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    • 8. 发明授权
    • Caphalosporin compounds having at position-7 an .alpha.-etherified
hydroxyiminoarylacetamido group
    • 在位置-7处具有α-乙酰化羟基亚氨基芳基乙酰胺基的咖啡糊精化合物
    • US4208517A
    • 1980-06-17
    • US855080
    • 1977-11-28
    • Michael W. FoxtonGordon I. GregoryDavid M. Rogers
    • Michael W. FoxtonGordon I. GregoryDavid M. Rogers
    • C07D307/54C07D501/32C07D501/34A61K31/545
    • C07D307/54
    • Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b, which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together wth the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; R.sup.c and R.sup.d, which may be the same or different, each represents a hydrogen atom or a substituting group e.g. an alkyl group or substituted alkyl group; or R.sup.c and R.sup.d together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring which contains 5-7 ring members and which may contain additional hetero atoms, and may be substituted by lower alkyl; R.sup.e represents hydrogen or C.sub.1-4 alkyl; m and n are each 0 or 1 such that the sum of m and n is 0 or 1 and Y is selected from various oxygen and sulphur nucleophiles] and non-toxic derivatives thereof.
    • 通式(I)的抗生素化合物[其中R是苯基,噻吩基或呋喃基; R a和R b可以相同或不同,各自选自氢,C 1-4烷基,C 2-4烯基,C 3-7环烷基,苯基,萘基,噻吩基,呋喃基,羧基,C 2-5烷氧基羰基和氰基, 或者R a和R b一起与它们所连接的碳原子一起形成C 3-7亚环烷基或亚环烯基; R c和R d可以相同或不同,表示氢原子或取代基团。 烷基或取代的烷基; 或Rc和Rd与它们所连接的氮原子一起形成饱和或不饱和的杂环,其含有5-7个环成员并且可以含有另外的杂原子,并且可以被低级烷基取代; Re表示氢或C 1-4烷基; m和n各自为0或1,使得m和n的和为0或1,Y选自各种氧和硫亲核试剂]及其无毒的衍生物。