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1. 发明授权

US07655641B2 Sulfonamide derivatives as PPAR modulators 失效
标题翻译：磺酰胺衍生物作为PPAR调节剂
公开(公告)号：US07655641B2
公开(公告)日：2010-02-02
申请号：US10542579
申请日：2004-02-10
申请人： Scott Eugene Conner , Lynn Stacy Gossett , Jonathan Edward Green , Winton Dennis Jones, Jr. , Nathan Bryan Mantlo , Donald Paul Matthews , Daniel Ray Mayhugh , Daryl Lynn Smith , Jennifer Ann Vance , Xiaodong Wang , Alan M Warshawsky , Leonard Larry Winneroski, Jr. , Yanping Xu , Guoxin Zhu
发明人： Scott Eugene Conner , Lynn Stacy Gossett , Jonathan Edward Green , Winton Dennis Jones, Jr. , Nathan Bryan Mantlo , Donald Paul Matthews , Daniel Ray Mayhugh , Daryl Lynn Smith , Jennifer Ann Vance , Xiaodong Wang , Alan M Warshawsky , Leonard Larry Winneroski, Jr. , Yanping Xu , Guoxin Zhu
IPC分类号： A61K31/66 , A61K31/38 , C07D409/12 , C07D209/04
CPC分类号： C07D207/08 , A61K31/00 , A61K45/06 , C07C311/13 , C07C311/17 , C07C311/19 , C07C311/29 , C07C317/14 , C07C323/49 , C07C323/52 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/48 , C07D213/64 , C07D213/71 , C07D213/74 , C07D215/36 , C07D231/12 , C07D231/18 , C07D263/32 , C07D271/12 , C07D277/36 , C07D307/79 , C07D307/82 , C07D319/18 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/12 , C07D413/04 , A61K2300/00
摘要： The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，溶剂合物，水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，例如综合征X型 II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X综合症和心血管疾病有关的其他疾病。

2. 发明授权

US07595339B2 CB1 modulator compounds 失效
标题翻译： CB1调节剂化合物
公开(公告)号：US07595339B2
公开(公告)日：2009-09-29
申请号：US11840417
申请日：2007-08-17
申请人： Jennifer Rebecca Allen , Albert Kudzovi Amegadzie , Kevin Matthew Gardinier , George Stuart Gregory , Stephen Andrew Hitchcock , Paul J. Hoogestraat , Winton Dennis Jones, Jr. , Daryl Lynn Smith
发明人： Jennifer Rebecca Allen , Albert Kudzovi Amegadzie , Kevin Matthew Gardinier , George Stuart Gregory , Stephen Andrew Hitchcock , Paul J. Hoogestraat , Winton Dennis Jones, Jr. , Daryl Lynn Smith
IPC分类号： A61K31/40
CPC分类号： C07D209/10 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/40 , C07D209/42 , C07D209/96 , C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D417/04 , C07D471/04 , C07D471/10 , C07D491/10
摘要： Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.
摘要翻译：公开了结构式（I）的新型化合物。作为大麻素-1（CB1）受体的调节剂，这些化合物可用于治疗，预防和抑制由CB1受体介导的疾病。因此，本发明的化合物可用于治疗，预防和抑制精神病，记忆缺陷，认知障碍，偏头痛，神经病，神经炎症性疾病（例如，多发性硬化症，吉兰巴利综合症和炎性后遗症病毒性脑炎），脑血管意外，头部创伤，焦虑症，压力，癫痫，帕金森病和精神分裂症。这些化合物也可用于治疗药物滥用障碍，特别是鸦片剂，酒精和尼古丁。所述化合物还可用于治疗与过量食物摄入和与其相关的并发症相关的肥胖或进食障碍。

3. 外观设计

USD593400S1 Caster 有权
公开(公告)号：USD593400S1
公开(公告)日：2009-06-02
申请号：US29307405
申请日：2008-04-18
申请人： Dennis Jones , Patrick Peck
设计人： Dennis Jones , Patrick Peck

