210/00 , B32B37/00
CPC分类号： C08F120/10 , B32B38/0008 , B32B2309/02 , B32B2310/0831 , B32B2310/14 , Y10T428/31504
摘要： The present invention relates to a method for bonding two surfaces to one another. The invention particularly pertains to the use of such method in which one of the surfaces is a polymeric plastic (and more preferably a polymeric thermoplastic (especially poly-(methyl methacrylate) (“PMMA”) or cyclic olefin copolymer (“COC”)). More particularly, the invention relates to treating at least one of the contacting surfaces with UV in the presence of oxygen to thereby generate ozone (O3) and atomic oxygen under conditions of temperature below that of the glass transition temperature of the polymeric plastic. The UV/O3-mediated bonding results in high bond strength and zero-deformation method. This bonding method can be applied to micro/nano-scale polymer devices, and particularly to microfluidic devices, for a low cost, high throughput, high yield advantage.
摘要翻译：本发明涉及一种将两个表面彼此粘合的方法。本发明特别涉及使用这样的方法，其中一个表面是聚合塑料（更优选聚合物热塑性材料（特别是聚甲基丙烯酸甲酯）（“PMMA”）或环烯烃共聚物（“COC”））更具体地说，本发明涉及在氧气存在下用UV处理至少一个接触表面，从而在温度低于聚合物塑料的玻璃化转变温度的条件下产生臭氧（O3）和原子氧。 UV / O3介导的粘合导致高粘结强度和零变形方法，这种粘合方法可以应用于微/纳米级聚合物装置，特别是微流体装置，用于低成本，高产量，高产量优点。

6. 发明授权

US06664126B1 Process for fabrication of 3-dimensional micromechanisms 失效
标题翻译： 3维微机械制造工艺
公开(公告)号：US06664126B1
公开(公告)日：2003-12-16
申请号：US10069616
申请日：2002-02-27
申请人： Donald Lad Devoe , Lung-Wen Tsai
发明人： Donald Lad Devoe , Lung-Wen Tsai
IPC分类号： H01L2100
CPC分类号： H01L21/00 , B81C99/002 , B81C2201/019 , Y10S977/889
摘要： This invention provides a fabrication process for manufacturing of truly 3-dimensional micromechanisms which takes advantages of SOI (silicon-on-insulator) wafers each of which is processed to create a respective structural element of the 3-dimensional micromechanisms by DRIE (deep reactive ion etching) of the wafer and thermal oxidation of the trenches opened during the DRIE etching. The wafers are sequentially bonded into a multistack structure from which the 3-D micromechanism. is released by XeF2 etching. Thermally grown SiO2 is used as structural material for the 3-D micromechanism.
摘要翻译：本发明提供了一种用于制造真正的三维微机械的制造方法，其利用SOI（绝缘体上硅）晶片的优点，每个硅晶片被处理以通过DRIE（深反应离子）产生三维微机械的相应结构元件蚀刻）和在DRIE蚀刻期间打开的沟槽的热氧化。晶片顺序地结合到多层结构中，由此可以获得三维微机构。由XeF2蚀刻释放。热成长的SiO2用作3-D微机械的结构材料。

7. 发明申请

US20150115488A1 Microfluidic Liposome Synthesis, Purification and Active Drug Loading 有权
标题翻译：微流体脂质体合成，纯化和活性药物加载
公开(公告)号：US20150115488A1
公开(公告)日：2015-04-30
申请号：US14524797
申请日：2014-10-27
申请人： Renee Hood , Donald Lad DeVoe
发明人： Renee Hood , Donald Lad DeVoe
IPC分类号： A61K9/127 , A61K31/704
CPC分类号： A61K9/1277 , A61K9/1278 , A61K31/00 , A61K31/5415 , A61K31/704 , A61K31/7048 , A61K31/7068 , B01J13/08 , B01J19/0093 , B01J2219/0086 , B01J2219/00894
摘要： Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.
摘要翻译：提供微流体方法和系统用于脂质体的连续流动合成和活性加载，其包括配置成形成脂质体群体的脂质体形成区域和脂质体形成区域下游的微透析区域并且构造成形成用于活性药物负载的跨膜梯度的脂质体。还提供用于高通量生产脂质体的微流体方法和系统，其具有高纵横比微通道。

8. 发明授权

US08293061B2 Low temperature polymer bonding using UV/ozone surface treatment 有权
标题翻译：使用UV /臭氧表面处理的低温聚合物粘合
公开(公告)号：US08293061B2
公开(公告)日：2012-10-23
申请号：US12399178
申请日：2009-03-06
申请人： Donald Lad DeVoe , Chia-Wen Tsao
发明人： Donald Lad DeVoe , Chia-Wen Tsao
IPC分类号： C08J3/28 , B29C65/14 , B29C65/00 , B32B37/06 , B32B37/00
CPC分类号： C08F120/10 , B32B38/0008 , B32B2309/02 , B32B2310/0831 , B32B2310/14 , Y10T428/31504
摘要： The present invention relates to a method for bonding two surfaces to one another. The invention particularly pertains to the use of such method in which one of the surfaces is a polymeric plastic (and more preferably a polymeric thermoplastic (especially poly-(methyl methacrylate) (“PMMA”) or cyclic olefin copolymer (“COC”)). More particularly, the invention relates to treating at least one of the contacting surfaces with UV in the presence of oxygen to thereby generate ozone (O3) and atomic oxygen under conditions of temperature below that of the glass transition temperature of the polymeric plastic. The UV/O3-mediated bonding results in high bond strength and zero-deformation method. This bonding method can be applied to micro/nano-scale polymer devices, and particularly to microfluidic devices, for a low cost, high throughput, high yield advantage.
摘要翻译：本发明涉及一种将两个表面彼此粘合的方法。本发明特别涉及使用这样的方法，其中一个表面是聚合物塑料（更优选聚合物热塑性材料（特别是聚甲基丙烯酸甲酯）（PMMA）或环烯烃共聚物（COC）），更具体地说，本发明涉及在氧气存在下用UV处理至少一个接触表面，从而在温度低于聚合物塑料的玻璃化转变温度的条件下产生臭氧（O3）和原子氧，UV / O3- 介导的粘合导致高粘结强度和零变形方法。这种粘合方法可以应用于微/纳米级聚合物装置，特别是微流体装置，用于低成本，高产量，高产率优点。

9. 发明授权

US09592198B2 Microfluidic liposome synthesis, purification and active drug loading 有权
标题翻译：微流体脂质体合成，纯化和活性药物加载
公开(公告)号：US09592198B2
公开(公告)日：2017-03-14
申请号：US14524797
申请日：2014-10-27
申请人： Renee Hood , Donald Lad DeVoe
发明人： Renee Hood , Donald Lad DeVoe
IPC分类号： A61K9/127 , A61K31/704 , A61K31/00
CPC分类号： A61K9/1277 , A61K9/1278 , A61K31/00 , A61K31/5415 , A61K31/704 , A61K31/7048 , A61K31/7068 , B01J13/08 , B01J19/0093 , B01J2219/0086 , B01J2219/00894
摘要： Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.
摘要翻译：提供微流体方法和系统用于脂质体的连续流动合成和活性加载，其包括配置成形成脂质体群体的脂质体形成区域和脂质体形成区域下游的微透析区域并且构造成形成用于活性药物负载的跨膜梯度的脂质体。还提供用于高通量生产脂质体的微流体方法和系统，其具有高纵横比微通道。

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