4. 发明申请

US20090118560A1 Nuclear waste removal system and method using wet oxidation 有权
标题翻译：核废物清除系统和湿法氧化法
公开(公告)号：US20090118560A1
公开(公告)日：2009-05-07
申请号：US11982640
申请日：2007-11-02
申请人： Sidney Dennis Jones, III , Ray Beatty , John Remark , Wesley Hudson
发明人： Sidney Dennis Jones, III , Ray Beatty , John Remark , Wesley Hudson
IPC分类号： G21F9/06 , G21C1/00
CPC分类号： G21F9/06
摘要： Methods for removing nuclear waste from a component are provided. In one embodiment, the method includes the steps of supplying oxalic acid to the nuclear waste on the component to form an oxalic acid/waste solution, feeding the oxalic acid/waste solution from the component, feeding an oxidant to the oxalic acid/waste solution to form carbon-dioxide, water and a precipitate, and separating the precipitate from the water. A system for removing nuclear waste is also provided.
摘要翻译：提供了从组件中去除核废料的方法。在一个实施方案中，该方法包括以下步骤：将草酸向组分上的核废料提供以形成草酸/废溶液，从组分中喂出草酸/废溶液，将氧化剂进料到草酸/废溶液形成二氧化碳，水和沉淀物，并将沉淀物与水分离。还提供了一个消除核废料的系统。

5. 发明申请

US20070009742A1 Corrosion and alkali-resistant compositions and methods for using the same 有权
公开(公告)号：US20070009742A1
公开(公告)日：2007-01-11
申请号：US11521823
申请日：2006-09-15
申请人： Michael Pawlik , Dennis Jones , Ralph Gray , Richard Nugent , Yves Disert , Laurent Deronne
发明人： Michael Pawlik , Dennis Jones , Ralph Gray , Richard Nugent , Yves Disert , Laurent Deronne
IPC分类号： B32B27/38 , B32B15/092 , B32B15/08 , B32B37/00
CPC分类号： C09D5/08 , C08G59/1488 , C08G59/4071 , C09D163/00 , Y10T428/265 , Y10T428/31511 , Y10T428/31515 , Y10T428/31522 , Y10T428/31529 , Y10T428/31678 , C08L2666/16 , C08L2666/40
摘要： A corrosion resistant, alkali resistant coating composition is disclosed. The composition comprises a binder comprising a reaction product of an epoxy-containing material and a phosphorus-containing material together with a curing agent. Aminoplasts, especially melamine-based aminoplasts, are particularly suitable curing agents. A source of silicon can optionally be included. The compositions also provide excellent adhesion and can be used with or without a weldable primer. The compositions are applied to and cured on a metal substrate.

6. 发明申请

US20060035010A1 Confectionery product made of protein and carbohydrate materials present in a relative weight ratio higher than 1 失效
标题翻译：由蛋白质和碳水化合物材料制成的糖果产品以相对重量比高于1存在
公开(公告)号：US20060035010A1
公开(公告)日：2006-02-16
申请号：US11199203
申请日：2005-08-09
申请人： Dennis Jones
发明人： Dennis Jones
IPC分类号： A23G3/00
CPC分类号： A23G3/0021 , Y10S426/81
摘要： The invention provides a confectionery bar comprising a proteinaceous material and a carbohydrate material in a relative weight ratio higher than 1 (from 1:0 to about 1:0.999). The bar produced is very palatable and chewy and has good organolepetic properties. It may be coated (enrobed) or not as desired. The product of the invention provides a meal replacement for very low calorie diets, diet supplement or protein supplement, and may optionally comprise a carbohydrate material of low digestibility or indigestible nature.
摘要翻译：本发明提供一种糖果条，其包含相对重量比高于1（从1:0至约1:0.999）的蛋白质材料和碳水化合物材料。生产的酒吧非常可口，耐嚼，具有良好的有机物性。它可以根据需要被涂覆（被包裹）或不被涂覆。本发明的产品为非常低热量的饮食，饮食补充剂或蛋白质补充剂提供膳食替代物，并且可以任选地包含低消化性或难消化性质的碳水化合物材料。

7. 发明申请

US20050150057A1 Methods of treating and cleaning fibers, carpet yarns and carpets 有权
标题翻译：处理和清洁纤维，地毯纱和地毯的方法
公开(公告)号：US20050150057A1
公开(公告)日：2005-07-14
申请号：US11007840
申请日：2004-12-08
申请人： Dennis Jones
发明人： Dennis Jones
IPC分类号： A47G27/02 , D06L1/00 , D06L1/12 , D06M10/00 , D06M11/00 , D06M11/20 , D06M11/83 , D06M13/152 , D06M13/207 , D06M13/238 , D06M13/432 , D06M13/513 , D06M15/233 , D06M15/248 , D06M15/256 , D06M15/263 , D06M15/277 , D06M15/41
CPC分类号： D06M13/238 , D06M11/20 , D06M13/207 , D06M13/513 , D06M15/248 , D06M15/263 , D06M15/277 , D06M15/412
摘要： Methods of enhancing stain resistance of fibers, carpet yarns and carpets are disclosed. Treating compositions used to enhance the stain resistance of fibers, carpet yarns and carpets are also disclosed.
摘要翻译：公开了提高纤维，地毯纱和地毯的抗污性的方法。还公开了用于增强纤维，地毯纱和地毯的抗污性的处理组合物。

8. 发明授权

US06713516B2 Sulphonamide derivatives 失效
公开(公告)号：US06713516B2
公开(公告)日：2004-03-30
申请号：US10318483
申请日：2002-12-12
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.

9. 发明授权

US06299929B1 Confectionery product made of protein and carbohydrate materials present in a relative weight ratio higher than 1 失效
标题翻译：由蛋白质和碳水化合物材料制成的糖果产品以相对重量比高于1存在
公开(公告)号：US06299929B1
公开(公告)日：2001-10-09
申请号：US09639851
申请日：2000-08-16
申请人： Dennis Jones
发明人： Dennis Jones
IPC分类号： A23J100
CPC分类号： A23G3/44 , A23G3/46 , A23J3/00 , Y10S426/80 , Y10S426/801 , Y10S426/81
摘要： A confectionery bar made up of a proteinaceous material and a carbohydrate material in a relative weight ratio higher than 1 and low in calorie content. The bar is made from (A) a proteinaceous material having a water absorption property of less than 2.5 grams of water per gram of protein at pH 5.5, and that is capable of emulsification with (B) a carbohydrate material that is digestible or indigestible. The bar is produced by cold extrusion. The proteinaceous material and the carbohydrate material are both present in a protein to carbohydrate ratio higher than 1. The proteinaceous material has a filler protein and a binding protein. The bar produced is very palatable, easy to masticate and has good organoleptic properties. It may be coated or not as desired.
摘要翻译：由蛋白质材料和碳水化合物材料组成的糖果条，其重量比高于1且卡路里含量低。该条由（A）在pH5.5下每克蛋白质具有小于2.5克水的吸水性的蛋白质材料制成，并且能够与（B）可消化或不消化的碳水化合物材料乳化。该棒通过冷挤压生产。蛋白质材料和碳水化合物材料都以高于1的蛋白质与碳水化合物比率存在。蛋白质材料具有填充蛋白和结合蛋白。生产的酒吧非常可口，容易咀嚼，具有良好的感官特性。它可以根据需要被涂覆或不被涂覆。

10. 发明授权

US06224873B1 Regulation of appetite, body weight and athletic function with materials derived from citrus varieties 失效
标题翻译：调节柑橘品种的食欲，体重和运动功能
公开(公告)号：US06224873B1
公开(公告)日：2001-05-01
申请号：US09142197
申请日：1998-08-31
申请人： Dennis Jones
发明人： Dennis Jones
IPC分类号： A61K3578
CPC分类号： A61K31/24 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/16 , A61K36/75 , A61K36/752 , Y10S514/909 , A61K2300/00
摘要： Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
摘要翻译：衍生自柑橘植物的材料可以口服给人以产生或维持体重减轻以及改善人的身体表现并增加人的瘦肌肉质量。柑橘材料包括植物通常被认为是废弃物或不可食用的部分，例如叶子，果皮和未成熟的未成熟果实。该物质含有至少一种生物碱，由生物碱组成，该组由昔萘福林，麦角碱，章鱼胺，酪胺和N-甲基酪胺组成（1）。两种品种，柑橘和柑橘柑橘，特别有用。这些材料可以以其天然形式或作为提取物施用，并且可以以各种方式施用，包括胶囊和片剂。柑橘材料也可以用作茶。对于体重减轻和体重控制，材料可以与热量限制同时施用或在不存在热量限制的情况下进行。也可以施用这些材料以与高蛋白质饮食以及运动程序同时增加肌肉质量。

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